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Protein

Protein odd-skipped-related 1

Gene

OSR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor that plays a role in the regulation of embryonic heart and urogenital development.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri175 – 197C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri203 – 225C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri231 – 253C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • nucleic acid binding Source: InterPro
  • protein kinase binding Source: ParkinsonsUK-UCL
  • protein serine/threonine kinase activity Source: ParkinsonsUK-UCL
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein odd-skipped-related 1
Gene namesi
Name:OSR1
Synonyms:ODD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000143867.6
HGNCiHGNC:8111 OSR1
MIMi608891 gene
neXtProtiNX_Q8TAX0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi130497
OpenTargetsiENSG00000143867
PharmGKBiPA164742217

Polymorphism and mutation databases

BioMutaiOSR1
DMDMi74762600

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000470041 – 266Protein odd-skipped-related 1Add BLAST266

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei116Asymmetric dimethylarginineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiQ8TAX0
PeptideAtlasiQ8TAX0
PRIDEiQ8TAX0
ProteomicsDBi73932

PTM databases

iPTMnetiQ8TAX0
PhosphoSitePlusiQ8TAX0

Expressioni

Tissue specificityi

Expressed in adult colon, small intestine, prostate, testis, and fetal lung.1 Publication

Gene expression databases

BgeeiENSG00000143867 Expressed in 114 organ(s), highest expression level in urinary bladder
CleanExiHS_OSR1
GenevisibleiQ8TAX0 HS

Organism-specific databases

HPAiHPA015525

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi126234, 2 interactors
STRINGi9606.ENSP00000272223

Structurei

3D structure databases

ProteinModelPortaliQ8TAX0
SMRiQ8TAX0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri175 – 197C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri203 – 225C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri231 – 253C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00880000137939
HOGENOMiHOG000013107
HOVERGENiHBG054398
InParanoidiQ8TAX0
KOiK09215
OMAiATQEDHL
OrthoDBiEOG091G0LRE
PhylomeDBiQ8TAX0
TreeFamiTF350876

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequencei

Sequence statusi: Complete.

Q8TAX0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSKTLPAPV PIHPSLQLTN YSFLQAVNGL PTVPSDHLPN LYGFSALHAV
60 70 80 90 100
HLHQWTLGYP AMHLPRSSFS KVPGTVSSLV DARFQLPAFP WFPHVIQPKP
110 120 130 140 150
EITAGGSVPA LKTKPRFDFA NLALAATQED PAKLGRGEGP GSPAGGLGAL
160 170 180 190 200
LDVTKLSPEK KPTRGRLPSK TKKEFVCKFC GRHFTKSYNL LIHERTHTDE
210 220 230 240 250
RPYTCDICHK AFRRQDHLRD HRYIHSKEKP FKCQECGKGF CQSRTLAVHK
260
TLHSQVKELK TSKIKC
Length:266
Mass (Da):29,611
Last modified:June 1, 2002 - v1
Checksum:i3D15ED2565C954E3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti214R → G in BAG53709 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB082568 mRNA Translation: BAB92079.1
AK074591 mRNA Translation: BAC11079.1
AK122756 mRNA Translation: BAG53709.1
DQ021502 Genomic DNA Translation: AAY26397.1
AC018741 Genomic DNA Translation: AAY14760.1
CH471053 Genomic DNA Translation: EAX00846.1
CH471053 Genomic DNA Translation: EAX00848.1
BC025712 mRNA Translation: AAH25712.1
CCDSiCCDS1694.1
RefSeqiNP_660303.1, NM_145260.2
XP_006712005.1, XM_006711942.3
UniGeneiHs.123933

Genome annotation databases

EnsembliENST00000272223; ENSP00000272223; ENSG00000143867
GeneIDi130497
KEGGihsa:130497
UCSCiuc002rdc.4 human

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB082568 mRNA Translation: BAB92079.1
AK074591 mRNA Translation: BAC11079.1
AK122756 mRNA Translation: BAG53709.1
DQ021502 Genomic DNA Translation: AAY26397.1
AC018741 Genomic DNA Translation: AAY14760.1
CH471053 Genomic DNA Translation: EAX00846.1
CH471053 Genomic DNA Translation: EAX00848.1
BC025712 mRNA Translation: AAH25712.1
CCDSiCCDS1694.1
RefSeqiNP_660303.1, NM_145260.2
XP_006712005.1, XM_006711942.3
UniGeneiHs.123933

3D structure databases

ProteinModelPortaliQ8TAX0
SMRiQ8TAX0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126234, 2 interactors
STRINGi9606.ENSP00000272223

PTM databases

iPTMnetiQ8TAX0
PhosphoSitePlusiQ8TAX0

Polymorphism and mutation databases

BioMutaiOSR1
DMDMi74762600

Proteomic databases

PaxDbiQ8TAX0
PeptideAtlasiQ8TAX0
PRIDEiQ8TAX0
ProteomicsDBi73932

Protocols and materials databases

DNASUi130497
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272223; ENSP00000272223; ENSG00000143867
GeneIDi130497
KEGGihsa:130497
UCSCiuc002rdc.4 human

Organism-specific databases

CTDi130497
DisGeNETi130497
EuPathDBiHostDB:ENSG00000143867.6
GeneCardsiOSR1
HGNCiHGNC:8111 OSR1
HPAiHPA015525
MIMi608891 gene
neXtProtiNX_Q8TAX0
OpenTargetsiENSG00000143867
PharmGKBiPA164742217
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00880000137939
HOGENOMiHOG000013107
HOVERGENiHBG054398
InParanoidiQ8TAX0
KOiK09215
OMAiATQEDHL
OrthoDBiEOG091G0LRE
PhylomeDBiQ8TAX0
TreeFamiTF350876

Miscellaneous databases

GeneWikiiOSR1
GenomeRNAii130497
PROiPR:Q8TAX0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143867 Expressed in 114 organ(s), highest expression level in urinary bladder
CleanExiHS_OSR1
GenevisibleiQ8TAX0 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiOSR1_HUMAN
AccessioniPrimary (citable) accession number: Q8TAX0
Secondary accession number(s): B3KV97, D6W521
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: June 1, 2002
Last modified: October 10, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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