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UniProtKB - Q8TAS1 (UHMK1_HUMAN)
Protein
Serine/threonine-protein kinase Kist
Gene
UHMK1
Organism
Homo sapiens (Human)
Status
Functioni
Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity).
By similarityCatalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 54 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 158 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 29 – 37 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: HGNC-UCL
- enzyme binding Source: Ensembl
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: HGNC-UCL
- protein serine kinase activity Source: RHEA
- ribonucleoprotein complex binding Source: BHF-UCL
- RNA binding Source: UniProtKB-KW
- splicing factor binding Source: Ensembl
- transferase activity Source: HGNC-UCL
GO - Biological processi
- neuron projection development Source: BHF-UCL
- peptidyl-serine phosphorylation Source: HGNC-UCL
- positive regulation of translational initiation Source: BHF-UCL
- protein autophosphorylation Source: HGNC-UCL
- regulation of cell cycle Source: HGNC-UCL
- regulation of protein export from nucleus Source: HGNC-UCL
Keywordsi
Molecular function | Kinase, RNA-binding, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q8TAS1 |
Reactomei | R-HSA-9634638, Estrogen-dependent nuclear events downstream of ESR-membrane signaling |
SignaLinki | Q8TAS1 |
SIGNORi | Q8TAS1 |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein kinase Kist (EC:2.7.11.1)Alternative name(s): Kinase interacting with stathmin PAM COOH-terminal interactor protein 2 Short name: P-CIP2 U2AF homology motif kinase 1 |
Gene namesi | Name:UHMK1 Synonyms:KIS, KIST |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19683, UHMK1 |
MIMi | 608849, gene |
neXtProti | NX_Q8TAS1 |
VEuPathDBi | HostDB:ENSG00000152332 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Golgi apparatus
- Golgi apparatus Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: HGNC-UCL
Other locations
- axon Source: BHF-UCL
- dendrite cytoplasm Source: BHF-UCL
- midbody Source: HPA
- neuronal ribonucleoprotein granule Source: BHF-UCL
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 54 | K → A: Loss of kinase activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 127933 |
OpenTargetsi | ENSG00000152332 |
PharmGKBi | PA134974001 |
Miscellaneous databases
Pharosi | Q8TAS1, Tbio |
Genetic variation databases
BioMutai | UHMK1 |
DMDMi | 24211880 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086777 | 1 – 419 | Serine/threonine-protein kinase KistAdd BLAST | 419 |
Proteomic databases
EPDi | Q8TAS1 |
jPOSTi | Q8TAS1 |
MassIVEi | Q8TAS1 |
PaxDbi | Q8TAS1 |
PeptideAtlasi | Q8TAS1 |
PRIDEi | Q8TAS1 |
ProteomicsDBi | 32376 73913 [Q8TAS1-1] 73914 [Q8TAS1-2] |
PTM databases
iPTMneti | Q8TAS1 |
PhosphoSitePlusi | Q8TAS1 |
Expressioni
Tissue specificityi
Widely expressed, with highest levels in skeletal muscle, kidney, placenta and peripheral blood leukocytes.1 Publication
Developmental stagei
Regulated in a cell-cycle dependent manner, with lowest levels during S phase and highest at G1 phase (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000152332, Expressed in substantia nigra and 225 other tissues |
Genevisiblei | Q8TAS1, HS |
Organism-specific databases
HPAi | ENSG00000152332, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with stathmin and CDKN1B/p27Kip1 (By similarity).
Interacts with PAM.
By similarity2 PublicationsBinary interactionsi
Q8TAS1
With | #Exp. | IntAct |
---|---|---|
SF1 [Q15637] | 4 | EBI-1753608,EBI-744603 |
Isoform 2 [Q8TAS1-2]
GO - Molecular functioni
- enzyme binding Source: Ensembl
- splicing factor binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 126088, 15 interactors |
IntActi | Q8TAS1, 10 interactors |
STRINGi | 9606.ENSP00000420270 |
Miscellaneous databases
RNActi | Q8TAS1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 304 | Protein kinasePROSITE-ProRule annotationCuratedAdd BLAST | 282 | |
Domaini | 324 – 406 | RRMPROSITE-ProRule annotationCuratedAdd BLAST | 83 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0032, Eukaryota |
GeneTreei | ENSGT00940000157769 |
HOGENOMi | CLU_693633_0_0_1 |
InParanoidi | Q8TAS1 |
OMAi | VFTNHSC |
OrthoDBi | 1490376at2759 |
PhylomeDBi | Q8TAS1 |
TreeFami | TF331856 |
Family and domain databases
CDDi | cd12465, RRM_UHMK1, 1 hit |
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR012677, Nucleotide-bd_a/b_plait_sf IPR000719, Prot_kinase_dom IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR034372, UHMK1 IPR034371, UHMK1_RRM |
PANTHERi | PTHR46962, PTHR46962, 1 hit |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS50102, RRM, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q8TAS1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAGSGCAWGA EPPRFLEAFG RLWQVQSRLG SGSSASVYRV RCCGNPGSPP
60 70 80 90 100
GALKQFLPPG TTGAAASAAE YGFRKERAAL EQLQGHRNIV TLYGVFTIHF
110 120 130 140 150
SPNVPSRCLL LELLDVSVSE LLLYSSHQGC SMWMIQHCAR DVLEALAFLH
160 170 180 190 200
HEGYVHADLK PRNILWSAEN ECFKLIDFGL SFKEGNQDVK YIQTDGYRAP
210 220 230 240 250
EAELQNCLAQ AGLQSDTECT SAVDLWSLGI ILLEMFSGMK LKHTVRSQEW
260 270 280 290 300
KANSSAIIDH IFASKAVVNA AIPAYHLRDL IKSMLHDDPS RRIPAEMALC
310 320 330 340 350
SPFFSIPFAP HIEDLVMLPT PVLRLLNVLD DDYLENEEEY EDVVEDVKEE
360 370 380 390 400
CQKYGPVVSL LVPKENPGRG QVFVEYANAG DSKAAQKLLT GRMFDGKFVV
410
ATFYPLSAYK RGYLYQTLL
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_041272 | 159 | L → V1 PublicationCorresponds to variant dbSNP:rs34466082Ensembl. | 1 | |
Natural variantiVAR_041273 | 197 | Y → D1 PublicationCorresponds to variant dbSNP:rs56201055Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046145 | 1 – 89 | MAGSG…GHRNI → MFLTRPKVCVDLNRR in isoform 3. 1 PublicationAdd BLAST | 89 | |
Alternative sequenceiVSP_004908 | 342 – 344 | DVV → GLC in isoform 2. 1 Publication | 3 | |
Alternative sequenceiVSP_004909 | 345 – 419 | Missing in isoform 2. 1 PublicationAdd BLAST | 75 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ536197 mRNA Translation: CAD60192.1 AK058195 mRNA No translation available. AK292369 mRNA Translation: BAF85058.1 AL359699 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW90706.1 CH471067 Genomic DNA Translation: EAW90707.1 BC014917 mRNA Translation: AAH14917.1 BC026046 mRNA Translation: AAH26046.1 |
CCDSi | CCDS1239.1 [Q8TAS1-1] CCDS53423.1 [Q8TAS1-3] CCDS53424.1 [Q8TAS1-2] |
RefSeqi | NP_001171692.1, NM_001184763.1 [Q8TAS1-3] NP_653225.2, NM_144624.2 [Q8TAS1-2] NP_787062.1, NM_175866.4 [Q8TAS1-1] |
Genome annotation databases
Ensembli | ENST00000489294; ENSP00000420270; ENSG00000152332 ENST00000538489; ENSP00000446416; ENSG00000152332 [Q8TAS1-2] ENST00000545294; ENSP00000441226; ENSG00000152332 [Q8TAS1-3] |
GeneIDi | 127933 |
KEGGi | hsa:127933 |
MANE-Selecti | ENST00000489294.2; ENSP00000420270.1; NM_175866.5; NP_787062.1 |
UCSCi | uc001gcc.3, human [Q8TAS1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ536197 mRNA Translation: CAD60192.1 AK058195 mRNA No translation available. AK292369 mRNA Translation: BAF85058.1 AL359699 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW90706.1 CH471067 Genomic DNA Translation: EAW90707.1 BC014917 mRNA Translation: AAH14917.1 BC026046 mRNA Translation: AAH26046.1 |
CCDSi | CCDS1239.1 [Q8TAS1-1] CCDS53423.1 [Q8TAS1-3] CCDS53424.1 [Q8TAS1-2] |
RefSeqi | NP_001171692.1, NM_001184763.1 [Q8TAS1-3] NP_653225.2, NM_144624.2 [Q8TAS1-2] NP_787062.1, NM_175866.4 [Q8TAS1-1] |
3D structure databases
SMRi | Q8TAS1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 126088, 15 interactors |
IntActi | Q8TAS1, 10 interactors |
STRINGi | 9606.ENSP00000420270 |
PTM databases
iPTMneti | Q8TAS1 |
PhosphoSitePlusi | Q8TAS1 |
Genetic variation databases
BioMutai | UHMK1 |
DMDMi | 24211880 |
Proteomic databases
EPDi | Q8TAS1 |
jPOSTi | Q8TAS1 |
MassIVEi | Q8TAS1 |
PaxDbi | Q8TAS1 |
PeptideAtlasi | Q8TAS1 |
PRIDEi | Q8TAS1 |
ProteomicsDBi | 32376 73913 [Q8TAS1-1] 73914 [Q8TAS1-2] |
Protocols and materials databases
Antibodypediai | 34322, 333 antibodies from 29 providers |
DNASUi | 127933 |
Genome annotation databases
Ensembli | ENST00000489294; ENSP00000420270; ENSG00000152332 ENST00000538489; ENSP00000446416; ENSG00000152332 [Q8TAS1-2] ENST00000545294; ENSP00000441226; ENSG00000152332 [Q8TAS1-3] |
GeneIDi | 127933 |
KEGGi | hsa:127933 |
MANE-Selecti | ENST00000489294.2; ENSP00000420270.1; NM_175866.5; NP_787062.1 |
UCSCi | uc001gcc.3, human [Q8TAS1-1] |
Organism-specific databases
CTDi | 127933 |
DisGeNETi | 127933 |
GeneCardsi | UHMK1 |
HGNCi | HGNC:19683, UHMK1 |
HPAi | ENSG00000152332, Low tissue specificity |
MIMi | 608849, gene |
neXtProti | NX_Q8TAS1 |
OpenTargetsi | ENSG00000152332 |
PharmGKBi | PA134974001 |
VEuPathDBi | HostDB:ENSG00000152332 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0032, Eukaryota |
GeneTreei | ENSGT00940000157769 |
HOGENOMi | CLU_693633_0_0_1 |
InParanoidi | Q8TAS1 |
OMAi | VFTNHSC |
OrthoDBi | 1490376at2759 |
PhylomeDBi | Q8TAS1 |
TreeFami | TF331856 |
Enzyme and pathway databases
PathwayCommonsi | Q8TAS1 |
Reactomei | R-HSA-9634638, Estrogen-dependent nuclear events downstream of ESR-membrane signaling |
SignaLinki | Q8TAS1 |
SIGNORi | Q8TAS1 |
Miscellaneous databases
BioGRID-ORCSi | 127933, 9 hits in 1079 CRISPR screens |
ChiTaRSi | UHMK1, human |
GeneWikii | UHMK1 |
GenomeRNAii | 127933 |
Pharosi | Q8TAS1, Tbio |
PROi | PR:Q8TAS1 |
RNActi | Q8TAS1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000152332, Expressed in substantia nigra and 225 other tissues |
Genevisiblei | Q8TAS1, HS |
Family and domain databases
CDDi | cd12465, RRM_UHMK1, 1 hit |
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR012677, Nucleotide-bd_a/b_plait_sf IPR000719, Prot_kinase_dom IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR034372, UHMK1 IPR034371, UHMK1_RRM |
PANTHERi | PTHR46962, PTHR46962, 1 hit |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS50102, RRM, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | UHMK1_HUMAN | |
Accessioni | Q8TAS1Primary (citable) accession number: Q8TAS1 Secondary accession number(s): A0A0A6YYC2 Q96C22 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 19, 2002 |
Last sequence update: | October 19, 2002 | |
Last modified: | February 23, 2022 | |
This is version 185 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families