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Entry version 138 (11 Dec 2019)
Sequence version 3 (02 Nov 2010)
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Protein

Spermatogenesis-associated protein 20

Gene

SPATA20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in fertility regulation.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Spermatogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Spermatogenesis-associated protein 20
Alternative name(s):
Sperm-specific protein 411
Short name:
Ssp411
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPATA20
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000006282.20

Human Gene Nomenclature Database

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HGNCi
HGNC:26125 SPATA20

Online Mendelian Inheritance in Man (OMIM)

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MIMi
613939 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q8TB22

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
64847

Open Targets

More...
OpenTargetsi
ENSG00000006282

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670885

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TB22 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SPATA20

Domain mapping of disease mutations (DMDM)

More...
DMDMi
311033529

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000027845023 – 786Spermatogenesis-associated protein 20Add BLAST764

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei649PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8TB22

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TB22

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q8TB22

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8TB22

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8TB22

PeptideAtlas

More...
PeptideAtlasi
Q8TB22

PRoteomics IDEntifications database

More...
PRIDEi
Q8TB22

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
73947 [Q8TB22-1]
73948 [Q8TB22-2]
73949 [Q8TB22-3]
73950 [Q8TB22-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TB22

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q8TB22

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000006282 Expressed in 220 organ(s), highest expression level in right testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TB22 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8TB22 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA022023
HPA027144
HPA031442

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
122320, 41 interactors

Protein interaction database and analysis system

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IntActi
Q8TB22, 65 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000006658

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q8TB22 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8TB22

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2244 Eukaryota
COG1331 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000004836

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231201

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TB22

Identification of Orthologs from Complete Genome Data

More...
OMAi
KATAYVC

Database of Orthologous Groups

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OrthoDBi
332120at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TB22

TreeFam database of animal gene trees

More...
TreeFami
TF105663

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02955 SSP411, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.50.10.10, 2 hits
3.40.30.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR004879 DUF255
IPR024705 Ssp411
IPR036249 Thioredoxin-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR42899 PTHR42899, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03190 Thioredox_DsbH, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF006402 UCP006402_thioredoxin, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48208 SSF48208, 1 hit
SSF52833 SSF52833, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TB22-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLGARAWLGR VLLLPRAGAG LAASRRGSSS RDKDRSATVS SSVPMPAGGK
60 70 80 90 100
GSHPSSTPQR VPNRLIHEKS PYLLQHAYNP VDWYPWGQEA FDKARKENKP
110 120 130 140 150
IFLSVGYSTC HWCHMMEEES FQNEEIGRLL SEDFVSVKVD REERPDVDKV
160 170 180 190 200
YMTFVQATSS GGGWPMNVWL TPNLQPFVGG TYFPPEDGLT RVGFRTVLLR
210 220 230 240 250
IREQWKQNKN TLLENSQRVT TALLARSEIS VGDRQLPPSA ATVNNRCFQQ
260 270 280 290 300
LDEGYDEEYG GFAEAPKFPT PVILSFLFSY WLSHRLTQDG SRAQQMALHT
310 320 330 340 350
LKMMANGGIR DHVGQGFHRY STDRQWHVPH FEKMLYDQAQ LAVAYSQAFQ
360 370 380 390 400
LSGDEFYSDV AKGILQYVAR SLSHRSGGFY SAEDADSPPE RGQRPKEGAY
410 420 430 440 450
YVWTVKEVQQ LLPEPVLGAT EPLTSGQLLM KHYGLTEAGN ISPSQDPKGE
460 470 480 490 500
LQGQNVLTVR YSLELTAARF GLDVEAVRTL LNSGLEKLFQ ARKHRPKPHL
510 520 530 540 550
DSKMLAAWNG LMVSGYAVTG AVLGQDRLIN YATNGAKFLK RHMFDVASGR
560 570 580 590 600
LMRTCYTGPG GTVEHSNPPC WGFLEDYAFV VRGLLDLYEA SQESAWLEWA
610 620 630 640 650
LRLQDTQDKL FWDSQGGGYF CSEAELGAGL PLRLKDDQDG AEPSANSVSA
660 670 680 690 700
HNLLRLHGFT GHKDWMDKCV CLLTAFSERM RRVPVALPEM VRALSAQQQT
710 720 730 740 750
LKQIVICGDR QAKDTKALVQ CVHSVYIPNK VLILADGDPS SFLSRQLPFL
760 770 780
STLRRLEDQA TAYVCENQAC SVPITDPCEL RKLLHP
Length:786
Mass (Da):87,899
Last modified:November 2, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i00C3CCE7C7BD8438
GO
Isoform 2 (identifier: Q8TB22-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-26: R → RCPGVWPRTWPHRSPSR

Show »
Length:802
Mass (Da):89,800
Checksum:iB5198C26A4BBD7FD
GO
Isoform 3 (identifier: Q8TB22-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-44: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:742
Mass (Da):83,378
Checksum:i3FD77F6806458D03
GO
Isoform 4 (identifier: Q8TB22-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MLGARAWLGRVLLLPRAGAGLAASR → MSHLSSPPKKHKGEHKGHSLPHGSE
     511-521: LMVSGYAVTGA → GAAHLRPSLSA
     522-786: Missing.

Show »
Length:521
Mass (Da):58,463
Checksum:i513594E2A330256A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RRL8A0A0U1RRL8_HUMAN
Spermatogenesis-associated protein ...
SPATA20
786Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RC70D6RC70_HUMAN
Spermatogenesis-associated protein ...
SPATA20
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9W3H0Y9W3_HUMAN
Spermatogenesis-associated protein ...
SPATA20
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R947D6R947_HUMAN
Spermatogenesis-associated protein ...
SPATA20
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9M1H0Y9M1_HUMAN
Spermatogenesis-associated protein ...
SPATA20
247Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RIU6D6RIU6_HUMAN
Spermatogenesis-associated protein ...
SPATA20
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti356F → L in BAB15051 (PubMed:14702039).Curated1
Sequence conflicti540K → E in BAB15051 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03077788Q → E1 PublicationCorresponds to variant dbSNP:rs8076632Ensembl.1
Natural variantiVAR_030778483S → T1 PublicationCorresponds to variant dbSNP:rs9913430Ensembl.1
Natural variantiVAR_030779609K → R2 PublicationsCorresponds to variant dbSNP:rs8065903Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0232881 – 44Missing in isoform 3. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_0232891 – 25MLGAR…LAASR → MSHLSSPPKKHKGEHKGHSL PHGSE in isoform 4. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_02329026R → RCPGVWPRTWPHRSPSR in isoform 2. 1 Publication1
Alternative sequenceiVSP_023291511 – 521LMVSGYAVTGA → GAAHLRPSLSA in isoform 4. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_023292522 – 786Missing in isoform 4. 1 PublicationAdd BLAST265

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ238597 mRNA Translation: ABB54669.1
AK025000 mRNA Translation: BAB15051.1
AC021491 Genomic DNA No translation available.
BC017468 mRNA Translation: AAH17468.1
BC025255 mRNA Translation: AAH25255.1
BC111029 mRNA Translation: AAI11030.1
BC065526 mRNA Translation: AAH65526.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11571.1 [Q8TB22-2]
CCDS58563.1 [Q8TB22-1]
CCDS58564.1 [Q8TB22-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001245301.1, NM_001258372.1 [Q8TB22-1]
NP_001245302.1, NM_001258373.1 [Q8TB22-3]
NP_073738.2, NM_022827.3 [Q8TB22-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000006658; ENSP00000006658; ENSG00000006282 [Q8TB22-2]
ENST00000356488; ENSP00000348878; ENSG00000006282 [Q8TB22-1]
ENST00000511937; ENSP00000489476; ENSG00000006282 [Q8TB22-4]
ENST00000619622; ENSP00000483295; ENSG00000006282 [Q8TB22-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
64847

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:64847

UCSC genome browser

More...
UCSCi
uc002ird.4 human [Q8TB22-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ238597 mRNA Translation: ABB54669.1
AK025000 mRNA Translation: BAB15051.1
AC021491 Genomic DNA No translation available.
BC017468 mRNA Translation: AAH17468.1
BC025255 mRNA Translation: AAH25255.1
BC111029 mRNA Translation: AAI11030.1
BC065526 mRNA Translation: AAH65526.1
CCDSiCCDS11571.1 [Q8TB22-2]
CCDS58563.1 [Q8TB22-1]
CCDS58564.1 [Q8TB22-3]
RefSeqiNP_001245301.1, NM_001258372.1 [Q8TB22-1]
NP_001245302.1, NM_001258373.1 [Q8TB22-3]
NP_073738.2, NM_022827.3 [Q8TB22-2]

3D structure databases

SMRiQ8TB22
ModBaseiSearch...

Protein-protein interaction databases

BioGridi122320, 41 interactors
IntActiQ8TB22, 65 interactors
STRINGi9606.ENSP00000006658

PTM databases

iPTMnetiQ8TB22
PhosphoSitePlusiQ8TB22

Polymorphism and mutation databases

BioMutaiSPATA20
DMDMi311033529

Proteomic databases

EPDiQ8TB22
jPOSTiQ8TB22
MassIVEiQ8TB22
MaxQBiQ8TB22
PaxDbiQ8TB22
PeptideAtlasiQ8TB22
PRIDEiQ8TB22
ProteomicsDBi73947 [Q8TB22-1]
73948 [Q8TB22-2]
73949 [Q8TB22-3]
73950 [Q8TB22-4]

Genome annotation databases

EnsembliENST00000006658; ENSP00000006658; ENSG00000006282 [Q8TB22-2]
ENST00000356488; ENSP00000348878; ENSG00000006282 [Q8TB22-1]
ENST00000511937; ENSP00000489476; ENSG00000006282 [Q8TB22-4]
ENST00000619622; ENSP00000483295; ENSG00000006282 [Q8TB22-3]
GeneIDi64847
KEGGihsa:64847
UCSCiuc002ird.4 human [Q8TB22-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64847
DisGeNETi64847
EuPathDBiHostDB:ENSG00000006282.20

GeneCards: human genes, protein and diseases

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GeneCardsi
SPATA20
HGNCiHGNC:26125 SPATA20
HPAiHPA022023
HPA027144
HPA031442
MIMi613939 gene
neXtProtiNX_Q8TB22
OpenTargetsiENSG00000006282
PharmGKBiPA142670885

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2244 Eukaryota
COG1331 LUCA
GeneTreeiENSGT00390000004836
HOGENOMiHOG000231201
InParanoidiQ8TB22
OMAiKATAYVC
OrthoDBi332120at2759
PhylomeDBiQ8TB22
TreeFamiTF105663

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SPATA20 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
64847
PharosiQ8TB22 Tdark

Protein Ontology

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PROi
PR:Q8TB22
RNActiQ8TB22 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000006282 Expressed in 220 organ(s), highest expression level in right testis
ExpressionAtlasiQ8TB22 baseline and differential
GenevisibleiQ8TB22 HS

Family and domain databases

CDDicd02955 SSP411, 1 hit
Gene3Di1.50.10.10, 2 hits
3.40.30.10, 1 hit
InterProiView protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR004879 DUF255
IPR024705 Ssp411
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR42899 PTHR42899, 1 hit
PfamiView protein in Pfam
PF03190 Thioredox_DsbH, 1 hit
PIRSFiPIRSF006402 UCP006402_thioredoxin, 1 hit
SUPFAMiSSF48208 SSF48208, 1 hit
SSF52833 SSF52833, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPT20_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TB22
Secondary accession number(s): Q2TA99
, Q2XUZ6, Q6P0P1, Q8WVW3, Q9H747
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: November 2, 2010
Last modified: December 11, 2019
This is version 138 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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