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Entry version 113 (31 Jul 2019)
Sequence version 1 (01 Jun 2002)
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Protein

Uncharacterized protein CXorf38

Gene

CXorf38

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein CXorf38
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CXorf38
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:28589 CXorf38

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TB03

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000185753

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134955144

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CXorf38

Domain mapping of disease mutations (DMDM)

More...
DMDMi
71153249

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000797321 – 319Uncharacterized protein CXorf38Add BLAST319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei61Omega-N-methylarginineBy similarity1
Modified residuei314PhosphothreonineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8TB03

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8TB03

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8TB03

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8TB03

PeptideAtlas

More...
PeptideAtlasi
Q8TB03

PRoteomics IDEntifications database

More...
PRIDEi
Q8TB03

ProteomicsDB human proteome resource

More...
ProteomicsDBi
73942 [Q8TB03-1]
73943 [Q8TB03-2]
73944 [Q8TB03-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TB03

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q8TB03

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000185753 Expressed in 199 organ(s), highest expression level in amniotic fluid

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TB03 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA050120

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q8TB03, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000330488

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8TB03

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IKE6 Eukaryota
ENOG4111IY3 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000006290

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000232085

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TB03

Identification of Orthologs from Complete Genome Data

More...
OMAi
CRNELMH

Database of Orthologous Groups

More...
OrthoDBi
1360283at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TB03

TreeFam database of animal gene trees

More...
TreeFami
TF333077

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027897 DUF4559

The PANTHER Classification System

More...
PANTHERi
PTHR35083 PTHR35083, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15112 DUF4559, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8TB03-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVLSELAARL NCAEYKNWVK AGHCLLLLRS CLQGFVGREV LSFHRGLLAA
60 70 80 90 100
APGLGPRAVC RGGSRCSPRA RQFQPQCQVC AEWKREILRH HVNRNGDVHW
110 120 130 140 150
GNCRPGRWPV DAWEVAKAFM PRGLADKQGP EECDAVALLS LINSCDHFVV
160 170 180 190 200
DRKKVTEVIK CRNEIMHSSE MKVSSTWLRD FQMKIQNFLN EFKNIPEIVA
210 220 230 240 250
VYSRIEQLLT SDWAVHIPEE DQRDGCECEM GTYLSESQVN EIEMQLLKEK
260 270 280 290 300
LQEIYLQAEE QEVLPEELSN RLEVVKEFLR NNEDLRNGLT EDMQKLDSLC
310
LHQKLDSQEP GRQTPDRKA
Note: No experimental confirmation available.
Length:319
Mass (Da):36,670
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6614EFF8D47953D9
GO
Isoform 2 (identifier: Q8TB03-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-119: Missing.

Note: No experimental confirmation available.
Show »
Length:200
Mass (Da):23,284
Checksum:iF8AA3AE7B36C67B2
GO
Isoform 3 (identifier: Q8TB03-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-155: AFMPRGLADK...DHFVVDRKKV → GLDLLSRLEC...LPQPLEYLGL
     156-319: Missing.

Note: No experimental confirmation available.
Show »
Length:155
Mass (Da):17,295
Checksum:i6306B0DC74F87037
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050936176T → A. Corresponds to variant dbSNP:rs17145855Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0146201 – 119Missing in isoform 2. 1 PublicationAdd BLAST119
Alternative sequenceiVSP_014621118 – 155AFMPR…DRKKV → GLDLLSRLECSGESELIATL NSWAQAILLPQPLEYLGL in isoform 3. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_014622156 – 319Missing in isoform 3. 1 PublicationAdd BLAST164

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK095710 mRNA Translation: BAC04615.1
AK123989 mRNA Translation: BAG53990.1
AL832829 mRNA Translation: CAI46149.1
CH471141 Genomic DNA Translation: EAW59422.1
CH471141 Genomic DNA Translation: EAW59423.1
BC025334 mRNA Translation: AAH25334.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14253.1 [Q8TB03-1]
CCDS83467.1 [Q8TB03-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001317384.1, NM_001330455.1 [Q8TB03-2]
NP_659407.1, NM_144970.2 [Q8TB03-1]
XP_005272646.2, XM_005272589.2 [Q8TB03-1]
XP_016884793.1, XM_017029304.1 [Q8TB03-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000327877; ENSP00000330488; ENSG00000185753 [Q8TB03-1]
ENST00000378421; ENSP00000367677; ENSG00000185753 [Q8TB03-2]
ENST00000378426; ENSP00000367683; ENSG00000185753 [Q8TB03-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
159013

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:159013

UCSC genome browser

More...
UCSCi
uc004dev.2 human [Q8TB03-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095710 mRNA Translation: BAC04615.1
AK123989 mRNA Translation: BAG53990.1
AL832829 mRNA Translation: CAI46149.1
CH471141 Genomic DNA Translation: EAW59422.1
CH471141 Genomic DNA Translation: EAW59423.1
BC025334 mRNA Translation: AAH25334.1
CCDSiCCDS14253.1 [Q8TB03-1]
CCDS83467.1 [Q8TB03-2]
RefSeqiNP_001317384.1, NM_001330455.1 [Q8TB03-2]
NP_659407.1, NM_144970.2 [Q8TB03-1]
XP_005272646.2, XM_005272589.2 [Q8TB03-1]
XP_016884793.1, XM_017029304.1 [Q8TB03-2]

3D structure databases

SMRiQ8TB03
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ8TB03, 6 interactors
STRINGi9606.ENSP00000330488

PTM databases

iPTMnetiQ8TB03
PhosphoSitePlusiQ8TB03

Polymorphism and mutation databases

BioMutaiCXorf38
DMDMi71153249

Proteomic databases

EPDiQ8TB03
jPOSTiQ8TB03
MaxQBiQ8TB03
PaxDbiQ8TB03
PeptideAtlasiQ8TB03
PRIDEiQ8TB03
ProteomicsDBi73942 [Q8TB03-1]
73943 [Q8TB03-2]
73944 [Q8TB03-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
159013
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327877; ENSP00000330488; ENSG00000185753 [Q8TB03-1]
ENST00000378421; ENSP00000367677; ENSG00000185753 [Q8TB03-2]
ENST00000378426; ENSP00000367683; ENSG00000185753 [Q8TB03-2]
GeneIDi159013
KEGGihsa:159013
UCSCiuc004dev.2 human [Q8TB03-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
159013

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CXorf38
HGNCiHGNC:28589 CXorf38
HPAiHPA050120
neXtProtiNX_Q8TB03
OpenTargetsiENSG00000185753
PharmGKBiPA134955144

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IKE6 Eukaryota
ENOG4111IY3 LUCA
GeneTreeiENSGT00390000006290
HOGENOMiHOG000232085
InParanoidiQ8TB03
OMAiCRNELMH
OrthoDBi1360283at2759
PhylomeDBiQ8TB03
TreeFamiTF333077

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CXorf38 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
159013

Protein Ontology

More...
PROi
PR:Q8TB03

Gene expression databases

BgeeiENSG00000185753 Expressed in 199 organ(s), highest expression level in amniotic fluid
GenevisibleiQ8TB03 HS

Family and domain databases

InterProiView protein in InterPro
IPR027897 DUF4559
PANTHERiPTHR35083 PTHR35083, 1 hit
PfamiView protein in Pfam
PF15112 DUF4559, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCX038_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TB03
Secondary accession number(s): B3KW28
, D3DWB5, Q5JPF5, Q8N941
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 1, 2002
Last modified: July 31, 2019
This is version 113 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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