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Entry version 163 (02 Jun 2021)
Sequence version 3 (31 Aug 2004)
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Protein

F-box only protein 30

Gene

FBXO30

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri48 – 109TRAF-typePROSITE-ProRule annotationAdd BLAST62

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8TB52

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8951664, Neddylation
R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q8TB52

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
F-box only protein 30
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FBXO30
Synonyms:FBX30
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15600, FBXO30

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609101, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TB52

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000118496.4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
84085

Open Targets

More...
OpenTargetsi
ENSG00000118496

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28041

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TB52, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FBXO30

Domain mapping of disease mutations (DMDM)

More...
DMDMi
51704325

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001199181 – 745F-box only protein 30Add BLAST745

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Auto-ubiquitinated.By similarity
May be neddylated. Neddylation may be required for E3 ligase activity (By similarity).By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TB52

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TB52

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8TB52

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8TB52

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TB52

PeptideAtlas

More...
PeptideAtlasi
Q8TB52

PRoteomics IDEntifications database

More...
PRIDEi
Q8TB52

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
73962

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TB52

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TB52

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000118496, Expressed in secondary oocyte and 222 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TB52, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000118496, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex.

Interacts with SKP1, CUL1 and RBX1/ROC1 (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
123879, 29 interactors

Protein interaction database and analysis system

More...
IntActi
Q8TB52, 18 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000237281

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8TB52, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1745
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TB52

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8TB52

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini610 – 658F-boxPROSITE-ProRule annotationAdd BLAST49

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni211 – 231DisorderedSequence analysisAdd BLAST21
Regioni305 – 324DisorderedSequence analysisAdd BLAST20

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri48 – 109TRAF-typePROSITE-ProRule annotationAdd BLAST62

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QTD9, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183204

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_013357_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TB52

Identification of Orthologs from Complete Genome Data

More...
OMAi
MVILLWE

Database of Orthologous Groups

More...
OrthoDBi
1009974at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TB52

TreeFam database of animal gene trees

More...
TreeFami
TF343227

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit
3.30.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036047, F-box-like_dom_sf
IPR001810, F-box_dom
IPR031890, Fbxo30/Fbxo40
IPR008974, TRAF-like
IPR013083, Znf_RING/FYVE/PHD
IPR001293, Znf_TRAF
IPR043013, Znf_TRAF_N

The PANTHER Classification System

More...
PANTHERi
PTHR15933, PTHR15933, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15966, F-box_4, 1 hit
PF15965, zf-TRAF_2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49599, SSF49599, 1 hit
SSF81383, SSF81383, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50181, FBOX, 1 hit
PS50145, ZF_TRAF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8TB52-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEELQHSHC VNCVSRRCMT RPEPGISCDL IGCPLVCGAV FHSCKADEHR
60 70 80 90 100
LLCPFERVPC LNSDFGCPFT MARNKVAEHL EMCPASVVCC TMEWNRWPVS
110 120 130 140 150
YADRKSYENL SRDVDEVAQL DMALALQDQR MLLESLKVAT MMSKATDKVS
160 170 180 190 200
KPREQISVKS SVPEIPHANG LVSVDEESYG ALYQATVETT RSLAAALDIL
210 220 230 240 250
NTATRDIGML NTSVPNDMDE QQNARESLED QNLKDQDHLY EEEIGAVGGI
260 270 280 290 300
DYNDTNQNAQ SEQNGSSDLL CDLNTSSYDT SALCNGFPLE NICTQVIDQN
310 320 330 340 350
QNLHGDSKQS NLTNGDCVAS SDGTSKPSSS LAVAAQLREI IPSSALPNGT
360 370 380 390 400
VQHILMPDDE GEGELCWKKV DLGDVKNVDV LSFSHAPSFN FLSNSCWSKP
410 420 430 440 450
KEDKAVDTSD LEVAEDPMGL QGIDLITAAL LFCLGDSPGG RGISDSRMAD
460 470 480 490 500
IYHIDVGTQT FSLPSAILAT STMVGEIASA SACDHANPQL SNPSPFQTLG
510 520 530 540 550
LDLVLECVAR YQPKQRSMFT FVCGQLFRRK EFSSHFKNVH GDIHAGLNGW
560 570 580 590 600
MEQRCPLAYY GCTYSQRRFC PSIQGAKIIH DRHLRSFGVQ PCVSTVLVEP
610 620 630 640 650
ARNCVLGLHN DHLSSLPFEV LQHIAGFLDG FSLCQLSCVS KLMRDVCGSL
660 670 680 690 700
LQSRGMVILQ WGKRKYPEGN SSWQIKEKVW RFSTAFCSVN EWKFADILSM
710 720 730 740
ADHLKKCSYN VVEKREEAIP LPCMCVTREL TKEGRSLRSV LKPVL
Length:745
Mass (Da):82,304
Last modified:August 31, 2004 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC2C010CF28568F9F
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK30299 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence AAK30299 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0360728S → C in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_024443375V → M1 PublicationCorresponds to variant dbSNP:rs9373475Ensembl.1
Natural variantiVAR_049044382S → C. Corresponds to variant dbSNP:rs17075385Ensembl.1
Natural variantiVAR_020410583H → Q1 PublicationCorresponds to variant dbSNP:rs3811102Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL356599 Genomic DNA No translation available.
BC024326 mRNA Translation: AAH24326.3
AF248640 mRNA Translation: AAK30299.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5208.1

NCBI Reference Sequences

More...
RefSeqi
NP_001335021.1, NM_001348092.1
NP_115521.3, NM_032145.4
XP_011534479.1, XM_011536177.2
XP_016866842.1, XM_017011353.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000237281; ENSP00000237281; ENSG00000118496

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84085

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84085

UCSC genome browser

More...
UCSCi
uc003qla.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356599 Genomic DNA No translation available.
BC024326 mRNA Translation: AAH24326.3
AF248640 mRNA Translation: AAK30299.1 Different initiation.
CCDSiCCDS5208.1
RefSeqiNP_001335021.1, NM_001348092.1
NP_115521.3, NM_032145.4
XP_011534479.1, XM_011536177.2
XP_016866842.1, XM_017011353.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YRENMR-A1-87[»]
SMRiQ8TB52
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi123879, 29 interactors
IntActiQ8TB52, 18 interactors
STRINGi9606.ENSP00000237281

PTM databases

iPTMnetiQ8TB52
PhosphoSitePlusiQ8TB52

Genetic variation databases

BioMutaiFBXO30
DMDMi51704325

Proteomic databases

EPDiQ8TB52
jPOSTiQ8TB52
MassIVEiQ8TB52
MaxQBiQ8TB52
PaxDbiQ8TB52
PeptideAtlasiQ8TB52
PRIDEiQ8TB52
ProteomicsDBi73962

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
33222, 45 antibodies

The DNASU plasmid repository

More...
DNASUi
84085

Genome annotation databases

EnsembliENST00000237281; ENSP00000237281; ENSG00000118496
GeneIDi84085
KEGGihsa:84085
UCSCiuc003qla.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84085
DisGeNETi84085

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FBXO30
HGNCiHGNC:15600, FBXO30
HPAiENSG00000118496, Low tissue specificity
MIMi609101, gene
neXtProtiNX_Q8TB52
OpenTargetsiENSG00000118496
PharmGKBiPA28041
VEuPathDBiHostDB:ENSG00000118496.4

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QTD9, Eukaryota
GeneTreeiENSGT00950000183204
HOGENOMiCLU_013357_0_0_1
InParanoidiQ8TB52
OMAiMVILLWE
OrthoDBi1009974at2759
PhylomeDBiQ8TB52
TreeFamiTF343227

Enzyme and pathway databases

UniPathwayiUPA00143
PathwayCommonsiQ8TB52
ReactomeiR-HSA-8951664, Neddylation
R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation
SIGNORiQ8TB52

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
84085, 4 hits in 996 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FBXO30, human
EvolutionaryTraceiQ8TB52

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84085
PharosiQ8TB52, Tdark

Protein Ontology

More...
PROi
PR:Q8TB52
RNActiQ8TB52, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000118496, Expressed in secondary oocyte and 222 other tissues
GenevisibleiQ8TB52, HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
3.30.40.150, 1 hit
InterProiView protein in InterPro
IPR036047, F-box-like_dom_sf
IPR001810, F-box_dom
IPR031890, Fbxo30/Fbxo40
IPR008974, TRAF-like
IPR013083, Znf_RING/FYVE/PHD
IPR001293, Znf_TRAF
IPR043013, Znf_TRAF_N
PANTHERiPTHR15933, PTHR15933, 1 hit
PfamiView protein in Pfam
PF15966, F-box_4, 1 hit
PF15965, zf-TRAF_2, 1 hit
SUPFAMiSSF49599, SSF49599, 1 hit
SSF81383, SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181, FBOX, 1 hit
PS50145, ZF_TRAF, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFBX30_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TB52
Secondary accession number(s): Q9BXZ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: August 31, 2004
Last modified: June 2, 2021
This is version 163 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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