Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/threonine-protein kinase Kist

Gene

UHMK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei54ATPPROSITE-ProRule annotation1
Active sitei158Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi29 – 37ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: HGNC
  • poly-pyrimidine tract binding Source: GO_Central
  • pre-mRNA 3'-splice site binding Source: GO_Central
  • protein serine/threonine kinase activity Source: HGNC
  • ribonucleoprotein complex binding Source: BHF-UCL
  • transferase activity Source: HGNC

GO - Biological processi

  • cell cycle arrest Source: HGNC
  • neuron projection development Source: BHF-UCL
  • peptidyl-serine phosphorylation Source: HGNC
  • positive regulation of translational initiation Source: BHF-UCL
  • protein autophosphorylation Source: HGNC
  • regulation of protein export from nucleus Source: HGNC

Keywordsi

Molecular functionKinase, RNA-binding, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ8TAS1
SIGNORiQ8TAS1

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase Kist (EC:2.7.11.1)
Alternative name(s):
Kinase interacting with stathmin
PAM COOH-terminal interactor protein 2
Short name:
P-CIP2
U2AF homology motif kinase 1
Gene namesi
Name:UHMK1
Synonyms:KIS, KIST
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000152332.15
HGNCiHGNC:19683 UHMK1
MIMi608849 gene
neXtProtiNX_Q8TAS1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi54K → A: Loss of kinase activity. 1 Publication1

Organism-specific databases

DisGeNETi127933
OpenTargetsiENSG00000152332
PharmGKBiPA134974001

Polymorphism and mutation databases

BioMutaiUHMK1
DMDMi24211880

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000867771 – 419Serine/threonine-protein kinase KistAdd BLAST419

Proteomic databases

EPDiQ8TAS1
PaxDbiQ8TAS1
PeptideAtlasiQ8TAS1
PRIDEiQ8TAS1
ProteomicsDBi73913
73914 [Q8TAS1-2]

PTM databases

iPTMnetiQ8TAS1
PhosphoSitePlusiQ8TAS1

Expressioni

Tissue specificityi

Widely expressed, with highest levels in skeletal muscle, kidney, placenta and peripheral blood leukocytes.1 Publication

Developmental stagei

Regulated in a cell-cycle dependent manner, with lowest levels during S phase and highest at G1 phase (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000152332
CleanExiHS_UHMK1
GenevisibleiQ8TAS1 HS

Organism-specific databases

HPAiHPA071190

Interactioni

Subunit structurei

Interacts with stathmin and CDKN1B/p27Kip1 (By similarity). Interacts with PAM.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SF1Q156374EBI-1753608,EBI-744603

Protein-protein interaction databases

BioGridi126088, 2 interactors
IntActiQ8TAS1, 8 interactors
STRINGi9606.ENSP00000420270

Structurei

3D structure databases

ProteinModelPortaliQ8TAS1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 304Protein kinasePROSITE-ProRule annotationCuratedAdd BLAST282
Domaini324 – 406RRMPROSITE-ProRule annotationCuratedAdd BLAST83

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0032 Eukaryota
ENOG410XRMJ LUCA
GeneTreeiENSGT00790000123065
HOGENOMiHOG000013166
HOVERGENiHBG056149
InParanoidiQ8TAS1
KOiK08877
OMAiDMKEECQ
OrthoDBiEOG091G08EY
PhylomeDBiQ8TAS1
TreeFamiTF331856

Family and domain databases

CDDicd12465 RRM_UHMK1, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR000719 Prot_kinase_dom
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034372 UHMK1
IPR034371 UHMK1_RRM
PANTHERiPTHR23139:SF14 PTHR23139:SF14, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS50102 RRM, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TAS1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGSGCAWGA EPPRFLEAFG RLWQVQSRLG SGSSASVYRV RCCGNPGSPP
60 70 80 90 100
GALKQFLPPG TTGAAASAAE YGFRKERAAL EQLQGHRNIV TLYGVFTIHF
110 120 130 140 150
SPNVPSRCLL LELLDVSVSE LLLYSSHQGC SMWMIQHCAR DVLEALAFLH
160 170 180 190 200
HEGYVHADLK PRNILWSAEN ECFKLIDFGL SFKEGNQDVK YIQTDGYRAP
210 220 230 240 250
EAELQNCLAQ AGLQSDTECT SAVDLWSLGI ILLEMFSGMK LKHTVRSQEW
260 270 280 290 300
KANSSAIIDH IFASKAVVNA AIPAYHLRDL IKSMLHDDPS RRIPAEMALC
310 320 330 340 350
SPFFSIPFAP HIEDLVMLPT PVLRLLNVLD DDYLENEEEY EDVVEDVKEE
360 370 380 390 400
CQKYGPVVSL LVPKENPGRG QVFVEYANAG DSKAAQKLLT GRMFDGKFVV
410
ATFYPLSAYK RGYLYQTLL
Length:419
Mass (Da):46,546
Last modified:October 19, 2002 - v2
Checksum:i903E982EE12A8CF8
GO
Isoform 2 (identifier: Q8TAS1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     342-344: DVV → GLC
     345-419: Missing.

Note: No experimental confirmation available.
Show »
Length:344
Mass (Da):38,130
Checksum:iF17050CA387CCA9B
GO
Isoform 3 (identifier: Q8TAS1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: MAGSGCAWGA...LEQLQGHRNI → MFLTRPKVCVDLNRR

Note: No experimental confirmation available.
Show »
Length:345
Mass (Da):39,044
Checksum:i2D542DC30505CF01
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_041272159L → V1 PublicationCorresponds to variant dbSNP:rs34466082Ensembl.1
Natural variantiVAR_041273197Y → D1 PublicationCorresponds to variant dbSNP:rs56201055Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0461451 – 89MAGSG…GHRNI → MFLTRPKVCVDLNRR in isoform 3. 1 PublicationAdd BLAST89
Alternative sequenceiVSP_004908342 – 344DVV → GLC in isoform 2. 1 Publication3
Alternative sequenceiVSP_004909345 – 419Missing in isoform 2. 1 PublicationAdd BLAST75

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ536197 mRNA Translation: CAD60192.1
AK058195 mRNA No translation available.
AK292369 mRNA Translation: BAF85058.1
AL359699 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90706.1
CH471067 Genomic DNA Translation: EAW90707.1
BC014917 mRNA Translation: AAH14917.1
BC026046 mRNA Translation: AAH26046.1
CCDSiCCDS1239.1 [Q8TAS1-1]
CCDS53423.1 [Q8TAS1-3]
CCDS53424.1 [Q8TAS1-2]
RefSeqiNP_001171692.1, NM_001184763.1 [Q8TAS1-3]
NP_653225.2, NM_144624.2 [Q8TAS1-2]
NP_787062.1, NM_175866.4 [Q8TAS1-1]
UniGeneiHs.127310

Genome annotation databases

EnsembliENST00000489294; ENSP00000420270; ENSG00000152332 [Q8TAS1-1]
ENST00000538489; ENSP00000446416; ENSG00000152332 [Q8TAS1-2]
ENST00000545294; ENSP00000441226; ENSG00000152332 [Q8TAS1-3]
GeneIDi127933
KEGGihsa:127933
UCSCiuc001gcc.3 human [Q8TAS1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiUHMK1_HUMAN
AccessioniPrimary (citable) accession number: Q8TAS1
Secondary accession number(s): A0A0A6YYC2
, A8K8K4, G3V1M1, Q96C22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: July 18, 2018
This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health