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UniProtKB - Q8TAS1 (UHMK1_HUMAN)

Entry version 185 (23 Feb 2022)
Sequence version 2 (19 Oct 2002)
Previous versions | rss
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Protein

Serine/threonine-protein kinase Kist

Gene

UHMK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity).

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei54ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei158Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi29 – 37ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, RNA-binding, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8TAS1

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-9634638, Estrogen-dependent nuclear events downstream of ESR-membrane signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8TAS1

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q8TAS1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase Kist (EC:2.7.11.1)
Alternative name(s):
Kinase interacting with stathmin
PAM COOH-terminal interactor protein 2
Short name:
P-CIP2
U2AF homology motif kinase 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UHMK1
Synonyms:KIS, KIST
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:19683, UHMK1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608849, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8TAS1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000152332

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi54K → A: Loss of kinase activity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		127933

Open Targets

More...OpenTargetsi		ENSG00000152332

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134974001

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8TAS1, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		UHMK1

Domain mapping of disease mutations (DMDM)

More...DMDMi		24211880

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000867771 – 419Serine/threonine-protein kinase KistAdd BLAST419

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8TAS1

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8TAS1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8TAS1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8TAS1

PeptideAtlas

More...PeptideAtlasi		Q8TAS1

PRoteomics IDEntifications database

More...PRIDEi		Q8TAS1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		32376
73913 [Q8TAS1-1]
73914 [Q8TAS1-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8TAS1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8TAS1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with highest levels in skeletal muscle, kidney, placenta and peripheral blood leukocytes.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Regulated in a cell-cycle dependent manner, with lowest levels during S phase and highest at G1 phase (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000152332, Expressed in substantia nigra and 225 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8TAS1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000152332, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with stathmin and CDKN1B/p27Kip1 (By similarity).

Interacts with PAM.

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		126088, 15 interactors

Protein interaction database and analysis system

More...IntActi		Q8TAS1, 10 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000420270

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8TAS1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8TAS1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 304Protein kinasePROSITE-ProRule annotationCuratedAdd BLAST282
Domaini324 – 406RRMPROSITE-ProRule annotationCuratedAdd BLAST83

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0032, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157769

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_693633_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8TAS1

Identification of Orthologs from Complete Genome Data

More...OMAi		VFTNHSC

Database of Orthologous Groups

More...OrthoDBi		1490376at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8TAS1

TreeFam database of animal gene trees

More...TreeFami		TF331856

Family and domain databases

Conserved Domains Database

More...CDDi		cd12465, RRM_UHMK1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR000719, Prot_kinase_dom
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR034372, UHMK1
IPR034371, UHMK1_RRM

The PANTHER Classification System

More...PANTHERi		PTHR46962, PTHR46962, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00069, Pkinase, 1 hit
PF00076, RRM_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00360, RRM, 1 hit
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54928, SSF54928, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS50102, RRM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8TAS1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGSGCAWGA EPPRFLEAFG RLWQVQSRLG SGSSASVYRV RCCGNPGSPP 
        60         70         80         90        100
GALKQFLPPG TTGAAASAAE YGFRKERAAL EQLQGHRNIV TLYGVFTIHF 
       110        120        130        140        150
SPNVPSRCLL LELLDVSVSE LLLYSSHQGC SMWMIQHCAR DVLEALAFLH 
       160        170        180        190        200
HEGYVHADLK PRNILWSAEN ECFKLIDFGL SFKEGNQDVK YIQTDGYRAP 
       210        220        230        240        250
EAELQNCLAQ AGLQSDTECT SAVDLWSLGI ILLEMFSGMK LKHTVRSQEW 
       260        270        280        290        300
KANSSAIIDH IFASKAVVNA AIPAYHLRDL IKSMLHDDPS RRIPAEMALC 
       310        320        330        340        350
SPFFSIPFAP HIEDLVMLPT PVLRLLNVLD DDYLENEEEY EDVVEDVKEE 
       360        370        380        390        400
CQKYGPVVSL LVPKENPGRG QVFVEYANAG DSKAAQKLLT GRMFDGKFVV 
       410 
ATFYPLSAYK RGYLYQTLL
Length:419
Mass (Da):46,546
Last modified:October 19, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i903E982EE12A8CF8
GO
Isoform 2 (identifier: Q8TAS1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     342-344: DVV → GLC
     345-419: Missing.

Show »
Length:344
Mass (Da):38,130
Checksum:iF17050CA387CCA9B
GO
Isoform 3 (identifier: Q8TAS1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: MAGSGCAWGA...LEQLQGHRNI → MFLTRPKVCVDLNRR

Show »
Length:345
Mass (Da):39,044
Checksum:i2D542DC30505CF01
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_041272159L → V1 PublicationCorresponds to variant dbSNP:rs34466082Ensembl.1
Natural variantiVAR_041273197Y → D1 PublicationCorresponds to variant dbSNP:rs56201055Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0461451 – 89MAGSG…GHRNI → MFLTRPKVCVDLNRR in isoform 3. 1 PublicationAdd BLAST89
Alternative sequenceiVSP_004908342 – 344DVV → GLC in isoform 2. 1 Publication3
Alternative sequenceiVSP_004909345 – 419Missing in isoform 2. 1 PublicationAdd BLAST75

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ536197 mRNA Translation: CAD60192.1
AK058195 mRNA No translation available.
AK292369 mRNA Translation: BAF85058.1
AL359699 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90706.1
CH471067 Genomic DNA Translation: EAW90707.1
BC014917 mRNA Translation: AAH14917.1
BC026046 mRNA Translation: AAH26046.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1239.1 [Q8TAS1-1]
CCDS53423.1 [Q8TAS1-3]
CCDS53424.1 [Q8TAS1-2]

NCBI Reference Sequences

More...RefSeqi		NP_001171692.1, NM_001184763.1 [Q8TAS1-3]
NP_653225.2, NM_144624.2 [Q8TAS1-2]
NP_787062.1, NM_175866.4 [Q8TAS1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000489294; ENSP00000420270; ENSG00000152332
ENST00000538489; ENSP00000446416; ENSG00000152332 [Q8TAS1-2]
ENST00000545294; ENSP00000441226; ENSG00000152332 [Q8TAS1-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		127933

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:127933

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000489294.2; ENSP00000420270.1; NM_175866.5; NP_787062.1

UCSC genome browser

More...UCSCi		uc001gcc.3, human [Q8TAS1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ536197 mRNA Translation: CAD60192.1
AK058195 mRNA No translation available.
AK292369 mRNA Translation: BAF85058.1
AL359699 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90706.1
CH471067 Genomic DNA Translation: EAW90707.1
BC014917 mRNA Translation: AAH14917.1
BC026046 mRNA Translation: AAH26046.1
CCDSiCCDS1239.1 [Q8TAS1-1]
CCDS53423.1 [Q8TAS1-3]
CCDS53424.1 [Q8TAS1-2]
RefSeqiNP_001171692.1, NM_001184763.1 [Q8TAS1-3]
NP_653225.2, NM_144624.2 [Q8TAS1-2]
NP_787062.1, NM_175866.4 [Q8TAS1-1]

3D structure databases

SMRiQ8TAS1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi126088, 15 interactors
IntActiQ8TAS1, 10 interactors
STRINGi9606.ENSP00000420270

PTM databases

iPTMnetiQ8TAS1
PhosphoSitePlusiQ8TAS1

Genetic variation databases

BioMutaiUHMK1
DMDMi24211880

Proteomic databases

EPDiQ8TAS1
jPOSTiQ8TAS1
MassIVEiQ8TAS1
PaxDbiQ8TAS1
PeptideAtlasiQ8TAS1
PRIDEiQ8TAS1
ProteomicsDBi32376
73913 [Q8TAS1-1]
73914 [Q8TAS1-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		34322, 333 antibodies from 29 providers

The DNASU plasmid repository

More...DNASUi		127933

Genome annotation databases

EnsembliENST00000489294; ENSP00000420270; ENSG00000152332
ENST00000538489; ENSP00000446416; ENSG00000152332 [Q8TAS1-2]
ENST00000545294; ENSP00000441226; ENSG00000152332 [Q8TAS1-3]
GeneIDi127933
KEGGihsa:127933
MANE-SelectiENST00000489294.2; ENSP00000420270.1; NM_175866.5; NP_787062.1
UCSCiuc001gcc.3, human [Q8TAS1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		127933
DisGeNETi127933

GeneCards: human genes, protein and diseases

More...GeneCardsi		UHMK1
HGNCiHGNC:19683, UHMK1
HPAiENSG00000152332, Low tissue specificity
MIMi608849, gene
neXtProtiNX_Q8TAS1
OpenTargetsiENSG00000152332
PharmGKBiPA134974001
VEuPathDBiHostDB:ENSG00000152332

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0032, Eukaryota
GeneTreeiENSGT00940000157769
HOGENOMiCLU_693633_0_0_1
InParanoidiQ8TAS1
OMAiVFTNHSC
OrthoDBi1490376at2759
PhylomeDBiQ8TAS1
TreeFamiTF331856

Enzyme and pathway databases

PathwayCommonsiQ8TAS1
ReactomeiR-HSA-9634638, Estrogen-dependent nuclear events downstream of ESR-membrane signaling
SignaLinkiQ8TAS1
SIGNORiQ8TAS1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		127933, 9 hits in 1079 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		UHMK1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		UHMK1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		127933
PharosiQ8TAS1, Tbio

Protein Ontology

More...PROi		PR:Q8TAS1
RNActiQ8TAS1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000152332, Expressed in substantia nigra and 225 other tissues
GenevisibleiQ8TAS1, HS

Family and domain databases

CDDicd12465, RRM_UHMK1, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR000719, Prot_kinase_dom
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR034372, UHMK1
IPR034371, UHMK1_RRM
PANTHERiPTHR46962, PTHR46962, 1 hit
PfamiView protein in Pfam
PF00069, Pkinase, 1 hit
PF00076, RRM_1, 1 hit
SMARTiView protein in SMART
SM00360, RRM, 1 hit
SM00220, S_TKc, 1 hit
SUPFAMiSSF54928, SSF54928, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS50102, RRM, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUHMK1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TAS1
Secondary accession number(s): A0A0A6YYC2
, A8K8K4, G3V1M1, Q96C22
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: February 23, 2022
This is version 185 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families
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