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Entry version 103 (07 Apr 2021)
Sequence version 2 (01 Mar 2004)
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Protein
Submitted name:

LAMB1 protein

Gene

LAMB1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
LAMB1 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LAMB1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30275

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi70 ↔ 82PROSITE-ProRule annotation
Disulfide bondi72 ↔ 89PROSITE-ProRule annotation
Disulfide bondi91 ↔ 100PROSITE-ProRule annotation
Disulfide bondi118 ↔ 130PROSITE-ProRule annotation
Disulfide bondi120 ↔ 137PROSITE-ProRule annotation
Disulfide bondi139 ↔ 148PROSITE-ProRule annotation
Disulfide bondi183 ↔ 192PROSITE-ProRule annotation
Disulfide bondi243 ↔ 252PROSITE-ProRule annotation
Disulfide bondi297 ↔ 306PROSITE-ProRule annotation
Disulfide bondi325 ↔ 337PROSITE-ProRule annotation
Disulfide bondi353 ↔ 362PROSITE-ProRule annotation
Disulfide bondi381 ↔ 393PROSITE-ProRule annotation
Disulfide bondi383 ↔ 400PROSITE-ProRule annotation
Disulfide bondi402 ↔ 411PROSITE-ProRule annotation
Disulfide bondi429 ↔ 441PROSITE-ProRule annotation
Disulfide bondi431 ↔ 448PROSITE-ProRule annotation
Disulfide bondi450 ↔ 459PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q8TAS6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TAS6, HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8TAS6, 3 interactors

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 64Laminin IV type BInterPro annotationAdd BLAST64
Domaini70 – 117Laminin EGF-likeInterPro annotationAdd BLAST48
Domaini118 – 163Laminin EGF-likeInterPro annotationAdd BLAST46
Domaini164 – 213Laminin EGF-likeInterPro annotationAdd BLAST50
Domaini214 – 272Laminin EGF-likeInterPro annotationAdd BLAST59
Domaini273 – 324Laminin EGF-likeInterPro annotationAdd BLAST52
Domaini325 – 380Laminin EGF-likeInterPro annotationAdd BLAST56
Domaini381 – 428Laminin EGF-likeInterPro annotationAdd BLAST48
Domaini429 – 475Laminin EGF-likeInterPro annotationAdd BLAST47

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili547 – 567Sequence analysisAdd BLAST21
Coiled coili575 – 609Sequence analysisAdd BLAST35
Coiled coili755 – 775Sequence analysisAdd BLAST21
Coiled coili783 – 810Sequence analysisAdd BLAST28
Coiled coili858 – 885Sequence analysisAdd BLAST28
Coiled coili889 – 930Sequence analysisAdd BLAST42
Coiled coili938 – 965Sequence analysisAdd BLAST28
Coiled coili995 – 1071Sequence analysisAdd BLAST77

Keywords - Domaini

Coiled coilSequence analysis, Laminin EGF-like domainPROSITE-ProRule annotation

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000742, EGF-like_dom
IPR002049, Laminin_EGF
IPR013015, Laminin_IV_B

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00053, Laminin_EGF, 8 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 8 hits
SM00180, EGF_Lam, 8 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01248, EGF_LAM_1, 3 hits
PS50027, EGF_LAM_2, 8 hits
PS51116, LAMININ_IVB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q8TAS6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
LVLMPYCKSL DIFTVGGSGD GVVTNSAWET FQRYRCLENS RSVVKTPMTD
60 70 80 90 100
VCRNIIFSIS ALLHQTGLAC ECDPQGSLSS VCDPNGGQCQ CRPNVVGRTC
110 120 130 140 150
NRCAPGTFGF GPSGCKPCEC HLQGSVNAFC NPVTGQCHCF QGVYARQCDR
160 170 180 190 200
CLPGHWGFPS CQPCQCNGHA DDCDPVTGEC LNCQDYTMGH NCERCLAGYY
210 220 230 240 250
GDPIIGSGDH CRPCPCPDGP DSGRQFARSC YQDPVTLQLA CVCDPGYIGS
260 270 280 290 300
RCDDCASGYF GNPSEVGGSC QPCQCHNNID TTDPEACDKE TGRCLKCLYH
310 320 330 340 350
TEGEHCQFCR FGYYGDALQQ DCRKCVCNYL GTVQEHCNGS DCQCDKATGQ
360 370 380 390 400
CLCLPNVIGQ NCDRCAPNTW QLASGTGCDP CNCNAAHSFG PSCNEFTGQC
410 420 430 440 450
QCMPGFGGRT CSECQELFWG DPDVECRACD CDPRGIETPQ CDQSTGQCVC
460 470 480 490 500
VEGVEGPRCD KCTRGYSGVF PDCTPCHQCF ALWDVIIAEL TNRTHRFLEK
510 520 530 540 550
AKALKISGVI GPYRETVDSV ERKVSEIKDI LAQSPAAEPL KNIGNLFEEA
560 570 580 590 600
EKLIKDVTEM MAQVEVKLSD TTSQSNSTAK ELDSLQTEAE SLDNTVKELA
610 620 630 640 650
EQLEFIKNSD IRGALDSITK YFQMSLEAEE RVNASTTEPN STVEQSALMR
660 670 680 690 700
DRVEDVMMER ESQFKEKQEE QARLLYELAG KLQSLDLSAA AEMTCGTPPG
710 720 730 740 750
ASCSETECGG PNCRTDEGER KCGGPGCGGL VTVAHNAWQK AMDLDQDVLS
760 770 780 790 800
ALAEVEQLSK MVSEAKLRAD EAKQSAEDIL LKTNATKEKM DKSNEELRNL
810 820 830 840 850
IKQIRNFLTQ DSADLDSIEA VANEVLKMEM PSTPQQLQNL TEDIRERVES
860 870 880 890 900
LSQVEVILQH SAADIARAEM LLEEAKRASK SATDVKVTAD MVKEALEEAE
910 920 930 940 950
KAQVAAEKAI KQADEDIQGT QNLLTSIESE TAASEETLFN ASQRISELER
960 970 980 990 1000
NVEELKRKAA QNSGEAEYIE KVVYTVKQSA EDVKKTLDGE LDEKYKKVEN
1010 1020 1030 1040 1050
LIAKKTEESA DARRKAEMLQ NEAKTLLAQA NSKLQLLKDL ERKYEDNQRY
1060 1070 1080
LEDKAQELAR LEGEVRSLLK DISQKVAVYS TCL
Length:1,083
Mass (Da):118,913
Last modified:March 1, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i80F48466F457C222
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC026018 mRNA Translation: AAH26018.2

NCBI Reference Sequences

More...
RefSeqi
NP_002282.2, NM_002291.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3912

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3912

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC026018 mRNA Translation: AAH26018.2
RefSeqiNP_002282.2, NM_002291.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ8TAS6, 3 interactors

Proteomic databases

PeptideAtlasiQ8TAS6

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3912

Genome annotation databases

GeneIDi3912
KEGGihsa:3912

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3912
PharmGKBiPA30275

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
3912, 8 hits in 1000 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LAMB1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3912

Gene expression databases

GenevisibleiQ8TAS6, HS

Family and domain databases

InterProiView protein in InterPro
IPR000742, EGF-like_dom
IPR002049, Laminin_EGF
IPR013015, Laminin_IV_B
PfamiView protein in Pfam
PF00053, Laminin_EGF, 8 hits
SMARTiView protein in SMART
SM00181, EGF, 8 hits
SM00180, EGF_Lam, 8 hits
PROSITEiView protein in PROSITE
PS01248, EGF_LAM_1, 3 hits
PS50027, EGF_LAM_2, 8 hits
PS51116, LAMININ_IVB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8TAS6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TAS6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: March 1, 2004
Last modified: April 7, 2021
This is version 103 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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