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UniProtKB - Q8TAU3 (ZN417_HUMAN)

Entry version 154 (02 Dec 2020)
Sequence version 2 (18 May 2010)
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Protein

Zinc finger protein 417

Gene

ZNF417

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri92 – 114C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri520 – 542C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri548 – 570C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8TAU3

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-212436, Generic Transcription Pathway

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...MoonDBi		Q8TAU3, Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 417
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF417
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000173480.10

Human Gene Nomenclature Database

More...HGNCi		HGNC:20646, ZNF417

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8TAU3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		147687

Open Targets

More...OpenTargetsi		ENSG00000173480

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134863699

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8TAU3, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF417

Domain mapping of disease mutations (DMDM)

More...DMDMi		296453053

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002339851 – 575Zinc finger protein 417Add BLAST575

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8TAU3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8TAU3

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8TAU3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8TAU3

PeptideAtlas

More...PeptideAtlasi		Q8TAU3

PRoteomics IDEntifications database

More...PRIDEi		Q8TAU3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		3983
73921 [Q8TAU3-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8TAU3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8TAU3

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q8TAU3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000173480, Expressed in corpus callosum and 148 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8TAU3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8TAU3, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000173480, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q8TAU3
With#Exp.IntAct
ADAMTSL4 - isoform 3 [Q6UY14-3]6EBI-740727,EBI-10173507
AXIN2 [Q9Y2T1]3EBI-740727,EBI-4400025
BEGAIN [Q9BUH8]6EBI-740727,EBI-742722
BEND5 [Q7L4P6]3EBI-740727,EBI-724373
BEX3 [Q00994]3EBI-740727,EBI-741753
BHLHB9 [Q6PI77]3EBI-740727,EBI-11519926
BICD2 - isoform 2 [Q8TD16-2]3EBI-740727,EBI-11975051
BLZF1 [Q9H2G9]3EBI-740727,EBI-2548012
C4orf17 [Q53FE4]3EBI-740727,EBI-715110
CARD9 [Q9H257]3EBI-740727,EBI-751319
CBY2 - isoform 2 [Q8NA61-2]3EBI-740727,EBI-11524851
CCDC120 [Q96HB5]3EBI-740727,EBI-744556
CCDC125 [Q86Z20]3EBI-740727,EBI-11977221
CCDC136 - isoform 2 [Q96JN2-2]3EBI-740727,EBI-10171416
CCDC57 [Q2TAC2]3EBI-740727,EBI-2808286
CCNDBP1 [O95273]4EBI-740727,EBI-748961
CDR2 [Q01850]3EBI-740727,EBI-1181367
CDR2L [Q86X02]3EBI-740727,EBI-11063830
CEP44 [Q9C0F1]4EBI-740727,EBI-744115
CEP70 [Q8NHQ1]6EBI-740727,EBI-739624
CEP85L - isoform 5 [Q5SZL2-5]3EBI-740727,EBI-12344751
CHRDL2 - isoform 2 [Q6WN34-2]3EBI-740727,EBI-12593838
COG6 [Q9Y2V7]3EBI-740727,EBI-3866319
CSRNP1 [Q96S65]3EBI-740727,EBI-4311573
CYSRT1 [A8MQ03]5EBI-740727,EBI-3867333
DEF8 - isoform 2 [Q6ZN54-2]3EBI-740727,EBI-12346463
DVL3 [Q92997]3EBI-740727,EBI-739789
EFS [O43281]3EBI-740727,EBI-718488
EZHIP [Q86X51]3EBI-740727,EBI-12827735
FAM221A [A4D161]3EBI-740727,EBI-11960181
FHL2 [Q14192]3EBI-740727,EBI-701903
FHL3 [Q13643]3EBI-740727,EBI-741101
FHL5 [Q5TD97]3EBI-740727,EBI-750641
FRS3 [O43559]3EBI-740727,EBI-725515
FSD2 [A1L4K1]6EBI-740727,EBI-5661036
FST [P19883]3EBI-740727,EBI-1571188
FXR1 - isoform 2 [P51114-2]3EBI-740727,EBI-11022345
GOLGA2 [Q08379]6EBI-740727,EBI-618309
GOLGA6L9 [A6NEM1]3EBI-740727,EBI-5916454
HMBOX1 [Q6NT76]6EBI-740727,EBI-2549423
HOOK2 - isoform 2 [Q96ED9-2]3EBI-740727,EBI-10961706
HOXA1 [P49639]5EBI-740727,EBI-740785
HSF2BP [O75031]3EBI-740727,EBI-7116203
IGFBP6 [P24592]5EBI-740727,EBI-947015
IHO1 [Q8IYA8]3EBI-740727,EBI-8638439
IKZF1 [Q13422]3EBI-740727,EBI-745305
IKZF1 - isoform Ik7 [Q13422-7]3EBI-740727,EBI-11522367
IKZF3 [Q9UKT9]3EBI-740727,EBI-747204
INKA1 [Q96EL1]3EBI-740727,EBI-10285157
JADE2 [A0A0C4DFT8]3EBI-740727,EBI-12094820
JRK - isoform 2 [O75564-2]3EBI-740727,EBI-17181882
KANK2 [Q63ZY3]3EBI-740727,EBI-2556193
KAT5 [Q92993]3EBI-740727,EBI-399080
KATNBL1 [Q9H079]3EBI-740727,EBI-715394
KCTD7 - isoform 2 [Q96MP8-2]3EBI-740727,EBI-11954971
KIAA1328 [Q86T90]3EBI-740727,EBI-3437878
KIF9 [Q9HAQ2]3EBI-740727,EBI-8472129
KIFC3 - isoform 4 [Q9BVG8-5]3EBI-740727,EBI-14069005
KLC3 [Q6P597]3EBI-740727,EBI-1643885
KRT15 [P19012]3EBI-740727,EBI-739566
KRT31 [Q15323]3EBI-740727,EBI-948001
KRT35 [Q92764]3EBI-740727,EBI-1058674
KRT38 [O76015]6EBI-740727,EBI-1047263
KRT39 [Q6A163]3EBI-740727,EBI-11958242
KRT40 [Q6A162]6EBI-740727,EBI-10171697
KRTAP10-5 [P60370]5EBI-740727,EBI-10172150
KRTAP10-7 [P60409]6EBI-740727,EBI-10172290
KRTAP10-8 [P60410]6EBI-740727,EBI-10171774
KRTAP10-9 [P60411]3EBI-740727,EBI-10172052
KRTAP12-3 [P60328]3EBI-740727,EBI-11953334
KRTAP4-11 [Q9BYQ6]3EBI-740727,EBI-10302392
KRTAP4-2 [Q9BYR5]3EBI-740727,EBI-10172511
KRTAP5-9 [P26371]6EBI-740727,EBI-3958099
KXD1 [Q9BQD3]6EBI-740727,EBI-739657
LHX3 - isoform B [Q9UBR4-2]3EBI-740727,EBI-12039345
LIMS1 - isoform 3 [P48059-3]3EBI-740727,EBI-12864460
LMO1 [P25800]3EBI-740727,EBI-8639312
LURAP1 [Q96LR2]3EBI-740727,EBI-741355
LZTS1 [Q9Y250]3EBI-740727,EBI-1216080
LZTS2 [Q9BRK4]6EBI-740727,EBI-741037
MAGEA8 [P43361]3EBI-740727,EBI-10182930
MCC [P23508]3EBI-740727,EBI-307531
MCCD1 [P59942]3EBI-740727,EBI-11987923
MDFI [Q99750]7EBI-740727,EBI-724076
MEIS3 - isoform 3 [Q99687-3]3EBI-740727,EBI-18582591
MEOX2 [P50222]3EBI-740727,EBI-748397
MEOX2 [Q6FHY5]3EBI-740727,EBI-16439278
MID2 - isoform 2 [Q9UJV3-2]6EBI-740727,EBI-10172526
MIIP [Q5JXC2]3EBI-740727,EBI-2801965
MRFAP1L1 [Q96HT8]3EBI-740727,EBI-748896
MTUS2 [Q5JR59]3EBI-740727,EBI-742948
MTUS2 - isoform 2 [Q5JR59-3]3EBI-740727,EBI-11522433
MYF5 [P13349]3EBI-740727,EBI-17491620
MYLIP [Q8WY64]3EBI-740727,EBI-6952711
NAB2 [Q15742]3EBI-740727,EBI-8641936
NDEL1 [Q9GZM8]3EBI-740727,EBI-928842
NDUFB7 [P17568]3EBI-740727,EBI-1246238
NINL [Q9Y2I6]4EBI-740727,EBI-719716
NKAPL [Q5M9Q1]3EBI-740727,EBI-11423380
NKX3-1 [Q99801]3EBI-740727,EBI-1385894
NOTCH2NLA [Q7Z3S9]3EBI-740727,EBI-945833
NOTCH2NLC [P0DPK4]3EBI-740727,EBI-22310682
OIP5 [O43482]3EBI-740727,EBI-536879
PHC2 [Q8IXK0]3EBI-740727,EBI-713786
PICK1 [Q9NRD5]3EBI-740727,EBI-79165
PIH1D2 [Q8WWB5]3EBI-740727,EBI-10232538
PLSCR1 [O15162]3EBI-740727,EBI-740019
PNMA2 [Q9UL42]4EBI-740727,EBI-302355
PRPF31 [Q8WWY3]3EBI-740727,EBI-1567797
RCN3 [Q96D15]3EBI-740727,EBI-746283
REL [Q04864]3EBI-740727,EBI-307352
RHOQ [P17081]3EBI-740727,EBI-689202
RNF187 [Q5TA31]3EBI-740727,EBI-6868977
RORB - isoform 1 [Q92753-1]3EBI-740727,EBI-18560266
RPGRIP1 [Q96KN7]3EBI-740727,EBI-1050213
RUNDC3A [Q59EK9]3EBI-740727,EBI-747225
RUNDC3A - isoform 3 [Q59EK9-3]3EBI-740727,EBI-11957366
SH2B2 - isoform 2 [O14492-2]3EBI-740727,EBI-19952306
SMARCD1 [Q96GM5]3EBI-740727,EBI-358489
SMYD5 [Q6GMV2]3EBI-740727,EBI-11057552
SPRED1 [Q7Z699]3EBI-740727,EBI-5235340
SPRED2 [Q7Z698]3EBI-740727,EBI-7082156
SPRY1 [O43609]3EBI-740727,EBI-3866665
SPRY2 [O43597]3EBI-740727,EBI-742487
SSX2IP [Q9Y2D8]3EBI-740727,EBI-2212028
STX11 [O75558]6EBI-740727,EBI-714135
SUV39H1 [O43463]3EBI-740727,EBI-349968
TADA2A [O75478]3EBI-740727,EBI-742268
TCF4 [P15884]3EBI-740727,EBI-533224
TEKT4 [Q8WW24]3EBI-740727,EBI-750487
TFIP11 [Q9UBB9]4EBI-740727,EBI-1105213
TLE5 - isoform 2 [Q08117-2]3EBI-740727,EBI-11741437
TNS2 [Q63HR2]9EBI-740727,EBI-949753
TRAF1 [Q13077]3EBI-740727,EBI-359224
TRAF2 [Q12933]3EBI-740727,EBI-355744
TRIB3 [Q96RU7]3EBI-740727,EBI-492476
TRIM23 [P36406]3EBI-740727,EBI-740098
TRIM27 [P14373]7EBI-740727,EBI-719493
TRIM36 [Q9NQ86]3EBI-740727,EBI-2341518
TRIM37 [O94972]4EBI-740727,EBI-741602
TRIM41 [Q8WV44]8EBI-740727,EBI-725997
TRIM54 [Q9BYV2]6EBI-740727,EBI-2130429
TSC1 [Q86WV8]3EBI-740727,EBI-12806590
TSGA10 [Q9BZW7]3EBI-740727,EBI-744794
TTC23 - isoform 3 [Q5W5X9-3]3EBI-740727,EBI-9090990
TXNDC11 [Q6PKC3]3EBI-740727,EBI-749812
U2AF1L5 [P0DN76]3EBI-740727,EBI-14082807
USHBP1 [Q8N6Y0]3EBI-740727,EBI-739895
VASN [Q6EMK4]3EBI-740727,EBI-10249550
VPS16 [Q6GMQ7]3EBI-740727,EBI-17974829
VPS52 [Q8N1B4]3EBI-740727,EBI-2799833
VWC2 [Q2TAL6]3EBI-740727,EBI-11957238
ZBTB1 [Q9Y2K1]3EBI-740727,EBI-2682961
ZBTB10 [Q96DT7]3EBI-740727,EBI-10235384
ZBTB10 - isoform 3 [Q96DT7-3]3EBI-740727,EBI-12017160
ZBTB43 [O43298]4EBI-740727,EBI-740718
ZBTB8A [Q96BR9]6EBI-740727,EBI-742740
ZBTB9 [Q96C00]3EBI-740727,EBI-395708
ZMAT5 [Q9UDW3]3EBI-740727,EBI-7850213
ZNF165 [P49910]3EBI-740727,EBI-741694
ZNF19 [P17023]3EBI-740727,EBI-12884200
ZNF20 [P17024]3EBI-740727,EBI-717634
ZNF547 [Q8IVP9]3EBI-740727,EBI-12895421
ZNF572 [Q7Z3I7]3EBI-740727,EBI-10172590
ZNF587 [Q96SQ5]3EBI-740727,EBI-6427977
ZNF69 - isoform 2 [Q9UC07-2]3EBI-740727,EBI-12310821
ZNF71 [Q9NQZ8]3EBI-740727,EBI-7138235
ZNF768 [Q9H5H4]3EBI-740727,EBI-1210580
ZNF774 [Q6NX45]3EBI-740727,EBI-10251462
ZNF837 [Q96EG3]6EBI-740727,EBI-11962574
ZNF85 [Q49A12]3EBI-740727,EBI-18141506
ZRANB1 [Q9UGI0]3EBI-740727,EBI-527853

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		127075, 170 interactors

Protein interaction database and analysis system

More...IntActi		Q8TAU3, 175 interactors

Molecular INTeraction database

More...MINTi		Q8TAU3

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000311319

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8TAU3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8TAU3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini15 – 88KRABPROSITE-ProRule annotationAdd BLAST74

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri92 – 114C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri520 – 542C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri548 – 570C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000164176

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8TAU3

Identification of Orthologs from Complete Genome Data

More...OMAi		SKEEWCL

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8TAU3

TreeFam database of animal gene trees

More...TreeFami		TF339848

Family and domain databases

Conserved Domains Database

More...CDDi		cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 10 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 13 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 8 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 12 hits
PS50157, ZINC_FINGER_C2H2_2, 13 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TAU3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAAPRRPT QQGTVTFEDV AVNFSQEEWC LLSEAQRCLY RDVMLENLAL 
        60         70         80         90        100
ISSLGCWCGS KDEEAPCKQR ISVQRESQSR TPRAGVSPKK AHPCEMCGLI 
       110        120        130        140        150
LEDVFHFADH QETHHKQKLN RSGACGKNLD DTAYLHQHQK QHIGEKFYRK 
       160        170        180        190        200
SVREASFVKK RKLRVSQEPF VFREFGKDVL PSSGLCQEAA AVEKTDSETM 
       210        220        230        240        250
HGPPFQEGKT NYSCGKRTKA FSTKHSVIPH QKLFTRDGCY VCSDCGKSFS 
       260        270        280        290        300
RYVSFSNHQR DHTAKGPYDC GECGKSYSRK SSLIQHQRVH TGKTAYPCEE 
       310        320        330        340        350
CGKSFSQKGS LISHQRVHTG ERPYECREYG KSFGQKGNLI QHQQGHTGER 
       360        370        380        390        400
AYHCGECGKS FRQKFCFINH QRVHTGERPY KCGECGKSFG QKGNLVQHQR 
       410        420        430        440        450
GHTGERPYEC KECGKSFRYR SHLTEHQRLH TGERPYNCRE CGKLFNRKYH 
       460        470        480        490        500
LLVHERVHTG ERPYACEVCG KLFGNKNCVT IHQRIHTGER PYECNECGKS 
       510        520        530        540        550
FLSSSALHVH KRVHSGQKPY KCSECGKSFA ECSSLIKHRR IHTGERPYEC 
       560        570 
TKCGKTFQRS STLLHHQSSH RRKAL
Length:575
Mass (Da):65,733
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8CE2FB25CBE474F5
GO
Isoform 2 (identifier: Q8TAU3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-199: Missing.

Show »
Length:376
Mass (Da):43,212
Checksum:i9E787AC7E84A2898
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R230M0R230_HUMAN
Zinc finger protein 417
ZNF417
574Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R267M0R267_HUMAN
Zinc finger protein 417
ZNF417
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R0M6M0R0M6_HUMAN
Zinc finger protein 417
ZNF417
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R178M0R178_HUMAN
Zinc finger protein 417
ZNF417
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXH9M0QXH9_HUMAN
Zinc finger protein 417
ZNF417
15Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R0V5M0R0V5_HUMAN
Zinc finger protein 417
ZNF417
21Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti173R → H in AAH25783 (PubMed:15489334).Curated1
Sequence conflicti316R → L in AAH25783 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_060275495N → S1 PublicationCorresponds to variant dbSNP:rs10416584Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0559501 – 199Missing in isoform 2. 1 PublicationAdd BLAST199

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK293789 mRNA Translation: BAG57202.1
AC010326 Genomic DNA No translation available.
BC025783 mRNA Translation: AAH25783.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12965.1 [Q8TAU3-1]

NCBI Reference Sequences

More...RefSeqi		NP_689688.2, NM_152475.2 [Q8TAU3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000312026; ENSP00000311319; ENSG00000173480 [Q8TAU3-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		147687

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:147687

UCSC genome browser

More...UCSCi		uc002qqq.4, human [Q8TAU3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK293789 mRNA Translation: BAG57202.1
AC010326 Genomic DNA No translation available.
BC025783 mRNA Translation: AAH25783.1
CCDSiCCDS12965.1 [Q8TAU3-1]
RefSeqiNP_689688.2, NM_152475.2 [Q8TAU3-1]

3D structure databases

SMRiQ8TAU3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi127075, 170 interactors
IntActiQ8TAU3, 175 interactors
MINTiQ8TAU3
STRINGi9606.ENSP00000311319

Protein family/group databases

MoonDBiQ8TAU3, Predicted

PTM databases

iPTMnetiQ8TAU3
PhosphoSitePlusiQ8TAU3
SwissPalmiQ8TAU3

Polymorphism and mutation databases

BioMutaiZNF417
DMDMi296453053

Proteomic databases

EPDiQ8TAU3
MassIVEiQ8TAU3
MaxQBiQ8TAU3
PaxDbiQ8TAU3
PeptideAtlasiQ8TAU3
PRIDEiQ8TAU3
ProteomicsDBi3983
73921 [Q8TAU3-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		33317, 99 antibodies

Genome annotation databases

EnsembliENST00000312026; ENSP00000311319; ENSG00000173480 [Q8TAU3-1]
GeneIDi147687
KEGGihsa:147687
UCSCiuc002qqq.4, human [Q8TAU3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		147687
DisGeNETi147687
EuPathDBiHostDB:ENSG00000173480.10

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF417
HGNCiHGNC:20646, ZNF417
HPAiENSG00000173480, Low tissue specificity
neXtProtiNX_Q8TAU3
OpenTargetsiENSG00000173480
PharmGKBiPA134863699

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000164176
InParanoidiQ8TAU3
OMAiSKEEWCL
OrthoDBi1318335at2759
PhylomeDBiQ8TAU3
TreeFamiTF339848

Enzyme and pathway databases

PathwayCommonsiQ8TAU3
ReactomeiR-HSA-212436, Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		147687, 8 hits in 833 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF417, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		147687
PharosiQ8TAU3, Tdark

Protein Ontology

More...PROi		PR:Q8TAU3
RNActiQ8TAU3, protein

Gene expression databases

BgeeiENSG00000173480, Expressed in corpus callosum and 148 other tissues
ExpressionAtlasiQ8TAU3, baseline and differential
GenevisibleiQ8TAU3, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 10 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 13 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 12 hits
PS50157, ZINC_FINGER_C2H2_2, 13 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN417_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TAU3
Secondary accession number(s): B4DEU1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 18, 2010
Last modified: December 2, 2020
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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