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Protein

Ras and Rab interactor 3

Gene

RIN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function.2 Publications

GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB-KW
  • Rab GTPase binding Source: UniProtKB
  • Rab guanyl-nucleotide exchange factor activity Source: UniProtKB

GO - Biological processi

  • endocytosis Source: UniProtKB
  • signal transduction Source: InterPro

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Protein family/group databases

MoonDBiQ8TB24 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Ras and Rab interactor 3
Alternative name(s):
Ras interaction/interference protein 3
Gene namesi
Name:RIN3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000100599.15
HGNCiHGNC:18751 RIN3
MIMi610223 gene
neXtProtiNX_Q8TB24

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi825Y → A: Strongly reduced guanine nucleotide exchange factor activity toward RAB31; when associated with A-828. 1 Publication1
Mutagenesisi828T → A: Strongly reduced guanine nucleotide exchange factor activity toward RAB31; when associated with A-825. 1 Publication1

Organism-specific databases

DisGeNETi79890
OpenTargetsiENSG00000100599
PharmGKBiPA38673

Polymorphism and mutation databases

BioMutaiRIN3
DMDMi209572780

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001913221 – 985Ras and Rab interactor 3Add BLAST985

Proteomic databases

EPDiQ8TB24
PaxDbiQ8TB24
PeptideAtlasiQ8TB24
PRIDEiQ8TB24
ProteomicsDBi73951
73952 [Q8TB24-4]

PTM databases

iPTMnetiQ8TB24
PhosphoSitePlusiQ8TB24

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000100599
CleanExiHS_RIN3
ExpressionAtlasiQ8TB24 baseline and differential
GenevisibleiQ8TB24 HS

Organism-specific databases

HPAiHPA039836

Interactioni

Subunit structurei

Interacts with CD2AP, RAB5B, RAB31 and BIN1.3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • Rab GTPase binding Source: UniProtKB
  • Rab guanyl-nucleotide exchange factor activity Source: UniProtKB

Protein-protein interaction databases

BioGridi122974, 41 interactors
IntActiQ8TB24, 46 interactors
MINTiQ8TB24
STRINGi9606.ENSP00000216487

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3U23X-ray1.11B452-467[»]
4WCIX-ray1.65B/D/F378-393[»]
ProteinModelPortaliQ8TB24
SMRiQ8TB24
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 158SH2PROSITE-ProRule annotationAdd BLAST96
Domaini703 – 846VPS9PROSITE-ProRule annotationAdd BLAST144
Domaini877 – 963Ras-associatingPROSITE-ProRule annotationAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni587 – 732Interaction with RAB5B1 PublicationAdd BLAST146

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi24 – 29Poly-Glu6
Compositional biasi248 – 514Pro-richAdd BLAST267
Compositional biasi722 – 725Poly-Thr4
Compositional biasi965 – 972Poly-Gly8

Sequence similaritiesi

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG2320 Eukaryota
ENOG410ZZW5 LUCA
GeneTreeiENSGT00530000063053
HOVERGENiHBG038998
InParanoidiQ8TB24
OMAiRLWFVNP
OrthoDBiEOG091G02V2
PhylomeDBiQ8TB24
TreeFamiTF331067

Family and domain databases

CDDicd10395 SH2_RIN3, 1 hit
Gene3Di1.20.1050.80, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000159 RA_dom
IPR035869 RIN3_SH2
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR003123 VPS9
IPR037191 VPS9_dom_sf
PfamiView protein in Pfam
PF02204 VPS9, 1 hit
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00167 VPS9, 1 hit
SUPFAMiSSF109993 SSF109993, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50200 RA, 1 hit
PS50001 SH2, 1 hit
PS51205 VPS9, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TB24-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIRHAGAPAR GDPTGPVPVV GKGEEEEEED GMRLCLPANP KNCLPHRRGI
60 70 80 90 100
SILEKLIKTC PVWLQLSLGQ AEVARILHRV VAGMFLVRRD SSSKQLVLCV
110 120 130 140 150
HFPSLNESSA EVLEYTIKEE KSILYLEGSA LVFEDIFRLI AFYCVSRDLL
160 170 180 190 200
PFTLRLPQAI LEASSFTDLE TIANLGLGFW DSSLNPPQER GKPAEPPRDR
210 220 230 240 250
APGFPLVSSL RPTAHDANCA CEIELSVGND RLWFVNPIFI EDCSSALPTD
260 270 280 290 300
QPPLGNCPAR PLPPTSDATS PTSRWAPRRP PPPPPVLPLQ PCSPAQPPVL
310 320 330 340 350
PALAPAPACP LPTSPPVPAP HVTPHAPGPP DHPNQPPMMT CERLPCPTAG
360 370 380 390 400
LGPLREEAMK PGAASSPLQQ VPAPPLPAKK NLPTAPPRRR VSERVSLEDQ
410 420 430 440 450
SPGMAAEGDQ LSLPPQGTSD GPEDTPREST EQGQDTEVKA SDPHSMPELP
460 470 480 490 500
RTAKQPPVPP PRKKRISRQL ASTLPAPLEN AELCTQAMAL ETPTPGPPRE
510 520 530 540 550
GQSPASQAGT QHPPAQATAH SQSSPEFKGS LASLSDSLGV SVMATDQDSY
560 570 580 590 600
STSSTEEELE QFSSPSVKKK PSMILGKARH RLSFASFSSM FHAFLSNNRK
610 620 630 640 650
LYKKVVELAQ DKGSYFGSLV QDYKVYSLEM MARQTSSTEM LQEIRTMMTQ
660 670 680 690 700
LKSYLLQSTE LKALVDPALH SEEELEAIVE SALYKCVLKP LKEAINSCLH
710 720 730 740 750
QIHSKDGSLQ QLKENQLVIL ATTTTDLGVT TSVPEVPMME KILQKFTSMH
760 770 780 790 800
KAYSPEKKIS ILLKTCKLIY DSMALGNPGK PYGADDFLPV LMYVLARSNL
810 820 830 840 850
TEMLLNVEYM MELMDPALQL GEGSYYLTTT YGALEHIKSY DKITVTRQLS
860 870 880 890 900
VEVQDSIHRW ERRRTLNKAR ASRSSVQDFI CVSYLEPEQQ ARTLASRADT
910 920 930 940 950
QAQALCAQCA EKFAVERPQA HRLFVLVDGR CFQLADDALP HCIKGYLLRS
960 970 980
EPKRDFHFVY RPLDGGGGGG GGSPPCLVVR EPNFL
Length:985
Mass (Da):107,854
Last modified:October 14, 2008 - v4
Checksum:iA8949EA0D61570BB
GO
Isoform 4 (identifier: Q8TB24-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     878-903: DFICVSYLEPEQQARTLASRADTQAQ → VRPESGRGPVGPCPRHHPCCLLAKEP
     904-985: Missing.

Note: No experimental confirmation available.
Show »
Length:903
Mass (Da):98,739
Checksum:i562A82ADCBD13127
GO

Sequence cautioni

The sequence BAB13888 differs from that shown. Aberrant splicing.Curated
The sequence BAB15357 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC03432 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti742I → F in AAH25248 (PubMed:15489334).Curated1
Sequence conflicti965Missing in BAB15357 (PubMed:14702039).Curated1
Sequence conflicti965Missing in AAH25248 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_046645111E → K. Corresponds to variant dbSNP:rs2274542Ensembl.1
Natural variantiVAR_059960215H → L. Corresponds to variant dbSNP:rs3829947Ensembl.1
Natural variantiVAR_046646215H → P. Corresponds to variant dbSNP:rs3829947Ensembl.1
Natural variantiVAR_059961215H → R. Corresponds to variant dbSNP:rs3829947Ensembl.1
Natural variantiVAR_052946425T → I. Corresponds to variant dbSNP:rs3742717Ensembl.1
Natural variantiVAR_046647425T → M1 PublicationCorresponds to variant dbSNP:rs3742717Ensembl.1
Natural variantiVAR_046648613G → A. Corresponds to variant dbSNP:rs12434929Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007587878 – 903DFICV…DTQAQ → VRPESGRGPVGPCPRHHPCC LLAKEP in isoform 4. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_007588904 – 985Missing in isoform 4. 1 PublicationAdd BLAST82

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB081753 mRNA Translation: BAC16513.1
AL136332 Genomic DNA No translation available.
AL159141 Genomic DNA No translation available.
AK021762 mRNA Translation: BAB13888.1 Sequence problems.
AK026092 mRNA Translation: BAB15357.1 Different initiation.
AK074176 mRNA Translation: BAB85002.1
AK090451 mRNA Translation: BAC03432.1 Sequence problems.
BC025248 mRNA Translation: AAH25248.2
AB060338 mRNA Translation: BAB84316.1
CCDSiCCDS32144.1 [Q8TB24-1]
PIRiT50623
RefSeqiNP_001306916.1, NM_001319987.1
NP_079108.3, NM_024832.4 [Q8TB24-1]
UniGeneiHs.326822

Genome annotation databases

EnsembliENST00000216487; ENSP00000216487; ENSG00000100599 [Q8TB24-1]
GeneIDi79890
KEGGihsa:79890
UCSCiuc001yap.4 human [Q8TB24-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRIN3_HUMAN
AccessioniPrimary (citable) accession number: Q8TB24
Secondary accession number(s): Q76LB3
, Q8NF30, Q8TEE8, Q8WYP4, Q9H6A5, Q9HAG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: October 14, 2008
Last modified: June 20, 2018
This is version 142 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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