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Entry version 119 (17 Jun 2020)
Sequence version 2 (08 Apr 2008)
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Protein

Gasdermin-B

Gene

GSDMB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores (PubMed:27281216). The physiological relevance of this observation is unknown (Probable).Curated1 Publication

Miscellaneous

The GSDML gene is predicted to be generated due to a duplication of GSDM gene; the rodent GSDML ortholog failed to be yet identified. The evolutionary recombination hotspot around GSDML-GSDM locus is closely related to the oncogenomic recombination hotspot or fragile sites within the human genome.
Long terminal repeat (LTR) of endogenous retroviruse HERV-H with reverse orientation may serve as alternative promoters of GSDML gene.
GSDML may be used as predictive markers of cervical lymph node metastasis and may help, with a panel of other genes, to discriminate between primary tumors of oral squamous cell carcinoma that metastasize to cervical lymph node and those that do not metastasize.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processNecrosis

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.C.123.1.3 the pore-forming gasdermin (gasdermin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Gasdermin-B
Alternative name(s):
Gasdermin-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GSDMB
Synonyms:GSDML
ORF Names:PP4052, PRO2521
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000073605.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23690 GSDMB

Online Mendelian Inheritance in Man (OMIM)

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MIMi
611221 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TAX9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55876

Open Targets

More...
OpenTargetsi
ENSG00000073605

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162390303

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TAX9 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GSDMB

Domain mapping of disease mutations (DMDM)

More...
DMDMi
182647404

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003290581 – 411Gasdermin-BAdd BLAST411

Keywords - PTMi

Disulfide bond

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TAX9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8TAX9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TAX9

PeptideAtlas

More...
PeptideAtlasi
Q8TAX9

PRoteomics IDEntifications database

More...
PRIDEi
Q8TAX9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
73934 [Q8TAX9-1]
73935 [Q8TAX9-2]
73936 [Q8TAX9-3]
73937 [Q8TAX9-4]
73938 [Q8TAX9-5]
73939 [Q8TAX9-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TAX9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TAX9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In the gastrointestinal tract, expressed in proliferating cells, including in the basal cell layer of esophagus and in isthmus/neck of stomach.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000073605 Expressed in right lobe of liver and 159 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TAX9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TAX9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000073605 Tissue enhanced (intestine)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The N-terminal moiety forms homooligomer; disulfide-linked. May form an 16-mer complex. Oligomerization occurs in the presence of membranes.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
120972, 8 interactors

Protein interaction database and analysis system

More...
IntActi
Q8TAX9, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000415049

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8TAX9 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1411
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TAX9

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 275Triggers pyroptosis1 PublicationAdd BLAST275

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili243 – 271Sequence analysisAdd BLAST29

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Intramolecular interactions between N- and C-terminal domains may be important for autoinhibition in the absence of activation signal. The intrinsic pyroptosis-inducing activity is carried by the N-terminal domain.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the gasdermin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IVE6 Eukaryota
ENOG41115RT LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183140

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_058837_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TAX9

KEGG Orthology (KO)

More...
KOi
K22142

Identification of Orthologs from Complete Genome Data

More...
OMAi
DADKFHC

Database of Orthologous Groups

More...
OrthoDBi
1170047at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TAX9

TreeFam database of animal gene trees

More...
TreeFami
TF331886

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007677 Gasdermin
IPR040460 Gasdermin_pore
IPR041263 Gasdermin_PUB

The PANTHER Classification System

More...
PANTHERi
PTHR16399 PTHR16399, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04598 Gasdermin, 1 hit
PF17708 Gasdermin_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Isoforms expression varies between tumor and non-tumor cells and changes in the regulation of isoforms transcription and translation may be seen in the development of gastrointestinal and hepatic cancers.

This entry has 6 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TAX9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFSVFEEITR IVVKEMDAGG DMIAVRSLVD ADRFRCFHLV GEKRTFFGCR
60 70 80 90 100
HYTTGLTLMD ILDTDGDKWL DELDSGLQGQ KAEFQILDNV DSTGELIVRL
110 120 130 140 150
PKEITISGSF QGFHHQKIKI SENRISQQYL ATLENRKLKR ELPFSFRSIN
160 170 180 190 200
TRENLYLVTE TLETVKEETL KSDRQYKFWS QISQGHLSYK HKGQREVTIP
210 220 230 240 250
PNRVLSYRVK QLVFPNKETM SAGLDIHFRG KTKSFPEGKS LGSEDSRNMK
260 270 280 290 300
EKLEDMESVL KDLTEEKRKD VLNSLAKCLG KEDIRQDLEQ RVSEVLISGE
310 320 330 340 350
LHMEDPDKPL LSSLFNAAGV LVEARAKAIL DFLDALLELS EEQQFVAEAL
360 370 380 390 400
EKGTLPLLKD QVKSVMEQNW DELASSPPDM DYDPEARILC ALYVVVSILL
410
ELAEGPTSVS S
Length:411
Mass (Da):46,786
Last modified:April 8, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC40823DA13F8E11A
GO
Isoform 2 (identifier: Q8TAX9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     221-238: SAGLDIHFRGKTKSFPEG → R

Show »
Length:394
Mass (Da):45,013
Checksum:i5515F6FE2A8492B6
GO
Isoform 3 (identifier: Q8TAX9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     221-237: SAGLDIHFRGKTKSFPE → KKDGASSCL

Show »
Length:403
Mass (Da):45,804
Checksum:iBEE14FA3CF1F54E2
GO
Isoform 4 (identifier: Q8TAX9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     221-225: SAGLD → N
     237-237: E → EEKDGASSCL

Show »
Length:416
Mass (Da):47,348
Checksum:i04DDA43952EF603F
GO
Isoform 5 (identifier: Q8TAX9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-248: Missing.

Show »
Length:163
Mass (Da):18,159
Checksum:i04613B3AE40027BE
GO
Isoform 6 (identifier: Q8TAX9-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     221-225: SAGLD → N

Show »
Length:407
Mass (Da):46,457
Checksum:iA9A4BEEA1E39BE54
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B2CM73B2CM73_HUMAN
Gasdermin-B
GSDMB GSDML
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B2CM72B2CM72_HUMAN
Gasdermin-B
GSDMB GSDML
200Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B2CM71B2CM71_HUMAN
Gasdermin-B
GSDMB GSDML
203Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QLF0J3QLF0_HUMAN
Gasdermin-B
GSDMB
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti65D → H in AAF69638 (PubMed:11483580).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_042632122E → G. Corresponds to variant dbSNP:rs12450091Ensembl.1
Natural variantiVAR_042633132T → A. Corresponds to variant dbSNP:rs4619433Ensembl.1
Natural variantiVAR_042634245D → G in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_042635299G → R2 PublicationsCorresponds to variant dbSNP:rs2305479Ensembl.1
Natural variantiVAR_042636306P → S2 PublicationsCorresponds to variant dbSNP:rs2305480Ensembl.1
Natural variantiVAR_042637325R → C. Corresponds to variant dbSNP:rs16965388Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0329361 – 248Missing in isoform 5. 1 PublicationAdd BLAST248
Alternative sequenceiVSP_032937221 – 238SAGLD…SFPEG → R in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_032938221 – 237SAGLD…KSFPE → KKDGASSCL in isoform 3. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_032939221 – 225SAGLD → N in isoform 4 and isoform 6. 2 Publications5
Alternative sequenceiVSP_032940237E → EEKDGASSCL in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF119884 mRNA Translation: AAF69638.1
AK000409 mRNA Translation: BAA91146.1
AK296607 mRNA Translation: BAG59219.1
AF258572 mRNA Translation: AAG23775.1
AC090844 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60614.1
BC025682 mRNA Translation: AAH25682.1
BX538068 mRNA Translation: CAD97998.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11354.1 [Q8TAX9-2]
CCDS42313.1 [Q8TAX9-3]
CCDS54119.1 [Q8TAX9-6]
CCDS54120.1 [Q8TAX9-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001035936.1, NM_001042471.1 [Q8TAX9-3]
NP_001159430.1, NM_001165958.1 [Q8TAX9-4]
NP_001159431.1, NM_001165959.1 [Q8TAX9-6]
NP_061000.2, NM_018530.2 [Q8TAX9-2]
XP_016880339.1, XM_017024850.1
XP_016880340.1, XM_017024851.1
XP_016880341.1, XM_017024852.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000309481; ENSP00000312584; ENSG00000073605 [Q8TAX9-3]
ENST00000360317; ENSP00000353465; ENSG00000073605 [Q8TAX9-4]
ENST00000394175; ENSP00000377729; ENSG00000073605 [Q8TAX9-2]
ENST00000394179; ENSP00000377733; ENSG00000073605 [Q8TAX9-3]
ENST00000418519; ENSP00000415049; ENSG00000073605 [Q8TAX9-4]
ENST00000520542; ENSP00000430157; ENSG00000073605 [Q8TAX9-6]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55876

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55876

UCSC genome browser

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UCSCi
uc002htg.3 human [Q8TAX9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF119884 mRNA Translation: AAF69638.1
AK000409 mRNA Translation: BAA91146.1
AK296607 mRNA Translation: BAG59219.1
AF258572 mRNA Translation: AAG23775.1
AC090844 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60614.1
BC025682 mRNA Translation: AAH25682.1
BX538068 mRNA Translation: CAD97998.1
CCDSiCCDS11354.1 [Q8TAX9-2]
CCDS42313.1 [Q8TAX9-3]
CCDS54119.1 [Q8TAX9-6]
CCDS54120.1 [Q8TAX9-4]
RefSeqiNP_001035936.1, NM_001042471.1 [Q8TAX9-3]
NP_001159430.1, NM_001165958.1 [Q8TAX9-4]
NP_001159431.1, NM_001165959.1 [Q8TAX9-6]
NP_061000.2, NM_018530.2 [Q8TAX9-2]
XP_016880339.1, XM_017024850.1
XP_016880340.1, XM_017024851.1
XP_016880341.1, XM_017024852.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5TIBX-ray2.60A/B220-406[»]
5TJ2X-ray2.80A/B/C/D220-406[»]
5TJ4X-ray3.50A/B/C/D/E/F/G/H/I/J221-410[»]
SMRiQ8TAX9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120972, 8 interactors
IntActiQ8TAX9, 6 interactors
STRINGi9606.ENSP00000415049

Protein family/group databases

TCDBi1.C.123.1.3 the pore-forming gasdermin (gasdermin) family

PTM databases

iPTMnetiQ8TAX9
PhosphoSitePlusiQ8TAX9

Polymorphism and mutation databases

BioMutaiGSDMB
DMDMi182647404

Proteomic databases

jPOSTiQ8TAX9
MassIVEiQ8TAX9
PaxDbiQ8TAX9
PeptideAtlasiQ8TAX9
PRIDEiQ8TAX9
ProteomicsDBi73934 [Q8TAX9-1]
73935 [Q8TAX9-2]
73936 [Q8TAX9-3]
73937 [Q8TAX9-4]
73938 [Q8TAX9-5]
73939 [Q8TAX9-6]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
4429 212 antibodies

The DNASU plasmid repository

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DNASUi
55876

Genome annotation databases

EnsembliENST00000309481; ENSP00000312584; ENSG00000073605 [Q8TAX9-3]
ENST00000360317; ENSP00000353465; ENSG00000073605 [Q8TAX9-4]
ENST00000394175; ENSP00000377729; ENSG00000073605 [Q8TAX9-2]
ENST00000394179; ENSP00000377733; ENSG00000073605 [Q8TAX9-3]
ENST00000418519; ENSP00000415049; ENSG00000073605 [Q8TAX9-4]
ENST00000520542; ENSP00000430157; ENSG00000073605 [Q8TAX9-6]
GeneIDi55876
KEGGihsa:55876
UCSCiuc002htg.3 human [Q8TAX9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55876
DisGeNETi55876
EuPathDBiHostDB:ENSG00000073605.18

GeneCards: human genes, protein and diseases

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GeneCardsi
GSDMB
HGNCiHGNC:23690 GSDMB
HPAiENSG00000073605 Tissue enhanced (intestine)
MIMi611221 gene
neXtProtiNX_Q8TAX9
OpenTargetsiENSG00000073605
PharmGKBiPA162390303

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IVE6 Eukaryota
ENOG41115RT LUCA
GeneTreeiENSGT00950000183140
HOGENOMiCLU_058837_0_0_1
InParanoidiQ8TAX9
KOiK22142
OMAiDADKFHC
OrthoDBi1170047at2759
PhylomeDBiQ8TAX9
TreeFamiTF331886

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
55876 11 hits in 786 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GSDMB human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55876
PharosiQ8TAX9 Tbio

Protein Ontology

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PROi
PR:Q8TAX9
RNActiQ8TAX9 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000073605 Expressed in right lobe of liver and 159 other tissues
ExpressionAtlasiQ8TAX9 baseline and differential
GenevisibleiQ8TAX9 HS

Family and domain databases

InterProiView protein in InterPro
IPR007677 Gasdermin
IPR040460 Gasdermin_pore
IPR041263 Gasdermin_PUB
PANTHERiPTHR16399 PTHR16399, 1 hit
PfamiView protein in Pfam
PF04598 Gasdermin, 1 hit
PF17708 Gasdermin_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGSDMB_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TAX9
Secondary accession number(s): B4DKK7
, Q7Z377, Q8WY76, Q9NX71, Q9P163
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: June 17, 2020
This is version 119 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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