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Entry version 135 (13 Feb 2019)
Sequence version 2 (07 Jul 2009)
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Protein

DEP domain-containing mTOR-interacting protein

Gene

DEPTOR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q8TB45

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DEP domain-containing mTOR-interacting protein
Alternative name(s):
DEP domain-containing protein 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DEPTOR
Synonyms:DEPDC6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000155792.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:22953 DEPTOR

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612974 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TB45

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
64798

Open Targets

More...
OpenTargetsi
ENSG00000155792

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134897957

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DEPTOR

Domain mapping of disease mutations (DMDM)

More...
DMDMi
251757257

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002847841 – 409DEP domain-containing mTOR-interacting proteinAdd BLAST409

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei241Phosphothreonine1 Publication1
Modified residuei244PhosphoserineCombined sources1 Publication1
Modified residuei258Phosphoserine1 Publication1
Modified residuei259Phosphothreonine1 Publication1
Modified residuei263Phosphoserine1 Publication1
Modified residuei265Phosphoserine1 Publication1
Modified residuei280PhosphoserineBy similarity1
Modified residuei282Phosphoserine1 Publication1
Modified residuei283Phosphoserine1 Publication1
Modified residuei287Phosphoserine1 Publication1
Modified residuei293Phosphoserine1 Publication1
Modified residuei297Phosphoserine1 Publication1
Modified residuei298Phosphoserine1 Publication1
Modified residuei299Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. Phosphorylation weakens interaction with MTOR within mTORC1 and mTORC2.1 Publication
Ubiquitinated; ubiquitination leads to proteasomal degradation.1 Publication

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8TB45

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8TB45

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8TB45

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TB45

PeptideAtlas

More...
PeptideAtlasi
Q8TB45

PRoteomics IDEntifications database

More...
PRIDEi
Q8TB45

ProteomicsDB human proteome resource

More...
ProteomicsDBi
73961

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TB45

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TB45

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is negatively regulated by both mTORC1 and mTORC2 (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000155792 Expressed in 222 organ(s), highest expression level in saliva-secreting gland

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TB45 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB020841
HPA023938
HPA023945
HPA024011

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PROTOR1, RICTOR, MAPKAP1 and DEPTOR. Interacts (via PDZ domain) with MTOR; interacts with MTOR within both mammalian target of rapamycin complexes mTORC1 and mTORC2 (PubMed:19446321). Interacts (via PDZ domain) with MINAR1 (via N-terminus) (PubMed:30080879).2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122304, 24 interactors

Protein interaction database and analysis system

More...
IntActi
Q8TB45, 11 interactors

Molecular INTeraction database

More...
MINTi
Q8TB45

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000286234

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8TB45

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TB45

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 119DEP 1PROSITE-ProRule annotationAdd BLAST84
Domaini145 – 219DEP 2PROSITE-ProRule annotationAdd BLAST75
Domaini330 – 407PDZPROSITE-ProRule annotationAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi222 – 226Poly-Arg5
Compositional biasi235 – 299Ser-richAdd BLAST65

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IKSC Eukaryota
ENOG4110T1J LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00520000055667

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000294178

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG056008

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TB45

KEGG Orthology (KO)

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KOi
K20402

Identification of Orthologs from Complete Genome Data

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OMAi
AHDSPFC

Database of Orthologous Groups

More...
OrthoDBi
1289616at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TB45

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04442 DEP_1_DEP6, 1 hit
cd04441 DEP_2_DEP6, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000591 DEP_dom
IPR037589 DEPTOR
IPR037335 DEPTOR_DEP_1
IPR037336 DEPTOR_DEP_2
IPR001478 PDZ
IPR036034 PDZ_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

The PANTHER Classification System

More...
PANTHERi
PTHR22829:SF18 PTHR22829:SF18, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00610 DEP, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00049 DEP, 2 hits
SM00228 PDZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 2 hits
SSF50156 SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50186 DEP, 2 hits
PS50106 PDZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8TB45-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEEGGSTGSA GSDSSTSGSG GAQQRELERM AEVLVTGEQL RLRLHEEKVI
60 70 80 90 100
KDRRHHLKTY PNCFVAKELI DWLIEHKEAS DRETAIKLMQ KLADRGIIHH
110 120 130 140 150
VCDEHKEFKD VKLFYRFRKD DGTFPLDNEV KAFMRGQRLY EKLMSPENTL
160 170 180 190 200
LQPREEEGVK YERTFMASEF LDWLVQEGEA TTRKEAEQLC HRLMEHGIIQ
210 220 230 240 250
HVSNKHPFVD SNLLYQFRMN FRRRRRLMEL LNEKSPSSQE THDSPFCLRK
260 270 280 290 300
QSHDNRKSTS FMSVSPSKEI KIVSAVRRSS MSSCGSSGYF SSSPTLSSSP
310 320 330 340 350
PVLCNPKSVL KRPVTSEELL TPGAPYARKT FTIVGDAVGW GFVVRGSKPC
360 370 380 390 400
HIQAVDPSGP AAAAGMKVCQ FVVSVNGLNV LHVDYRTVSN LILTGPRTIV

MEVMEELEC
Length:409
Mass (Da):46,294
Last modified:July 7, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAD132F0E9AFFB90C
GO
Isoform 2 (identifier: Q8TB45-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-142: Missing.

Note: No experimental confirmation available.
Show »
Length:308
Mass (Da):34,006
Checksum:i257BE95DD14DE19C
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14723 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti166M → V in BAB14054 (PubMed:14702039).Curated1
Sequence conflicti249R → G in CAB66613 (PubMed:11230166).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031816148N → S. Corresponds to variant dbSNP:rs34057546Ensembl.1
Natural variantiVAR_031817204N → S3 PublicationsCorresponds to variant dbSNP:rs2271900Ensembl.1
Natural variantiVAR_031818389S → N2 PublicationsCorresponds to variant dbSNP:rs4871827Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05468142 – 142Missing in isoform 2. 1 PublicationAdd BLAST101

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL136678 mRNA Translation: CAB66613.1
AK022490 mRNA Translation: BAB14054.1
AK023916 mRNA Translation: BAB14723.1 Different initiation.
AK297822 mRNA Translation: BAG60159.1
AK315175 mRNA Translation: BAG37616.1
AC091563 Genomic DNA No translation available.
AP005717 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW91997.1
BC012040 mRNA Translation: AAH12040.1
BC024746 mRNA Translation: AAH24746.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6331.1 [Q8TB45-1]
CCDS64960.1 [Q8TB45-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001269941.1, NM_001283012.1 [Q8TB45-2]
NP_073620.2, NM_022783.3 [Q8TB45-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.112981

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000286234; ENSP00000286234; ENSG00000155792 [Q8TB45-1]
ENST00000523492; ENSP00000430457; ENSG00000155792 [Q8TB45-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
64798

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:64798

UCSC genome browser

More...
UCSCi
uc003yow.6 human [Q8TB45-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136678 mRNA Translation: CAB66613.1
AK022490 mRNA Translation: BAB14054.1
AK023916 mRNA Translation: BAB14723.1 Different initiation.
AK297822 mRNA Translation: BAG60159.1
AK315175 mRNA Translation: BAG37616.1
AC091563 Genomic DNA No translation available.
AP005717 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW91997.1
BC012040 mRNA Translation: AAH12040.1
BC024746 mRNA Translation: AAH24746.1
CCDSiCCDS6331.1 [Q8TB45-1]
CCDS64960.1 [Q8TB45-2]
RefSeqiNP_001269941.1, NM_001283012.1 [Q8TB45-2]
NP_073620.2, NM_022783.3 [Q8TB45-1]
UniGeneiHs.112981

3D structure databases

ProteinModelPortaliQ8TB45
SMRiQ8TB45
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122304, 24 interactors
IntActiQ8TB45, 11 interactors
MINTiQ8TB45
STRINGi9606.ENSP00000286234

PTM databases

iPTMnetiQ8TB45
PhosphoSitePlusiQ8TB45

Polymorphism and mutation databases

BioMutaiDEPTOR
DMDMi251757257

Proteomic databases

EPDiQ8TB45
jPOSTiQ8TB45
MaxQBiQ8TB45
PaxDbiQ8TB45
PeptideAtlasiQ8TB45
PRIDEiQ8TB45
ProteomicsDBi73961

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
64798
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000286234; ENSP00000286234; ENSG00000155792 [Q8TB45-1]
ENST00000523492; ENSP00000430457; ENSG00000155792 [Q8TB45-2]
GeneIDi64798
KEGGihsa:64798
UCSCiuc003yow.6 human [Q8TB45-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64798
DisGeNETi64798
EuPathDBiHostDB:ENSG00000155792.9

GeneCards: human genes, protein and diseases

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GeneCardsi
DEPTOR

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0017353
HIX0025586
HGNCiHGNC:22953 DEPTOR
HPAiCAB020841
HPA023938
HPA023945
HPA024011
MIMi612974 gene
neXtProtiNX_Q8TB45
OpenTargetsiENSG00000155792
PharmGKBiPA134897957

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IKSC Eukaryota
ENOG4110T1J LUCA
GeneTreeiENSGT00520000055667
HOGENOMiHOG000294178
HOVERGENiHBG056008
InParanoidiQ8TB45
KOiK20402
OMAiAHDSPFC
OrthoDBi1289616at2759
PhylomeDBiQ8TB45

Enzyme and pathway databases

SIGNORiQ8TB45

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
DEPTOR human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
DEPTOR

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
64798

Protein Ontology

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PROi
PR:Q8TB45

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000155792 Expressed in 222 organ(s), highest expression level in saliva-secreting gland
GenevisibleiQ8TB45 HS

Family and domain databases

CDDicd04442 DEP_1_DEP6, 1 hit
cd04441 DEP_2_DEP6, 1 hit
Gene3Di1.10.10.10, 2 hits
InterProiView protein in InterPro
IPR000591 DEP_dom
IPR037589 DEPTOR
IPR037335 DEPTOR_DEP_1
IPR037336 DEPTOR_DEP_2
IPR001478 PDZ
IPR036034 PDZ_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR22829:SF18 PTHR22829:SF18, 1 hit
PfamiView protein in Pfam
PF00610 DEP, 2 hits
SMARTiView protein in SMART
SM00049 DEP, 2 hits
SM00228 PDZ, 1 hit
SUPFAMiSSF46785 SSF46785, 2 hits
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 2 hits
PS50106 PDZ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPTOR_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TB45
Secondary accession number(s): B2RCL9
, B4DN97, E7EV87, Q96EQ1, Q9H0R7, Q9H894, Q9HA07
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: July 7, 2009
Last modified: February 13, 2019
This is version 135 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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