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Protein

Zinc finger protein 671

Gene

ZNF671

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri192 – 214C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri451 – 473C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri479 – 501C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri507 – 529C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 671
Gene namesi
Name:ZNF671
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000083814.12
HGNCiHGNC:26279 ZNF671
neXtProtiNX_Q8TAW3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi79891
OpenTargetsiENSG00000083814
PharmGKBiPA142670518

Polymorphism and mutation databases

BioMutaiZNF671
DMDMi229462791

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002339901 – 534Zinc finger protein 671Add BLAST534

Proteomic databases

EPDiQ8TAW3
MaxQBiQ8TAW3
PaxDbiQ8TAW3
PeptideAtlasiQ8TAW3
PRIDEiQ8TAW3
ProteomicsDBi73931

PTM databases

iPTMnetiQ8TAW3
PhosphoSitePlusiQ8TAW3

Expressioni

Gene expression databases

BgeeiENSG00000083814 Expressed in 143 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_ZNF671
ExpressionAtlasiQ8TAW3 baseline and differential
GenevisibleiQ8TAW3 HS

Organism-specific databases

HPAiHPA046099

Interactioni

Protein-protein interaction databases

BioGridi122975, 2 interactors
IntActiQ8TAW3, 1 interactor
MINTiQ8TAW3
STRINGi9606.ENSP00000321848

Structurei

3D structure databases

ProteinModelPortaliQ8TAW3
SMRiQ8TAW3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 120KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri192 – 214C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri451 – 473C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri479 – 501C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri507 – 529C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119107
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8TAW3
KOiK09228
OMAiGGKLFPR
PhylomeDBiQ8TAW3
TreeFamiTF342033

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q8TAW3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSPVSRDAS DALQGRKCLR PRSRRLPLPA AVRAHGPMAE LTDSARGCVV
60 70 80 90 100
FEDVFVYFSR EEWELLDDAQ RLLYHDVMLE NFALLASLGI AFSRSRAVMK
110 120 130 140 150
LERGEEPWVY DQVDMTSATE REAQRGLRPG CWHGVEDEEV SSEQSIFVAG
160 170 180 190 200
VSEVRTLMAE LESHPCDICG PILKDTLHLA KYHGGKARQK PYLCGACGKQ
210 220 230 240 250
FWFSTDFDQH QNQPNGGKLF PRKEGRDSVK SCRVHVPEKT LTCGKGRRDF
260 270 280 290 300
SATSGLLQHQ ASLSSMKPHK STKLVSGFLM GQRYHRCGEC GKAFTRKDTL
310 320 330 340 350
ARHQRIHTGE RPYECNECGK FFSQSYDLFK HQTVHTGERP YECSECGKFF
360 370 380 390 400
RQISGLIEHR RVHTGERLYQ CGKCGKFFSS KSNLIRHQEV HTGARPYVCS
410 420 430 440 450
ECGKEFSRKH TLVLHQRTHT GERPYECSEC GKAFSQSSHL NVHWRIHSSD
460 470 480 490 500
YECSRCGKAF SCISKLIQHQ KVHSGEKPYE CSKCGKAFTQ RPNLIRHWKV
510 520 530
HTGERPYVCS ECGREFIRKQ TLVLHQRVHA GEKL
Length:534
Mass (Da):60,972
Last modified:May 5, 2009 - v2
Checksum:i701BC2C02BC95124
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R091M0R091_HUMAN
Zinc finger protein 671
ZNF671
107Annotation score:
M0QX87M0QX87_HUMAN
Zinc finger protein 671
ZNF671
56Annotation score:

Sequence cautioni

The sequence AAH25728 differs from that shown. Reason: Frameshift at position 534.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026151149A → V1 PublicationCorresponds to variant dbSNP:rs3746207Ensembl.1
Natural variantiVAR_055240237P → S. Corresponds to variant dbSNP:rs34419645Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027159 mRNA Translation: BAB15677.1
AC003006 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72529.1
BC025728 mRNA Translation: AAH25728.1 Frameshift.
CCDSiCCDS12961.1
RefSeqiNP_079109.2, NM_024833.2
UniGeneiHs.180402

Genome annotation databases

EnsembliENST00000317398; ENSP00000321848; ENSG00000083814
GeneIDi79891
KEGGihsa:79891
UCSCiuc002qpz.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN671_HUMAN
AccessioniPrimary (citable) accession number: Q8TAW3
Secondary accession number(s): A6NF07, Q9H5E9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 5, 2009
Last modified: September 12, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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