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Protein

SUN domain-containing protein 3

Gene

SUN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

As a probable component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nuclear remodeling during sperm head formation in spermatogenenis. A probable SUN3:SYNE1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette.By similarity

GO - Molecular functioni

  • protein membrane anchor Source: GO_Central

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
SUN domain-containing protein 3
Alternative name(s):
Sad1/unc-84 domain-containing protein 1
Gene namesi
Name:SUN3
Synonyms:SUNC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000164744.12
HGNCiHGNC:22429 SUN3
neXtProtiNX_Q8TAQ9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 47NuclearCuratedAdd BLAST47
Transmembranei48 – 64HelicalSequence analysisAdd BLAST17
Topological domaini65 – 357Perinuclear spaceCuratedAdd BLAST293

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi256979
OpenTargetsiENSG00000164744
PharmGKBiPA165618375

Polymorphism and mutation databases

BioMutaiSUN3
DMDMi162416243

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003122201 – 357SUN domain-containing protein 3Add BLAST357

Proteomic databases

PaxDbiQ8TAQ9
PeptideAtlasiQ8TAQ9
PRIDEiQ8TAQ9
ProteomicsDBi73909
73910 [Q8TAQ9-2]

PTM databases

iPTMnetiQ8TAQ9
PhosphoSitePlusiQ8TAQ9

Expressioni

Gene expression databases

BgeeiENSG00000164744 Expressed in 67 organ(s), highest expression level in right testis
CleanExiHS_SUNC1
ExpressionAtlasiQ8TAQ9 baseline and differential
GenevisibleiQ8TAQ9 HS

Organism-specific databases

HPAiHPA008344

Interactioni

Subunit structurei

Self-associates. Interacts with SYNE1 and SPAG4/SUN4. Proposed to form a spermatogenesis-specific LINC complex with SYNE1 during sperm head formation possibly implicating a SUN domain-based heterotrimer with SPAG4/SUN4 associating with SYNE1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000297325

Structurei

3D structure databases

ProteinModelPortaliQ8TAQ9
SMRiQ8TAQ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini193 – 354SUNPROSITE-ProRule annotationAdd BLAST162

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili98 – 146Sequence analysisAdd BLAST49

Domaini

The short coiled coil domain is proposed to be not involved in load-bearing and force transmission from the cytoskeleton but in mere nucleus anchorage instead.

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2687 Eukaryota
ENOG410YM6S LUCA
GeneTreeiENSGT00390000011587
HOGENOMiHOG000007503
HOVERGENiHBG108520
InParanoidiQ8TAQ9
KOiK21874
OMAiCVKLKIL
OrthoDBiEOG091G0AZ8
PhylomeDBiQ8TAQ9
TreeFamiTF323915

Family and domain databases

Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR008979 Galactose-bd-like_sf
IPR030274 SUN3
IPR012919 SUN_dom
PANTHERiPTHR12911:SF24 PTHR12911:SF24, 1 hit
PfamiView protein in Pfam
PF07738 Sad1_UNC, 1 hit
PROSITEiView protein in PROSITE
PS51469 SUN, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TAQ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGKTKARRA AMFFRRCSED ASGSASGNAL LSEDENPDAN GVTRSWKIIL
60 70 80 90 100
STMLTLTFLL VGLLNHQWLK ETDVPQKSRQ LYAIIAEYGS RLYKYQARLR
110 120 130 140 150
MPKEQLELLK KESQNLENNF RQILFLIEQI DVLKALLRDM KDGMDNNHNW
160 170 180 190 200
NTHGDPVEDP DHTEEVSNLV NYVLKKLRED QVEMADYALK SAGASIIEAG
210 220 230 240 250
TSESYKNNKA KLYWHGIGFL NHEMPPDIIL QPDVYPGKCW AFPGSQGHTL
260 270 280 290 300
IKLATKIIPT AVTMEHISEK VSPSGNISSA PKEFSVYGIT KKCEGEEIFL
310 320 330 340 350
GQFIYNKTGT TVQTFELQHA VSEYLLCVKL NIFSNWGHPK YTCLYRFRVH

GTPGKHI
Length:357
Mass (Da):40,503
Last modified:December 4, 2007 - v4
Checksum:i5E63D57F1806753B
GO
Isoform 2 (identifier: Q8TAQ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-100: Missing.
     287-287: Y → YVQRYMCRFVIQA

Show »
Length:269
Mass (Da):30,703
Checksum:i57908C8B09119E5D
GO
Isoform 3 (identifier: Q8TAQ9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-61: SGKTKARRAA...TMLTLTFLLV → EDYSKYNAYT...ASASRVAGTT

Note: No experimental confirmation available.
Show »
Length:345
Mass (Da):39,079
Checksum:i712063DFF09C7F05
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WDT4F8WDT4_HUMAN
SUN domain-containing protein 3
SUN3
89Annotation score:
H7BZA7H7BZA7_HUMAN
SUN domain-containing protein 3
SUN3
281Annotation score:
H7C2N0H7C2N0_HUMAN
SUN domain-containing protein 3
SUN3
170Annotation score:
A0A0A0MSG9A0A0A0MSG9_HUMAN
SUN domain-containing protein 3
SUN3
266Annotation score:

Sequence cautioni

The sequence AAP97300 differs from that shown. Reason: Frameshift at positions 233 and 242.Curated
The sequence EAL23808 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti231 – 232Missing in AAP97300 (Ref. 1) Curated2
Sequence conflicti292K → R in BAG63413 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037458127I → V1 PublicationCorresponds to variant dbSNP:rs17852360Ensembl.1
Natural variantiVAR_037459177L → V. Corresponds to variant dbSNP:rs7797657Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0297481 – 100Missing in isoform 2. 1 PublicationAdd BLAST100
Alternative sequenceiVSP_0556242 – 61SGKTK…TFLLV → EDYSKYNAYTDFSSCRLECS GAILAHCNLHLLGSSISPAS ASRVAGTT in isoform 3. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_029749287Y → YVQRYMCRFVIQA in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF429967 mRNA Translation: AAP97300.1 Frameshift.
AK302011 mRNA Translation: BAG63413.1
DQ099386 mRNA Translation: AAZ13762.1
AC069279 Genomic DNA No translation available.
CH236958 Genomic DNA Translation: EAL23808.1 Sequence problems.
CH471128 Genomic DNA Translation: EAW60999.1
CH471128 Genomic DNA Translation: EAW61000.1
BC026189 mRNA Translation: AAH26189.3
CCDSiCCDS34636.1 [Q8TAQ9-1]
CCDS64647.1 [Q8TAQ9-3]
RefSeqiNP_001025190.1, NM_001030019.1 [Q8TAQ9-1]
NP_001271279.1, NM_001284350.1 [Q8TAQ9-3]
NP_689995.3, NM_152782.3 [Q8TAQ9-1]
XP_016867419.1, XM_017011930.1 [Q8TAQ9-1]
UniGeneiHs.406741

Genome annotation databases

EnsembliENST00000297325; ENSP00000297325; ENSG00000164744 [Q8TAQ9-1]
ENST00000395572; ENSP00000378939; ENSG00000164744 [Q8TAQ9-1]
ENST00000412142; ENSP00000410204; ENSG00000164744 [Q8TAQ9-3]
ENST00000438771; ENSP00000409077; ENSG00000164744 [Q8TAQ9-2]
GeneIDi256979
KEGGihsa:256979
UCSCiuc003tof.4 human [Q8TAQ9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF429967 mRNA Translation: AAP97300.1 Frameshift.
AK302011 mRNA Translation: BAG63413.1
DQ099386 mRNA Translation: AAZ13762.1
AC069279 Genomic DNA No translation available.
CH236958 Genomic DNA Translation: EAL23808.1 Sequence problems.
CH471128 Genomic DNA Translation: EAW60999.1
CH471128 Genomic DNA Translation: EAW61000.1
BC026189 mRNA Translation: AAH26189.3
CCDSiCCDS34636.1 [Q8TAQ9-1]
CCDS64647.1 [Q8TAQ9-3]
RefSeqiNP_001025190.1, NM_001030019.1 [Q8TAQ9-1]
NP_001271279.1, NM_001284350.1 [Q8TAQ9-3]
NP_689995.3, NM_152782.3 [Q8TAQ9-1]
XP_016867419.1, XM_017011930.1 [Q8TAQ9-1]
UniGeneiHs.406741

3D structure databases

ProteinModelPortaliQ8TAQ9
SMRiQ8TAQ9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000297325

PTM databases

iPTMnetiQ8TAQ9
PhosphoSitePlusiQ8TAQ9

Polymorphism and mutation databases

BioMutaiSUN3
DMDMi162416243

Proteomic databases

PaxDbiQ8TAQ9
PeptideAtlasiQ8TAQ9
PRIDEiQ8TAQ9
ProteomicsDBi73909
73910 [Q8TAQ9-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297325; ENSP00000297325; ENSG00000164744 [Q8TAQ9-1]
ENST00000395572; ENSP00000378939; ENSG00000164744 [Q8TAQ9-1]
ENST00000412142; ENSP00000410204; ENSG00000164744 [Q8TAQ9-3]
ENST00000438771; ENSP00000409077; ENSG00000164744 [Q8TAQ9-2]
GeneIDi256979
KEGGihsa:256979
UCSCiuc003tof.4 human [Q8TAQ9-1]

Organism-specific databases

CTDi256979
DisGeNETi256979
EuPathDBiHostDB:ENSG00000164744.12
GeneCardsiSUN3
HGNCiHGNC:22429 SUN3
HPAiHPA008344
neXtProtiNX_Q8TAQ9
OpenTargetsiENSG00000164744
PharmGKBiPA165618375
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2687 Eukaryota
ENOG410YM6S LUCA
GeneTreeiENSGT00390000011587
HOGENOMiHOG000007503
HOVERGENiHBG108520
InParanoidiQ8TAQ9
KOiK21874
OMAiCVKLKIL
OrthoDBiEOG091G0AZ8
PhylomeDBiQ8TAQ9
TreeFamiTF323915

Miscellaneous databases

GenomeRNAii256979
PROiPR:Q8TAQ9

Gene expression databases

BgeeiENSG00000164744 Expressed in 67 organ(s), highest expression level in right testis
CleanExiHS_SUNC1
ExpressionAtlasiQ8TAQ9 baseline and differential
GenevisibleiQ8TAQ9 HS

Family and domain databases

Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR008979 Galactose-bd-like_sf
IPR030274 SUN3
IPR012919 SUN_dom
PANTHERiPTHR12911:SF24 PTHR12911:SF24, 1 hit
PfamiView protein in Pfam
PF07738 Sad1_UNC, 1 hit
PROSITEiView protein in PROSITE
PS51469 SUN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSUN3_HUMAN
AccessioniPrimary (citable) accession number: Q8TAQ9
Secondary accession number(s): A4D2F3
, B4DXK1, D3DVM3, E7EWC8, Q4F965, Q7Z4U8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: November 7, 2018
This is version 128 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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