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Entry version 151 (18 Sep 2019)
Sequence version 1 (01 Jun 2002)
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Protein

Adenosine 3'-phospho 5'-phosphosulfate transporter 1

Gene

SLC35B2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. May indirectly participate in activation of the NF-kappa-B and MAPK pathways.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.8 µM for PAPS1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Biological processTransport

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-174362 Transport and synthesis of PAPS
    R-HSA-727802 Transport of nucleotide sugars

    Protein family/group databases

    Transport Classification Database

    More...
    TCDBi
    2.A.7.11.3 the drug/metabolite transporter (dmt) superfamily

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Adenosine 3'-phospho 5'-phosphosulfate transporter 1
    Alternative name(s):
    PAPS transporter 1
    Putative MAPK-activating protein PM15
    Putative NF-kappa-B-activating protein 48
    Solute carrier family 35 member B2
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:SLC35B2
    Synonyms:PAPST1
    ORF Names:PSEC0149
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:16872 SLC35B2

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    610788 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q8TB61

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
    Transmembranei40 – 60HelicalSequence analysisAdd BLAST21
    Transmembranei109 – 129HelicalSequence analysisAdd BLAST21
    Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
    Transmembranei238 – 258HelicalSequence analysisAdd BLAST21
    Transmembranei265 – 285HelicalSequence analysisAdd BLAST21
    Transmembranei299 – 319HelicalSequence analysisAdd BLAST21
    Transmembranei353 – 373HelicalSequence analysisAdd BLAST21
    Transmembranei387 – 407HelicalSequence analysisAdd BLAST21

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    347734

    Open Targets

    More...
    OpenTargetsi
    ENSG00000157593

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA134927864

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    SLC35B2

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    67461576

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002133741 – 432Adenosine 3'-phospho 5'-phosphosulfate transporter 1Add BLAST432

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei427PhosphoserineCombined sources1

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q8TB61

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q8TB61

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q8TB61

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q8TB61

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q8TB61

    PeptideAtlas

    More...
    PeptideAtlasi
    Q8TB61

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q8TB61

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    27631
    3871
    73963 [Q8TB61-1]
    73964 [Q8TB61-2]
    73965 [Q8TB61-3]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q8TB61

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q8TB61

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    Q8TB61

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Highly expressed in the placenta, pancreas, mammary gland and skeletal muscle. Weakly or not expressed in colon, heart and prostate.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000157593 Expressed in 94 organ(s), highest expression level in C1 segment of cervical spinal cord

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q8TB61 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q8TB61 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA029638

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    131484, 37 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q8TB61, 35 interactors

    Molecular INTeraction database

    More...
    MINTi
    Q8TB61

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000377401

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    Q8TB61

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1581 Eukaryota
    COG0697 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000157927

    KEGG Orthology (KO)

    More...
    KOi
    K15276

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    QMMCGVN

    Database of Orthologous Groups

    More...
    OrthoDBi
    820879at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q8TB61

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF105926

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR013657 UAA

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF08449 UAA, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q8TB61-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MDARWWAVVV LAAFPSLGAG GETPEAPPES WTQLWFFRFV VNAAGYASFM
    60 70 80 90 100
    VPGYLLVQYF RRKNYLETGR GLCFPLVKAC VFGNEPKASD EVPLAPRTEA
    110 120 130 140 150
    AETTPMWQAL KLLFCATGLQ VSYLTWGVLQ ERVMTRSYGA TATSPGERFT
    160 170 180 190 200
    DSQFLVLMNR VLALIVAGLS CVLCKQPRHG APMYRYSFAS LSNVLSSWCQ
    210 220 230 240 250
    YEALKFVSFP TQVLAKASKV IPVMLMGKLV SRRSYEHWEY LTATLISIGV
    260 270 280 290 300
    SMFLLSSGPE PRSSPATTLS GLILLAGYIA FDSFTSNWQD ALFAYKMSSV
    310 320 330 340 350
    QMMFGVNFFS CLFTVGSLLE QGALLEGTRF MGRHSEFAAH ALLLSICSAC
    360 370 380 390 400
    GQLFIFYTIG QFGAAVFTII MTLRQAFAIL LSCLLYGHTV TVVGGLGVAV
    410 420 430
    VFAALLLRVY ARGRLKQRGK KAVPVESPVQ KV
    Length:432
    Mass (Da):47,515
    Last modified:June 1, 2002 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7E4E9E87231072FB
    GO
    Isoform 2 (identifier: Q8TB61-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         272-311: Missing.

    Show »
    Length:392
    Mass (Da):42,967
    Checksum:i9B7BACC7F3F670DD
    GO
    Isoform 3 (identifier: Q8TB61-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-49: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:383
    Mass (Da):42,128
    Checksum:i49A2443E2C37F263
    GO
    Isoform 4 (identifier: Q8TB61-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-27: MDARWWAVVVLAAFPSLGAGGETPEAP → MLLAMPALWYLATSWCSTSGGRTTWRP
         28-120: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:339
    Mass (Da):37,235
    Checksum:iBD3CA2176C9D31C8
    GO
    Isoform 5 (identifier: Q8TB61-5) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-133: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:299
    Mass (Da):32,664
    Checksum:iC2DB27B67918AABB
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A0A0MS46A0A0A0MS46_HUMAN
    Adenosine 3'-phospho 5'-phosphosulf...
    SLC35B2
    94Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti214L → P in BAD96748 (Ref. 8) Curated1
    Sequence conflicti336E → G in BAC11631 (PubMed:16303743).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_022657342L → V1 PublicationCorresponds to variant dbSNP:rs3734707Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0574361 – 133Missing in isoform 5. 1 PublicationAdd BLAST133
    Alternative sequenceiVSP_0269491 – 49Missing in isoform 3. 1 PublicationAdd BLAST49
    Alternative sequenceiVSP_0546961 – 27MDARW…TPEAP → MLLAMPALWYLATSWCSTSG GRTTWRP in isoform 4. 1 PublicationAdd BLAST27
    Alternative sequenceiVSP_05469728 – 120Missing in isoform 4. 1 PublicationAdd BLAST93
    Alternative sequenceiVSP_014084272 – 311Missing in isoform 2. 1 PublicationAdd BLAST40

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AB106538 mRNA Translation: BAC79117.1
    AY491520 mRNA Translation: AAS79661.1
    AB097021 mRNA Translation: BAC77374.1
    AB097039 mRNA Translation: BAC77392.1
    AK293251 mRNA Translation: BAG56783.1
    AK293344 mRNA Translation: BAG56860.1
    AK075456 mRNA Translation: BAC11631.1
    AL139392 Genomic DNA No translation available.
    BC016839 mRNA Translation: AAH16839.1
    BC024288 mRNA Translation: AAH24288.1
    AK223028 mRNA Translation: BAD96748.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS34462.1 [Q8TB61-1]
    CCDS69127.1 [Q8TB61-4]
    CCDS75462.1 [Q8TB61-5]
    CCDS75463.1 [Q8TB61-3]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001273438.1, NM_001286509.1
    NP_001273439.1, NM_001286510.1
    NP_001273440.1, NM_001286511.1 [Q8TB61-3]
    NP_001273441.1, NM_001286512.1 [Q8TB61-3]
    NP_001273442.1, NM_001286513.1 [Q8TB61-4]
    NP_001273446.1, NM_001286517.1
    NP_001273448.1, NM_001286519.1 [Q8TB61-5]
    NP_001273449.1, NM_001286520.1 [Q8TB61-5]
    NP_835361.1, NM_178148.3 [Q8TB61-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000393812; ENSP00000377401; ENSG00000157593 [Q8TB61-1]
    ENST00000537814; ENSP00000440340; ENSG00000157593 [Q8TB61-5]
    ENST00000538577; ENSP00000443845; ENSG00000157593 [Q8TB61-4]
    ENST00000615337; ENSP00000480681; ENSG00000157593 [Q8TB61-3]
    ENST00000619636; ENSP00000483181; ENSG00000157593 [Q8TB61-3]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    347734

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:347734

    UCSC genome browser

    More...
    UCSCi
    uc003oxd.5 human [Q8TB61-1]
    uc011dvu.4 human

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB106538 mRNA Translation: BAC79117.1
    AY491520 mRNA Translation: AAS79661.1
    AB097021 mRNA Translation: BAC77374.1
    AB097039 mRNA Translation: BAC77392.1
    AK293251 mRNA Translation: BAG56783.1
    AK293344 mRNA Translation: BAG56860.1
    AK075456 mRNA Translation: BAC11631.1
    AL139392 Genomic DNA No translation available.
    BC016839 mRNA Translation: AAH16839.1
    BC024288 mRNA Translation: AAH24288.1
    AK223028 mRNA Translation: BAD96748.1
    CCDSiCCDS34462.1 [Q8TB61-1]
    CCDS69127.1 [Q8TB61-4]
    CCDS75462.1 [Q8TB61-5]
    CCDS75463.1 [Q8TB61-3]
    RefSeqiNP_001273438.1, NM_001286509.1
    NP_001273439.1, NM_001286510.1
    NP_001273440.1, NM_001286511.1 [Q8TB61-3]
    NP_001273441.1, NM_001286512.1 [Q8TB61-3]
    NP_001273442.1, NM_001286513.1 [Q8TB61-4]
    NP_001273446.1, NM_001286517.1
    NP_001273448.1, NM_001286519.1 [Q8TB61-5]
    NP_001273449.1, NM_001286520.1 [Q8TB61-5]
    NP_835361.1, NM_178148.3 [Q8TB61-1]

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    BioGridi131484, 37 interactors
    IntActiQ8TB61, 35 interactors
    MINTiQ8TB61
    STRINGi9606.ENSP00000377401

    Chemistry databases

    BindingDBiQ8TB61

    Protein family/group databases

    TCDBi2.A.7.11.3 the drug/metabolite transporter (dmt) superfamily

    PTM databases

    iPTMnetiQ8TB61
    PhosphoSitePlusiQ8TB61
    SwissPalmiQ8TB61

    Polymorphism and mutation databases

    BioMutaiSLC35B2
    DMDMi67461576

    Proteomic databases

    EPDiQ8TB61
    jPOSTiQ8TB61
    MassIVEiQ8TB61
    MaxQBiQ8TB61
    PaxDbiQ8TB61
    PeptideAtlasiQ8TB61
    PRIDEiQ8TB61
    ProteomicsDBi27631
    3871
    73963 [Q8TB61-1]
    73964 [Q8TB61-2]
    73965 [Q8TB61-3]

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    347734
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000393812; ENSP00000377401; ENSG00000157593 [Q8TB61-1]
    ENST00000537814; ENSP00000440340; ENSG00000157593 [Q8TB61-5]
    ENST00000538577; ENSP00000443845; ENSG00000157593 [Q8TB61-4]
    ENST00000615337; ENSP00000480681; ENSG00000157593 [Q8TB61-3]
    ENST00000619636; ENSP00000483181; ENSG00000157593 [Q8TB61-3]
    GeneIDi347734
    KEGGihsa:347734
    UCSCiuc003oxd.5 human [Q8TB61-1]
    uc011dvu.4 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    347734
    DisGeNETi347734

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    SLC35B2
    HGNCiHGNC:16872 SLC35B2
    HPAiHPA029638
    MIMi610788 gene
    neXtProtiNX_Q8TB61
    OpenTargetsiENSG00000157593
    PharmGKBiPA134927864

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1581 Eukaryota
    COG0697 LUCA
    GeneTreeiENSGT00940000157927
    KOiK15276
    OMAiQMMCGVN
    OrthoDBi820879at2759
    PhylomeDBiQ8TB61
    TreeFamiTF105926

    Enzyme and pathway databases

    ReactomeiR-HSA-174362 Transport and synthesis of PAPS
    R-HSA-727802 Transport of nucleotide sugars

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    SLC35B2 human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    SLC35B2

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    347734

    Pharos

    More...
    Pharosi
    Q8TB61

    Protein Ontology

    More...
    PROi
    PR:Q8TB61

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000157593 Expressed in 94 organ(s), highest expression level in C1 segment of cervical spinal cord
    ExpressionAtlasiQ8TB61 baseline and differential
    GenevisibleiQ8TB61 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR013657 UAA
    PfamiView protein in Pfam
    PF08449 UAA, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS35B2_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TB61
    Secondary accession number(s): B4DDM2
    , B4DDU9, F5H7Y9, Q2VY06, Q53GA3, Q5T9W1, Q5T9W2, Q7Z2G3, Q8NBK6, Q96AR6
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: June 1, 2002
    Last modified: September 18, 2019
    This is version 151 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    UniProt is an ELIXIR core data resource
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