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Protein

Zinc finger protein 417

Gene

ZNF417

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri92 – 114C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri520 – 542C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri548 – 570C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436 Generic Transcription Pathway

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

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MoonDBi
Q8TAU3 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 417
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF417
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000173480.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20646 ZNF417

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TAU3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000173480

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134863699

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF417

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296453053

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002339851 – 575Zinc finger protein 417Add BLAST575

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TAU3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8TAU3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TAU3

PeptideAtlas

More...
PeptideAtlasi
Q8TAU3

PRoteomics IDEntifications database

More...
PRIDEi
Q8TAU3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
73921

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TAU3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TAU3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000173480 Expressed in 128 organ(s), highest expression level in corpus callosum

CleanEx database of gene expression profiles

More...
CleanExi
HS_ZNF417

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TAU3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TAU3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042125
HPA043288
HPA056213

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ADAMTSL4Q6UY14-35EBI-740727,EBI-10173507
BEND5Q7L4P63EBI-740727,EBI-724373
CARD9Q9H2573EBI-740727,EBI-751319
CCDC136Q96JN2-23EBI-740727,EBI-10171416
CCDC57Q2TAC23EBI-740727,EBI-2808286
CCNDBP1O952733EBI-740727,EBI-748961
CEP44Q9C0F14EBI-740727,EBI-744115
CEP70Q8NHQ15EBI-740727,EBI-739624
CSRNP1Q96S653EBI-740727,EBI-4311573
EFSO432813EBI-740727,EBI-718488
FHL2Q141923EBI-740727,EBI-701903
FHL3Q136433EBI-740727,EBI-741101
FSD2A1L4K15EBI-740727,EBI-5661036
GOLGA2Q083793EBI-740727,EBI-618309
HMBOX1Q6NT765EBI-740727,EBI-2549423
IKZF1Q134223EBI-740727,EBI-745305
KLC3Q6P5973EBI-740727,EBI-1643885
KRT15P190123EBI-740727,EBI-739566
KRT38O760155EBI-740727,EBI-1047263
KRT40Q6A1625EBI-740727,EBI-10171697
KRTAP10-5P603705EBI-740727,EBI-10172150
KRTAP10-7P604093EBI-740727,EBI-10172290
KRTAP10-8P604105EBI-740727,EBI-10171774
KRTAP10-9P604113EBI-740727,EBI-10172052
KRTAP4-2Q9BYR53EBI-740727,EBI-10172511
KRTAP5-9P263715EBI-740727,EBI-3958099
KXD1Q9BQD35EBI-740727,EBI-739657
LURAP1Q96LR23EBI-740727,EBI-741355
LZTS2Q9BRK45EBI-740727,EBI-741037
MDFIQ997506EBI-740727,EBI-724076
MEOX2P502223EBI-740727,EBI-748397
MID2Q9UJV3-25EBI-740727,EBI-10172526
MTUS2Q5JR593EBI-740727,EBI-742948
NDEL1Q9GZM83EBI-740727,EBI-928842
NINLQ9Y2I64EBI-740727,EBI-719716
NOTCH2NLAQ7Z3S95EBI-740727,EBI-945833
PHC2Q8IXK03EBI-740727,EBI-713786
PLSCR1O151623EBI-740727,EBI-740019
PNMA2Q9UL424EBI-740727,EBI-302355
PRPF31Q8WWY33EBI-740727,EBI-1567797
RELQ048643EBI-740727,EBI-307352
RPGRIP1Q96KN73EBI-740727,EBI-1050213
RUNDC3AQ59EK93EBI-740727,EBI-747225
SPRY2O435973EBI-740727,EBI-742487
SSX2IPQ9Y2D83EBI-740727,EBI-2212028
STX11O755585EBI-740727,EBI-714135
TCF4P158843EBI-740727,EBI-533224
TFIP11Q9UBB94EBI-740727,EBI-1105213
TMCC2O75069-43EBI-740727,EBI-10177480
TNS2Q63HR25EBI-740727,EBI-949753
TRAF1Q130773EBI-740727,EBI-359224
TRIM27P143736EBI-740727,EBI-719493
TRIM36Q9NQ863EBI-740727,EBI-2341518
TRIM37O949724EBI-740727,EBI-741602
TRIM41Q8WV445EBI-740727,EBI-725997
TRIM54Q9BYV25EBI-740727,EBI-2130429
TSGA10Q9BZW73EBI-740727,EBI-744794
ZBTB1Q9Y2K13EBI-740727,EBI-2682961
ZBTB10Q96DT73EBI-740727,EBI-10235384
ZBTB43O432983EBI-740727,EBI-740718
ZBTB8AQ96BR95EBI-740727,EBI-742740
ZNF587Q96SQ53EBI-740727,EBI-6427977
ZNF837Q96EG34EBI-740727,EBI-11962574

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127075, 67 interactors

Protein interaction database and analysis system

More...
IntActi
Q8TAU3, 163 interactors

Molecular INTeraction database

More...
MINTi
Q8TAU3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000311319

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8TAU3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TAU3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini15 – 88KRABPROSITE-ProRule annotationAdd BLAST74

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri92 – 114C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri520 – 542C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri548 – 570C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164176

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234617

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG018163

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TAU3

KEGG Orthology (KO)

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KOi
K09228

Identification of Orthologs from Complete Genome Data

More...
OMAi
EPFVFHE

Database of Orthologous Groups

More...
OrthoDBi
EOG091G02KC

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TAU3

TreeFam database of animal gene trees

More...
TreeFami
TF339848

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 10 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TAU3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAAPRRPT QQGTVTFEDV AVNFSQEEWC LLSEAQRCLY RDVMLENLAL
60 70 80 90 100
ISSLGCWCGS KDEEAPCKQR ISVQRESQSR TPRAGVSPKK AHPCEMCGLI
110 120 130 140 150
LEDVFHFADH QETHHKQKLN RSGACGKNLD DTAYLHQHQK QHIGEKFYRK
160 170 180 190 200
SVREASFVKK RKLRVSQEPF VFREFGKDVL PSSGLCQEAA AVEKTDSETM
210 220 230 240 250
HGPPFQEGKT NYSCGKRTKA FSTKHSVIPH QKLFTRDGCY VCSDCGKSFS
260 270 280 290 300
RYVSFSNHQR DHTAKGPYDC GECGKSYSRK SSLIQHQRVH TGKTAYPCEE
310 320 330 340 350
CGKSFSQKGS LISHQRVHTG ERPYECREYG KSFGQKGNLI QHQQGHTGER
360 370 380 390 400
AYHCGECGKS FRQKFCFINH QRVHTGERPY KCGECGKSFG QKGNLVQHQR
410 420 430 440 450
GHTGERPYEC KECGKSFRYR SHLTEHQRLH TGERPYNCRE CGKLFNRKYH
460 470 480 490 500
LLVHERVHTG ERPYACEVCG KLFGNKNCVT IHQRIHTGER PYECNECGKS
510 520 530 540 550
FLSSSALHVH KRVHSGQKPY KCSECGKSFA ECSSLIKHRR IHTGERPYEC
560 570
TKCGKTFQRS STLLHHQSSH RRKAL
Length:575
Mass (Da):65,733
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8CE2FB25CBE474F5
GO
Isoform 2 (identifier: Q8TAU3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-199: Missing.

Note: No experimental confirmation available.
Show »
Length:376
Mass (Da):43,212
Checksum:i9E787AC7E84A2898
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R230M0R230_HUMAN
Zinc finger protein 417
ZNF417
574Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R267M0R267_HUMAN
Zinc finger protein 417
ZNF417
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R0M6M0R0M6_HUMAN
Zinc finger protein 417
ZNF417
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R178M0R178_HUMAN
Zinc finger protein 417
ZNF417
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R0V5M0R0V5_HUMAN
Zinc finger protein 417
ZNF417
21Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXH9M0QXH9_HUMAN
Zinc finger protein 417
ZNF417
15Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti173R → H in AAH25783 (PubMed:15489334).Curated1
Sequence conflicti316R → L in AAH25783 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_060275495N → S1 PublicationCorresponds to variant dbSNP:rs10416584Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0559501 – 199Missing in isoform 2. 1 PublicationAdd BLAST199

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK293789 mRNA Translation: BAG57202.1
AC010326 Genomic DNA No translation available.
BC025783 mRNA Translation: AAH25783.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS12965.1 [Q8TAU3-1]

NCBI Reference Sequences

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RefSeqi
NP_689688.2, NM_152475.2 [Q8TAU3-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.567710

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000312026; ENSP00000311319; ENSG00000173480 [Q8TAU3-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
147687

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:147687

UCSC genome browser

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UCSCi
uc002qqq.4 human [Q8TAU3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK293789 mRNA Translation: BAG57202.1
AC010326 Genomic DNA No translation available.
BC025783 mRNA Translation: AAH25783.1
CCDSiCCDS12965.1 [Q8TAU3-1]
RefSeqiNP_689688.2, NM_152475.2 [Q8TAU3-1]
UniGeneiHs.567710

3D structure databases

ProteinModelPortaliQ8TAU3
SMRiQ8TAU3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127075, 67 interactors
IntActiQ8TAU3, 163 interactors
MINTiQ8TAU3
STRINGi9606.ENSP00000311319

Protein family/group databases

MoonDBiQ8TAU3 Predicted

PTM databases

iPTMnetiQ8TAU3
PhosphoSitePlusiQ8TAU3

Polymorphism and mutation databases

BioMutaiZNF417
DMDMi296453053

Proteomic databases

EPDiQ8TAU3
MaxQBiQ8TAU3
PaxDbiQ8TAU3
PeptideAtlasiQ8TAU3
PRIDEiQ8TAU3
ProteomicsDBi73921

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312026; ENSP00000311319; ENSG00000173480 [Q8TAU3-1]
GeneIDi147687
KEGGihsa:147687
UCSCiuc002qqq.4 human [Q8TAU3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
147687
EuPathDBiHostDB:ENSG00000173480.10

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF417
HGNCiHGNC:20646 ZNF417
HPAiHPA042125
HPA043288
HPA056213
neXtProtiNX_Q8TAU3
OpenTargetsiENSG00000173480
PharmGKBiPA134863699

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000164176
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8TAU3
KOiK09228
OMAiEPFVFHE
OrthoDBiEOG091G02KC
PhylomeDBiQ8TAU3
TreeFamiTF339848

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
147687

Protein Ontology

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PROi
PR:Q8TAU3

Gene expression databases

BgeeiENSG00000173480 Expressed in 128 organ(s), highest expression level in corpus callosum
CleanExiHS_ZNF417
ExpressionAtlasiQ8TAU3 baseline and differential
GenevisibleiQ8TAU3 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 10 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN417_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TAU3
Secondary accession number(s): B4DEU1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 18, 2010
Last modified: December 5, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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