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Entry version 149 (07 Oct 2020)
Sequence version 1 (01 Jun 2002)
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Protein

Centrosomal protein of 76 kDa

Gene

CEP76

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q8TAP6

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259, Loss of Nlp from mitotic centrosomes
R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320, Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912, Anchoring of the basal body to the plasma membrane
R-HSA-8854518, AURKA Activation by TPX2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Centrosomal protein of 76 kDa
Short name:
Cep76
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CEP76
Synonyms:C18orf9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000101624.10

Human Gene Nomenclature Database

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HGNCi
HGNC:25727, CEP76

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q8TAP6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
79959

Open Targets

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OpenTargetsi
ENSG00000101624

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134916911

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q8TAP6, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
CEP76

Domain mapping of disease mutations (DMDM)

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DMDMi
59797956

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000895011 – 659Centrosomal protein of 76 kDaAdd BLAST659

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei75PhosphoserineBy similarity1
Modified residuei83PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TAP6

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8TAP6

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q8TAP6

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8TAP6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TAP6

PeptideAtlas

More...
PeptideAtlasi
Q8TAP6

PRoteomics IDEntifications database

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PRIDEi
Q8TAP6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
73901 [Q8TAP6-1]
73902 [Q8TAP6-2]
73903 [Q8TAP6-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TAP6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TAP6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8TAP6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed at low level in G1 and is induced in S and G2 phase, during which point centrioles have already commenced duplication (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000101624, Expressed in secondary oocyte and 197 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8TAP6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TAP6, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000101624, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CCP110 and CEP97.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q8TAP6
With#Exp.IntAct
AKAP7 - isoform Alpha [O43687-2]6EBI-742887,EBI-10185182
AKT1 [P31749]3EBI-742887,EBI-296087
ANKRD36 [A1A5B0]3EBI-742887,EBI-14100900
ASH2L [Q9UBL3]3EBI-742887,EBI-540797
BANP [A0A0S2Z5G4]3EBI-742887,EBI-16429704
BANP [B4DE54]3EBI-742887,EBI-16429313
BANP [Q8N9N5]3EBI-742887,EBI-744695
BANP - isoform 2 [Q8N9N5-2]3EBI-742887,EBI-11524452
BANP - isoform 7 [Q8N9N5-7]3EBI-742887,EBI-16429296
C22orf39 [Q6P5X5]6EBI-742887,EBI-7317823
CABP5 [Q9NP86]8EBI-742887,EBI-10311131
CACNB3 [P54284]3EBI-742887,EBI-1184651
CAPN3 [A0A0S2Z3E6]3EBI-742887,EBI-16430532
CAVIN3 [Q969G5]3EBI-742887,EBI-3893101
CCDC92 [Q53HC0]3EBI-742887,EBI-719994
CDK18 [Q07002]3EBI-742887,EBI-746238
CENPI [Q92674]3EBI-742887,EBI-11085153
CIR1 [Q86X95]3EBI-742887,EBI-627102
CRYBA4 [P53673]9EBI-742887,EBI-7519711
CSNK1G1 [Q9HCP0]3EBI-742887,EBI-1383814
CUTC [Q9NTM9]3EBI-742887,EBI-714918
CWF19L2 [Q2TBE0]3EBI-742887,EBI-5453285
DDX6 [P26196]3EBI-742887,EBI-351257
DEAF1 [O75398]3EBI-742887,EBI-718185
DMTN [Q08495]3EBI-742887,EBI-715275
DVL3 [Q92997]3EBI-742887,EBI-739789
DZIP1L [Q8IYY4]5EBI-742887,EBI-10264440
EAF1 [Q96JC9]3EBI-742887,EBI-769261
EIF1AD [Q8N9N8]3EBI-742887,EBI-750700
ERCC3 [P19447]3EBI-742887,EBI-1183307
FAM90A1 [Q86YD7]6EBI-742887,EBI-6658203
GDAP2 [Q9NXN4]3EBI-742887,EBI-10316460
GORASP2 [Q9H8Y8]3EBI-742887,EBI-739467
HSF2 [Q03933]3EBI-742887,EBI-2556750
HSPB7 [Q9UBY9]6EBI-742887,EBI-739361
ILVBL [A1L0T0]3EBI-742887,EBI-720553
IQUB [Q8NA54]3EBI-742887,EBI-10220600
KDM1A [O60341]3EBI-742887,EBI-710124
KDM4D [Q6B0I6]3EBI-742887,EBI-4311651
KIAA1143 [Q96AT1]7EBI-742887,EBI-2548425
KLHDC4 [Q8TBB5]3EBI-742887,EBI-8472352
L3MBTL2 [Q969R5]3EBI-742887,EBI-739909
LATS1 [Q6PJG3]3EBI-742887,EBI-10253976
LNX1 [Q8TBB1]3EBI-742887,EBI-739832
MBD3 [O95983]3EBI-742887,EBI-1783068
MBD3 - isoform 2 [O95983-2]3EBI-742887,EBI-11978579
MFAP1 [P55081]3EBI-742887,EBI-1048159
MISP [Q8IVT2]3EBI-742887,EBI-2555085
MYOZ1 [Q9NP98]3EBI-742887,EBI-744402
NEK6 - isoform 4 [Q9HC98-4]3EBI-742887,EBI-11750983
NFYC - isoform 1 [Q13952-2]3EBI-742887,EBI-11956831
NHLRC2 [Q8NBF2]3EBI-742887,EBI-10269163
NHLRC2 - isoform 2 [Q8NBF2-2]3EBI-742887,EBI-10697320
NME5 [A0A0S2Z4M0]4EBI-742887,EBI-16430544
PARD6B [Q9BYG5]6EBI-742887,EBI-295391
PATZ1 - isoform 4 [Q9HBE1-4]3EBI-742887,EBI-11022007
PDGFRB [P09619]3EBI-742887,EBI-641237
PDRG1 [Q9NUG6]3EBI-742887,EBI-307050
PDZD4 [Q17RL8]3EBI-742887,EBI-10239064
PIN1 [Q13526]6EBI-742887,EBI-714158
PKP1 - isoform 1 [Q13835-2]3EBI-742887,EBI-9087684
PLA2G6 [O60733]3EBI-742887,EBI-12089905
PLCB1 [Q9NQ66]3EBI-742887,EBI-3396023
POM121 [Q96HA1]3EBI-742887,EBI-739990
POM121 - isoform 2 [Q96HA1-2]3EBI-742887,EBI-11956563
RADIL [Q96JH8]3EBI-742887,EBI-744267
RALGPS1 - isoform 3 [Q5JS13-3]3EBI-742887,EBI-12217281
RBM41 [Q96IZ5]3EBI-742887,EBI-740773
RIPPLY3 [P57055]3EBI-742887,EBI-12092053
RNF128 [Q8TEB7]6EBI-742887,EBI-2341619
RPL9P9 [P32969]7EBI-742887,EBI-358122
SALL2 [Q9Y467]4EBI-742887,EBI-746180
SCNM1 [Q9BWG6]3EBI-742887,EBI-748391
SH2D4A [Q9H788]3EBI-742887,EBI-747035
SMG9 [Q9H0W8]3EBI-742887,EBI-2872322
SPG21 [Q9NZD8]3EBI-742887,EBI-742688
SUOX [P51687]3EBI-742887,EBI-3921347
TCEA2 [Q15560]3EBI-742887,EBI-710310
TCEANC - isoform 2 [Q8N8B7-2]3EBI-742887,EBI-11955057
TCF19 [Q9Y242]3EBI-742887,EBI-7413767
TFAP2D [Q7Z6R9]3EBI-742887,EBI-11952651
THRA [P10827]4EBI-742887,EBI-286285
TOB2 [Q14106]3EBI-742887,EBI-2562000
TSSC4 [Q9Y5U2]3EBI-742887,EBI-717229
TTC21A [A0A0B4J1Y2]6EBI-742887,EBI-10220701
TTLL10 - isoform 3 [Q6ZVT0-3]3EBI-742887,EBI-11979997
TUFT1 [Q9NNX1]3EBI-742887,EBI-2557363
TXNDC9 [O14530]3EBI-742887,EBI-707554
VEZF1 [Q14119]3EBI-742887,EBI-11980193
WDFY3 - isoform 2 [Q8IZQ1-2]3EBI-742887,EBI-10264625
YY1 [P25490]3EBI-742887,EBI-765538
ZBTB24 [O43167]6EBI-742887,EBI-744471
ZBTB4 [Q9P1Z0]3EBI-742887,EBI-2564133
ZMAT2 [Q96NC0]3EBI-742887,EBI-2682299
ZNF185 [O15231]3EBI-742887,EBI-6874731
ZNF653 [Q96CK0]3EBI-742887,EBI-12217757
ZNF76 [P36508]3EBI-742887,EBI-7254550
ZNF85 - isoform 3 [Q03923-3]3EBI-742887,EBI-10223330

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
123028, 227 interactors

Protein interaction database and analysis system

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IntActi
Q8TAP6, 117 interactors

Molecular INTeraction database

More...
MINTi
Q8TAP6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000262127

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8TAP6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TAP6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CEP76 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502QQEI, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00390000000781

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_027144_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8TAP6

KEGG Orthology (KO)

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KOi
K16457

Identification of Orthologs from Complete Genome Data

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OMAi
RIRYKEE

Database of Orthologous Groups

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OrthoDBi
560461at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TAP6

TreeFam database of animal gene trees

More...
TreeFami
TF329324

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR028926, CEP76-C2
IPR038765, Papain-like_cys_pep_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15627, CEP76-C2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001, SSF54001, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TAP6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLPPEKASE LKQLIHQQLS KMDVHGRIRE ILAETIREEL APDQQHLSTE
60 70 80 90 100
DLIKALRRRG IIDDVMKELN FVTDSVEQEL PSSPKQPICF DRQSTLKKTN
110 120 130 140 150
IDPTRRYLYL QVLGGKAFLE HLQEPEPLPG QVCSTFTLCL HYRNQRFRSK
160 170 180 190 200
PVPCACEPDF HDGFLLEVHR ESLGDGTRMA DSTTMLSISD PIHMVLIKTD
210 220 230 240 250
IFGETTLVAS YFLEWRSVLG SENGVTSLTV ELMGVGTESK VSVGILNIKL
260 270 280 290 300
EMYPPLNQTL SQEVVNTQLA LERQKTAEKE RLFLVYAKQW WREYLQIRPS
310 320 330 340 350
HNSRLVKIFA QDENGINRPV CSYVKPLRAG RLLDTPRQAA RFVNVLGYER
360 370 380 390 400
APVIGGGGKQ EQWCTLLAFL CRNKGDCEDH ANLLCSLLLG YGLEAFVCVG
410 420 430 440 450
TKAKGVPHAW VMTCGTDGAI TFWESLTGHR YIHKPTNPDE PPVAEQPKPL
460 470 480 490 500
YPYRTIGCVF NHQMFLGNCQ PSDAVETCVF DLNDESKWKP MSEEAIKSVC
510 520 530 540 550
APGATTSLPP FPPLCASTID ASVTSNEIEM QLRLLVSEHR KDLGLTTVWE
560 570 580 590 600
DQLSYLLSPA LASYEFERTT SISAGNEEFQ DAIRRAVPDG HTFKGFPIHF
610 620 630 640 650
VYRNARRAFA TCLRSPFCEE IICCRGDQVR LAVRVRVFTY PESACAVWIM

FACKYRSVL
Length:659
Mass (Da):74,413
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i66EB85DCDCBEE518
GO
Isoform 2 (identifier: Q8TAP6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     99-174: TNIDPTRRYL...LLEVHRESLG → S

Show »
Length:584
Mass (Da):65,733
Checksum:i32792B1A54D92636
GO
Isoform 3 (identifier: Q8TAP6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-178: Missing.
     431-445: YIHKPTNPDEPPVAE → LCFQPSDVPGKLSTL
     446-659: Missing.

Show »
Length:267
Mass (Da):29,669
Checksum:i3DB77E46396240EF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EP44K7EP44_HUMAN
Centrosomal protein of 76 kDa
CEP76
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DP81B4DP81_HUMAN
Centrosomal protein of 76 kDa
CEP76
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EIV8K7EIV8_HUMAN
Centrosomal protein of 76 kDa
CEP76
178Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPF5K7EPF5_HUMAN
Centrosomal protein of 76 kDa
CEP76
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EII2K7EII2_HUMAN
Centrosomal protein of 76 kDa
CEP76
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAG64223 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti314N → S in BAB14123 (PubMed:14702039).Curated1
Sequence conflicti606R → G in BAB14123 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0376101 – 178Missing in isoform 3. 1 PublicationAdd BLAST178
Alternative sequenceiVSP_03761199 – 174TNIDP…RESLG → S in isoform 2. 1 PublicationAdd BLAST76
Alternative sequenceiVSP_037612431 – 445YIHKP…PPVAE → LCFQPSDVPGKLSTL in isoform 3. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_037613446 – 659Missing in isoform 3. 1 PublicationAdd BLAST214

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK022604 mRNA Translation: BAB14123.1
AK301964 mRNA Translation: BAG63377.1
AK303117 mRNA Translation: BAG64223.1 Sequence problems.
EF445040 Genomic DNA Translation: ACA06091.1
AP005482 Genomic DNA No translation available.
CH471113 Genomic DNA Translation: EAX01543.1
BC026307 mRNA Translation: AAH26307.1
AL833727 mRNA Translation: CAH56252.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11861.1 [Q8TAP6-1]
CCDS62390.1 [Q8TAP6-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001258918.1, NM_001271989.1 [Q8TAP6-2]
NP_079175.2, NM_024899.3 [Q8TAP6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000262127; ENSP00000262127; ENSG00000101624 [Q8TAP6-1]
ENST00000423709; ENSP00000403074; ENSG00000101624 [Q8TAP6-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
79959

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:79959

UCSC genome browser

More...
UCSCi
uc002kri.5, human [Q8TAP6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022604 mRNA Translation: BAB14123.1
AK301964 mRNA Translation: BAG63377.1
AK303117 mRNA Translation: BAG64223.1 Sequence problems.
EF445040 Genomic DNA Translation: ACA06091.1
AP005482 Genomic DNA No translation available.
CH471113 Genomic DNA Translation: EAX01543.1
BC026307 mRNA Translation: AAH26307.1
AL833727 mRNA Translation: CAH56252.1
CCDSiCCDS11861.1 [Q8TAP6-1]
CCDS62390.1 [Q8TAP6-2]
RefSeqiNP_001258918.1, NM_001271989.1 [Q8TAP6-2]
NP_079175.2, NM_024899.3 [Q8TAP6-1]

3D structure databases

SMRiQ8TAP6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123028, 227 interactors
IntActiQ8TAP6, 117 interactors
MINTiQ8TAP6
STRINGi9606.ENSP00000262127

PTM databases

iPTMnetiQ8TAP6
PhosphoSitePlusiQ8TAP6
SwissPalmiQ8TAP6

Polymorphism and mutation databases

BioMutaiCEP76
DMDMi59797956

Proteomic databases

EPDiQ8TAP6
jPOSTiQ8TAP6
MassIVEiQ8TAP6
MaxQBiQ8TAP6
PaxDbiQ8TAP6
PeptideAtlasiQ8TAP6
PRIDEiQ8TAP6
ProteomicsDBi73901 [Q8TAP6-1]
73902 [Q8TAP6-2]
73903 [Q8TAP6-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
21948, 135 antibodies

Genome annotation databases

EnsembliENST00000262127; ENSP00000262127; ENSG00000101624 [Q8TAP6-1]
ENST00000423709; ENSP00000403074; ENSG00000101624 [Q8TAP6-2]
GeneIDi79959
KEGGihsa:79959
UCSCiuc002kri.5, human [Q8TAP6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79959
DisGeNETi79959
EuPathDBiHostDB:ENSG00000101624.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CEP76
HGNCiHGNC:25727, CEP76
HPAiENSG00000101624, Low tissue specificity
neXtProtiNX_Q8TAP6
OpenTargetsiENSG00000101624
PharmGKBiPA134916911

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QQEI, Eukaryota
GeneTreeiENSGT00390000000781
HOGENOMiCLU_027144_0_0_1
InParanoidiQ8TAP6
KOiK16457
OMAiRIRYKEE
OrthoDBi560461at2759
PhylomeDBiQ8TAP6
TreeFamiTF329324

Enzyme and pathway databases

PathwayCommonsiQ8TAP6
ReactomeiR-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259, Loss of Nlp from mitotic centrosomes
R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320, Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912, Anchoring of the basal body to the plasma membrane
R-HSA-8854518, AURKA Activation by TPX2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
79959, 3 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CEP76, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CEP76

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
79959
PharosiQ8TAP6, Tdark

Protein Ontology

More...
PROi
PR:Q8TAP6
RNActiQ8TAP6, protein

Gene expression databases

BgeeiENSG00000101624, Expressed in secondary oocyte and 197 other tissues
ExpressionAtlasiQ8TAP6, baseline and differential
GenevisibleiQ8TAP6, HS

Family and domain databases

InterProiView protein in InterPro
IPR028926, CEP76-C2
IPR038765, Papain-like_cys_pep_sf
PfamiView protein in Pfam
PF15627, CEP76-C2, 1 hit
SUPFAMiSSF54001, SSF54001, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCEP76_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TAP6
Secondary accession number(s): B0YJB2
, B4DXG5, B4DZW1, Q658N5, Q9H9U7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: June 1, 2002
Last modified: October 7, 2020
This is version 149 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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