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Protein

Zinc finger protein 420

Gene

ZNF420

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri139 – 161C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri167 – 189C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri195 – 217C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri223 – 245C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri251 – 273C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 301C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri391 – 413C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri419 – 441C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri447 – 469C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri475 – 497C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri503 – 525C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri531 – 553C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri559 – 581C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri587 – 609C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri615 – 637C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri643 – 665C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 420
Gene namesi
Name:ZNF420
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000197050.10
HGNCiHGNC:20649 ZNF420
neXtProtiNX_Q8TAQ5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197050
PharmGKBiPA134958420

Polymorphism and mutation databases

BioMutaiZNF420
DMDMi71153480

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475751 – 688Zinc finger protein 420Add BLAST688

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki298Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ8TAQ5
PaxDbiQ8TAQ5
PeptideAtlasiQ8TAQ5
PRIDEiQ8TAQ5
ProteomicsDBi73908

PTM databases

iPTMnetiQ8TAQ5
PhosphoSitePlusiQ8TAQ5

Expressioni

Gene expression databases

BgeeiENSG00000197050 Expressed in 205 organ(s), highest expression level in amniotic fluid
CleanExiHS_ZNF420
ExpressionAtlasiQ8TAQ5 baseline and differential
GenevisibleiQ8TAQ5 HS

Organism-specific databases

HPAiHPA059675

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi127098, 18 interactors
IntActiQ8TAQ5, 13 interactors
MINTiQ8TAQ5
STRINGi9606.ENSP00000338770

Structurei

3D structure databases

ProteinModelPortaliQ8TAQ5
SMRiQ8TAQ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 86KRABPROSITE-ProRule annotationAdd BLAST81

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri139 – 161C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri167 – 189C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri195 – 217C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri223 – 245C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri251 – 273C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 301C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri391 – 413C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri419 – 441C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri447 – 469C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri475 – 497C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri503 – 525C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri531 – 553C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri559 – 581C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri587 – 609C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri615 – 637C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri643 – 665C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150816
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8TAQ5
KOiK09228
OMAiFNQHAYL
OrthoDBiEOG091G02KC
PhylomeDBiQ8TAQ5
TreeFamiTF341817

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 18 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 19 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 19 hits
PS50157 ZINC_FINGER_C2H2_2, 19 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TAQ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARKLVMFRD VAIDFSQEEW ECLDSAQRDL YRDVMLENYS NLVSLDLPSR
60 70 80 90 100
CASKDLSPEK NTYETELSQW EMSDRLENCD LEESNSRDYL EAKGKMEKQQ
110 120 130 140 150
ENQKEYFRQG MIIYDKMSIF NQHTYLSQHS RCHSTEKPYK CKECGKAFRR
160 170 180 190 200
ASHLTQHQSI HTGEKPYECK QCGKAFSRDS QLSLHQRLHT GEKPYACKEC
210 220 230 240 250
GKAFTQSSQL ILHHRIHTGE KPYKCEECGK AFIRSSQLTR HQKVHTGEKP
260 270 280 290 300
YECKECGKAF TQNSQLTLHQ RLHTGEKLYE CKECRKVFTQ LSQLILHKRI
310 320 330 340 350
HTGEKPYECK ECGKAFICGS QLSQHQKIHN GEKPYECKEC GRAFIRGSLL
360 370 380 390 400
MQHQRIHTGE KPYKCEECGK AFIRGSQLTQ HQRIHTNEKP YECKECGKMF
410 420 430 440 450
SHGSQLTQHQ RIHTGEKPYQ CKECGKAFNR GSLLTRHQRI HTGEKPYECK
460 470 480 490 500
ECGKTFSRGS ELTQHERIHT GEKPYECKEC GKSFIRGSQL TQHQRIHTGE
510 520 530 540 550
KPYECKECRM AFTQSSHLSQ HQRLHTGEKP YVCNECGKAF ARGLLLIQHQ
560 570 580 590 600
RIHTGEKPYQ CKECGKAFIR GSQLTQHQRI HTGEKPYECK ECGKAFSHGS
610 620 630 640 650
QLTLHQRIHT GEKPYECREC RKAFTQSSHL SRHQRIHTGE KPYQCKECGK
660 670 680
AFTRGSQLTQ HQRIHISEKS FEYKECGIDF SHGSQVYM
Length:688
Mass (Da):80,247
Last modified:June 1, 2002 - v1
Checksum:i70E984F166F8A975
GO
Isoform 2 (identifier: Q8TAQ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     471-536: GEKPYECKEC...GEKPYVCNEC → AFLAGQQDRS...EQKYRRSLQP
     537-688: Missing.

Note: No experimental confirmation available.
Show »
Length:536
Mass (Da):62,957
Checksum:iF98B57D73A99A255
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EQC9K7EQC9_HUMAN
Zinc finger protein 420
ZNF420
163Annotation score:
K7EJW2K7EJW2_HUMAN
Zinc finger protein 420
ZNF420
51Annotation score:
K7EPG0K7EPG0_HUMAN
Zinc finger protein 420
ZNF420
47Annotation score:
K7ELF6K7ELF6_HUMAN
Zinc finger protein 420
ZNF420
88Annotation score:
K7ESJ1K7ESJ1_HUMAN
Zinc finger protein 420
ZNF420
89Annotation score:
K7ERS3K7ERS3_HUMAN
Zinc finger protein 420
ZNF420
79Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055951471 – 536GEKPY…VCNEC → AFLAGQQDRSDIYMSRRFTK SIFPVFFSVPTMWTSKLELR YSHGDFENGIWVLWIMEQKY RRSLQP in isoform 2. 1 PublicationAdd BLAST66
Alternative sequenceiVSP_055952537 – 688Missing in isoform 2. 1 PublicationAdd BLAST152

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056753 mRNA Translation: BAB71272.1
AK315728 mRNA Translation: BAG38083.1
AC008733 Genomic DNA No translation available.
AC010632 Genomic DNA No translation available.
AC012309 Genomic DNA No translation available.
BC026210 mRNA Translation: AAH26210.1
CCDSiCCDS12498.1 [Q8TAQ5-1]
CCDS86757.1 [Q8TAQ5-2]
RefSeqiNP_001316451.1, NM_001329522.1 [Q8TAQ5-2]
NP_653290.2, NM_144689.4 [Q8TAQ5-1]
XP_011524805.1, XM_011526503.2 [Q8TAQ5-1]
XP_011524806.1, XM_011526504.2 [Q8TAQ5-1]
UniGeneiHs.444992

Genome annotation databases

EnsembliENST00000304239; ENSP00000306102; ENSG00000197050 [Q8TAQ5-2]
ENST00000337995; ENSP00000338770; ENSG00000197050 [Q8TAQ5-1]
GeneIDi147923
KEGGihsa:147923
UCSCiuc002ofl.4 human [Q8TAQ5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056753 mRNA Translation: BAB71272.1
AK315728 mRNA Translation: BAG38083.1
AC008733 Genomic DNA No translation available.
AC010632 Genomic DNA No translation available.
AC012309 Genomic DNA No translation available.
BC026210 mRNA Translation: AAH26210.1
CCDSiCCDS12498.1 [Q8TAQ5-1]
CCDS86757.1 [Q8TAQ5-2]
RefSeqiNP_001316451.1, NM_001329522.1 [Q8TAQ5-2]
NP_653290.2, NM_144689.4 [Q8TAQ5-1]
XP_011524805.1, XM_011526503.2 [Q8TAQ5-1]
XP_011524806.1, XM_011526504.2 [Q8TAQ5-1]
UniGeneiHs.444992

3D structure databases

ProteinModelPortaliQ8TAQ5
SMRiQ8TAQ5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127098, 18 interactors
IntActiQ8TAQ5, 13 interactors
MINTiQ8TAQ5
STRINGi9606.ENSP00000338770

PTM databases

iPTMnetiQ8TAQ5
PhosphoSitePlusiQ8TAQ5

Polymorphism and mutation databases

BioMutaiZNF420
DMDMi71153480

Proteomic databases

EPDiQ8TAQ5
PaxDbiQ8TAQ5
PeptideAtlasiQ8TAQ5
PRIDEiQ8TAQ5
ProteomicsDBi73908

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304239; ENSP00000306102; ENSG00000197050 [Q8TAQ5-2]
ENST00000337995; ENSP00000338770; ENSG00000197050 [Q8TAQ5-1]
GeneIDi147923
KEGGihsa:147923
UCSCiuc002ofl.4 human [Q8TAQ5-1]

Organism-specific databases

CTDi147923
EuPathDBiHostDB:ENSG00000197050.10
GeneCardsiZNF420
HGNCiHGNC:20649 ZNF420
HPAiHPA059675
neXtProtiNX_Q8TAQ5
OpenTargetsiENSG00000197050
PharmGKBiPA134958420
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150816
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8TAQ5
KOiK09228
OMAiFNQHAYL
OrthoDBiEOG091G02KC
PhylomeDBiQ8TAQ5
TreeFamiTF341817

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release

Miscellaneous databases

ChiTaRSiZNF420 human
GenomeRNAii147923
PROiPR:Q8TAQ5

Gene expression databases

BgeeiENSG00000197050 Expressed in 205 organ(s), highest expression level in amniotic fluid
CleanExiHS_ZNF420
ExpressionAtlasiQ8TAQ5 baseline and differential
GenevisibleiQ8TAQ5 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 18 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 19 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 19 hits
PS50157 ZINC_FINGER_C2H2_2, 19 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN420_HUMAN
AccessioniPrimary (citable) accession number: Q8TAQ5
Secondary accession number(s): B2RDY6, Q96ML5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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