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Protein

DEP domain-containing mTOR-interacting protein

Gene

DEPTOR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes.1 Publication

GO - Biological processi

Enzyme and pathway databases

SIGNORiQ8TB45

Names & Taxonomyi

Protein namesi
Recommended name:
DEP domain-containing mTOR-interacting protein
Alternative name(s):
DEP domain-containing protein 6
Gene namesi
Name:DEPTOR
Synonyms:DEPDC6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000155792.9
HGNCiHGNC:22953 DEPTOR
MIMi612974 gene
neXtProtiNX_Q8TB45

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi64798
OpenTargetsiENSG00000155792
PharmGKBiPA134897957

Polymorphism and mutation databases

BioMutaiDEPTOR
DMDMi251757257

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002847841 – 409DEP domain-containing mTOR-interacting proteinAdd BLAST409

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei241Phosphothreonine1 Publication1
Modified residuei244PhosphoserineCombined sources1 Publication1
Modified residuei258Phosphoserine1 Publication1
Modified residuei259Phosphothreonine1 Publication1
Modified residuei263Phosphoserine1 Publication1
Modified residuei265Phosphoserine1 Publication1
Modified residuei280PhosphoserineBy similarity1
Modified residuei282Phosphoserine1 Publication1
Modified residuei283Phosphoserine1 Publication1
Modified residuei287Phosphoserine1 Publication1
Modified residuei293Phosphoserine1 Publication1
Modified residuei297Phosphoserine1 Publication1
Modified residuei298Phosphoserine1 Publication1
Modified residuei299Phosphoserine1 Publication1

Post-translational modificationi

Phosphorylated. Phosphorylation weakens interaction with MTOR within mTORC1 and mTORC2.1 Publication
Ubiquitinated; ubiquitination leads to proteasomal degradation.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8TB45
MaxQBiQ8TB45
PaxDbiQ8TB45
PeptideAtlasiQ8TB45
PRIDEiQ8TB45
ProteomicsDBi73961

PTM databases

iPTMnetiQ8TB45
PhosphoSitePlusiQ8TB45

Expressioni

Inductioni

Expression is negatively regulated by both mTORC1 and mTORC2 (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000155792 Expressed in 222 organ(s), highest expression level in saliva-secreting gland
CleanExiHS_DEPDC6
GenevisibleiQ8TB45 HS

Organism-specific databases

HPAiCAB020841
HPA023938
HPA023945
HPA024011

Interactioni

Subunit structurei

Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PROTOR1, RICTOR, MAPKAP1 and DEPTOR. Interacts (via PDZ domain) with MTOR; interacts with MTOR within both mammalian target of rapamycin complexes mTORC1 and mTORC2 (PubMed:19446321). Interacts (via PDZ domain) with MINAR1 (via N-terminus) (PubMed:30080879).2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi122304, 23 interactors
IntActiQ8TB45, 11 interactors
MINTiQ8TB45
STRINGi9606.ENSP00000286234

Structurei

3D structure databases

ProteinModelPortaliQ8TB45
SMRiQ8TB45
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 119DEP 1PROSITE-ProRule annotationAdd BLAST84
Domaini145 – 219DEP 2PROSITE-ProRule annotationAdd BLAST75
Domaini330 – 407PDZPROSITE-ProRule annotationAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi222 – 226Poly-Arg5
Compositional biasi235 – 299Ser-richAdd BLAST65

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IKSC Eukaryota
ENOG4110T1J LUCA
GeneTreeiENSGT00520000055667
HOGENOMiHOG000294178
HOVERGENiHBG056008
InParanoidiQ8TB45
KOiK20402
OMAiAHDSPFC
OrthoDBiEOG091G0AB3
PhylomeDBiQ8TB45

Family and domain databases

CDDicd04442 DEP_1_DEP6, 1 hit
cd04441 DEP_2_DEP6, 1 hit
Gene3Di1.10.10.10, 2 hits
InterProiView protein in InterPro
IPR000591 DEP_dom
IPR037589 DEPTOR
IPR037335 DEPTOR_DEP_1
IPR037336 DEPTOR_DEP_2
IPR001478 PDZ
IPR036034 PDZ_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR22829:SF18 PTHR22829:SF18, 1 hit
PfamiView protein in Pfam
PF00610 DEP, 2 hits
SMARTiView protein in SMART
SM00049 DEP, 2 hits
SM00228 PDZ, 1 hit
SUPFAMiSSF46785 SSF46785, 2 hits
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 2 hits
PS50106 PDZ, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8TB45-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEEGGSTGSA GSDSSTSGSG GAQQRELERM AEVLVTGEQL RLRLHEEKVI
60 70 80 90 100
KDRRHHLKTY PNCFVAKELI DWLIEHKEAS DRETAIKLMQ KLADRGIIHH
110 120 130 140 150
VCDEHKEFKD VKLFYRFRKD DGTFPLDNEV KAFMRGQRLY EKLMSPENTL
160 170 180 190 200
LQPREEEGVK YERTFMASEF LDWLVQEGEA TTRKEAEQLC HRLMEHGIIQ
210 220 230 240 250
HVSNKHPFVD SNLLYQFRMN FRRRRRLMEL LNEKSPSSQE THDSPFCLRK
260 270 280 290 300
QSHDNRKSTS FMSVSPSKEI KIVSAVRRSS MSSCGSSGYF SSSPTLSSSP
310 320 330 340 350
PVLCNPKSVL KRPVTSEELL TPGAPYARKT FTIVGDAVGW GFVVRGSKPC
360 370 380 390 400
HIQAVDPSGP AAAAGMKVCQ FVVSVNGLNV LHVDYRTVSN LILTGPRTIV

MEVMEELEC
Length:409
Mass (Da):46,294
Last modified:July 7, 2009 - v2
Checksum:iAD132F0E9AFFB90C
GO
Isoform 2 (identifier: Q8TB45-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-142: Missing.

Note: No experimental confirmation available.
Show »
Length:308
Mass (Da):34,006
Checksum:i257BE95DD14DE19C
GO

Sequence cautioni

The sequence BAB14723 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti166M → V in BAB14054 (PubMed:14702039).Curated1
Sequence conflicti249R → G in CAB66613 (PubMed:11230166).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031816148N → S. Corresponds to variant dbSNP:rs34057546Ensembl.1
Natural variantiVAR_031817204N → S3 PublicationsCorresponds to variant dbSNP:rs2271900Ensembl.1
Natural variantiVAR_031818389S → N2 PublicationsCorresponds to variant dbSNP:rs4871827Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05468142 – 142Missing in isoform 2. 1 PublicationAdd BLAST101

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136678 mRNA Translation: CAB66613.1
AK022490 mRNA Translation: BAB14054.1
AK023916 mRNA Translation: BAB14723.1 Different initiation.
AK297822 mRNA Translation: BAG60159.1
AK315175 mRNA Translation: BAG37616.1
AC091563 Genomic DNA No translation available.
AP005717 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW91997.1
BC012040 mRNA Translation: AAH12040.1
BC024746 mRNA Translation: AAH24746.1
CCDSiCCDS6331.1 [Q8TB45-1]
CCDS64960.1 [Q8TB45-2]
RefSeqiNP_001269941.1, NM_001283012.1 [Q8TB45-2]
NP_073620.2, NM_022783.3 [Q8TB45-1]
UniGeneiHs.112981

Genome annotation databases

EnsembliENST00000286234; ENSP00000286234; ENSG00000155792 [Q8TB45-1]
ENST00000523492; ENSP00000430457; ENSG00000155792 [Q8TB45-2]
GeneIDi64798
KEGGihsa:64798
UCSCiuc003yow.6 human [Q8TB45-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136678 mRNA Translation: CAB66613.1
AK022490 mRNA Translation: BAB14054.1
AK023916 mRNA Translation: BAB14723.1 Different initiation.
AK297822 mRNA Translation: BAG60159.1
AK315175 mRNA Translation: BAG37616.1
AC091563 Genomic DNA No translation available.
AP005717 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW91997.1
BC012040 mRNA Translation: AAH12040.1
BC024746 mRNA Translation: AAH24746.1
CCDSiCCDS6331.1 [Q8TB45-1]
CCDS64960.1 [Q8TB45-2]
RefSeqiNP_001269941.1, NM_001283012.1 [Q8TB45-2]
NP_073620.2, NM_022783.3 [Q8TB45-1]
UniGeneiHs.112981

3D structure databases

ProteinModelPortaliQ8TB45
SMRiQ8TB45
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122304, 23 interactors
IntActiQ8TB45, 11 interactors
MINTiQ8TB45
STRINGi9606.ENSP00000286234

PTM databases

iPTMnetiQ8TB45
PhosphoSitePlusiQ8TB45

Polymorphism and mutation databases

BioMutaiDEPTOR
DMDMi251757257

Proteomic databases

EPDiQ8TB45
MaxQBiQ8TB45
PaxDbiQ8TB45
PeptideAtlasiQ8TB45
PRIDEiQ8TB45
ProteomicsDBi73961

Protocols and materials databases

DNASUi64798
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000286234; ENSP00000286234; ENSG00000155792 [Q8TB45-1]
ENST00000523492; ENSP00000430457; ENSG00000155792 [Q8TB45-2]
GeneIDi64798
KEGGihsa:64798
UCSCiuc003yow.6 human [Q8TB45-1]

Organism-specific databases

CTDi64798
DisGeNETi64798
EuPathDBiHostDB:ENSG00000155792.9
GeneCardsiDEPTOR
H-InvDBiHIX0017353
HIX0025586
HGNCiHGNC:22953 DEPTOR
HPAiCAB020841
HPA023938
HPA023945
HPA024011
MIMi612974 gene
neXtProtiNX_Q8TB45
OpenTargetsiENSG00000155792
PharmGKBiPA134897957
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKSC Eukaryota
ENOG4110T1J LUCA
GeneTreeiENSGT00520000055667
HOGENOMiHOG000294178
HOVERGENiHBG056008
InParanoidiQ8TB45
KOiK20402
OMAiAHDSPFC
OrthoDBiEOG091G0AB3
PhylomeDBiQ8TB45

Enzyme and pathway databases

SIGNORiQ8TB45

Miscellaneous databases

ChiTaRSiDEPTOR human
GeneWikiiDEPTOR
GenomeRNAii64798
PROiPR:Q8TB45
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000155792 Expressed in 222 organ(s), highest expression level in saliva-secreting gland
CleanExiHS_DEPDC6
GenevisibleiQ8TB45 HS

Family and domain databases

CDDicd04442 DEP_1_DEP6, 1 hit
cd04441 DEP_2_DEP6, 1 hit
Gene3Di1.10.10.10, 2 hits
InterProiView protein in InterPro
IPR000591 DEP_dom
IPR037589 DEPTOR
IPR037335 DEPTOR_DEP_1
IPR037336 DEPTOR_DEP_2
IPR001478 PDZ
IPR036034 PDZ_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR22829:SF18 PTHR22829:SF18, 1 hit
PfamiView protein in Pfam
PF00610 DEP, 2 hits
SMARTiView protein in SMART
SM00049 DEP, 2 hits
SM00228 PDZ, 1 hit
SUPFAMiSSF46785 SSF46785, 2 hits
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 2 hits
PS50106 PDZ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDPTOR_HUMAN
AccessioniPrimary (citable) accession number: Q8TB45
Secondary accession number(s): B2RCL9
, B4DN97, E7EV87, Q96EQ1, Q9H0R7, Q9H894, Q9HA07
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: July 7, 2009
Last modified: November 7, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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