UniProtKB - Q8TAZ6 (CKLF2_HUMAN)

BLAST

>sp|Q8TAZ6|CKLF2_HUMAN CKLF-like MARVEL transmembrane domain-containing protein 2 OS=Homo sapiens OX=9606 GN=CMTM2 PE=2 SV=1
MAPKAAKGAKPEPAPAPPPPGAKPEEDKKDGKEPSDKPQKAVQDHKEPSDKPQKAVQPKH
EVGTRRGCRRYRWELKDSNKEFWLLGHAEIKIRSLGCLIAAMILLSSLTVHPILRLIITM
EISFFSFFILLYSFAIHRYIPFILWPISDLFNDLIACAFLVGAVVFAVRSRRSMNLHYLL
AVILIGAAGVFAFIDVCLQRNHFRGKKAKKHMLVPPPGKEKGPQQGKGPEPAKPPEPGKP
PGPAKGKK

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History
Entry version 121 (12 Sep 2018)
Sequence version 1 (01 Jun 2002)
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Protein

CKLF-like MARVEL transmembrane domain-containing protein 2

Gene

CMTM2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

GO - Molecular functionⁱ

cytokine activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

chemotaxis Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cytokine
Biological process	Chemotaxis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: CKLF-like MARVEL transmembrane domain-containing protein 2 Alternative name(s): Chemokine-like factor superfamily member 2
Gene namesⁱ	Name:CMTM2 Synonyms:CKLFSF2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000140932.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19173 CMTM2
MIMⁱ	607885 gene
neXtProtⁱ	NX_Q8TAZ6

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	116 – 136	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	147 – 167	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	178 – 198	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	146225
Open Targets More...OpenTargetsⁱ	ENSG00000140932
PharmGKBⁱ	PA38812

Polymorphism and mutation databases

BioMutaⁱ	CMTM2
DMDMⁱ	34921873

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000186098	1 – 248	CKLF-like MARVEL transmembrane domain-containing protein 2Add BLAST		248

Proteomic databases

PaxDbⁱ	Q8TAZ6
PeptideAtlas More...PeptideAtlasⁱ	Q8TAZ6
PRIDEⁱ	Q8TAZ6
ProteomicsDBⁱ	73941

PTM databases

iPTMnetⁱ	Q8TAZ6
PhosphoSitePlusⁱ	Q8TAZ6

Expressionⁱ

Tissue specificityⁱ

Highly expressed in testis.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000140932 Expressed in 103 organ(s), highest expression level in testis
CleanExⁱ	HS_CMTM2
ExpressionAtlasⁱ	Q8TAZ6 baseline and differential
Genevisibleⁱ	Q8TAZ6 HS

Interactionⁱ

GO - Molecular functionⁱ

cytokine activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	126973, 1 interactor
IntActⁱ	Q8TAZ6, 12 interactors
STRINGⁱ	9606.ENSP00000268595

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8TAZ6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	82 – 204	MARVELPROSITE-ProRule annotationAdd BLAST		123

Sequence similaritiesⁱ

Belongs to the chemokine-like factor family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4788 Eukaryota ENOG4111IAF LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000005715
HOGENOMⁱ	HOG000111750
HOVERGENⁱ	HBG050993
InParanoidⁱ	Q8TAZ6
OMAⁱ	PFILWPI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0POB
PhylomeDBⁱ	Q8TAZ6
TreeFamⁱ	TF338711

Family and domain databases

InterProⁱ	View protein in InterPro IPR008253 Marvel
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01284 MARVEL, 1 hit
PROSITEⁱ	View protein in PROSITE PS51225 MARVEL, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q8TAZ6-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPKAAKGAK PEPAPAPPPP GAKPEEDKKD GKEPSDKPQK AVQDHKEPSD 
        60         70         80         90        100
KPQKAVQPKH EVGTRRGCRR YRWELKDSNK EFWLLGHAEI KIRSLGCLIA 
       110        120        130        140        150
AMILLSSLTV HPILRLIITM EISFFSFFIL LYSFAIHRYI PFILWPISDL 
       160        170        180        190        200
FNDLIACAFL VGAVVFAVRS RRSMNLHYLL AVILIGAAGV FAFIDVCLQR 
       210        220        230        240 
NHFRGKKAKK HMLVPPPGKE KGPQQGKGPE PAKPPEPGKP PGPAKGKK

Length:248

Mass (Da):27,496

Last modified:June 1, 2002 - v1

Checksum:ⁱ9E2E8FEB4554D84F

Isoform 2 (identifier: Q8TAZ6-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
96-148: Missing.

« Hide

        10         20         30         40         50
MAPKAAKGAK PEPAPAPPPP GAKPEEDKKD GKEPSDKPQK AVQDHKEPSD 
        60         70         80         90        100
KPQKAVQPKH EVGTRRGCRR YRWELKDSNK EFWLLGHAEI KIRSLDLFND 
       110        120        130        140        150
LIACAFLVGA VVFAVRSRRS MNLHYLLAVI LIGAAGVFAF IDVCLQRNHF 
       160        170        180        190 
RGKKAKKHML VPPPGKEKGP QQGKGPEPAK PPEPGKPPGP AKGKK

Show »

Length:195

Mass (Da):21,370

Checksum:ⁱ27E032F0F16E1DA0

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	H3BMC0	H3BMC0_HUMAN		CKLF-like MARVEL transmembrane doma... CKLF-like MARVEL transmembrane domain-containing protein 2	CMTM2	51	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	172	R → Q in BAC05345 (PubMed:15896670).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_022154	122	I → T. Corresponds to variant dbSNP:rs2290182Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_047061	96 – 148	Missing in isoform 2. 1 PublicationAdd BLAST		53

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF479260 mRNA Translation: AAN73038.1 AY862139 mRNA Translation: AAW51946.1 AK098598 mRNA Translation: BAC05345.1 AC010542 Genomic DNA No translation available. BC025354 mRNA Translation: AAH25354.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10814.1 [Q8TAZ6-1] CCDS56001.1 [Q8TAZ6-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001186246.1, NM_001199317.1 [Q8TAZ6-2] NP_653274.1, NM_144673.2 [Q8TAZ6-1]
UniGeneⁱ	Hs.195685

Genome annotation databases

Ensemblⁱ	ENST00000268595; ENSP00000268595; ENSG00000140932 [Q8TAZ6-1] ENST00000379486; ENSP00000368800; ENSG00000140932 [Q8TAZ6-2]
GeneIDⁱ	146225
KEGGⁱ	hsa:146225
UCSC genome browser More...UCSCⁱ	uc002ept.4 human [Q8TAZ6-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8TAZ6	CMTM2 isoform 2		PONAB		248	UniRef90_Q8TAZ6
CKLF like MARVEL transmembrane domain containing 2		GORGO		248
Uncharacterized protein		NOMLE		234
CMTM2 isoform 3		PANTR		233
UPI0000E242D5		PANPA		234
+1
Q8TAZ6-2	CKLF like MARVEL transmembrane domain containing 2		GORGO		195	UniRef90_Q8TAZ6-2
CKLF like MARVEL transmembrane domain containing 2		PANTR		181

Protein	Similar proteins		Species	Score	Length	Source
Q8TAZ6	CKLF like MARVEL transmembrane domain containing 2		GORGO		248	UniRef50_Q8TAZ6
CMTM2 isoform 2		PONAB		248
Uncharacterized protein		NOMLE		234
CMTM2 isoform 3		PANTR		233
CKLF-like MARVEL transmembrane domain-containing protein 2-like		LIPVE		228
+53
Q8TAZ6-2	CKLF like MARVEL transmembrane domain containing 2		GORGO		195	UniRef50_Q8TAZ6-2
CKLF like MARVEL transmembrane domain containing 2		PANTR		181
Uncharacterized protein		PROCO		199
CMTM2 isoform 1		PONAB		195
Uncharacterized protein		NOMLE		181
+19

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF479260 mRNA Translation: AAN73038.1 AY862139 mRNA Translation: AAW51946.1 AK098598 mRNA Translation: BAC05345.1 AC010542 Genomic DNA No translation available. BC025354 mRNA Translation: AAH25354.1
CCDSⁱ	CCDS10814.1 [Q8TAZ6-1] CCDS56001.1 [Q8TAZ6-2]
RefSeqⁱ	NP_001186246.1, NM_001199317.1 [Q8TAZ6-2] NP_653274.1, NM_144673.2 [Q8TAZ6-1]
UniGeneⁱ	Hs.195685

3D structure databases

ProteinModelPortalⁱ	Q8TAZ6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	126973, 1 interactor
IntActⁱ	Q8TAZ6, 12 interactors
STRINGⁱ	9606.ENSP00000268595

PTM databases

iPTMnetⁱ	Q8TAZ6
PhosphoSitePlusⁱ	Q8TAZ6

Polymorphism and mutation databases

BioMutaⁱ	CMTM2
DMDMⁱ	34921873

Proteomic databases

PaxDbⁱ	Q8TAZ6
PeptideAtlasⁱ	Q8TAZ6
PRIDEⁱ	Q8TAZ6
ProteomicsDBⁱ	73941

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	146225
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000268595; ENSP00000268595; ENSG00000140932 [Q8TAZ6-1] ENST00000379486; ENSP00000368800; ENSG00000140932 [Q8TAZ6-2]
GeneIDⁱ	146225
KEGGⁱ	hsa:146225
UCSCⁱ	uc002ept.4 human [Q8TAZ6-1]

Organism-specific databases

CTDⁱ	146225
DisGeNETⁱ	146225
EuPathDBⁱ	HostDB:ENSG00000140932.9
GeneCardsⁱ	CMTM2
HGNCⁱ	HGNC:19173 CMTM2
MIMⁱ	607885 gene
neXtProtⁱ	NX_Q8TAZ6
OpenTargetsⁱ	ENSG00000140932
PharmGKBⁱ	PA38812
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4788 Eukaryota ENOG4111IAF LUCA
GeneTreeⁱ	ENSGT00390000005715
HOGENOMⁱ	HOG000111750
HOVERGENⁱ	HBG050993
InParanoidⁱ	Q8TAZ6
OMAⁱ	PFILWPI
OrthoDBⁱ	EOG091G0POB
PhylomeDBⁱ	Q8TAZ6
TreeFamⁱ	TF338711

Miscellaneous databases

GeneWikiⁱ	CMTM2
GenomeRNAiⁱ	146225
Protein Ontology More...PROⁱ	PR:Q8TAZ6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000140932 Expressed in 103 organ(s), highest expression level in testis
CleanExⁱ	HS_CMTM2
ExpressionAtlasⁱ	Q8TAZ6 baseline and differential
Genevisibleⁱ	Q8TAZ6 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR008253 Marvel
Pfamⁱ	View protein in Pfam PF01284 MARVEL, 1 hit
PROSITEⁱ	View protein in PROSITE PS51225 MARVEL, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CKLF2_HUMAN
Accessionⁱ	Q8TAZ6Primary (citable) accession number: Q8TAZ6 Secondary accession number(s): Q5I2A4, Q8N7E5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 19, 2003
	Last sequence update:	June 1, 2002
	Last modified:	September 12, 2018
	This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8TAZ6 (CKLF2_HUMAN)

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CKLF-like MARVEL transmembrane domain-containing protein 2

CMTM2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Extracellular region or secreted

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ