UniProtKB - Q8TAU3 (ZN417_HUMAN)
Protein
Zinc finger protein 417
Gene
ZNF417
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 92 – 114 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 240 – 262 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 268 – 290 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 296 – 318 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 324 – 346 | C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 352 – 374 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 380 – 402 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 408 – 430 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 436 – 458 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 464 – 486 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 492 – 514 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 520 – 542 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 548 – 570 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8TAU3 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Protein family/group databases
MoonDBi | Q8TAU3, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 417 |
Gene namesi | Name:ZNF417 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000173480.10 |
HGNCi | HGNC:20646, ZNF417 |
neXtProti | NX_Q8TAU3 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 147687 |
OpenTargetsi | ENSG00000173480 |
PharmGKBi | PA134863699 |
Miscellaneous databases
Pharosi | Q8TAU3, Tdark |
Polymorphism and mutation databases
BioMutai | ZNF417 |
DMDMi | 296453053 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000233985 | 1 – 575 | Zinc finger protein 417Add BLAST | 575 |
Proteomic databases
EPDi | Q8TAU3 |
MassIVEi | Q8TAU3 |
MaxQBi | Q8TAU3 |
PaxDbi | Q8TAU3 |
PeptideAtlasi | Q8TAU3 |
PRIDEi | Q8TAU3 |
ProteomicsDBi | 3983 73921 [Q8TAU3-1] |
PTM databases
iPTMneti | Q8TAU3 |
PhosphoSitePlusi | Q8TAU3 |
SwissPalmi | Q8TAU3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000173480, Expressed in corpus callosum and 148 other tissues |
ExpressionAtlasi | Q8TAU3, baseline and differential |
Genevisiblei | Q8TAU3, HS |
Organism-specific databases
HPAi | ENSG00000173480, Low tissue specificity |
Interactioni
Binary interactionsi
Q8TAU3
Protein-protein interaction databases
BioGRIDi | 127075, 170 interactors |
IntActi | Q8TAU3, 175 interactors |
MINTi | Q8TAU3 |
STRINGi | 9606.ENSP00000311319 |
Miscellaneous databases
RNActi | Q8TAU3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 15 – 88 | KRABPROSITE-ProRule annotationAdd BLAST | 74 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 92 – 114 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 240 – 262 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 268 – 290 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 296 – 318 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 324 – 346 | C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 352 – 374 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 380 – 402 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 408 – 430 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 436 – 458 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 464 – 486 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 492 – 514 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 520 – 542 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 548 – 570 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000164176 |
InParanoidi | Q8TAU3 |
OMAi | SKEEWCL |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8TAU3 |
TreeFami | TF339848 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 10 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 13 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 12 hits PS50157, ZINC_FINGER_C2H2_2, 13 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8TAU3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAAAPRRPT QQGTVTFEDV AVNFSQEEWC LLSEAQRCLY RDVMLENLAL
60 70 80 90 100
ISSLGCWCGS KDEEAPCKQR ISVQRESQSR TPRAGVSPKK AHPCEMCGLI
110 120 130 140 150
LEDVFHFADH QETHHKQKLN RSGACGKNLD DTAYLHQHQK QHIGEKFYRK
160 170 180 190 200
SVREASFVKK RKLRVSQEPF VFREFGKDVL PSSGLCQEAA AVEKTDSETM
210 220 230 240 250
HGPPFQEGKT NYSCGKRTKA FSTKHSVIPH QKLFTRDGCY VCSDCGKSFS
260 270 280 290 300
RYVSFSNHQR DHTAKGPYDC GECGKSYSRK SSLIQHQRVH TGKTAYPCEE
310 320 330 340 350
CGKSFSQKGS LISHQRVHTG ERPYECREYG KSFGQKGNLI QHQQGHTGER
360 370 380 390 400
AYHCGECGKS FRQKFCFINH QRVHTGERPY KCGECGKSFG QKGNLVQHQR
410 420 430 440 450
GHTGERPYEC KECGKSFRYR SHLTEHQRLH TGERPYNCRE CGKLFNRKYH
460 470 480 490 500
LLVHERVHTG ERPYACEVCG KLFGNKNCVT IHQRIHTGER PYECNECGKS
510 520 530 540 550
FLSSSALHVH KRVHSGQKPY KCSECGKSFA ECSSLIKHRR IHTGERPYEC
560 570
TKCGKTFQRS STLLHHQSSH RRKAL
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0R230 | M0R230_HUMAN | Zinc finger protein 417 | ZNF417 | 574 | Annotation score: | ||
M0R267 | M0R267_HUMAN | Zinc finger protein 417 | ZNF417 | 90 | Annotation score: | ||
M0R0M6 | M0R0M6_HUMAN | Zinc finger protein 417 | ZNF417 | 51 | Annotation score: | ||
M0R178 | M0R178_HUMAN | Zinc finger protein 417 | ZNF417 | 57 | Annotation score: | ||
M0QXH9 | M0QXH9_HUMAN | Zinc finger protein 417 | ZNF417 | 15 | Annotation score: | ||
M0R0V5 | M0R0V5_HUMAN | Zinc finger protein 417 | ZNF417 | 21 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 173 | R → H in AAH25783 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 316 | R → L in AAH25783 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_060275 | 495 | N → S1 PublicationCorresponds to variant dbSNP:rs10416584Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055950 | 1 – 199 | Missing in isoform 2. 1 PublicationAdd BLAST | 199 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK293789 mRNA Translation: BAG57202.1 AC010326 Genomic DNA No translation available. BC025783 mRNA Translation: AAH25783.1 |
CCDSi | CCDS12965.1 [Q8TAU3-1] |
RefSeqi | NP_689688.2, NM_152475.2 [Q8TAU3-1] |
Genome annotation databases
Ensembli | ENST00000312026; ENSP00000311319; ENSG00000173480 [Q8TAU3-1] |
GeneIDi | 147687 |
KEGGi | hsa:147687 |
UCSCi | uc002qqq.4, human [Q8TAU3-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK293789 mRNA Translation: BAG57202.1 AC010326 Genomic DNA No translation available. BC025783 mRNA Translation: AAH25783.1 |
CCDSi | CCDS12965.1 [Q8TAU3-1] |
RefSeqi | NP_689688.2, NM_152475.2 [Q8TAU3-1] |
3D structure databases
SMRi | Q8TAU3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127075, 170 interactors |
IntActi | Q8TAU3, 175 interactors |
MINTi | Q8TAU3 |
STRINGi | 9606.ENSP00000311319 |
Protein family/group databases
MoonDBi | Q8TAU3, Predicted |
PTM databases
iPTMneti | Q8TAU3 |
PhosphoSitePlusi | Q8TAU3 |
SwissPalmi | Q8TAU3 |
Polymorphism and mutation databases
BioMutai | ZNF417 |
DMDMi | 296453053 |
Proteomic databases
EPDi | Q8TAU3 |
MassIVEi | Q8TAU3 |
MaxQBi | Q8TAU3 |
PaxDbi | Q8TAU3 |
PeptideAtlasi | Q8TAU3 |
PRIDEi | Q8TAU3 |
ProteomicsDBi | 3983 73921 [Q8TAU3-1] |
Protocols and materials databases
Antibodypediai | 33317, 99 antibodies |
Genome annotation databases
Ensembli | ENST00000312026; ENSP00000311319; ENSG00000173480 [Q8TAU3-1] |
GeneIDi | 147687 |
KEGGi | hsa:147687 |
UCSCi | uc002qqq.4, human [Q8TAU3-1] |
Organism-specific databases
CTDi | 147687 |
DisGeNETi | 147687 |
EuPathDBi | HostDB:ENSG00000173480.10 |
GeneCardsi | ZNF417 |
HGNCi | HGNC:20646, ZNF417 |
HPAi | ENSG00000173480, Low tissue specificity |
neXtProti | NX_Q8TAU3 |
OpenTargetsi | ENSG00000173480 |
PharmGKBi | PA134863699 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000164176 |
InParanoidi | Q8TAU3 |
OMAi | SKEEWCL |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8TAU3 |
TreeFami | TF339848 |
Enzyme and pathway databases
PathwayCommonsi | Q8TAU3 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 147687, 8 hits in 833 CRISPR screens |
ChiTaRSi | ZNF417, human |
GenomeRNAii | 147687 |
Pharosi | Q8TAU3, Tdark |
PROi | PR:Q8TAU3 |
RNActi | Q8TAU3, protein |
Gene expression databases
Bgeei | ENSG00000173480, Expressed in corpus callosum and 148 other tissues |
ExpressionAtlasi | Q8TAU3, baseline and differential |
Genevisiblei | Q8TAU3, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 10 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 13 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 12 hits PS50157, ZINC_FINGER_C2H2_2, 13 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN417_HUMAN | |
Accessioni | Q8TAU3Primary (citable) accession number: Q8TAU3 Secondary accession number(s): B4DEU1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2006 |
Last sequence update: | May 18, 2010 | |
Last modified: | December 2, 2020 | |
This is version 154 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations