Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 156 (11 Dec 2019)
Sequence version 3 (22 Jul 2008)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Exocyst complex component 6

Gene

EXOC6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Together with RAB11A, RAB3IP, RAB8A, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processExocytosis, Protein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-264876 Insulin processing
R-HSA-5620916 VxPx cargo-targeting to cilium

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.F.2.1.2 the octameric exocyst (exocyst) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Exocyst complex component 6
Alternative name(s):
Exocyst complex component Sec15A
SEC15-like protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EXOC6
Synonyms:SEC15A, SEC15L, SEC15L1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000138190.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23196 EXOC6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609672 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TAG9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54536

Open Targets

More...
OpenTargetsi
ENSG00000138190

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134908462

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TAG9 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EXOC6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
212287926

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001189511 – 804Exocyst complex component 6Add BLAST804

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TAG9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TAG9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8TAG9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8TAG9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TAG9

PeptideAtlas

More...
PeptideAtlasi
Q8TAG9

PRoteomics IDEntifications database

More...
PRIDEi
Q8TAG9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
20542
73883 [Q8TAG9-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TAG9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TAG9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000138190 Expressed in 201 organ(s), highest expression level in deltoid

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TAG9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TAG9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036285
HPA059111

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (By similarity).

Interacts with CNTRL.

Interacts with RAB11A in a GTP-dependent manner (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
O004715EBI-1223394,EBI-949824

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120023, 54 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q8TAG9

Protein interaction database and analysis system

More...
IntActi
Q8TAG9, 35 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000260762

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8TAG9 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TAG9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SEC15 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2176 Eukaryota
ENOG410XQAE LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005739

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000290640

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TAG9

KEGG Orthology (KO)

More...
KOi
K19985

Identification of Orthologs from Complete Genome Data

More...
OMAi
IIRCRVQ

Database of Orthologous Groups

More...
OrthoDBi
185623at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TAG9

TreeFam database of animal gene trees

More...
TreeFami
TF315199

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.357.30, 1 hit
1.20.58.670, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007225 EXOC6/Sec15
IPR042045 EXOC6/Sec15_C_dom1
IPR042044 EXOC6/Sec15_C_dom2

The PANTHER Classification System

More...
PANTHERi
PTHR12702 PTHR12702, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04091 Sec15, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF025007 Sec15, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TAG9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAENSESLGT VPEHERILQE IESTDTACVG PTLRSVYDDQ PNAHKKFMEK
60 70 80 90 100
LDACIRNHDK EIEKMCNFHH QGFVDAITEL LKVRTDAEKL KVQVTDTNRR
110 120 130 140 150
FQDAGKEVIV HTEDIIRCRI QQRNITTVVE KLQLCLPVLE MYSKLKEQMS
160 170 180 190 200
AKRYYSALKT MEQLENVYFP WVSQYRFCQL MIENLPKLRE DIKEISMSDL
210 220 230 240 250
KDFLESIRKH SDKIGETAMK QAQHQKTFSV SLQKQNKMKF GKNMYINRDR
260 270 280 290 300
IPEERNETVL KHSLEEEDEN EEEILTVQDL VDFSPVYRCL HIYSVLGDEE
310 320 330 340 350
TFENYYRKQR KKQARLVLQP QSNMHETVDG YRRYFTQIVG FFVVEDHILH
360 370 380 390 400
VTQGLVTRAY TDELWNMALS KIIAVLRAHS SYCTDPDLVL ELKNLTVIFA
410 420 430 440 450
DTLQGYGFPV NRLFDLLFEI RDQYNETLLK KWAGVFRDIF EEDNYSPIPV
460 470 480 490 500
VNEEEYKIVI SKFPFQDPDL EKQSFPKKFP MSQSVPHIYI QVKEFIYASL
510 520 530 540 550
KFSESLHRSS TEIDDMLRKS TNLLLTRTLS SCLLNLIRKP HIGLTELVQI
560 570 580 590 600
IINTTHLEQA CKYLEDFITN ITNISQETVH TTRLYGLSTF KDARHAAEGE
610 620 630 640 650
IYTKLNQKID EFVQLADYDW TMSEPDGRAS GYLMDLINFL RSIFQVFTHL
660 670 680 690 700
PGKVAQTACM SACQHLSTSL MQMLLDSELK QISMGAVQQF NLDVIQCELF
710 720 730 740 750
ASSEPVPGFQ GDTLQLAFID LRQLLDLFMV WDWSTYLADY GQPASKYLRV
760 770 780 790 800
NPNTALTLLE KMKDTSKKNN IFAQFRKNDR DKQKLIETVV KQLRSLVNGM

SQHM
Length:804
Mass (Da):93,722
Last modified:July 22, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i413251A5BA6543C4
GO
Isoform 2 (identifier: Q8TAG9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-31: AENSESLGTVPEHERILQEIESTDTACVGP → LEEETDQTYENVLAEIQSFELPVEA

Show »
Length:799
Mass (Da):93,407
Checksum:i8A90434F0409E992
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EW84E7EW84_HUMAN
Exocyst complex component
EXOC6
701Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z3K0F2Z3K0_HUMAN
Exocyst complex component 6
EXOC6
404Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AP46B1AP46_HUMAN
Exocyst complex component 6
EXOC6
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y5J8H0Y5J8_HUMAN
Exocyst complex component 6
EXOC6
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF37262 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti776R → G in AAH28395 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_044522396T → I1 PublicationCorresponds to variant dbSNP:rs1326331Ensembl.1
Natural variantiVAR_044523523L → V. Corresponds to variant dbSNP:rs11187225Ensembl.1
Natural variantiVAR_044524578T → I. Corresponds to variant dbSNP:rs35647717Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0471602 – 31AENSE…ACVGP → LEEETDQTYENVLAEIQSFE LPVEA in isoform 2. CuratedAdd BLAST30

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL157705 Genomic DNA No translation available.
AL358613 Genomic DNA No translation available.
AL392103 Genomic DNA No translation available.
AL590080 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW50083.1
BC028395 mRNA Translation: AAH28395.2
AF220217 mRNA Translation: AAF37262.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31247.1 [Q8TAG9-2]
CCDS7424.2 [Q8TAG9-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001013870.1, NM_001013848.3 [Q8TAG9-2]
NP_001306123.1, NM_001319194.1
NP_001306124.1, NM_001319195.1
NP_001306129.1, NM_001319200.1
NP_061926.3, NM_019053.5 [Q8TAG9-1]
XP_016871834.1, XM_017016345.1 [Q8TAG9-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000260762; ENSP00000260762; ENSG00000138190 [Q8TAG9-1]
ENST00000371552; ENSP00000360607; ENSG00000138190 [Q8TAG9-2]
ENST00000671701; ENSP00000500529; ENSG00000138190 [Q8TAG9-2]
ENST00000672817; ENSP00000500468; ENSG00000138190 [Q8TAG9-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54536

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54536

UCSC genome browser

More...
UCSCi
uc001kie.4 human [Q8TAG9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157705 Genomic DNA No translation available.
AL358613 Genomic DNA No translation available.
AL392103 Genomic DNA No translation available.
AL590080 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW50083.1
BC028395 mRNA Translation: AAH28395.2
AF220217 mRNA Translation: AAF37262.1 Different initiation.
CCDSiCCDS31247.1 [Q8TAG9-2]
CCDS7424.2 [Q8TAG9-1]
RefSeqiNP_001013870.1, NM_001013848.3 [Q8TAG9-2]
NP_001306123.1, NM_001319194.1
NP_001306124.1, NM_001319195.1
NP_001306129.1, NM_001319200.1
NP_061926.3, NM_019053.5 [Q8TAG9-1]
XP_016871834.1, XM_017016345.1 [Q8TAG9-2]

3D structure databases

SMRiQ8TAG9
ModBaseiSearch...

Protein-protein interaction databases

BioGridi120023, 54 interactors
CORUMiQ8TAG9
IntActiQ8TAG9, 35 interactors
STRINGi9606.ENSP00000260762

Protein family/group databases

TCDBi1.F.2.1.2 the octameric exocyst (exocyst) family

PTM databases

iPTMnetiQ8TAG9
PhosphoSitePlusiQ8TAG9

Polymorphism and mutation databases

BioMutaiEXOC6
DMDMi212287926

Proteomic databases

EPDiQ8TAG9
jPOSTiQ8TAG9
MassIVEiQ8TAG9
MaxQBiQ8TAG9
PaxDbiQ8TAG9
PeptideAtlasiQ8TAG9
PRIDEiQ8TAG9
ProteomicsDBi20542
73883 [Q8TAG9-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
54536

Genome annotation databases

EnsembliENST00000260762; ENSP00000260762; ENSG00000138190 [Q8TAG9-1]
ENST00000371552; ENSP00000360607; ENSG00000138190 [Q8TAG9-2]
ENST00000671701; ENSP00000500529; ENSG00000138190 [Q8TAG9-2]
ENST00000672817; ENSP00000500468; ENSG00000138190 [Q8TAG9-2]
GeneIDi54536
KEGGihsa:54536
UCSCiuc001kie.4 human [Q8TAG9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54536
DisGeNETi54536
EuPathDBiHostDB:ENSG00000138190.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
EXOC6
HGNCiHGNC:23196 EXOC6
HPAiHPA036285
HPA059111
MIMi609672 gene
neXtProtiNX_Q8TAG9
OpenTargetsiENSG00000138190
PharmGKBiPA134908462

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2176 Eukaryota
ENOG410XQAE LUCA
GeneTreeiENSGT00390000005739
HOGENOMiHOG000290640
InParanoidiQ8TAG9
KOiK19985
OMAiIIRCRVQ
OrthoDBi185623at2759
PhylomeDBiQ8TAG9
TreeFamiTF315199

Enzyme and pathway databases

ReactomeiR-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-264876 Insulin processing
R-HSA-5620916 VxPx cargo-targeting to cilium

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
EXOC6 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
54536
PharosiQ8TAG9 Tbio

Protein Ontology

More...
PROi
PR:Q8TAG9
RNActiQ8TAG9 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000138190 Expressed in 201 organ(s), highest expression level in deltoid
ExpressionAtlasiQ8TAG9 baseline and differential
GenevisibleiQ8TAG9 HS

Family and domain databases

Gene3Di1.10.357.30, 1 hit
1.20.58.670, 1 hit
InterProiView protein in InterPro
IPR007225 EXOC6/Sec15
IPR042045 EXOC6/Sec15_C_dom1
IPR042044 EXOC6/Sec15_C_dom2
PANTHERiPTHR12702 PTHR12702, 1 hit
PfamiView protein in Pfam
PF04091 Sec15, 1 hit
PIRSFiPIRSF025007 Sec15, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEXOC6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TAG9
Secondary accession number(s): E9PHI3, Q5VXH8, Q9NZ24
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: July 22, 2008
Last modified: December 11, 2019
This is version 156 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again