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Protein

Zinc finger protein 417

Gene

ZNF417

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri92 – 114C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri520 – 542C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri548 – 570C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: GO_Central

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Protein family/group databases

MoonDBiQ8TAU3 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 417
Gene namesi
Name:ZNF417
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000173480.10
HGNCiHGNC:20646 ZNF417
neXtProtiNX_Q8TAU3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000173480
PharmGKBiPA134863699

Polymorphism and mutation databases

BioMutaiZNF417
DMDMi296453053

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002339851 – 575Zinc finger protein 417Add BLAST575

Proteomic databases

EPDiQ8TAU3
MaxQBiQ8TAU3
PaxDbiQ8TAU3
PeptideAtlasiQ8TAU3
PRIDEiQ8TAU3
ProteomicsDBi73921

PTM databases

iPTMnetiQ8TAU3
PhosphoSitePlusiQ8TAU3

Expressioni

Gene expression databases

BgeeiENSG00000173480 Expressed in 128 organ(s), highest expression level in corpus callosum
CleanExiHS_ZNF417
ExpressionAtlasiQ8TAU3 baseline and differential
GenevisibleiQ8TAU3 HS

Organism-specific databases

HPAiHPA042125
HPA043288
HPA056213

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ADAMTSL4Q6UY14-35EBI-740727,EBI-10173507
BEND5Q7L4P63EBI-740727,EBI-724373
CARD9Q9H2573EBI-740727,EBI-751319
CCDC136Q96JN2-23EBI-740727,EBI-10171416
CCDC57Q2TAC23EBI-740727,EBI-2808286
CCNDBP1O952733EBI-740727,EBI-748961
CEP44Q9C0F14EBI-740727,EBI-744115
CEP70Q8NHQ15EBI-740727,EBI-739624
CSRNP1Q96S653EBI-740727,EBI-4311573
EFSO432813EBI-740727,EBI-718488
FHL2Q141923EBI-740727,EBI-701903
FHL3Q136433EBI-740727,EBI-741101
FSD2A1L4K15EBI-740727,EBI-5661036
GOLGA2Q083793EBI-740727,EBI-618309
HMBOX1Q6NT765EBI-740727,EBI-2549423
IKZF1Q134223EBI-740727,EBI-745305
KLC3Q6P5973EBI-740727,EBI-1643885
KRT15P190123EBI-740727,EBI-739566
KRT38O760155EBI-740727,EBI-1047263
KRT40Q6A1625EBI-740727,EBI-10171697
KRTAP10-5P603705EBI-740727,EBI-10172150
KRTAP10-7P604093EBI-740727,EBI-10172290
KRTAP10-8P604105EBI-740727,EBI-10171774
KRTAP10-9P604113EBI-740727,EBI-10172052
KRTAP4-2Q9BYR53EBI-740727,EBI-10172511
KRTAP5-9P263715EBI-740727,EBI-3958099
KXD1Q9BQD35EBI-740727,EBI-739657
LURAP1Q96LR23EBI-740727,EBI-741355
LZTS2Q9BRK45EBI-740727,EBI-741037
MDFIQ997506EBI-740727,EBI-724076
MEOX2P502223EBI-740727,EBI-748397
MID2Q9UJV3-25EBI-740727,EBI-10172526
MTUS2Q5JR593EBI-740727,EBI-742948
NDEL1Q9GZM83EBI-740727,EBI-928842
NINLQ9Y2I64EBI-740727,EBI-719716
NOTCH2NLQ7Z3S95EBI-740727,EBI-945833
PHC2Q8IXK03EBI-740727,EBI-713786
PLSCR1O151623EBI-740727,EBI-740019
PNMA2Q9UL424EBI-740727,EBI-302355
PRPF31Q8WWY33EBI-740727,EBI-1567797
RELQ048643EBI-740727,EBI-307352
RPGRIP1Q96KN73EBI-740727,EBI-1050213
RUNDC3AQ59EK93EBI-740727,EBI-747225
SPRY2O435973EBI-740727,EBI-742487
SSX2IPQ9Y2D83EBI-740727,EBI-2212028
STX11O755585EBI-740727,EBI-714135
TCF4P158843EBI-740727,EBI-533224
TFIP11Q9UBB94EBI-740727,EBI-1105213
TMCC2O75069-43EBI-740727,EBI-10177480
TNS2Q63HR25EBI-740727,EBI-949753
TRAF1Q130773EBI-740727,EBI-359224
TRIM27P143736EBI-740727,EBI-719493
TRIM36Q9NQ863EBI-740727,EBI-2341518
TRIM37O949724EBI-740727,EBI-741602
TRIM41Q8WV445EBI-740727,EBI-725997
TRIM54Q9BYV25EBI-740727,EBI-2130429
TSGA10Q9BZW73EBI-740727,EBI-744794
ZBTB1Q9Y2K13EBI-740727,EBI-2682961
ZBTB10Q96DT73EBI-740727,EBI-10235384
ZBTB43O432983EBI-740727,EBI-740718
ZBTB8AQ96BR95EBI-740727,EBI-742740
ZNF587Q96SQ53EBI-740727,EBI-6427977
ZNF837Q96EG34EBI-740727,EBI-11962574

Protein-protein interaction databases

BioGridi127075, 67 interactors
IntActiQ8TAU3, 163 interactors
MINTiQ8TAU3
STRINGi9606.ENSP00000311319

Structurei

3D structure databases

ProteinModelPortaliQ8TAU3
SMRiQ8TAU3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 88KRABPROSITE-ProRule annotationAdd BLAST74

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri92 – 114C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri520 – 542C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri548 – 570C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119107
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8TAU3
KOiK09228
OMAiEPFVFHE
OrthoDBiEOG091G02KC
PhylomeDBiQ8TAU3
TreeFamiTF339848

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 10 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TAU3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAAPRRPT QQGTVTFEDV AVNFSQEEWC LLSEAQRCLY RDVMLENLAL
60 70 80 90 100
ISSLGCWCGS KDEEAPCKQR ISVQRESQSR TPRAGVSPKK AHPCEMCGLI
110 120 130 140 150
LEDVFHFADH QETHHKQKLN RSGACGKNLD DTAYLHQHQK QHIGEKFYRK
160 170 180 190 200
SVREASFVKK RKLRVSQEPF VFREFGKDVL PSSGLCQEAA AVEKTDSETM
210 220 230 240 250
HGPPFQEGKT NYSCGKRTKA FSTKHSVIPH QKLFTRDGCY VCSDCGKSFS
260 270 280 290 300
RYVSFSNHQR DHTAKGPYDC GECGKSYSRK SSLIQHQRVH TGKTAYPCEE
310 320 330 340 350
CGKSFSQKGS LISHQRVHTG ERPYECREYG KSFGQKGNLI QHQQGHTGER
360 370 380 390 400
AYHCGECGKS FRQKFCFINH QRVHTGERPY KCGECGKSFG QKGNLVQHQR
410 420 430 440 450
GHTGERPYEC KECGKSFRYR SHLTEHQRLH TGERPYNCRE CGKLFNRKYH
460 470 480 490 500
LLVHERVHTG ERPYACEVCG KLFGNKNCVT IHQRIHTGER PYECNECGKS
510 520 530 540 550
FLSSSALHVH KRVHSGQKPY KCSECGKSFA ECSSLIKHRR IHTGERPYEC
560 570
TKCGKTFQRS STLLHHQSSH RRKAL
Length:575
Mass (Da):65,733
Last modified:May 18, 2010 - v2
Checksum:i8CE2FB25CBE474F5
GO
Isoform 2 (identifier: Q8TAU3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-199: Missing.

Note: No experimental confirmation available.
Show »
Length:376
Mass (Da):43,212
Checksum:i9E787AC7E84A2898
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R230M0R230_HUMAN
Zinc finger protein 417
ZNF417
574Annotation score:
M0R267M0R267_HUMAN
Zinc finger protein 417
ZNF417
90Annotation score:
M0R0M6M0R0M6_HUMAN
Zinc finger protein 417
ZNF417
51Annotation score:
M0R178M0R178_HUMAN
Zinc finger protein 417
ZNF417
57Annotation score:
M0R0V5M0R0V5_HUMAN
Zinc finger protein 417
ZNF417
21Annotation score:
M0QXH9M0QXH9_HUMAN
Zinc finger protein 417
ZNF417
15Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti173R → H in AAH25783 (PubMed:15489334).Curated1
Sequence conflicti316R → L in AAH25783 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060275495N → S1 PublicationCorresponds to variant dbSNP:rs10416584Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0559501 – 199Missing in isoform 2. 1 PublicationAdd BLAST199

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK293789 mRNA Translation: BAG57202.1
AC010326 Genomic DNA No translation available.
BC025783 mRNA Translation: AAH25783.1
CCDSiCCDS12965.1 [Q8TAU3-1]
RefSeqiNP_689688.2, NM_152475.2 [Q8TAU3-1]
UniGeneiHs.567710

Genome annotation databases

EnsembliENST00000312026; ENSP00000311319; ENSG00000173480 [Q8TAU3-1]
GeneIDi147687
KEGGihsa:147687
UCSCiuc002qqq.4 human [Q8TAU3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK293789 mRNA Translation: BAG57202.1
AC010326 Genomic DNA No translation available.
BC025783 mRNA Translation: AAH25783.1
CCDSiCCDS12965.1 [Q8TAU3-1]
RefSeqiNP_689688.2, NM_152475.2 [Q8TAU3-1]
UniGeneiHs.567710

3D structure databases

ProteinModelPortaliQ8TAU3
SMRiQ8TAU3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127075, 67 interactors
IntActiQ8TAU3, 163 interactors
MINTiQ8TAU3
STRINGi9606.ENSP00000311319

Protein family/group databases

MoonDBiQ8TAU3 Predicted

PTM databases

iPTMnetiQ8TAU3
PhosphoSitePlusiQ8TAU3

Polymorphism and mutation databases

BioMutaiZNF417
DMDMi296453053

Proteomic databases

EPDiQ8TAU3
MaxQBiQ8TAU3
PaxDbiQ8TAU3
PeptideAtlasiQ8TAU3
PRIDEiQ8TAU3
ProteomicsDBi73921

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312026; ENSP00000311319; ENSG00000173480 [Q8TAU3-1]
GeneIDi147687
KEGGihsa:147687
UCSCiuc002qqq.4 human [Q8TAU3-1]

Organism-specific databases

CTDi147687
EuPathDBiHostDB:ENSG00000173480.10
GeneCardsiZNF417
HGNCiHGNC:20646 ZNF417
HPAiHPA042125
HPA043288
HPA056213
neXtProtiNX_Q8TAU3
OpenTargetsiENSG00000173480
PharmGKBiPA134863699
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119107
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8TAU3
KOiK09228
OMAiEPFVFHE
OrthoDBiEOG091G02KC
PhylomeDBiQ8TAU3
TreeFamiTF339848

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

GenomeRNAii147687
PROiPR:Q8TAU3

Gene expression databases

BgeeiENSG00000173480 Expressed in 128 organ(s), highest expression level in corpus callosum
CleanExiHS_ZNF417
ExpressionAtlasiQ8TAU3 baseline and differential
GenevisibleiQ8TAU3 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 10 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN417_HUMAN
AccessioniPrimary (citable) accession number: Q8TAU3
Secondary accession number(s): B4DEU1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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