UniProtKB - Q8TAZ6 (CKLF2_HUMAN)
Protein
CKLF-like MARVEL transmembrane domain-containing protein 2
Gene
CMTM2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
GO - Biological processi
- chemotaxis Source: UniProtKB-KW
Keywordsi
Molecular function | Cytokine |
Biological process | Chemotaxis |
Enzyme and pathway databases
PathwayCommonsi | Q8TAZ6 |
Names & Taxonomyi
Protein namesi | Recommended name: CKLF-like MARVEL transmembrane domain-containing protein 2Alternative name(s): Chemokine-like factor superfamily member 2 |
Gene namesi | Name:CMTM2 Synonyms:CKLFSF2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19173, CMTM2 |
MIMi | 607885, gene |
neXtProti | NX_Q8TAZ6 |
VEuPathDBi | HostDB:ENSG00000140932.9 |
Subcellular locationi
Other locations
Extracellular region or secreted
- extracellular space Source: UniProtKB-KW
Other locations
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 116 – 136 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 147 – 167 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 178 – 198 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 146225 |
OpenTargetsi | ENSG00000140932 |
PharmGKBi | PA38812 |
Miscellaneous databases
Pharosi | Q8TAZ6, Tbio |
Genetic variation databases
BioMutai | CMTM2 |
DMDMi | 34921873 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000186098 | 1 – 248 | CKLF-like MARVEL transmembrane domain-containing protein 2Add BLAST | 248 |
Proteomic databases
PaxDbi | Q8TAZ6 |
PeptideAtlasi | Q8TAZ6 |
PRIDEi | Q8TAZ6 |
ProteomicsDBi | 62972 73941 [Q8TAZ6-1] |
PTM databases
iPTMneti | Q8TAZ6 |
PhosphoSitePlusi | Q8TAZ6 |
Expressioni
Tissue specificityi
Highly expressed in testis.1 Publication
Gene expression databases
Bgeei | ENSG00000140932, Expressed in testis and 124 other tissues |
ExpressionAtlasi | Q8TAZ6, baseline and differential |
Genevisiblei | Q8TAZ6, HS |
Organism-specific databases
HPAi | ENSG00000140932, Tissue enriched (testis) |
Interactioni
Binary interactionsi
Hide detailsQ8TAZ6
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
Protein-protein interaction databases
BioGRIDi | 126973, 12 interactors |
IntActi | Q8TAZ6, 13 interactors |
STRINGi | 9606.ENSP00000268595 |
Miscellaneous databases
RNActi | Q8TAZ6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 82 – 204 | MARVELPROSITE-ProRule annotationAdd BLAST | 123 |
Sequence similaritiesi
Belongs to the chemokine-like factor family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4788, Eukaryota |
GeneTreei | ENSGT00390000005715 |
HOGENOMi | CLU_106771_0_0_1 |
InParanoidi | Q8TAZ6 |
OMAi | HYFIAVI |
OrthoDBi | 1328400at2759 |
PhylomeDBi | Q8TAZ6 |
TreeFami | TF338711 |
Family and domain databases
InterProi | View protein in InterPro IPR008253, Marvel |
PROSITEi | View protein in PROSITE PS51225, MARVEL, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8TAZ6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAPKAAKGAK PEPAPAPPPP GAKPEEDKKD GKEPSDKPQK AVQDHKEPSD
60 70 80 90 100
KPQKAVQPKH EVGTRRGCRR YRWELKDSNK EFWLLGHAEI KIRSLGCLIA
110 120 130 140 150
AMILLSSLTV HPILRLIITM EISFFSFFIL LYSFAIHRYI PFILWPISDL
160 170 180 190 200
FNDLIACAFL VGAVVFAVRS RRSMNLHYLL AVILIGAAGV FAFIDVCLQR
210 220 230 240
NHFRGKKAKK HMLVPPPGKE KGPQQGKGPE PAKPPEPGKP PGPAKGKK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH3BMC0 | H3BMC0_HUMAN | CKLF-like MARVEL transmembrane doma... | CMTM2 | 51 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 172 | R → Q in BAC05345 (PubMed:15896670).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_022154 | 122 | I → T. Corresponds to variant dbSNP:rs2290182Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047061 | 96 – 148 | Missing in isoform 2. 1 PublicationAdd BLAST | 53 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF479260 mRNA Translation: AAN73038.1 AY862139 mRNA Translation: AAW51946.1 AK098598 mRNA Translation: BAC05345.1 AC010542 Genomic DNA No translation available. BC025354 mRNA Translation: AAH25354.1 |
CCDSi | CCDS10814.1 [Q8TAZ6-1] CCDS56001.1 [Q8TAZ6-2] |
RefSeqi | NP_001186246.1, NM_001199317.1 [Q8TAZ6-2] NP_653274.1, NM_144673.2 [Q8TAZ6-1] |
Genome annotation databases
Ensembli | ENST00000268595; ENSP00000268595; ENSG00000140932 [Q8TAZ6-1] ENST00000379486; ENSP00000368800; ENSG00000140932 [Q8TAZ6-2] |
GeneIDi | 146225 |
KEGGi | hsa:146225 |
UCSCi | uc002ept.4, human [Q8TAZ6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF479260 mRNA Translation: AAN73038.1 AY862139 mRNA Translation: AAW51946.1 AK098598 mRNA Translation: BAC05345.1 AC010542 Genomic DNA No translation available. BC025354 mRNA Translation: AAH25354.1 |
CCDSi | CCDS10814.1 [Q8TAZ6-1] CCDS56001.1 [Q8TAZ6-2] |
RefSeqi | NP_001186246.1, NM_001199317.1 [Q8TAZ6-2] NP_653274.1, NM_144673.2 [Q8TAZ6-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 126973, 12 interactors |
IntActi | Q8TAZ6, 13 interactors |
STRINGi | 9606.ENSP00000268595 |
PTM databases
iPTMneti | Q8TAZ6 |
PhosphoSitePlusi | Q8TAZ6 |
Genetic variation databases
BioMutai | CMTM2 |
DMDMi | 34921873 |
Proteomic databases
PaxDbi | Q8TAZ6 |
PeptideAtlasi | Q8TAZ6 |
PRIDEi | Q8TAZ6 |
ProteomicsDBi | 62972 73941 [Q8TAZ6-1] |
Protocols and materials databases
Antibodypediai | 3086, 144 antibodies |
DNASUi | 146225 |
Genome annotation databases
Ensembli | ENST00000268595; ENSP00000268595; ENSG00000140932 [Q8TAZ6-1] ENST00000379486; ENSP00000368800; ENSG00000140932 [Q8TAZ6-2] |
GeneIDi | 146225 |
KEGGi | hsa:146225 |
UCSCi | uc002ept.4, human [Q8TAZ6-1] |
Organism-specific databases
CTDi | 146225 |
DisGeNETi | 146225 |
GeneCardsi | CMTM2 |
HGNCi | HGNC:19173, CMTM2 |
HPAi | ENSG00000140932, Tissue enriched (testis) |
MIMi | 607885, gene |
neXtProti | NX_Q8TAZ6 |
OpenTargetsi | ENSG00000140932 |
PharmGKBi | PA38812 |
VEuPathDBi | HostDB:ENSG00000140932.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4788, Eukaryota |
GeneTreei | ENSGT00390000005715 |
HOGENOMi | CLU_106771_0_0_1 |
InParanoidi | Q8TAZ6 |
OMAi | HYFIAVI |
OrthoDBi | 1328400at2759 |
PhylomeDBi | Q8TAZ6 |
TreeFami | TF338711 |
Enzyme and pathway databases
PathwayCommonsi | Q8TAZ6 |
Miscellaneous databases
BioGRID-ORCSi | 146225, 4 hits in 874 CRISPR screens |
GeneWikii | CMTM2 |
GenomeRNAii | 146225 |
Pharosi | Q8TAZ6, Tbio |
PROi | PR:Q8TAZ6 |
RNActi | Q8TAZ6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000140932, Expressed in testis and 124 other tissues |
ExpressionAtlasi | Q8TAZ6, baseline and differential |
Genevisiblei | Q8TAZ6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR008253, Marvel |
PROSITEi | View protein in PROSITE PS51225, MARVEL, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CKLF2_HUMAN | |
Accessioni | Q8TAZ6Primary (citable) accession number: Q8TAZ6 Secondary accession number(s): Q5I2A4, Q8N7E5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2003 |
Last sequence update: | June 1, 2002 | |
Last modified: | February 10, 2021 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families