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UniProtKB - Q8TB24 (RIN3_HUMAN)

Protein

Ras and Rab interactor 3

Gene

RIN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function.2 Publications

GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB-KW
  • Rab GTPase binding Source: UniProtKB
  • Rab guanyl-nucleotide exchange factor activity Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • endocytosis Source: UniProtKB
  • signal transduction Source: InterPro
View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Protein family/group databases

MoonDBiQ8TB24 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Ras and Rab interactor 3
Alternative name(s):
Ras interaction/interference protein 3
Gene namesi
Name:RIN3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000100599.15
HGNCiHGNC:18751 RIN3
MIMi610223 gene
neXtProtiNX_Q8TB24

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi825Y → A: Strongly reduced guanine nucleotide exchange factor activity toward RAB31; when associated with A-828. 1 Publication1
Mutagenesisi828T → A: Strongly reduced guanine nucleotide exchange factor activity toward RAB31; when associated with A-825. 1 Publication1

Organism-specific databases

DisGeNETi79890
OpenTargetsiENSG00000100599
PharmGKBiPA38673

Polymorphism and mutation databases

BioMutaiRIN3
DMDMi209572780

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001913221 – 985Ras and Rab interactor 3Add BLAST985

Proteomic databases

EPDiQ8TB24
PaxDbiQ8TB24
PeptideAtlasiQ8TB24
PRIDEiQ8TB24
ProteomicsDBi73951
73952 [Q8TB24-4]

PTM databases

iPTMnetiQ8TB24
PhosphoSitePlusiQ8TB24

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000100599 Expressed in 165 organ(s), highest expression level in blood
CleanExiHS_RIN3
ExpressionAtlasiQ8TB24 baseline and differential
GenevisibleiQ8TB24 HS

Organism-specific databases

HPAiHPA039836

Interactioni

Subunit structurei

Interacts with CD2AP, RAB5B, RAB31 and BIN1.3 Publications

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi122974, 41 interactors
IntActiQ8TB24, 46 interactors
MINTiQ8TB24
STRINGi9606.ENSP00000216487

Structurei

3D structure databases

ProteinModelPortaliQ8TB24
SMRiQ8TB24
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 158SH2PROSITE-ProRule annotationAdd BLAST96
Domaini703 – 846VPS9PROSITE-ProRule annotationAdd BLAST144
Domaini877 – 963Ras-associatingPROSITE-ProRule annotationAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni587 – 732Interaction with RAB5B1 PublicationAdd BLAST146

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi24 – 29Poly-Glu6
Compositional biasi248 – 514Pro-richAdd BLAST267
Compositional biasi722 – 725Poly-Thr4
Compositional biasi965 – 972Poly-Gly8

Sequence similaritiesi

Belongs to the RIN (Ras interaction/interference) family.Curated

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG2320 Eukaryota
ENOG410ZZW5 LUCA
GeneTreeiENSGT00530000063053
HOVERGENiHBG038998
InParanoidiQ8TB24
OMAiIGNDRLW
OrthoDBiEOG091G02V2
PhylomeDBiQ8TB24
TreeFamiTF331067

Family and domain databases

CDDicd10395 SH2_RIN3, 1 hit
Gene3Di1.20.1050.80, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000159 RA_dom
IPR035869 RIN3_SH2
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR003123 VPS9
IPR037191 VPS9_dom_sf
PfamiView protein in Pfam
PF02204 VPS9, 1 hit
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00167 VPS9, 1 hit
SUPFAMiSSF109993 SSF109993, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50200 RA, 1 hit
PS50001 SH2, 1 hit
PS51205 VPS9, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TB24-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIRHAGAPAR GDPTGPVPVV GKGEEEEEED GMRLCLPANP KNCLPHRRGI 
        60         70         80         90        100
SILEKLIKTC PVWLQLSLGQ AEVARILHRV VAGMFLVRRD SSSKQLVLCV 
       110        120        130        140        150
HFPSLNESSA EVLEYTIKEE KSILYLEGSA LVFEDIFRLI AFYCVSRDLL 
       160        170        180        190        200
PFTLRLPQAI LEASSFTDLE TIANLGLGFW DSSLNPPQER GKPAEPPRDR 
       210        220        230        240        250
APGFPLVSSL RPTAHDANCA CEIELSVGND RLWFVNPIFI EDCSSALPTD 
       260        270        280        290        300
QPPLGNCPAR PLPPTSDATS PTSRWAPRRP PPPPPVLPLQ PCSPAQPPVL 
       310        320        330        340        350
PALAPAPACP LPTSPPVPAP HVTPHAPGPP DHPNQPPMMT CERLPCPTAG 
       360        370        380        390        400
LGPLREEAMK PGAASSPLQQ VPAPPLPAKK NLPTAPPRRR VSERVSLEDQ 
       410        420        430        440        450
SPGMAAEGDQ LSLPPQGTSD GPEDTPREST EQGQDTEVKA SDPHSMPELP 
       460        470        480        490        500
RTAKQPPVPP PRKKRISRQL ASTLPAPLEN AELCTQAMAL ETPTPGPPRE 
       510        520        530        540        550
GQSPASQAGT QHPPAQATAH SQSSPEFKGS LASLSDSLGV SVMATDQDSY 
       560        570        580        590        600
STSSTEEELE QFSSPSVKKK PSMILGKARH RLSFASFSSM FHAFLSNNRK 
       610        620        630        640        650
LYKKVVELAQ DKGSYFGSLV QDYKVYSLEM MARQTSSTEM LQEIRTMMTQ 
       660        670        680        690        700
LKSYLLQSTE LKALVDPALH SEEELEAIVE SALYKCVLKP LKEAINSCLH 
       710        720        730        740        750
QIHSKDGSLQ QLKENQLVIL ATTTTDLGVT TSVPEVPMME KILQKFTSMH 
       760        770        780        790        800
KAYSPEKKIS ILLKTCKLIY DSMALGNPGK PYGADDFLPV LMYVLARSNL 
       810        820        830        840        850
TEMLLNVEYM MELMDPALQL GEGSYYLTTT YGALEHIKSY DKITVTRQLS 
       860        870        880        890        900
VEVQDSIHRW ERRRTLNKAR ASRSSVQDFI CVSYLEPEQQ ARTLASRADT 
       910        920        930        940        950
QAQALCAQCA EKFAVERPQA HRLFVLVDGR CFQLADDALP HCIKGYLLRS 
       960        970        980 
EPKRDFHFVY RPLDGGGGGG GGSPPCLVVR EPNFL
Length:985
Mass (Da):107,854
Last modified:October 14, 2008 - v4
Checksum:iA8949EA0D61570BB
GO
Isoform 4 (identifier: Q8TB24-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     878-903: DFICVSYLEPEQQARTLASRADTQAQ → VRPESGRGPVGPCPRHHPCCLLAKEP
     904-985: Missing.

Note: No experimental confirmation available.
Show »
Length:903
Mass (Da):98,739
Checksum:i562A82ADCBD13127
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WWY9A0A087WWY9_HUMAN
Ras and Rab interactor 3
RIN3
913Annotation score:
H0YJ83H0YJ83_HUMAN
Ras and Rab interactor 3
RIN3
420Annotation score:
G3V2I7G3V2I7_HUMAN
Ras and Rab interactor 3
RIN3 hCG_2029104
159Annotation score:
G3V534G3V534_HUMAN
Ras and Rab interactor 3
RIN3
78Annotation score:

Sequence cautioni

The sequence BAB13888 differs from that shown. Aberrant splicing.Curated
The sequence BAB15357 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC03432 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti742I → F in AAH25248 (PubMed:15489334).Curated1
Sequence conflicti965Missing in BAB15357 (PubMed:14702039).Curated1
Sequence conflicti965Missing in AAH25248 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_046645111E → K. Corresponds to variant dbSNP:rs2274542Ensembl.1
Natural variantiVAR_059960215H → L. Corresponds to variant dbSNP:rs3829947Ensembl.1
Natural variantiVAR_046646215H → P. Corresponds to variant dbSNP:rs3829947Ensembl.1
Natural variantiVAR_059961215H → R. Corresponds to variant dbSNP:rs3829947Ensembl.1
Natural variantiVAR_052946425T → I. Corresponds to variant dbSNP:rs3742717Ensembl.1
Natural variantiVAR_046647425T → M1 PublicationCorresponds to variant dbSNP:rs3742717Ensembl.1
Natural variantiVAR_046648613G → A. Corresponds to variant dbSNP:rs12434929Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007587878 – 903DFICV…DTQAQ → VRPESGRGPVGPCPRHHPCC LLAKEP in isoform 4. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_007588904 – 985Missing in isoform 4. 1 PublicationAdd BLAST82

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB081753 mRNA Translation: BAC16513.1
AL136332 Genomic DNA No translation available.
AL159141 Genomic DNA No translation available.
AK021762 mRNA Translation: BAB13888.1 Sequence problems.
AK026092 mRNA Translation: BAB15357.1 Different initiation.
AK074176 mRNA Translation: BAB85002.1
AK090451 mRNA Translation: BAC03432.1 Sequence problems.
BC025248 mRNA Translation: AAH25248.2
AB060338 mRNA Translation: BAB84316.1
CCDSiCCDS32144.1 [Q8TB24-1]
PIRiT50623
RefSeqiNP_001306916.1, NM_001319987.1
NP_079108.3, NM_024832.4 [Q8TB24-1]
UniGeneiHs.326822

Genome annotation databases

EnsembliENST00000216487; ENSP00000216487; ENSG00000100599 [Q8TB24-1]
GeneIDi79890
KEGGihsa:79890
UCSCiuc001yap.4 human [Q8TB24-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB081753 mRNA Translation: BAC16513.1
AL136332 Genomic DNA No translation available.
AL159141 Genomic DNA No translation available.
AK021762 mRNA Translation: BAB13888.1 Sequence problems.
AK026092 mRNA Translation: BAB15357.1 Different initiation.
AK074176 mRNA Translation: BAB85002.1
AK090451 mRNA Translation: BAC03432.1 Sequence problems.
BC025248 mRNA Translation: AAH25248.2
AB060338 mRNA Translation: BAB84316.1
CCDSiCCDS32144.1 [Q8TB24-1]
PIRiT50623
RefSeqiNP_001306916.1, NM_001319987.1
NP_079108.3, NM_024832.4 [Q8TB24-1]
UniGeneiHs.326822

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3U23X-ray1.11B452-467[»]
4WCIX-ray1.65B/D/F378-393[»]
ProteinModelPortaliQ8TB24
SMRiQ8TB24
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122974, 41 interactors
IntActiQ8TB24, 46 interactors
MINTiQ8TB24
STRINGi9606.ENSP00000216487

Protein family/group databases

MoonDBiQ8TB24 Predicted

PTM databases

iPTMnetiQ8TB24
PhosphoSitePlusiQ8TB24

Polymorphism and mutation databases

BioMutaiRIN3
DMDMi209572780

Proteomic databases

EPDiQ8TB24
PaxDbiQ8TB24
PeptideAtlasiQ8TB24
PRIDEiQ8TB24
ProteomicsDBi73951
73952 [Q8TB24-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216487; ENSP00000216487; ENSG00000100599 [Q8TB24-1]
GeneIDi79890
KEGGihsa:79890
UCSCiuc001yap.4 human [Q8TB24-1]

Organism-specific databases

CTDi79890
DisGeNETi79890
EuPathDBiHostDB:ENSG00000100599.15
GeneCardsiRIN3
H-InvDBiHIX0011904
HGNCiHGNC:18751 RIN3
HPAiHPA039836
MIMi610223 gene
neXtProtiNX_Q8TB24
OpenTargetsiENSG00000100599
PharmGKBiPA38673
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2320 Eukaryota
ENOG410ZZW5 LUCA
GeneTreeiENSGT00530000063053
HOVERGENiHBG038998
InParanoidiQ8TB24
OMAiIGNDRLW
OrthoDBiEOG091G02V2
PhylomeDBiQ8TB24
TreeFamiTF331067

Enzyme and pathway databases

ReactomeiR-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRSiRIN3 human
GenomeRNAii79890
PROiPR:Q8TB24
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100599 Expressed in 165 organ(s), highest expression level in blood
CleanExiHS_RIN3
ExpressionAtlasiQ8TB24 baseline and differential
GenevisibleiQ8TB24 HS

Family and domain databases

CDDicd10395 SH2_RIN3, 1 hit
Gene3Di1.20.1050.80, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000159 RA_dom
IPR035869 RIN3_SH2
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR003123 VPS9
IPR037191 VPS9_dom_sf
PfamiView protein in Pfam
PF02204 VPS9, 1 hit
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00167 VPS9, 1 hit
SUPFAMiSSF109993 SSF109993, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50200 RA, 1 hit
PS50001 SH2, 1 hit
PS51205 VPS9, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRIN3_HUMAN
AccessioniPrimary (citable) accession number: Q8TB24
Secondary accession number(s): Q76LB3
, Q8NF30, Q8TEE8, Q8WYP4, Q9H6A5, Q9HAG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: October 14, 2008
Last modified: November 7, 2018
This is version 145 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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