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Protein

Cytochrome P450 2W1

Gene

CYP2W1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to have broad catalytic activity towards several chemicals, including polycyclic aromatic hydrocarbon dihydrodiols and aromatic amines (PubMed:16551781, PubMed:24278521). Active also in the metabolism of indoline substrates and is able to activate aflatoxin B1 into cytotoxic products (PubMed:20805301). Furthermore, it seems to be involved in the oxydation of lysophospholipids and fatty acids (PubMed:22591743).4 Publications

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi433Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-211958 Miscellaneous substrates
R-HSA-211981 Xenobiotics

Chemistry databases

SwissLipidsiSLP:000001619

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2W1 (EC:1.14.14.-)
Alternative name(s):
CYPIIW1
Gene namesi
Name:CYP2W1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000073067.13
HGNCiHGNC:20243 CYP2W1
MIMi615967 gene
neXtProtiNX_Q8TAV3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi177N → A: Loss of glycosylation. 1 Publication1

Organism-specific databases

DisGeNETi54905
OpenTargetsiENSG00000073067
PharmGKBiPA134992665

Chemistry databases

ChEMBLiCHEMBL2406897

Polymorphism and mutation databases

BioMutaiCYP2W1
DMDMi114152790

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000005178223 – 490Cytochrome P450 2W1Sequence analysisAdd BLAST468

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi177N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8TAV3
PaxDbiQ8TAV3
PeptideAtlasiQ8TAV3
PRIDEiQ8TAV3
ProteomicsDBi73927

PTM databases

iPTMnetiQ8TAV3
PhosphoSitePlusiQ8TAV3

Expressioni

Tissue specificityi

Very low levels are detected in fetal and adult tissues. Highly expressed in several tumor samples, in particular colon and adrenal tumors.1 Publication

Gene expression databases

BgeeiENSG00000073067 Expressed in 151 organ(s), highest expression level in right adrenal gland
CleanExiHS_CYP2W1
ExpressionAtlasiQ8TAV3 baseline and differential
GenevisibleiQ8TAV3 HS

Organism-specific databases

HPAiHPA012753

Interactioni

Protein-protein interaction databases

BioGridi120251, 5 interactors
IntActiQ8TAV3, 2 interactors
STRINGi9606.ENSP00000310149

Structurei

3D structure databases

ProteinModelPortaliQ8TAV3
SMRiQ8TAV3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140799
HOGENOMiHOG000036992
HOVERGENiHBG015789
InParanoidiQ8TAV3
KOiK07423
OMAiFNIYPWL
OrthoDBiEOG091G0BT8
PhylomeDBiQ8TAV3
TreeFamiTF352043

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8TAV3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALLLLLFLG LLGLWGLLCA CAQDPSPAAR WPPGPRPLPL VGNLHLLRLS
60 70 80 90 100
QQDRSLMELS ERYGPVFTVH LGRQKTVVLT GFEAVKEALA GPGQELADRP
110 120 130 140 150
PIAIFQLIQR GGGIFFSSGA RWRAARQFTV RALHSLGVGR EPVADKILQE
160 170 180 190 200
LKCLSGQLDG YRGRPFPLAL LGWAPSNITF ALLFGRRFDY RDPVFVSLLG
210 220 230 240 250
LIDEVMVLLG SPGLQLFNVY PWLGALLQLH RPVLRKIEEV RAILRTLLEA
260 270 280 290 300
RRPHVCPGDP VCSYVDALIQ QGQGDDPEGL FAEANAVACT LDMVMAGTET
310 320 330 340 350
TSATLQWAAL LMGRHPDVQG RVQEELDRVL GPGRTPRLED QQALPYTSAV
360 370 380 390 400
LHEVQRFITL LPHVPRCTAA DTQLGGFLLP KGTPVIPLLT SVLLDETQWQ
410 420 430 440 450
TPGQFNPGHF LDANGHFVKR EAFLPFSAGR RVCVGERLAR TELFLLFAGL
460 470 480 490
LQRYRLLPPP GVSPASLDTT PARAFTMRPR AQALCAVPRP
Length:490
Mass (Da):53,844
Last modified:September 5, 2006 - v2
Checksum:iBB84B2F1FEFEF5BC
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6NJ10A6NJ10_HUMAN
Cytochrome P450 2W1
CYP2W1
408Annotation score:
H7C015H7C015_HUMAN
Cytochrome P450 2W1
CYP2W1
288Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07191258E → A1 Publication1
Natural variantiVAR_027413181A → T Associated with increased colorectal cancer risk. 1 PublicationCorresponds to variant dbSNP:rs3735684Ensembl.1
Natural variantiVAR_071913432V → I1 PublicationCorresponds to variant dbSNP:rs78873069Ensembl.1
Natural variantiVAR_071914482Q → H1 PublicationCorresponds to variant dbSNP:rs773499447Ensembl.1
Natural variantiVAR_071915488P → L1 PublicationCorresponds to variant dbSNP:rs3808348Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073957 Genomic DNA No translation available.
BC025761 mRNA Translation: AAH25761.2
CCDSiCCDS5319.2
RefSeqiNP_060251.2, NM_017781.2
UniGeneiHs.272795

Genome annotation databases

EnsembliENST00000308919; ENSP00000310149; ENSG00000073067
GeneIDi54905
KEGGihsa:54905
UCSCiuc003sjq.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073957 Genomic DNA No translation available.
BC025761 mRNA Translation: AAH25761.2
CCDSiCCDS5319.2
RefSeqiNP_060251.2, NM_017781.2
UniGeneiHs.272795

3D structure databases

ProteinModelPortaliQ8TAV3
SMRiQ8TAV3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120251, 5 interactors
IntActiQ8TAV3, 2 interactors
STRINGi9606.ENSP00000310149

Chemistry databases

ChEMBLiCHEMBL2406897
SwissLipidsiSLP:000001619

PTM databases

iPTMnetiQ8TAV3
PhosphoSitePlusiQ8TAV3

Polymorphism and mutation databases

BioMutaiCYP2W1
DMDMi114152790

Proteomic databases

MaxQBiQ8TAV3
PaxDbiQ8TAV3
PeptideAtlasiQ8TAV3
PRIDEiQ8TAV3
ProteomicsDBi73927

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308919; ENSP00000310149; ENSG00000073067
GeneIDi54905
KEGGihsa:54905
UCSCiuc003sjq.1 human

Organism-specific databases

CTDi54905
DisGeNETi54905
EuPathDBiHostDB:ENSG00000073067.13
GeneCardsiCYP2W1
HGNCiHGNC:20243 CYP2W1
HPAiHPA012753
MIMi615967 gene
neXtProtiNX_Q8TAV3
OpenTargetsiENSG00000073067
PharmGKBiPA134992665
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140799
HOGENOMiHOG000036992
HOVERGENiHBG015789
InParanoidiQ8TAV3
KOiK07423
OMAiFNIYPWL
OrthoDBiEOG091G0BT8
PhylomeDBiQ8TAV3
TreeFamiTF352043

Enzyme and pathway databases

ReactomeiR-HSA-211958 Miscellaneous substrates
R-HSA-211981 Xenobiotics

Miscellaneous databases

GeneWikiiCYP2W1
GenomeRNAii54905
PROiPR:Q8TAV3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000073067 Expressed in 151 organ(s), highest expression level in right adrenal gland
CleanExiHS_CYP2W1
ExpressionAtlasiQ8TAV3 baseline and differential
GenevisibleiQ8TAV3 HS

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCP2W1_HUMAN
AccessioniPrimary (citable) accession number: Q8TAV3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: September 5, 2006
Last modified: November 7, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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