UniProtKB - Q8TB69 (ZN519_HUMAN)
Protein
Zinc finger protein 519
Gene
ZNF519
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 181 – 203 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 292 – 314 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 320 – 342 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 348 – 370 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 376 – 398 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 404 – 426 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 432 – 454 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 460 – 482 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 488 – 510 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 516 – 538 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8TB69 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 519 |
Gene namesi | Name:ZNF519 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000175322.11 |
HGNCi | HGNC:30574, ZNF519 |
neXtProti | NX_Q8TB69 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000175322 |
PharmGKBi | PA134863605 |
Miscellaneous databases
Pharosi | Q8TB69, Tdark |
Polymorphism and mutation databases
BioMutai | ZNF519 |
DMDMi | 296453045 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047637 | 1 – 540 | Zinc finger protein 519Add BLAST | 540 |
Proteomic databases
EPDi | Q8TB69 |
jPOSTi | Q8TB69 |
MassIVEi | Q8TB69 |
PaxDbi | Q8TB69 |
PeptideAtlasi | Q8TB69 |
PRIDEi | Q8TB69 |
ProteomicsDBi | 73968 |
PTM databases
iPTMneti | Q8TB69 |
PhosphoSitePlusi | Q8TB69 |
Expressioni
Gene expression databases
Bgeei | ENSG00000175322, Expressed in cerebellar vermis and 155 other tissues |
ExpressionAtlasi | Q8TB69, baseline and differential |
Organism-specific databases
HPAi | ENSG00000175322, Tissue enhanced (brain) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 127827, 1 interactor |
STRINGi | 9606.ENSP00000464872 |
Miscellaneous databases
RNActi | Q8TB69, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 78 | KRABPROSITE-ProRule annotationAdd BLAST | 75 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 181 – 203 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 292 – 314 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 320 – 342 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 348 – 370 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 376 – 398 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 404 – 426 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 432 – 454 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 460 – 482 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 488 – 510 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 516 – 538 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000153165 |
HOGENOMi | CLU_002678_44_17_1 |
InParanoidi | Q8TB69 |
OMAi | FNRGSYL |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8TB69 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 9 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 10 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 9 hits PS50157, ZINC_FINGER_C2H2_2, 10 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q8TB69-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MELLTFRDVA IEFSPEEWKC LDPAQQNLYR DVMLENYRNL VSLAVYSYYN
60 70 80 90 100
QGILPEQGIQ DSFKKATLGR YGSCGLENIC LWKNWESIGE GEGQKECYNL
110 120 130 140 150
CSQYLTTSHN KHLTVKGDKE YRIFQKKPQF LSAAPTEPCI PMNKYQHKFL
160 170 180 190 200
KSVFCNKNQI NFNHDSNISK HHSTHFLENY YNCNECEKVF YQSSKLIFPE
210 220 230 240 250
NIHIQKKPYN SNECGETSDP FSKLTQHQRI YIGESSQRCN KKCIIVFSQS
260 270 280 290 300
HLKGHKIINT GEKSVKYKER GKAFTRGLHL GHQKIHTGEK PYKCKKCDKA
310 320 330 340 350
FNKSSHLAQH QRIHTGEKPF KCKECGKAFN RGSYLTQHQR IHTGERAFKC
360 370 380 390 400
EECGKAFNRG SYLTQHQRIH TGEKPFRCKE CGKAFNRSSY VTQHQRMHTG
410 420 430 440 450
EKPFKCKECG KAFNRASHLT QHQRIHTGEK HFKCKECGKA FNRGSHLTRH
460 470 480 490 500
QRIHTGEKSF KCEECGKAFI WGSHLTQHQR VHTGEKFFKC KECGKAFTRS
510 520 530 540
SHLTQHQRIH TGEKPFKCKE CGKAFNRRST LTQHQIIHTR
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7EJG2 | K7EJG2_HUMAN | Zinc finger protein 519 | ZNF519 | 80 | Annotation score: | ||
K7ERG6 | K7ERG6_HUMAN | Zinc finger protein 519 | ZNF519 | 50 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 167 | N → D in AAH24227 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052854 | 18 | W → R. Corresponds to variant dbSNP:rs16941623Ensembl. | 1 | |
Natural variantiVAR_052855 | 89 | G → S. Corresponds to variant dbSNP:rs10221432Ensembl. | 1 | |
Natural variantiVAR_052856 | 206 | K → E1 PublicationCorresponds to variant dbSNP:rs2159940Ensembl. | 1 | |
Natural variantiVAR_052857 | 229 | R → I. Corresponds to variant dbSNP:rs8094412Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC006557 Genomic DNA No translation available. BC024227 mRNA Translation: AAH24227.1 |
CCDSi | CCDS32797.1 |
RefSeqi | NP_660330.2, NM_145287.3 XP_016881051.1, XM_017025562.1 XP_016881052.1, XM_017025563.1 XP_016881053.1, XM_017025564.1 XP_016881054.1, XM_017025565.1 |
Genome annotation databases
Ensembli | ENST00000590202; ENSP00000464872; ENSG00000175322 |
GeneIDi | 162655 |
KEGGi | hsa:162655 |
UCSCi | uc002kst.3, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC006557 Genomic DNA No translation available. BC024227 mRNA Translation: AAH24227.1 |
CCDSi | CCDS32797.1 |
RefSeqi | NP_660330.2, NM_145287.3 XP_016881051.1, XM_017025562.1 XP_016881052.1, XM_017025563.1 XP_016881053.1, XM_017025564.1 XP_016881054.1, XM_017025565.1 |
3D structure databases
SMRi | Q8TB69 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127827, 1 interactor |
STRINGi | 9606.ENSP00000464872 |
PTM databases
iPTMneti | Q8TB69 |
PhosphoSitePlusi | Q8TB69 |
Polymorphism and mutation databases
BioMutai | ZNF519 |
DMDMi | 296453045 |
Proteomic databases
EPDi | Q8TB69 |
jPOSTi | Q8TB69 |
MassIVEi | Q8TB69 |
PaxDbi | Q8TB69 |
PeptideAtlasi | Q8TB69 |
PRIDEi | Q8TB69 |
ProteomicsDBi | 73968 |
Protocols and materials databases
Antibodypediai | 21965, 27 antibodies |
DNASUi | 162655 |
Genome annotation databases
Ensembli | ENST00000590202; ENSP00000464872; ENSG00000175322 |
GeneIDi | 162655 |
KEGGi | hsa:162655 |
UCSCi | uc002kst.3, human |
Organism-specific databases
CTDi | 162655 |
EuPathDBi | HostDB:ENSG00000175322.11 |
GeneCardsi | ZNF519 |
HGNCi | HGNC:30574, ZNF519 |
HPAi | ENSG00000175322, Tissue enhanced (brain) |
neXtProti | NX_Q8TB69 |
OpenTargetsi | ENSG00000175322 |
PharmGKBi | PA134863605 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000153165 |
HOGENOMi | CLU_002678_44_17_1 |
InParanoidi | Q8TB69 |
OMAi | FNRGSYL |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8TB69 |
Enzyme and pathway databases
PathwayCommonsi | Q8TB69 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 162655, 25 hits in 844 CRISPR screens |
GenomeRNAii | 162655 |
Pharosi | Q8TB69, Tdark |
PROi | PR:Q8TB69 |
RNActi | Q8TB69, protein |
Gene expression databases
Bgeei | ENSG00000175322, Expressed in cerebellar vermis and 155 other tissues |
ExpressionAtlasi | Q8TB69, baseline and differential |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 9 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 10 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 9 hits PS50157, ZINC_FINGER_C2H2_2, 10 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN519_HUMAN | |
Accessioni | Q8TB69Primary (citable) accession number: Q8TB69 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 24, 2004 |
Last sequence update: | May 18, 2010 | |
Last modified: | December 2, 2020 | |
This is version 146 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations