Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

M-phase-specific PLK1-interacting protein

Gene

MPLKIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis.1 Publication

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

SIGNORiQ8TAP9

Names & Taxonomyi

Protein namesi
Recommended name:
M-phase-specific PLK1-interacting protein
Alternative name(s):
TTD non-photosensitive 1 protein
Gene namesi
Name:MPLKIP
Synonyms:C7orf11, TTDN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000168303.6
HGNCiHGNC:16002 MPLKIP
MIMi609188 gene
neXtProtiNX_Q8TAP9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Involvement in diseasei

Trichothiodystrophy 4, non-photosensitive (TTD4)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of trichothiodystrophy, an autosomal recessive disease characterized by sulfur-deficient brittle hair and multisystem variable abnormalities. The spectrum of clinical features varies from mild disease with only hair involvement to severe disease with cutaneous, neurologic and profound developmental defects. Ichthyosis, intellectual and developmental disabilities, decreased fertility, abnormal characteristics at birth, ocular abnormalities, short stature, and infections are common manifestations. There are both photosensitive and non-photosensitive forms of the disorder. TTD4 patients do not manifest cutaneous photosensitivity.
See also OMIM:234050
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022940144M → V in TTD4. 1 PublicationCorresponds to variant dbSNP:rs137853117EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi93S → A: Partially prevents phosphorylation. 1 Publication1
Mutagenesisi104S → A: Has no effect on interaction with PLK1 in mitosis. Partially prevents phosphorylation. 1 Publication1
Mutagenesisi120T → A: Abolishes interaction with PLK1 in mitosis. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi136647
MalaCardsiMPLKIP
MIMi234050 phenotype
OpenTargetsiENSG00000168303
Orphaneti33364 Trichothiodystrophy
PharmGKBiPA25943

Polymorphism and mutation databases

BioMutaiMPLKIP
DMDMi71153365

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000656741 – 179M-phase-specific PLK1-interacting proteinAdd BLAST179

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei37Asymmetric dimethylarginineBy similarity1
Modified residuei40PhosphoserineCombined sources1
Modified residuei47PhosphoserineCombined sources1
Modified residuei51PhosphothreonineCombined sources1
Modified residuei57Omega-N-methylarginineCombined sources1
Modified residuei59Asymmetric dimethylarginineCombined sources1
Modified residuei68Asymmetric dimethylarginineCombined sources1
Modified residuei72PhosphoserineCombined sources1
Modified residuei77Asymmetric dimethylarginineCombined sources1
Modified residuei80PhosphoserineCombined sources1
Modified residuei82PhosphoserineCombined sources1
Modified residuei93PhosphoserineCombined sources1 Publication1
Modified residuei104PhosphoserineCombined sources1 Publication1
Modified residuei115PhosphoserineCombined sources1
Modified residuei117Omega-N-methylarginineCombined sources1
Modified residuei120PhosphothreonineCombined sources1
Modified residuei124PhosphoserineCombined sources1
Modified residuei133PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated during mitosis in the cell cycle probably by CDK1.1 Publication

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ8TAP9
MaxQBiQ8TAP9
PaxDbiQ8TAP9
PeptideAtlasiQ8TAP9
PRIDEiQ8TAP9
ProteomicsDBi73905

PTM databases

iPTMnetiQ8TAP9
PhosphoSitePlusiQ8TAP9

Expressioni

Tissue specificityi

Expressed at highest levels in liver and kidney; intermediate expression in skeletal muscle, pancreas, heart and placenta; low expression in brain and lung. Expressed in epidermis and hair follicles.2 Publications

Gene expression databases

BgeeiENSG00000168303 Expressed in 211 organ(s), highest expression level in metanephros
CleanExiHS_C7orf11
ExpressionAtlasiQ8TAP9 baseline and differential
GenevisibleiQ8TAP9 HS

Organism-specific databases

HPAiHPA058457
HPA065463

Interactioni

Subunit structurei

Interacts with PLK1; phosphorylation-dependent.1 Publication

Protein-protein interaction databases

BioGridi126463, 20 interactors
IntActiQ8TAP9, 3 interactors
STRINGi9606.ENSP00000304553

Structurei

3D structure databases

ProteinModelPortaliQ8TAP9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410J0XS Eukaryota
ENOG4111V2F LUCA
GeneTreeiENSGT00390000002582
HOGENOMiHOG000252982
HOVERGENiHBG073319
InParanoidiQ8TAP9
OMAiHRPNFRP
OrthoDBiEOG091G13KW
PhylomeDBiQ8TAP9
TreeFamiTF335586

Family and domain databases

InterProiView protein in InterPro
IPR026618 MPLKIP-like_vertebrate
IPR028265 TTDN1/SICKLE
PANTHERiPTHR22446 PTHR22446, 1 hit
PfamiView protein in Pfam
PF15502 MPLKIP, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TAP9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQRQNFRPPT PPYPGPGGGG WGSGSSFRGT PGGGGPRPPS PRDGYGSPHH
60 70 80 90 100
TPPYGPRSRP YGSSHSPRHG GSFPGGRFGS PSPGGYPGSY SRSPAGSQQQ
110 120 130 140 150
FGYSPGQQQT HPQGSPRTST PFGSGRVREK RMSNELENYF KPSMLEDPWA
160 170
GLEPVSVVDI SQQYSNTQTF TGKKGRYFC
Length:179
Mass (Da):19,147
Last modified:June 1, 2002 - v1
Checksum:i77DBA4FBDF9C70CC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03627329G → E in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs565833937Ensembl.1
Natural variantiVAR_022940144M → V in TTD4. 1 PublicationCorresponds to variant dbSNP:rs137853117EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC026265 mRNA Translation: AAH26265.1
CCDSiCCDS5463.1
RefSeqiNP_619646.1, NM_138701.3
UniGeneiHs.654989

Genome annotation databases

EnsembliENST00000306984; ENSP00000304553; ENSG00000168303
ENST00000645701; ENSP00000495808; ENSG00000168303
GeneIDi136647
KEGGihsa:136647
UCSCiuc003thl.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC026265 mRNA Translation: AAH26265.1
CCDSiCCDS5463.1
RefSeqiNP_619646.1, NM_138701.3
UniGeneiHs.654989

3D structure databases

ProteinModelPortaliQ8TAP9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126463, 20 interactors
IntActiQ8TAP9, 3 interactors
STRINGi9606.ENSP00000304553

PTM databases

iPTMnetiQ8TAP9
PhosphoSitePlusiQ8TAP9

Polymorphism and mutation databases

BioMutaiMPLKIP
DMDMi71153365

Proteomic databases

EPDiQ8TAP9
MaxQBiQ8TAP9
PaxDbiQ8TAP9
PeptideAtlasiQ8TAP9
PRIDEiQ8TAP9
ProteomicsDBi73905

Protocols and materials databases

DNASUi136647
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306984; ENSP00000304553; ENSG00000168303
ENST00000645701; ENSP00000495808; ENSG00000168303
GeneIDi136647
KEGGihsa:136647
UCSCiuc003thl.5 human

Organism-specific databases

CTDi136647
DisGeNETi136647
EuPathDBiHostDB:ENSG00000168303.6
GeneCardsiMPLKIP
HGNCiHGNC:16002 MPLKIP
HPAiHPA058457
HPA065463
MalaCardsiMPLKIP
MIMi234050 phenotype
609188 gene
neXtProtiNX_Q8TAP9
OpenTargetsiENSG00000168303
Orphaneti33364 Trichothiodystrophy
PharmGKBiPA25943
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0XS Eukaryota
ENOG4111V2F LUCA
GeneTreeiENSGT00390000002582
HOGENOMiHOG000252982
HOVERGENiHBG073319
InParanoidiQ8TAP9
OMAiHRPNFRP
OrthoDBiEOG091G13KW
PhylomeDBiQ8TAP9
TreeFamiTF335586

Enzyme and pathway databases

SIGNORiQ8TAP9

Miscellaneous databases

ChiTaRSiMPLKIP human
GeneWikiiC7orf11
MPLKIP
GenomeRNAii136647
PROiPR:Q8TAP9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168303 Expressed in 211 organ(s), highest expression level in metanephros
CleanExiHS_C7orf11
ExpressionAtlasiQ8TAP9 baseline and differential
GenevisibleiQ8TAP9 HS

Family and domain databases

InterProiView protein in InterPro
IPR026618 MPLKIP-like_vertebrate
IPR028265 TTDN1/SICKLE
PANTHERiPTHR22446 PTHR22446, 1 hit
PfamiView protein in Pfam
PF15502 MPLKIP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMPLKI_HUMAN
AccessioniPrimary (citable) accession number: Q8TAP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 1, 2002
Last modified: September 12, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again