UniProtKB - Q8TAX7 (MUC7_HUMAN)
Protein
Mucin-7
Gene
MUC7
Organism
Homo sapiens (Human)
Status
Functioni
May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili.2 Publications
GO - Biological processi
- antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
- killing of cells of other organism Source: UniProtKB
- O-glycan processing Source: Reactome
- stimulatory C-type lectin receptor signaling pathway Source: Reactome
Enzyme and pathway databases
PathwayCommonsi | Q8TAX7 |
Reactomei | R-HSA-5083625, Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) R-HSA-5083632, Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) R-HSA-5083636, Defective GALNT12 causes colorectal cancer 1 (CRCS1) R-HSA-5621480, Dectin-2 family R-HSA-913709, O-linked glycosylation of mucins R-HSA-977068, Termination of O-glycan biosynthesis |
Names & Taxonomyi
Protein namesi | Recommended name: Mucin-7Short name: MUC-7 Alternative name(s): Apo-MG2 Salivary mucin-7 |
Gene namesi | Name:MUC7 Synonyms:MG2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7518, MUC7 |
MIMi | 158375, gene |
neXtProti | NX_Q8TAX7 |
VEuPathDBi | HostDB:ENSG00000171195.10 |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Golgi apparatus
- Golgi lumen Source: Reactome
Plasma Membrane
- plasma membrane Source: Reactome
Keywords - Cellular componenti
SecretedPathology & Biotechi
Involvement in diseasei
Asthma (ASTHMA)1 Publication
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Disease descriptionThe most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi.
Related information in OMIMKeywords - Diseasei
AsthmaOrganism-specific databases
DisGeNETi | 4589 |
MalaCardsi | MUC7 |
MIMi | 600807, phenotype |
OpenTargetsi | ENSG00000171195 |
PharmGKBi | PA31323 |
Miscellaneous databases
Pharosi | Q8TAX7, Tbio |
Genetic variation databases
BioMutai | MUC7 |
DMDMi | 296439230 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_0000239228 | 23 – 377 | Mucin-7Add BLAST | 355 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 97 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 128 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 135 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 146 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
N- and O-glycosylated. Contains fucose, mannose, galactose, N-acetylglucosamine and N-acetylgalactosamine.1 Publication
Keywords - PTMi
GlycoproteinProteomic databases
MassIVEi | Q8TAX7 |
PaxDbi | Q8TAX7 |
PeptideAtlasi | Q8TAX7 |
PRIDEi | Q8TAX7 |
ProteomicsDBi | 73933 |
PTM databases
GlyConnecti | 418, 14 O-Linked glycans |
GlyGeni | Q8TAX7, 4 sites |
Expressioni
Tissue specificityi
Expressed in salivary gland tissues and only in those that contain mucous acinar cells (e.g. sublingual and submandibular glands) and not in salivary glands containing only serous acinar cells (e.g. parotid gland).2 Publications
Gene expression databases
Bgeei | ENSG00000171195, Expressed in minor salivary gland and 110 other tissues |
ExpressionAtlasi | Q8TAX7, baseline and differential |
Genevisiblei | Q8TAX7, HS |
Organism-specific databases
HPAi | ENSG00000171195, Tissue enriched (salivary) |
Interactioni
Subunit structurei
Monomer.
Binary interactionsi
Hide detailsQ8TAX7
With | #Exp. | IntAct |
---|---|---|
AMY1A [P04745] | 2 | EBI-738582,EBI-738586 |
HTN1 [P15515] | 2 | EBI-738582,EBI-738638 |
PRH2 [P02810] | 2 | EBI-738582,EBI-738601 |
STATH [P02808] | 2 | EBI-738582,EBI-738687 |
Protein-protein interaction databases
BioGRIDi | 110676, 16 interactors |
IntActi | Q8TAX7, 20 interactors |
STRINGi | 9606.ENSP00000407422 |
Miscellaneous databases
RNActi | Q8TAX7, protein |
Structurei
3D structure databases
BMRBi | Q8TAX7 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 165 – 187 | 1Add BLAST | 23 | |
Repeati | 188 – 210 | 2Add BLAST | 23 | |
Repeati | 211 – 233 | 3Add BLAST | 23 | |
Repeati | 234 – 256 | 4Add BLAST | 23 | |
Repeati | 257 – 279 | 5Add BLAST | 23 | |
Repeati | 280 – 302 | 6Add BLAST | 23 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 104 – 348 | Thr-richAdd BLAST | 245 |
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502QU51, Eukaryota |
GeneTreei | ENSGT00730000111663 |
HOGENOMi | CLU_063474_0_0_1 |
InParanoidi | Q8TAX7 |
OMAi | SIGTNCL |
OrthoDBi | 1448371at2759 |
PhylomeDBi | Q8TAX7 |
TreeFami | TF341506 |
Family and domain databases
InterProi | View protein in InterPro IPR033529, MUC7 |
PANTHERi | PTHR41683, PTHR41683, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q8TAX7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKTLPLFVCI CALSACFSFS EGRERDHELR HRRHHHQSPK SHFELPHYPG
60 70 80 90 100
LLAHQKPFIR KSYKCLHKRC RPKLPPSPNN PPKFPNPHQP PKHPDKNSSV
110 120 130 140 150
VNPTLVATTQ IPSVTFPSAS TKITTLPNVT FLPQNATTIS SRENVNTSSS
160 170 180 190 200
VATLAPVNSP APQDTTAAPP TPSATTPAPP SSSAPPETTA APPTPSATTQ
210 220 230 240 250
APPSSSAPPE TTAAPPTPPA TTPAPPSSSA PPETTAAPPT PSATTPAPLS
260 270 280 290 300
SSAPPETTAV PPTPSATTLD PSSASAPPET TAAPPTPSAT TPAPPSSPAP
310 320 330 340 350
QETTAAPITT PNSSPTTLAP DTSETSAAPT HQTTTSVTTQ TTTTKQPTSA
360 370
PGQNKISRFL LYMKNLLNRI IDDMVEQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD6RHX1 | D6RHX1_HUMAN | Mucin-7 | MUC7 | 136 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 70 | C → S AA sequence (PubMed:1445223).Curated | 1 | |
Sequence conflicti | 92 | K → P AA sequence (PubMed:1445223).Curated | 1 | |
Sequence conflicti | 162 | P → A AA sequence (PubMed:1445223).Curated | 1 | |
Sequence conflicti | 162 | P → A AA sequence (PubMed:8104046).Curated | 1 | |
Sequence conflicti | 334 | T → I in AAH25688 (PubMed:15489334).Curated | 1 |
Polymorphismi
The most common allele, MUC7*6, contains a tandem repeat domain comprising 6 repeats (shown here) each composed of 23 amino acids. These repeats are very similar but not identical. In a large cohort of 375 individuals from a variety of ethnic backgrounds, three different alleles were detected, MUC7*6 being the most common, in all populations studied, followed by MUC7*5 (5 repeats), with frequency varying from 0.05 in Africans to 0.22 in East Asians. The MUC7*5 allele is less prevalent in patients with asthma than in controls, and seems to have a protective role in respiratory function. MUC7*8 (8 repeats), a novel rare allele, was identified in 1 Northern European individual.
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050451 | 80 | N → K. Corresponds to variant dbSNP:rs6826961Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC106884 Genomic DNA No translation available. AC108518 Genomic DNA No translation available. BC025688 mRNA Translation: AAH25688.1 |
CCDSi | CCDS3541.1 |
PIRi | A48018 |
RefSeqi | NP_001138478.1, NM_001145006.1 NP_001138479.1, NM_001145007.1 NP_689504.2, NM_152291.2 |
Genome annotation databases
Ensembli | ENST00000304887; ENSP00000302021; ENSG00000171195 ENST00000413702; ENSP00000407422; ENSG00000171195 ENST00000456088; ENSP00000400585; ENSG00000171195 |
GeneIDi | 4589 |
KEGGi | hsa:4589 |
UCSCi | uc003hfj.3, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Mucin database |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC106884 Genomic DNA No translation available. AC108518 Genomic DNA No translation available. BC025688 mRNA Translation: AAH25688.1 |
CCDSi | CCDS3541.1 |
PIRi | A48018 |
RefSeqi | NP_001138478.1, NM_001145006.1 NP_001138479.1, NM_001145007.1 NP_689504.2, NM_152291.2 |
3D structure databases
BMRBi | Q8TAX7 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 110676, 16 interactors |
IntActi | Q8TAX7, 20 interactors |
STRINGi | 9606.ENSP00000407422 |
PTM databases
GlyConnecti | 418, 14 O-Linked glycans |
GlyGeni | Q8TAX7, 4 sites |
Genetic variation databases
BioMutai | MUC7 |
DMDMi | 296439230 |
Proteomic databases
MassIVEi | Q8TAX7 |
PaxDbi | Q8TAX7 |
PeptideAtlasi | Q8TAX7 |
PRIDEi | Q8TAX7 |
ProteomicsDBi | 73933 |
Protocols and materials databases
Antibodypediai | 1459, 155 antibodies |
DNASUi | 4589 |
Genome annotation databases
Ensembli | ENST00000304887; ENSP00000302021; ENSG00000171195 ENST00000413702; ENSP00000407422; ENSG00000171195 ENST00000456088; ENSP00000400585; ENSG00000171195 |
GeneIDi | 4589 |
KEGGi | hsa:4589 |
UCSCi | uc003hfj.3, human |
Organism-specific databases
CTDi | 4589 |
DisGeNETi | 4589 |
GeneCardsi | MUC7 |
HGNCi | HGNC:7518, MUC7 |
HPAi | ENSG00000171195, Tissue enriched (salivary) |
MalaCardsi | MUC7 |
MIMi | 158375, gene 600807, phenotype |
neXtProti | NX_Q8TAX7 |
OpenTargetsi | ENSG00000171195 |
PharmGKBi | PA31323 |
VEuPathDBi | HostDB:ENSG00000171195.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QU51, Eukaryota |
GeneTreei | ENSGT00730000111663 |
HOGENOMi | CLU_063474_0_0_1 |
InParanoidi | Q8TAX7 |
OMAi | SIGTNCL |
OrthoDBi | 1448371at2759 |
PhylomeDBi | Q8TAX7 |
TreeFami | TF341506 |
Enzyme and pathway databases
PathwayCommonsi | Q8TAX7 |
Reactomei | R-HSA-5083625, Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) R-HSA-5083632, Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) R-HSA-5083636, Defective GALNT12 causes colorectal cancer 1 (CRCS1) R-HSA-5621480, Dectin-2 family R-HSA-913709, O-linked glycosylation of mucins R-HSA-977068, Termination of O-glycan biosynthesis |
Miscellaneous databases
BioGRID-ORCSi | 4589, 5 hits in 959 CRISPR screens |
ChiTaRSi | MUC7, human |
GeneWikii | MUC7 |
GenomeRNAii | 4589 |
Pharosi | Q8TAX7, Tbio |
PROi | PR:Q8TAX7 |
RNActi | Q8TAX7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000171195, Expressed in minor salivary gland and 110 other tissues |
ExpressionAtlasi | Q8TAX7, baseline and differential |
Genevisiblei | Q8TAX7, HS |
Family and domain databases
InterProi | View protein in InterPro IPR033529, MUC7 |
PANTHERi | PTHR41683, PTHR41683, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MUC7_HUMAN | |
Accessioni | Q8TAX7Primary (citable) accession number: Q8TAX7 Secondary accession number(s): Q9UCD7, Q9UCD8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2006 |
Last sequence update: | May 18, 2010 | |
Last modified: | April 7, 2021 | |
This is version 141 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot