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Protein

CKLF-like MARVEL transmembrane domain-containing protein 2

Gene

CMTM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
CKLF-like MARVEL transmembrane domain-containing protein 2
Alternative name(s):
Chemokine-like factor superfamily member 2
Gene namesi
Name:CMTM2
Synonyms:CKLFSF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000140932.9
HGNCiHGNC:19173 CMTM2
MIMi607885 gene
neXtProtiNX_Q8TAZ6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Transmembranei178 – 198HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi146225
OpenTargetsiENSG00000140932
PharmGKBiPA38812

Polymorphism and mutation databases

BioMutaiCMTM2
DMDMi34921873

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001860981 – 248CKLF-like MARVEL transmembrane domain-containing protein 2Add BLAST248

Proteomic databases

PaxDbiQ8TAZ6
PeptideAtlasiQ8TAZ6
PRIDEiQ8TAZ6
ProteomicsDBi73941

PTM databases

iPTMnetiQ8TAZ6
PhosphoSitePlusiQ8TAZ6

Expressioni

Tissue specificityi

Highly expressed in testis.1 Publication

Gene expression databases

BgeeiENSG00000140932 Expressed in 103 organ(s), highest expression level in testis
CleanExiHS_CMTM2
ExpressionAtlasiQ8TAZ6 baseline and differential
GenevisibleiQ8TAZ6 HS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi126973, 1 interactor
IntActiQ8TAZ6, 12 interactors
STRINGi9606.ENSP00000268595

Structurei

3D structure databases

ProteinModelPortaliQ8TAZ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini82 – 204MARVELPROSITE-ProRule annotationAdd BLAST123

Sequence similaritiesi

Belongs to the chemokine-like factor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4788 Eukaryota
ENOG4111IAF LUCA
GeneTreeiENSGT00390000005715
HOGENOMiHOG000111750
HOVERGENiHBG050993
InParanoidiQ8TAZ6
OMAiPFILWPI
OrthoDBiEOG091G0POB
PhylomeDBiQ8TAZ6
TreeFamiTF338711

Family and domain databases

InterProiView protein in InterPro
IPR008253 Marvel
PfamiView protein in Pfam
PF01284 MARVEL, 1 hit
PROSITEiView protein in PROSITE
PS51225 MARVEL, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TAZ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPKAAKGAK PEPAPAPPPP GAKPEEDKKD GKEPSDKPQK AVQDHKEPSD
60 70 80 90 100
KPQKAVQPKH EVGTRRGCRR YRWELKDSNK EFWLLGHAEI KIRSLGCLIA
110 120 130 140 150
AMILLSSLTV HPILRLIITM EISFFSFFIL LYSFAIHRYI PFILWPISDL
160 170 180 190 200
FNDLIACAFL VGAVVFAVRS RRSMNLHYLL AVILIGAAGV FAFIDVCLQR
210 220 230 240
NHFRGKKAKK HMLVPPPGKE KGPQQGKGPE PAKPPEPGKP PGPAKGKK
Length:248
Mass (Da):27,496
Last modified:June 1, 2002 - v1
Checksum:i9E2E8FEB4554D84F
GO
Isoform 2 (identifier: Q8TAZ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     96-148: Missing.

Show »
Length:195
Mass (Da):21,370
Checksum:i27E032F0F16E1DA0
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BMC0H3BMC0_HUMAN
CKLF-like MARVEL transmembrane doma...
CMTM2
51Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti172R → Q in BAC05345 (PubMed:15896670).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022154122I → T. Corresponds to variant dbSNP:rs2290182Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04706196 – 148Missing in isoform 2. 1 PublicationAdd BLAST53

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF479260 mRNA Translation: AAN73038.1
AY862139 mRNA Translation: AAW51946.1
AK098598 mRNA Translation: BAC05345.1
AC010542 Genomic DNA No translation available.
BC025354 mRNA Translation: AAH25354.1
CCDSiCCDS10814.1 [Q8TAZ6-1]
CCDS56001.1 [Q8TAZ6-2]
RefSeqiNP_001186246.1, NM_001199317.1 [Q8TAZ6-2]
NP_653274.1, NM_144673.2 [Q8TAZ6-1]
UniGeneiHs.195685

Genome annotation databases

EnsembliENST00000268595; ENSP00000268595; ENSG00000140932 [Q8TAZ6-1]
ENST00000379486; ENSP00000368800; ENSG00000140932 [Q8TAZ6-2]
GeneIDi146225
KEGGihsa:146225
UCSCiuc002ept.4 human [Q8TAZ6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF479260 mRNA Translation: AAN73038.1
AY862139 mRNA Translation: AAW51946.1
AK098598 mRNA Translation: BAC05345.1
AC010542 Genomic DNA No translation available.
BC025354 mRNA Translation: AAH25354.1
CCDSiCCDS10814.1 [Q8TAZ6-1]
CCDS56001.1 [Q8TAZ6-2]
RefSeqiNP_001186246.1, NM_001199317.1 [Q8TAZ6-2]
NP_653274.1, NM_144673.2 [Q8TAZ6-1]
UniGeneiHs.195685

3D structure databases

ProteinModelPortaliQ8TAZ6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126973, 1 interactor
IntActiQ8TAZ6, 12 interactors
STRINGi9606.ENSP00000268595

PTM databases

iPTMnetiQ8TAZ6
PhosphoSitePlusiQ8TAZ6

Polymorphism and mutation databases

BioMutaiCMTM2
DMDMi34921873

Proteomic databases

PaxDbiQ8TAZ6
PeptideAtlasiQ8TAZ6
PRIDEiQ8TAZ6
ProteomicsDBi73941

Protocols and materials databases

DNASUi146225
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000268595; ENSP00000268595; ENSG00000140932 [Q8TAZ6-1]
ENST00000379486; ENSP00000368800; ENSG00000140932 [Q8TAZ6-2]
GeneIDi146225
KEGGihsa:146225
UCSCiuc002ept.4 human [Q8TAZ6-1]

Organism-specific databases

CTDi146225
DisGeNETi146225
EuPathDBiHostDB:ENSG00000140932.9
GeneCardsiCMTM2
HGNCiHGNC:19173 CMTM2
MIMi607885 gene
neXtProtiNX_Q8TAZ6
OpenTargetsiENSG00000140932
PharmGKBiPA38812
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4788 Eukaryota
ENOG4111IAF LUCA
GeneTreeiENSGT00390000005715
HOGENOMiHOG000111750
HOVERGENiHBG050993
InParanoidiQ8TAZ6
OMAiPFILWPI
OrthoDBiEOG091G0POB
PhylomeDBiQ8TAZ6
TreeFamiTF338711

Miscellaneous databases

GeneWikiiCMTM2
GenomeRNAii146225
PROiPR:Q8TAZ6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140932 Expressed in 103 organ(s), highest expression level in testis
CleanExiHS_CMTM2
ExpressionAtlasiQ8TAZ6 baseline and differential
GenevisibleiQ8TAZ6 HS

Family and domain databases

InterProiView protein in InterPro
IPR008253 Marvel
PfamiView protein in Pfam
PF01284 MARVEL, 1 hit
PROSITEiView protein in PROSITE
PS51225 MARVEL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCKLF2_HUMAN
AccessioniPrimary (citable) accession number: Q8TAZ6
Secondary accession number(s): Q5I2A4, Q8N7E5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2002
Last modified: September 12, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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