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Protein
Submitted name:

SIX homeobox 2

Gene

SIX2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi124 – 183HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationImported

Names & Taxonomyi

Protein namesi
Submitted name:
SIX homeobox 2Imported
Gene namesi
Name:SIX2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35788

PTM / Processingi

Proteomic databases

PeptideAtlasiQ8TBA2
PRIDEiQ8TBA2

Expressioni

Gene expression databases

GenevisibleiQ8TBA2 HS

Structurei

3D structure databases

ProteinModelPortaliQ8TBA2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini122 – 182HomeoboxInterPro annotationAdd BLAST61

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili174 – 194Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, HomeoboxPROSITE-ProRule annotationImported

Phylogenomic databases

eggNOGiKOG0775 Eukaryota
ENOG410XRPB LUCA
HOVERGENiHBG003609
KOiK19472

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR031701 SIX1_SD
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF16878 SIX1_SD, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TBA2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSMLPTFGFT QEQVACVCEV LQQGGNIERL GRFLWSLPAC EHLHKNESVL
60 70 80 90 100
KAKAVVAFHR GNFRELYKIL ESHQFSPHNH AKLQQLWLKA HYIEAEKLRG
110 120 130 140 150
RPLGAVGKYR VRRKFPLPRS IWDGEETSYC FKEKSRSVLR EWYAHNPYPS
160 170 180 190 200
PREKRELTEA TGLTTTQVSN WFKNRRQRDR AAEAKERENN ENSNSNSHNP
210 220 230 240 250
LNGSGKSVLG SSEDEKTPSG TPDHSSSSPA LLLSPPPPGL PSLHSLGHPP
260 270 280 290
GPSAVPVPVP GGGGADPLQH HHGLQDSILN PMSANLVDLG S
Length:291
Mass (Da):32,316
Last modified:June 1, 2002 - v1
Checksum:iC288C3D3305B2AC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024033 mRNA Translation: AAH24033.1
RefSeqiNP_058628.3, NM_016932.4
UniGeneiHs.101937

Genome annotation databases

GeneIDi10736
KEGGihsa:10736

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024033 mRNA Translation: AAH24033.1
RefSeqiNP_058628.3, NM_016932.4
UniGeneiHs.101937

3D structure databases

ProteinModelPortaliQ8TBA2
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiQ8TBA2
PRIDEiQ8TBA2

Protocols and materials databases

DNASUi10736
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi10736
KEGGihsa:10736

Organism-specific databases

CTDi10736
PharmGKBiPA35788

Phylogenomic databases

eggNOGiKOG0775 Eukaryota
ENOG410XRPB LUCA
HOVERGENiHBG003609
KOiK19472

Miscellaneous databases

ChiTaRSiSIX2 human
GenomeRNAii10736

Gene expression databases

GenevisibleiQ8TBA2 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR031701 SIX1_SD
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF16878 SIX1_SD, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ8TBA2_HUMAN
AccessioniPrimary (citable) accession number: Q8TBA2
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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