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Protein

Homeobox protein Nkx-2.3

Gene

NKX2-3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi148 – 207HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Nkx-2.3
Alternative name(s):
Homeobox protein NK-2 homolog C
Gene namesi
Name:NKX2-3
Synonyms:NKX23, NKX2C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000119919.10
HGNCiHGNC:7836 NKX2-3
MIMi606727 gene
neXtProtiNX_Q8TAU0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi159296
OpenTargetsiENSG00000119919
PharmGKBiPA31643

Polymorphism and mutation databases

BioMutaiNKX2-3
DMDMi27923815

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000489331 – 364Homeobox protein Nkx-2.3Add BLAST364

Proteomic databases

EPDiQ8TAU0
PaxDbiQ8TAU0
PeptideAtlasiQ8TAU0
PRIDEiQ8TAU0
ProteomicsDBi73920

PTM databases

PhosphoSitePlusiQ8TAU0

Expressioni

Gene expression databases

BgeeiENSG00000119919 Expressed in 44 organ(s), highest expression level in spleen
CleanExiHS_NKX2-3
ExpressionAtlasiQ8TAU0 baseline and differential
GenevisibleiQ8TAU0 HS

Organism-specific databases

HPAiHPA047561

Interactioni

Protein-protein interaction databases

BioGridi127740, 3 interactors
IntActiQ8TAU0, 1 interactor
STRINGi9606.ENSP00000342828

Structurei

3D structure databases

ProteinModelPortaliQ8TAU0
SMRiQ8TAU0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi219 – 223Poly-Pro5
Compositional biasi271 – 286Poly-AlaAdd BLAST16
Compositional biasi298 – 305Poly-Gly8

Sequence similaritiesi

Belongs to the NK-2 homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0842 Eukaryota
ENOG410XR21 LUCA
GeneTreeiENSGT00910000144003
HOGENOMiHOG000231923
HOVERGENiHBG006689
InParanoidiQ8TAU0
KOiK09343
OMAiYGCAYPT
OrthoDBiEOG091G0LZ2
PhylomeDBiQ8TAU0
TreeFamiTF351204

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8TAU0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMLPSPVTST PFSVKDILNL EQQHQHFHGA HLQADLEHHF HSAPCMLAAA
60 70 80 90 100
EGTQFSDGGE EDEEDEGEKL SYLNSLAAAD GHGDSGLCPQ GYVHTVLRDS
110 120 130 140 150
CSEPKEHEEE PEVVRDRSQK SCQLKKSLET AGDCKAAEES ERPKPRSRRK
160 170 180 190 200
PRVLFSQAQV FELERRFKQQ RYLSAPEREH LASSLKLTST QVKIWFQNRR
210 220 230 240 250
YKCKRQRQDK SLELGAHAPP PPPRRVAVPV LVRDGKPCVT PSAQAYGAPY
260 270 280 290 300
SVGASAYSYN SFPAYGYGNS AAAAAAAAAA AAAAAAYSSS YGCAYPAGGG
310 320 330 340 350
GGGGGTSAAT TAMQPACSAA GGGPFVNVSN LGGFGSGGSA QPLHQGTAAG
360
AACAQGTLQG IRAW
Length:364
Mass (Da):38,406
Last modified:January 27, 2003 - v2
Checksum:i10A279CFA3C8A6DB
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WVU3A0A087WVU3_HUMAN
Homeobox protein Nkx-2.3
NKX2-3
296Annotation score:

Sequence cautioni

The sequence AAH25788 differs from that shown. The lack of 97 nucleotides within coding exon 2 produces a frameshift and results in a truncated protein.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300856 mRNA Translation: BAG62506.1
AL353719 Genomic DNA No translation available.
BC025788 mRNA Translation: AAH25788.1 Sequence problems.
AH009193 Genomic DNA Translation: AAF44651.1
CCDSiCCDS41558.1
RefSeqiNP_660328.2, NM_145285.2
UniGeneiHs.243272

Genome annotation databases

EnsembliENST00000344586; ENSP00000342828; ENSG00000119919
GeneIDi159296
KEGGihsa:159296
UCSCiuc009xwj.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300856 mRNA Translation: BAG62506.1
AL353719 Genomic DNA No translation available.
BC025788 mRNA Translation: AAH25788.1 Sequence problems.
AH009193 Genomic DNA Translation: AAF44651.1
CCDSiCCDS41558.1
RefSeqiNP_660328.2, NM_145285.2
UniGeneiHs.243272

3D structure databases

ProteinModelPortaliQ8TAU0
SMRiQ8TAU0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127740, 3 interactors
IntActiQ8TAU0, 1 interactor
STRINGi9606.ENSP00000342828

PTM databases

PhosphoSitePlusiQ8TAU0

Polymorphism and mutation databases

BioMutaiNKX2-3
DMDMi27923815

Proteomic databases

EPDiQ8TAU0
PaxDbiQ8TAU0
PeptideAtlasiQ8TAU0
PRIDEiQ8TAU0
ProteomicsDBi73920

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344586; ENSP00000342828; ENSG00000119919
GeneIDi159296
KEGGihsa:159296
UCSCiuc009xwj.4 human

Organism-specific databases

CTDi159296
DisGeNETi159296
EuPathDBiHostDB:ENSG00000119919.10
GeneCardsiNKX2-3
HGNCiHGNC:7836 NKX2-3
HPAiHPA047561
MIMi606727 gene
neXtProtiNX_Q8TAU0
OpenTargetsiENSG00000119919
PharmGKBiPA31643
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0842 Eukaryota
ENOG410XR21 LUCA
GeneTreeiENSGT00910000144003
HOGENOMiHOG000231923
HOVERGENiHBG006689
InParanoidiQ8TAU0
KOiK09343
OMAiYGCAYPT
OrthoDBiEOG091G0LZ2
PhylomeDBiQ8TAU0
TreeFamiTF351204

Miscellaneous databases

GeneWikiiNKX2-3
GenomeRNAii159296
PROiPR:Q8TAU0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000119919 Expressed in 44 organ(s), highest expression level in spleen
CleanExiHS_NKX2-3
ExpressionAtlasiQ8TAU0 baseline and differential
GenevisibleiQ8TAU0 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNKX23_HUMAN
AccessioniPrimary (citable) accession number: Q8TAU0
Secondary accession number(s): B4DUZ4, Q9NYS6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: January 27, 2003
Last modified: November 7, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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