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Protein

Centrosomal protein of 76 kDa

Gene

CEP76

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-8854518 AURKA Activation by TPX2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Centrosomal protein of 76 kDa
Short name:
Cep76
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CEP76
Synonyms:C18orf9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000101624.10

Human Gene Nomenclature Database

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HGNCi
HGNC:25727 CEP76

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q8TAP6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000101624

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134916911

Polymorphism and mutation databases

Domain mapping of disease mutations (DMDM)

More...
DMDMi
59797956

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000895011 – 659Centrosomal protein of 76 kDaAdd BLAST659

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei75PhosphoserineBy similarity1
Modified residuei83PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TAP6

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8TAP6

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8TAP6

PeptideAtlas

More...
PeptideAtlasi
Q8TAP6

PRoteomics IDEntifications database

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PRIDEi
Q8TAP6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
73901
73902 [Q8TAP6-2]
73903 [Q8TAP6-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TAP6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TAP6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed at low level in G1 and is induced in S and G2 phase, during which point centrioles have already commenced duplication (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000101624 Expressed in 183 organ(s), highest expression level in secondary oocyte

CleanEx database of gene expression profiles

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CleanExi
HS_CEP76

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8TAP6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8TAP6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039395

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CCP110 and CEP97.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
123028, 174 interactors

Protein interaction database and analysis system

More...
IntActi
Q8TAP6, 112 interactors

Molecular INTeraction database

More...
MINTi
Q8TAP6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000262127

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8TAP6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TAP6

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CEP76 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IFDB Eukaryota
ENOG410XWNZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000000781

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000008143

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG050901

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8TAP6

KEGG Orthology (KO)

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KOi
K16457

Identification of Orthologs from Complete Genome Data

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OMAi
PKQPVCF

Database of Orthologous Groups

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OrthoDBi
EOG091G02SF

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TAP6

TreeFam database of animal gene trees

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TreeFami
TF329324

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR028926 CEP76-C2
IPR038765 Papain_like_cys_pep_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15627 CEP76-C2, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF54001 SSF54001, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TAP6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLPPEKASE LKQLIHQQLS KMDVHGRIRE ILAETIREEL APDQQHLSTE
60 70 80 90 100
DLIKALRRRG IIDDVMKELN FVTDSVEQEL PSSPKQPICF DRQSTLKKTN
110 120 130 140 150
IDPTRRYLYL QVLGGKAFLE HLQEPEPLPG QVCSTFTLCL HYRNQRFRSK
160 170 180 190 200
PVPCACEPDF HDGFLLEVHR ESLGDGTRMA DSTTMLSISD PIHMVLIKTD
210 220 230 240 250
IFGETTLVAS YFLEWRSVLG SENGVTSLTV ELMGVGTESK VSVGILNIKL
260 270 280 290 300
EMYPPLNQTL SQEVVNTQLA LERQKTAEKE RLFLVYAKQW WREYLQIRPS
310 320 330 340 350
HNSRLVKIFA QDENGINRPV CSYVKPLRAG RLLDTPRQAA RFVNVLGYER
360 370 380 390 400
APVIGGGGKQ EQWCTLLAFL CRNKGDCEDH ANLLCSLLLG YGLEAFVCVG
410 420 430 440 450
TKAKGVPHAW VMTCGTDGAI TFWESLTGHR YIHKPTNPDE PPVAEQPKPL
460 470 480 490 500
YPYRTIGCVF NHQMFLGNCQ PSDAVETCVF DLNDESKWKP MSEEAIKSVC
510 520 530 540 550
APGATTSLPP FPPLCASTID ASVTSNEIEM QLRLLVSEHR KDLGLTTVWE
560 570 580 590 600
DQLSYLLSPA LASYEFERTT SISAGNEEFQ DAIRRAVPDG HTFKGFPIHF
610 620 630 640 650
VYRNARRAFA TCLRSPFCEE IICCRGDQVR LAVRVRVFTY PESACAVWIM

FACKYRSVL
Length:659
Mass (Da):74,413
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i66EB85DCDCBEE518
GO
Isoform 2 (identifier: Q8TAP6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     99-174: TNIDPTRRYL...LLEVHRESLG → S

Note: No experimental confirmation available.
Show »
Length:584
Mass (Da):65,733
Checksum:i32792B1A54D92636
GO
Isoform 3 (identifier: Q8TAP6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-178: Missing.
     431-445: YIHKPTNPDEPPVAE → LCFQPSDVPGKLSTL
     446-659: Missing.

Note: No experimental confirmation available.
Show »
Length:267
Mass (Da):29,669
Checksum:i3DB77E46396240EF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DP81B4DP81_HUMAN
cDNA FLJ61148, moderately similar t...
CEP76
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EP44K7EP44_HUMAN
Centrosomal protein of 76 kDa
CEP76
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPF5K7EPF5_HUMAN
Centrosomal protein of 76 kDa
CEP76
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EIV8K7EIV8_HUMAN
Centrosomal protein of 76 kDa
CEP76
178Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EII2K7EII2_HUMAN
Centrosomal protein of 76 kDa
CEP76
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAG64223 differs from that shown. Reason: Erroneous termination at position 648. Translated as Trp.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti314N → S in BAB14123 (PubMed:14702039).Curated1
Sequence conflicti606R → G in BAB14123 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0376101 – 178Missing in isoform 3. 1 PublicationAdd BLAST178
Alternative sequenceiVSP_03761199 – 174TNIDP…RESLG → S in isoform 2. 1 PublicationAdd BLAST76
Alternative sequenceiVSP_037612431 – 445YIHKP…PPVAE → LCFQPSDVPGKLSTL in isoform 3. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_037613446 – 659Missing in isoform 3. 1 PublicationAdd BLAST214

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK022604 mRNA Translation: BAB14123.1
AK301964 mRNA Translation: BAG63377.1
AK303117 mRNA Translation: BAG64223.1 Sequence problems.
EF445040 Genomic DNA Translation: ACA06091.1
AP005482 Genomic DNA No translation available.
CH471113 Genomic DNA Translation: EAX01543.1
BC026307 mRNA Translation: AAH26307.1
AL833727 mRNA Translation: CAH56252.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11861.1 [Q8TAP6-1]
CCDS62390.1 [Q8TAP6-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001258918.1, NM_001271989.1 [Q8TAP6-2]
NP_079175.2, NM_024899.3 [Q8TAP6-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.236940

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000262127; ENSP00000262127; ENSG00000101624 [Q8TAP6-1]
ENST00000423709; ENSP00000403074; ENSG00000101624 [Q8TAP6-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
79959

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79959

UCSC genome browser

More...
UCSCi
uc002kri.5 human [Q8TAP6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022604 mRNA Translation: BAB14123.1
AK301964 mRNA Translation: BAG63377.1
AK303117 mRNA Translation: BAG64223.1 Sequence problems.
EF445040 Genomic DNA Translation: ACA06091.1
AP005482 Genomic DNA No translation available.
CH471113 Genomic DNA Translation: EAX01543.1
BC026307 mRNA Translation: AAH26307.1
AL833727 mRNA Translation: CAH56252.1
CCDSiCCDS11861.1 [Q8TAP6-1]
CCDS62390.1 [Q8TAP6-2]
RefSeqiNP_001258918.1, NM_001271989.1 [Q8TAP6-2]
NP_079175.2, NM_024899.3 [Q8TAP6-1]
UniGeneiHs.236940

3D structure databases

ProteinModelPortaliQ8TAP6
SMRiQ8TAP6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123028, 174 interactors
IntActiQ8TAP6, 112 interactors
MINTiQ8TAP6
STRINGi9606.ENSP00000262127

PTM databases

iPTMnetiQ8TAP6
PhosphoSitePlusiQ8TAP6

Polymorphism and mutation databases

DMDMi59797956

Proteomic databases

EPDiQ8TAP6
MaxQBiQ8TAP6
PaxDbiQ8TAP6
PeptideAtlasiQ8TAP6
PRIDEiQ8TAP6
ProteomicsDBi73901
73902 [Q8TAP6-2]
73903 [Q8TAP6-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262127; ENSP00000262127; ENSG00000101624 [Q8TAP6-1]
ENST00000423709; ENSP00000403074; ENSG00000101624 [Q8TAP6-2]
GeneIDi79959
KEGGihsa:79959
UCSCiuc002kri.5 human [Q8TAP6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79959
EuPathDBiHostDB:ENSG00000101624.10

GeneCards: human genes, protein and diseases

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GeneCardsi
CEP76
HGNCiHGNC:25727 CEP76
HPAiHPA039395
neXtProtiNX_Q8TAP6
OpenTargetsiENSG00000101624
PharmGKBiPA134916911

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IFDB Eukaryota
ENOG410XWNZ LUCA
GeneTreeiENSGT00390000000781
HOGENOMiHOG000008143
HOVERGENiHBG050901
InParanoidiQ8TAP6
KOiK16457
OMAiPKQPVCF
OrthoDBiEOG091G02SF
PhylomeDBiQ8TAP6
TreeFamiTF329324

Enzyme and pathway databases

ReactomeiR-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-8854518 AURKA Activation by TPX2

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CEP76

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79959

Protein Ontology

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PROi
PR:Q8TAP6

Gene expression databases

BgeeiENSG00000101624 Expressed in 183 organ(s), highest expression level in secondary oocyte
CleanExiHS_CEP76
ExpressionAtlasiQ8TAP6 baseline and differential
GenevisibleiQ8TAP6 HS

Family and domain databases

InterProiView protein in InterPro
IPR028926 CEP76-C2
IPR038765 Papain_like_cys_pep_sf
PfamiView protein in Pfam
PF15627 CEP76-C2, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCEP76_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TAP6
Secondary accession number(s): B0YJB2
, B4DXG5, B4DZW1, Q658N5, Q9H9U7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
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