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Protein

Spermatogenesis-associated protein 20

Gene

SPATA20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in fertility regulation.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatogenesis-associated protein 20
Alternative name(s):
Sperm-specific protein 411
Short name:
Ssp411
Gene namesi
Name:SPATA20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000006282.20
HGNCiHGNC:26125 SPATA20
MIMi613939 gene
neXtProtiNX_Q8TB22

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi64847
OpenTargetsiENSG00000006282
PharmGKBiPA142670885

Polymorphism and mutation databases

BioMutaiSPATA20
DMDMi311033529

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000027845023 – 786Spermatogenesis-associated protein 20Add BLAST764

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei649PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8TB22
MaxQBiQ8TB22
PaxDbiQ8TB22
PeptideAtlasiQ8TB22
PRIDEiQ8TB22
ProteomicsDBi73947
73948 [Q8TB22-2]
73949 [Q8TB22-3]
73950 [Q8TB22-4]

PTM databases

iPTMnetiQ8TB22
PhosphoSitePlusiQ8TB22

Expressioni

Gene expression databases

BgeeiENSG00000006282 Expressed in 220 organ(s), highest expression level in right testis
CleanExiHS_SPATA20
ExpressionAtlasiQ8TB22 baseline and differential
GenevisibleiQ8TB22 HS

Organism-specific databases

HPAiHPA022023
HPA027144
HPA031442

Interactioni

Protein-protein interaction databases

BioGridi122320, 41 interactors
IntActiQ8TB22, 12 interactors
STRINGi9606.ENSP00000006658

Structurei

3D structure databases

ProteinModelPortaliQ8TB22
SMRiQ8TB22
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2244 Eukaryota
COG1331 LUCA
GeneTreeiENSGT00390000004836
HOGENOMiHOG000231201
HOVERGENiHBG093992
InParanoidiQ8TB22
OMAiSSCHWCT
OrthoDBiEOG091G02U2
PhylomeDBiQ8TB22
TreeFamiTF105663

Family and domain databases

CDDicd02955 SSP411, 1 hit
Gene3Di1.50.10.10, 2 hits
InterProiView protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR004879 DUF255
IPR024705 Ssp411
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR42899 PTHR42899, 1 hit
PfamiView protein in Pfam
PF03190 Thioredox_DsbH, 1 hit
PIRSFiPIRSF006402 UCP006402_thioredoxin, 1 hit
SUPFAMiSSF48208 SSF48208, 1 hit
SSF52833 SSF52833, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TB22-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLGARAWLGR VLLLPRAGAG LAASRRGSSS RDKDRSATVS SSVPMPAGGK
60 70 80 90 100
GSHPSSTPQR VPNRLIHEKS PYLLQHAYNP VDWYPWGQEA FDKARKENKP
110 120 130 140 150
IFLSVGYSTC HWCHMMEEES FQNEEIGRLL SEDFVSVKVD REERPDVDKV
160 170 180 190 200
YMTFVQATSS GGGWPMNVWL TPNLQPFVGG TYFPPEDGLT RVGFRTVLLR
210 220 230 240 250
IREQWKQNKN TLLENSQRVT TALLARSEIS VGDRQLPPSA ATVNNRCFQQ
260 270 280 290 300
LDEGYDEEYG GFAEAPKFPT PVILSFLFSY WLSHRLTQDG SRAQQMALHT
310 320 330 340 350
LKMMANGGIR DHVGQGFHRY STDRQWHVPH FEKMLYDQAQ LAVAYSQAFQ
360 370 380 390 400
LSGDEFYSDV AKGILQYVAR SLSHRSGGFY SAEDADSPPE RGQRPKEGAY
410 420 430 440 450
YVWTVKEVQQ LLPEPVLGAT EPLTSGQLLM KHYGLTEAGN ISPSQDPKGE
460 470 480 490 500
LQGQNVLTVR YSLELTAARF GLDVEAVRTL LNSGLEKLFQ ARKHRPKPHL
510 520 530 540 550
DSKMLAAWNG LMVSGYAVTG AVLGQDRLIN YATNGAKFLK RHMFDVASGR
560 570 580 590 600
LMRTCYTGPG GTVEHSNPPC WGFLEDYAFV VRGLLDLYEA SQESAWLEWA
610 620 630 640 650
LRLQDTQDKL FWDSQGGGYF CSEAELGAGL PLRLKDDQDG AEPSANSVSA
660 670 680 690 700
HNLLRLHGFT GHKDWMDKCV CLLTAFSERM RRVPVALPEM VRALSAQQQT
710 720 730 740 750
LKQIVICGDR QAKDTKALVQ CVHSVYIPNK VLILADGDPS SFLSRQLPFL
760 770 780
STLRRLEDQA TAYVCENQAC SVPITDPCEL RKLLHP
Length:786
Mass (Da):87,899
Last modified:November 2, 2010 - v3
Checksum:i00C3CCE7C7BD8438
GO
Isoform 2 (identifier: Q8TB22-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-26: R → RCPGVWPRTWPHRSPSR

Note: No experimental confirmation available.
Show »
Length:802
Mass (Da):89,800
Checksum:iB5198C26A4BBD7FD
GO
Isoform 3 (identifier: Q8TB22-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-44: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:742
Mass (Da):83,378
Checksum:i3FD77F6806458D03
GO
Isoform 4 (identifier: Q8TB22-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MLGARAWLGRVLLLPRAGAGLAASR → MSHLSSPPKKHKGEHKGHSLPHGSE
     511-521: LMVSGYAVTGA → GAAHLRPSLSA
     522-786: Missing.

Note: No experimental confirmation available.
Show »
Length:521
Mass (Da):58,463
Checksum:i513594E2A330256A
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RC70D6RC70_HUMAN
Spermatogenesis-associated protein ...
SPATA20
56Annotation score:
D6R947D6R947_HUMAN
Spermatogenesis-associated protein ...
SPATA20
43Annotation score:
H0Y9M1H0Y9M1_HUMAN
Spermatogenesis-associated protein ...
SPATA20
247Annotation score:
H0Y9W3H0Y9W3_HUMAN
Spermatogenesis-associated protein ...
SPATA20
110Annotation score:
A0A0U1RRL8A0A0U1RRL8_HUMAN
Spermatogenesis-associated protein ...
SPATA20
786Annotation score:
D6RIU6D6RIU6_HUMAN
Spermatogenesis-associated protein ...
SPATA20
67Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti356F → L in BAB15051 (PubMed:14702039).Curated1
Sequence conflicti540K → E in BAB15051 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03077788Q → E1 PublicationCorresponds to variant dbSNP:rs8076632Ensembl.1
Natural variantiVAR_030778483S → T1 PublicationCorresponds to variant dbSNP:rs9913430Ensembl.1
Natural variantiVAR_030779609K → R2 PublicationsCorresponds to variant dbSNP:rs8065903Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0232881 – 44Missing in isoform 3. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_0232891 – 25MLGAR…LAASR → MSHLSSPPKKHKGEHKGHSL PHGSE in isoform 4. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_02329026R → RCPGVWPRTWPHRSPSR in isoform 2. 1 Publication1
Alternative sequenceiVSP_023291511 – 521LMVSGYAVTGA → GAAHLRPSLSA in isoform 4. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_023292522 – 786Missing in isoform 4. 1 PublicationAdd BLAST265

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ238597 mRNA Translation: ABB54669.1
AK025000 mRNA Translation: BAB15051.1
AC021491 Genomic DNA No translation available.
BC017468 mRNA Translation: AAH17468.1
BC025255 mRNA Translation: AAH25255.1
BC111029 mRNA Translation: AAI11030.1
BC065526 mRNA Translation: AAH65526.1
CCDSiCCDS11571.1 [Q8TB22-2]
CCDS58563.1 [Q8TB22-1]
CCDS58564.1 [Q8TB22-3]
RefSeqiNP_001245301.1, NM_001258372.1 [Q8TB22-1]
NP_001245302.1, NM_001258373.1 [Q8TB22-3]
NP_073738.2, NM_022827.3 [Q8TB22-2]
UniGeneiHs.103147

Genome annotation databases

EnsembliENST00000006658; ENSP00000006658; ENSG00000006282 [Q8TB22-2]
ENST00000356488; ENSP00000348878; ENSG00000006282 [Q8TB22-1]
ENST00000511937; ENSP00000489476; ENSG00000006282 [Q8TB22-4]
ENST00000619622; ENSP00000483295; ENSG00000006282 [Q8TB22-3]
GeneIDi64847
KEGGihsa:64847
UCSCiuc002ird.4 human [Q8TB22-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ238597 mRNA Translation: ABB54669.1
AK025000 mRNA Translation: BAB15051.1
AC021491 Genomic DNA No translation available.
BC017468 mRNA Translation: AAH17468.1
BC025255 mRNA Translation: AAH25255.1
BC111029 mRNA Translation: AAI11030.1
BC065526 mRNA Translation: AAH65526.1
CCDSiCCDS11571.1 [Q8TB22-2]
CCDS58563.1 [Q8TB22-1]
CCDS58564.1 [Q8TB22-3]
RefSeqiNP_001245301.1, NM_001258372.1 [Q8TB22-1]
NP_001245302.1, NM_001258373.1 [Q8TB22-3]
NP_073738.2, NM_022827.3 [Q8TB22-2]
UniGeneiHs.103147

3D structure databases

ProteinModelPortaliQ8TB22
SMRiQ8TB22
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122320, 41 interactors
IntActiQ8TB22, 12 interactors
STRINGi9606.ENSP00000006658

PTM databases

iPTMnetiQ8TB22
PhosphoSitePlusiQ8TB22

Polymorphism and mutation databases

BioMutaiSPATA20
DMDMi311033529

Proteomic databases

EPDiQ8TB22
MaxQBiQ8TB22
PaxDbiQ8TB22
PeptideAtlasiQ8TB22
PRIDEiQ8TB22
ProteomicsDBi73947
73948 [Q8TB22-2]
73949 [Q8TB22-3]
73950 [Q8TB22-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000006658; ENSP00000006658; ENSG00000006282 [Q8TB22-2]
ENST00000356488; ENSP00000348878; ENSG00000006282 [Q8TB22-1]
ENST00000511937; ENSP00000489476; ENSG00000006282 [Q8TB22-4]
ENST00000619622; ENSP00000483295; ENSG00000006282 [Q8TB22-3]
GeneIDi64847
KEGGihsa:64847
UCSCiuc002ird.4 human [Q8TB22-1]

Organism-specific databases

CTDi64847
DisGeNETi64847
EuPathDBiHostDB:ENSG00000006282.20
GeneCardsiSPATA20
HGNCiHGNC:26125 SPATA20
HPAiHPA022023
HPA027144
HPA031442
MIMi613939 gene
neXtProtiNX_Q8TB22
OpenTargetsiENSG00000006282
PharmGKBiPA142670885
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2244 Eukaryota
COG1331 LUCA
GeneTreeiENSGT00390000004836
HOGENOMiHOG000231201
HOVERGENiHBG093992
InParanoidiQ8TB22
OMAiSSCHWCT
OrthoDBiEOG091G02U2
PhylomeDBiQ8TB22
TreeFamiTF105663

Miscellaneous databases

ChiTaRSiSPATA20 human
GenomeRNAii64847
PROiPR:Q8TB22
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000006282 Expressed in 220 organ(s), highest expression level in right testis
CleanExiHS_SPATA20
ExpressionAtlasiQ8TB22 baseline and differential
GenevisibleiQ8TB22 HS

Family and domain databases

CDDicd02955 SSP411, 1 hit
Gene3Di1.50.10.10, 2 hits
InterProiView protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR004879 DUF255
IPR024705 Ssp411
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR42899 PTHR42899, 1 hit
PfamiView protein in Pfam
PF03190 Thioredox_DsbH, 1 hit
PIRSFiPIRSF006402 UCP006402_thioredoxin, 1 hit
SUPFAMiSSF48208 SSF48208, 1 hit
SSF52833 SSF52833, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPT20_HUMAN
AccessioniPrimary (citable) accession number: Q8TB22
Secondary accession number(s): Q2TA99
, Q2XUZ6, Q6P0P1, Q8WVW3, Q9H747
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: November 2, 2010
Last modified: November 7, 2018
This is version 130 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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