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Protein

Pumilio homolog 2

Gene

PUM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:22345517). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). May regulate DCUN1D3 mRNA levels (PubMed:25349211). May support proliferation and self-renewal of stem cells. Binds specifically to miRNA MIR199A precursor, with PUM1, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233).8 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • miRNA binding Source: UniProtKB
  • mRNA 3'-UTR binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processTranslation regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8951664 Neddylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pumilio homolog 2
Short name:
Pumilio-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PUM2
Synonyms:KIAA0235, PUMH2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000055917.15

Human Gene Nomenclature Database

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HGNCi
HGNC:14958 PUM2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
607205 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TB72

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23369

Open Targets

More...
OpenTargetsi
ENSG00000055917

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34043

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PUM2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
41688714

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000759191 – 1066Pumilio homolog 2Add BLAST1066

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei67PhosphoserineCombined sources1
Modified residuei82PhosphoserineCombined sources1
Modified residuei102PhosphoserineBy similarity1
Modified residuei136PhosphoserineCombined sources1
Modified residuei178PhosphoserineCombined sources1
Modified residuei182PhosphoserineCombined sources1
Modified residuei184PhosphothreonineCombined sources1
Modified residuei396PhosphothreonineCombined sources1
Modified residuei587PhosphoserineCombined sources1
Modified residuei592PhosphoserineBy similarity1
Modified residuei674Omega-N-methylarginineBy similarity1
Modified residuei684PhosphoserineBy similarity1
Modified residuei700PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TB72

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8TB72

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8TB72

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8TB72

PeptideAtlas

More...
PeptideAtlasi
Q8TB72

PRoteomics IDEntifications database

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PRIDEi
Q8TB72

ProteomicsDB human proteome resource

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ProteomicsDBi
73970
73971 [Q8TB72-2]
73972 [Q8TB72-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TB72

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q8TB72

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in male germ cells of adult testis (at protein level). Highly expressed in testis and ovary. Predominantly expressed in stem cells and germ cells. Expressed at lower level in brain, heart, kidney, liver, muscle, placenta, intestine and stomach Expressed in cerebellum, corpus callosum, caudate nucleus, hippocampus, medulla oblongata and putamen. Expressed in all fetal tissues tested.3 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated in keratinocytes upon UVB irradiation.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000055917 Expressed in 235 organ(s), highest expression level in forebrain

CleanEx database of gene expression profiles

More...
CleanExi
HS_PUM2

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8TB72 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8TB72 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA030316
HPA049670

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; homodimerizes in vitro. Interacts with DAZ, DAZL and NANOS1 via its pumilio repeats. Interacts with NANOS3 (By similarity). Interacts with SNAPIN. Recruits the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Interacts with DDX20. In case of viral infection, interacts with DHX58 (PubMed:25340845). Interacts with TRIM71 (via NHL repeats) in an RNA-dependent manner (PubMed:23125361).By similarity8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116949, 43 interactors

Protein interaction database and analysis system

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IntActi
Q8TB72, 9 interactors

Molecular INTeraction database

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MINTi
Q8TB72

STRING: functional protein association networks

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STRINGi
9606.ENSP00000338173

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11066
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3Q0QX-ray2.00A706-1056[»]
3Q0RX-ray2.00A706-1056[»]
3Q0SX-ray2.00A706-1056[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q8TB72

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8TB72

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8TB72

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini706 – 1048PUM-HDPROSITE-ProRule annotationAdd BLAST343
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati726 – 761Pumilio 1PROSITE-ProRule annotation1 PublicationAdd BLAST36
Repeati762 – 797Pumilio 2PROSITE-ProRule annotation1 PublicationAdd BLAST36
Repeati798 – 835Pumilio 3PROSITE-ProRule annotation1 PublicationAdd BLAST38
Repeati836 – 871Pumilio 4PROSITE-ProRule annotation1 PublicationAdd BLAST36
Repeati872 – 907Pumilio 5PROSITE-ProRule annotation1 PublicationAdd BLAST36
Repeati908 – 943Pumilio 6PROSITE-ProRule annotation1 PublicationAdd BLAST36
Repeati944 – 979Pumilio 7PROSITE-ProRule annotation1 PublicationAdd BLAST36
Repeati983 – 1022Pumilio 8PROSITE-ProRule annotation1 PublicationAdd BLAST40

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 260Interaction with SNAPIN1 PublicationAdd BLAST260
Regioni741 – 745Adenine-nucleotide binding in RNA targetBy similarity5
Regioni777 – 781Uracil-nucleotide binding in RNA targetBy similarity5
Regioni813 – 817Adenine-nucleotide binding in RNA targetBy similarity5
Regioni851 – 855Non-specific-nucleotide binding in RNA targetBy similarity5
Regioni887 – 891Adenine-nucleotide binding in RNA targetBy similarity5
Regioni923 – 927Uracil-nucleotide binding in RNA targetBy similarity5
Regioni959 – 963Guanine-nucleotide binding in RNA targetBy similarity5
Regioni1002 – 1006Uracil-nucleotide binding in RNA targetBy similarity5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi278 – 488Ala-richAdd BLAST211
Compositional biasi359 – 405Gln-richAdd BLAST47
Compositional biasi520 – 687Ser-richAdd BLAST168

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The pumilio repeats mediate the association with RNA by packing together to form a right-handed superhelix that approximates a half donut. RNA-binding occurs on the concave side of the surface (PubMed:21397187). PUM2 is composed of 8 pumilio repeats of 36 residues; each repeat binds a single nucleotide in its RNA target. Residues at positions 12 and 16 of the pumilio repeat bind each RNA base via hydrogen bonding or van der Waals contacts with the Watson-Crick edge, while the amino acid at position 13 makes a stacking interaction. The recognition of RNA by pumilio repeats is base specific: cysteine and glutamine at position 12 and 16, respectively, bind adenine; asparagine and glutamine bind uracil; and serine and glutamate bind guanine.By similarity1 Publication

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1488 Eukaryota
COG5099 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157575

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000238461

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG049462

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8TB72

KEGG Orthology (KO)

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KOi
K17943

Identification of Orthologs from Complete Genome Data

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OMAi
LPAKKFW

Database of Orthologous Groups

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OrthoDBi
207351at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8TB72

TreeFam database of animal gene trees

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TreeFami
TF318160

Family and domain databases

Conserved Domains Database

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CDDi
cd07920 Pumilio, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR033133 PUM-HD
IPR033712 Pumilio_RNA-bd
IPR001313 Pumilio_RNA-bd_rpt

Pfam protein domain database

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Pfami
View protein in Pfam
PF00806 PUF, 8 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00025 Pumilio, 8 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48371 SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50302 PUM, 8 hits
PS50303 PUM_HD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TB72-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNHDFQALAL ESRGMGELLP TKKFWEPDDS TKDGQKGIFL GDDEWRETAW
60 70 80 90 100
GASHHSMSQP IMVQRRSGQG FHGNSEVNAI LSPRSESGGL GVSMVEYVLS
110 120 130 140 150
SSPADKLDSR FRKGNFGTRD AETDGPEKGD QKGKASPFEE DQNRDLKQGD
160 170 180 190 200
DDDSKINGRG LPNGMDADCK DFNRTPGSRQ ASPTEVVERL GPNTNPSEGL
210 220 230 240 250
GPLPNPTANK PLVEEFSNPE TQNLDAMEQV GLESLQFDYP GNQVPMDSSG
260 270 280 290 300
ATVGLFDYNS QQQLFQRTNA LTVQQLTAAQ QQQYALAAAQ QPHIAGVFSA
310 320 330 340 350
GLAPAAFVPN PYIISAAPPG TDPYTAAGLA AAATLAGPAV VPPQYYGVPW
360 370 380 390 400
GVYPANLFQQ QAAAAANNTA SQQAASQAQP GQQQVLRAGA GQRPLTPNQG
410 420 430 440 450
QQGQQAESLA AAAAANPTLA FGQGLATGMP GYQVLAPTAY YDQTGALVVG
460 470 480 490 500
PGARTGLGAP VRLMAPTPVL ISSAAAQAAA AAAAGGTASS LTGSTNGLFR
510 520 530 540 550
PIGTQPPQQQ QQQPSTNLQS NSFYGSSSLT NSSQSSSLFS HGPGQPGSTS
560 570 580 590 600
LGFGSGNSLG AAIGSALSGF GSSVGSSASS SATRRESLST SSDLYKRSSS
610 620 630 640 650
SLAPIGQPFY NSLGFSSSPS PIGMPLPSQT PGHSLTPPPS LSSHGSSSSL
660 670 680 690 700
HLGGLTNGSG RYISAAPGAE AKYRSASSTS SLFSSSSQLF PPSRLRYNRS
710 720 730 740 750
DIMPSGRSRL LEDFRNNRFP NLQLRDLIGH IVEFSQDQHG SRFIQQKLER
760 770 780 790 800
ATPAERQMVF NEILQAAYQL MTDVFGNYVI QKFFEFGSLD QKLALATRIR
810 820 830 840 850
GHVLPLALQM YGCRVIQKAL ESISSDQQVI SEMVKELDGH VLKCVKDQNG
860 870 880 890 900
NHVVQKCIEC VQPQSLQFII DAFKGQVFVL STHPYGCRVI QRILEHCTAE
910 920 930 940 950
QTLPILEELH QHTEQLVQDQ YGNYVIQHVL EHGRPEDKSK IVSEIRGKVL
960 970 980 990 1000
ALSQHKFASN VVEKCVTHAS RAERALLIDE VCCQNDGPHS ALYTMMKDQY
1010 1020 1030 1040 1050
ANYVVQKMID MAEPAQRKII MHKIRPHITT LRKYTYGKHI LAKLEKYYLK
1060
NSPDLGPIGG PPNGML
Length:1,066
Mass (Da):114,216
Last modified:February 2, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCF6F9D7998CD5D9E
GO
Isoform 2 (identifier: Q8TB72-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     574-652: Missing.

Show »
Length:987
Mass (Da):106,215
Checksum:i99F119F5E3CFCCCF
GO
Isoform 3 (identifier: Q8TB72-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     829-830: Missing.

Show »
Length:1,064
Mass (Da):114,003
Checksum:i99BC2A2711306F18
GO
Isoform 4 (identifier: Q8TB72-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.
     829-830: Missing.

Note: No experimental confirmation available.
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Length:1,008
Mass (Da):107,646
Checksum:i44DA760E31DD5F62
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MR59A0A0A0MR59_HUMAN
Pumilio homolog 2
PUM2
929Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DG68A0A0C4DG68_HUMAN
Pumilio homolog 2
PUM2
876Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JW01C9JW01_HUMAN
Pumilio homolog 2
PUM2
293Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WD57F8WD57_HUMAN
Pumilio homolog 2
PUM2
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JE24C9JE24_HUMAN
Pumilio homolog 2
PUM2
34Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z366F2Z366_HUMAN
Pumilio homolog 2
PUM2
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_057100367N → S. Corresponds to variant dbSNP:rs34032508Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0537051 – 56Missing in isoform 4. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_009319574 – 652Missing in isoform 2. 1 PublicationAdd BLAST79
Alternative sequenceiVSP_009320829 – 830Missing in isoform 3 and isoform 4. 4 Publications2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF315591 mRNA Translation: AAG31806.1
D87078 mRNA Translation: BAA19665.3
AK093847 mRNA Translation: BAG52772.1
AK304198 mRNA Translation: BAG65078.1
AC007041 Genomic DNA Translation: AAY15026.1
CH471053 Genomic DNA Translation: EAX00821.1
CH471053 Genomic DNA Translation: EAX00823.1
BC024218 mRNA Translation: AAH24218.2
BC112046 mRNA Translation: AAI12047.1
BC112048 mRNA Translation: AAI12049.1
AF272350 mRNA Translation: AAL36981.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS1698.1 [Q8TB72-3]
CCDS74487.1 [Q8TB72-4]

NCBI Reference Sequences

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RefSeqi
NP_001269681.1, NM_001282752.1 [Q8TB72-4]
NP_056132.1, NM_015317.2 [Q8TB72-3]
XP_005262664.1, XM_005262607.1 [Q8TB72-1]
XP_005262666.1, XM_005262609.1 [Q8TB72-2]
XP_006712036.1, XM_006711973.1
XP_006712037.1, XM_006711974.2 [Q8TB72-1]
XP_011531021.1, XM_011532719.1 [Q8TB72-1]
XP_011531022.1, XM_011532720.2 [Q8TB72-1]
XP_011531023.1, XM_011532721.2 [Q8TB72-1]
XP_016859190.1, XM_017003701.1
XP_016859191.1, XM_017003702.1
XP_016859196.1, XM_017003707.1
XP_016859197.1, XM_017003708.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.467824

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000338086; ENSP00000338173; ENSG00000055917 [Q8TB72-3]
ENST00000361078; ENSP00000354370; ENSG00000055917 [Q8TB72-4]
ENST00000403432; ENSP00000385992; ENSG00000055917 [Q8TB72-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23369

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23369

UCSC genome browser

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UCSCi
uc002rdt.2 human [Q8TB72-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF315591 mRNA Translation: AAG31806.1
D87078 mRNA Translation: BAA19665.3
AK093847 mRNA Translation: BAG52772.1
AK304198 mRNA Translation: BAG65078.1
AC007041 Genomic DNA Translation: AAY15026.1
CH471053 Genomic DNA Translation: EAX00821.1
CH471053 Genomic DNA Translation: EAX00823.1
BC024218 mRNA Translation: AAH24218.2
BC112046 mRNA Translation: AAI12047.1
BC112048 mRNA Translation: AAI12049.1
AF272350 mRNA Translation: AAL36981.1
CCDSiCCDS1698.1 [Q8TB72-3]
CCDS74487.1 [Q8TB72-4]
RefSeqiNP_001269681.1, NM_001282752.1 [Q8TB72-4]
NP_056132.1, NM_015317.2 [Q8TB72-3]
XP_005262664.1, XM_005262607.1 [Q8TB72-1]
XP_005262666.1, XM_005262609.1 [Q8TB72-2]
XP_006712036.1, XM_006711973.1
XP_006712037.1, XM_006711974.2 [Q8TB72-1]
XP_011531021.1, XM_011532719.1 [Q8TB72-1]
XP_011531022.1, XM_011532720.2 [Q8TB72-1]
XP_011531023.1, XM_011532721.2 [Q8TB72-1]
XP_016859190.1, XM_017003701.1
XP_016859191.1, XM_017003702.1
XP_016859196.1, XM_017003707.1
XP_016859197.1, XM_017003708.1
UniGeneiHs.467824

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3Q0QX-ray2.00A706-1056[»]
3Q0RX-ray2.00A706-1056[»]
3Q0SX-ray2.00A706-1056[»]
ProteinModelPortaliQ8TB72
SMRiQ8TB72
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116949, 43 interactors
IntActiQ8TB72, 9 interactors
MINTiQ8TB72
STRINGi9606.ENSP00000338173

PTM databases

iPTMnetiQ8TB72
PhosphoSitePlusiQ8TB72

Polymorphism and mutation databases

BioMutaiPUM2
DMDMi41688714

Proteomic databases

EPDiQ8TB72
jPOSTiQ8TB72
MaxQBiQ8TB72
PaxDbiQ8TB72
PeptideAtlasiQ8TB72
PRIDEiQ8TB72
ProteomicsDBi73970
73971 [Q8TB72-2]
73972 [Q8TB72-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338086; ENSP00000338173; ENSG00000055917 [Q8TB72-3]
ENST00000361078; ENSP00000354370; ENSG00000055917 [Q8TB72-4]
ENST00000403432; ENSP00000385992; ENSG00000055917 [Q8TB72-3]
GeneIDi23369
KEGGihsa:23369
UCSCiuc002rdt.2 human [Q8TB72-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23369
DisGeNETi23369
EuPathDBiHostDB:ENSG00000055917.15

GeneCards: human genes, protein and diseases

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GeneCardsi
PUM2
HGNCiHGNC:14958 PUM2
HPAiHPA030316
HPA049670
MIMi607205 gene
neXtProtiNX_Q8TB72
OpenTargetsiENSG00000055917
PharmGKBiPA34043

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1488 Eukaryota
COG5099 LUCA
GeneTreeiENSGT00940000157575
HOGENOMiHOG000238461
HOVERGENiHBG049462
InParanoidiQ8TB72
KOiK17943
OMAiLPAKKFW
OrthoDBi207351at2759
PhylomeDBiQ8TB72
TreeFamiTF318160

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PUM2 human
EvolutionaryTraceiQ8TB72

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PUM2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23369

Protein Ontology

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PROi
PR:Q8TB72

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000055917 Expressed in 235 organ(s), highest expression level in forebrain
CleanExiHS_PUM2
ExpressionAtlasiQ8TB72 baseline and differential
GenevisibleiQ8TB72 HS

Family and domain databases

CDDicd07920 Pumilio, 1 hit
Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR033133 PUM-HD
IPR033712 Pumilio_RNA-bd
IPR001313 Pumilio_RNA-bd_rpt
PfamiView protein in Pfam
PF00806 PUF, 8 hits
SMARTiView protein in SMART
SM00025 Pumilio, 8 hits
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50302 PUM, 8 hits
PS50303 PUM_HD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPUM2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TB72
Secondary accession number(s): B3KSL0
, B4E2B6, D6W527, O00234, Q53TV7, Q8WY43, Q9HAN2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: February 2, 2004
Last modified: January 16, 2019
This is version 156 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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