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Protein

Protein ABHD4

Gene

ABHD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine (By similarity).By similarity

Caution

Thr-291 is present instead of the conserved His which is expected to be an active site residue.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-HSA-1482839 Acyl chain remodelling of PE

Protein family/group databases

ESTHERihuman-ABHD4 CGI-58_ABHD5_ABHD4
MEROPSiS33.013

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ABHD4Curated (EC:3.-.-.-)
Alternative name(s):
Alpha/beta hydrolase domain-containing protein 4Curated
Short name:
Abhydrolase domain-containing protein 4Imported
Alpha/beta-hydrolase 4
Lyso-N-acylphosphatidylethanolamine lipase
Gene namesi
Name:ABHD4Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000100439.10
HGNCiHGNC:20154 ABHD4
neXtProtiNX_Q8TB40

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000100439
PharmGKBiPA128394705

Polymorphism and mutation databases

BioMutaiABHD4
DMDMi74762601

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000808641 – 342Protein ABHD4Add BLAST342

Proteomic databases

EPDiQ8TB40
MaxQBiQ8TB40
PaxDbiQ8TB40
PeptideAtlasiQ8TB40
PRIDEiQ8TB40
ProteomicsDBi73960

PTM databases

iPTMnetiQ8TB40
PhosphoSitePlusiQ8TB40

Expressioni

Gene expression databases

BgeeiENSG00000100439
CleanExiHS_ABHD4
ExpressionAtlasiQ8TB40 baseline and differential
GenevisibleiQ8TB40 HS

Organism-specific databases

HPAiHPA000600

Interactioni

Protein-protein interaction databases

BioGridi121967, 2 interactors
IntActiQ8TB40, 14 interactors
MINTiQ8TB40
STRINGi9606.ENSP00000414558

Structurei

3D structure databases

ProteinModelPortaliQ8TB40
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini70 – 201AB hydrolase-1Sequence analysisAdd BLAST132

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4409 Eukaryota
COG0596 LUCA
GeneTreeiENSGT00390000016277
HOGENOMiHOG000007445
HOVERGENiHBG054445
InParanoidiQ8TB40
KOiK13698
OMAiGWSPFQV
OrthoDBiEOG091G0AEW
PhylomeDBiQ8TB40
TreeFamiTF314196

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
PfamiView protein in Pfam
PF00561 Abhydrolase_1, 1 hit
PRINTSiPR00111 ABHYDROLASE
SUPFAMiSSF53474 SSF53474, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TB40-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADDLEQQSQ GWLSSWLPTW RPTSMSQLKN VEARILQCLQ NKFLARYVSL
60 70 80 90 100
PNQNKIWTVT VSPEQNDRTP LVMVHGFGGG VGLWILNMDS LSARRTLHTF
110 120 130 140 150
DLLGFGRSSR PAFPRDPEGA EDEFVTSIET WRETMGIPSM ILLGHSLGGF
160 170 180 190 200
LATSYSIKYP DRVKHLILVD PWGFPLRPTN PSEIRAPPAW VKAVASVLGR
210 220 230 240 250
SNPLAVLRVA GPWGPGLVQR FRPDFKRKFA DFFEDDTISE YIYHCNAQNP
260 270 280 290 300
SGETAFKAMM ESFGWARRPM LERIHLIRKD VPITMIYGSD TWIDTSTGKK
310 320 330 340
VKMQRPDSYV RDMEIKGASH HVYADQPHIF NAVVEEICDS VD
Length:342
Mass (Da):38,794
Last modified:June 1, 2002 - v1
Checksum:i867EA9E0092559CB
GO
Isoform 2 (identifier: Q8TB40-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     163-181: VKHLILVDPWGFPLRPTNP → AWSGAAIPAGLQTQVCRLL
     182-342: Missing.

Note: No experimental confirmation available.
Show »
Length:181
Mass (Da):20,239
Checksum:iABBBF26B35E97C0A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti183 – 185EIR → GIC in BAB14289 (PubMed:14702039).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056924163 – 181VKHLI…RPTNP → AWSGAAIPAGLQTQVCRLL in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_056925182 – 342Missing in isoform 2. 1 PublicationAdd BLAST161

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022878 mRNA Translation: BAB14289.1
AK293198 mRNA Translation: BAG56738.1
AL160314 Genomic DNA No translation available.
BC024779 mRNA Translation: AAH24779.1
CCDSiCCDS9572.1 [Q8TB40-1]
RefSeqiNP_071343.2, NM_022060.2 [Q8TB40-1]
UniGeneiHs.445665

Genome annotation databases

EnsembliENST00000418446; ENSP00000388751; ENSG00000100439 [Q8TB40-2]
ENST00000428304; ENSP00000414558; ENSG00000100439 [Q8TB40-1]
GeneIDi63874
KEGGihsa:63874
UCSCiuc001wgm.4 human [Q8TB40-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiABHD4_HUMAN
AccessioniPrimary (citable) accession number: Q8TB40
Secondary accession number(s): B4DDH7, Q9H9E0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: June 1, 2002
Last modified: July 18, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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