Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q8TAF8 (LHPL5_HUMAN)

Entry version 138 (12 Aug 2020)
Sequence version 1 (01 Jun 2002)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

LHFPL tetraspan subfamily member 5 protein

Gene

LHFPL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In the inner ear, may be a component of the hair cell's mechanotransduction machinery that functionally couples PCDH15 to the transduction channel. Regulates transducer channel conductance and is required for fast channel adaptation (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8TAF8

Protein family/group databases

Transport Classification Database

More...TCDBi		1.A.82.1.1, the lhfpl tetraspan protein (ltsp) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
LHFPL tetraspan subfamily member 5 proteinImported
Alternative name(s):
Lipoma HMGIC fusion partner-like 5 proteinImported
Tetraspan membrane protein of hair cell stereociliaBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LHFPL5Imported
Synonyms:TMHSBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000197753.8

Human Gene Nomenclature Database

More...HGNCi		HGNC:21253, LHFPL5

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609427, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8TAF8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 24CytoplasmicSequence analysisAdd BLAST24
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Topological domaini46 – 99ExtracellularSequence analysisAdd BLAST54
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Topological domaini121 – 128CytoplasmicSequence analysis8
Transmembranei129 – 149HelicalSequence analysisAdd BLAST21
Topological domaini150 – 178ExtracellularSequence analysisAdd BLAST29
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Topological domaini200 – 219CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Deafness, autosomal recessive, 67 (DFNB67)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032055127Y → C in DFNB67. 1 PublicationCorresponds to variant dbSNP:rs104893975EnsemblClinVar.1
Natural variantiVAR_079038158R → W in DFNB67. 1 PublicationCorresponds to variant dbSNP:rs753739358EnsemblClinVar.1
Natural variantiVAR_032056165T → M in DFNB67. 1 PublicationCorresponds to variant dbSNP:rs104893976EnsemblClinVar.1
Natural variantiVAR_032057176R → L in DFNB67. 1 PublicationCorresponds to variant dbSNP:rs774466373Ensembl.1

Keywords - Diseasei

Deafness, Disease mutation, Non-syndromic deafness

Organism-specific databases

DisGeNET

More...DisGeNETi		222662

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		LHFPL5

MalaCards human disease database

More...MalaCardsi		LHFPL5
MIMi610265, phenotype

Open Targets

More...OpenTargetsi		ENSG00000197753

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		90636, Autosomal recessive non-syndromic sensorineural deafness type DFNB

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134943389

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8TAF8, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LHFPL5

Domain mapping of disease mutations (DMDM)

More...DMDMi		74751349

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002859221 – 219LHFPL tetraspan subfamily member 5 proteinAdd BLAST219

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8TAF8

PRoteomics IDEntifications database

More...PRIDEi		Q8TAF8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		73878

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000197753, Expressed in body of pancreas and 51 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8TAF8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8TAF8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000197753, Group enriched (bone marrow, brain, epididymis, pancreas)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Found in a complex with TMIE and PCDH15.

Interacts with PCDH15; this interaction is required for efficient localization to hair bundles.

Interacts with TOMT.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q8TAF8
With#Exp.IntAct
ADGRG3 [Q86Y34]3EBI-2820517,EBI-17979264
APOL3 - isoform 2 [O95236-2]3EBI-2820517,EBI-11976321
AQP2 [P41181]3EBI-2820517,EBI-12701138
AQP6 [Q13520]3EBI-2820517,EBI-13059134
AQP9 [O43315]3EBI-2820517,EBI-17444777
BTN2A2 [Q8WVV5]3EBI-2820517,EBI-8648738
C16orf58 [Q96GQ5]3EBI-2820517,EBI-8636004
C5orf46 [Q6UWT4]3EBI-2820517,EBI-11986083
CCDC155 [Q8N6L0]9EBI-2820517,EBI-749265
CD37 [P11049]3EBI-2820517,EBI-6139068
CD53 [P19397]3EBI-2820517,EBI-6657396
CD72 [P21854]3EBI-2820517,EBI-307924
CD79A [P11912]3EBI-2820517,EBI-7797864
CD81 [P60033]3EBI-2820517,EBI-712921
CDS2 [O95674]3EBI-2820517,EBI-3913685
CERS4 [Q9HA82]3EBI-2820517,EBI-2622997
CLCN7 [P51798]3EBI-2820517,EBI-4402346
CLDN22 [Q8N7P3]3EBI-2820517,EBI-17766761
CLDN5 [O00501]3EBI-2820517,EBI-18400628
CLDND2 [Q8NHS1]3EBI-2820517,EBI-11959453
CLEC14A [Q86T13]3EBI-2820517,EBI-17710733
CMTM7 [Q96FZ5]3EBI-2820517,EBI-2807956
CREB3 - isoform 1 [O43889-2]4EBI-2820517,EBI-625022
CREB3L1 [Q96BA8]3EBI-2820517,EBI-6942903
CTXN3 [Q4LDR2]3EBI-2820517,EBI-12019274
CYB561 [P49447]3EBI-2820517,EBI-8646596
DAGLA [Q9Y4D2]3EBI-2820517,EBI-12808806
ELOVL4 [Q9GZR5]3EBI-2820517,EBI-18535450
EMP1 [P54849]3EBI-2820517,EBI-4319440
EMP3 [P54852]3EBI-2820517,EBI-3907816
ENTPD3 - isoform 2 [O75355-2]3EBI-2820517,EBI-12279764
ERG28 [Q9UKR5]3EBI-2820517,EBI-711490
ERGIC3 [Q9Y282]3EBI-2820517,EBI-781551
FAM209A [Q5JX71]3EBI-2820517,EBI-18304435
FCGR1A [P12314]3EBI-2820517,EBI-2869867
FFAR2 [O15552]3EBI-2820517,EBI-2833872
FNDC9 [Q8TBE3]3EBI-2820517,EBI-12142257
FXYD6 [Q9H0Q3]3EBI-2820517,EBI-713304
GGT7 [Q9UJ14]11EBI-2820517,EBI-1058791
GJA8 [P48165]3EBI-2820517,EBI-17458373
GJB2 [P29033]3EBI-2820517,EBI-3905204
GJB3 [O75712]3EBI-2820517,EBI-3908586
GJB4 [Q9NTQ9]3EBI-2820517,EBI-12831526
GJB6 [O95452]3EBI-2820517,EBI-13345609
GPR152 [Q8TDT2]3EBI-2820517,EBI-13345167
GPR37L1 [O60883]3EBI-2820517,EBI-2927498
GPR42 [O15529]3EBI-2820517,EBI-18076404
GPRC5D [Q9NZD1]3EBI-2820517,EBI-13067820
GPX8 [Q8TED1]3EBI-2820517,EBI-11721746
HAS3 - isoform 2 [O00219-2]3EBI-2820517,EBI-17186025
HLA-DQA2 [P01906]3EBI-2820517,EBI-19949550
INSIG2 [Q9Y5U4]3EBI-2820517,EBI-8503746
ITGB2 [P05107]3EBI-2820517,EBI-300173
JAGN1 [Q8N5M9]3EBI-2820517,EBI-10266796
KCNK5 [O95279]3EBI-2820517,EBI-3934936
KIR2DL3 [P43628]3EBI-2820517,EBI-8632435
KTN1 - isoform 3 [Q86UP2-3]3EBI-2820517,EBI-12007212
LAT - isoform 2 [O43561-2]3EBI-2820517,EBI-8070286
LIME1 [Q9H400]3EBI-2820517,EBI-2830566
LNPEP - isoform 2 [Q9UIQ6-2]3EBI-2820517,EBI-12133176
LPAR3 [Q9UBY5]3EBI-2820517,EBI-12033434
LRRC25 [Q8N386]3EBI-2820517,EBI-11304917
LRRC4C [Q9HCJ2]3EBI-2820517,EBI-3925442
MFF - isoform 5 [Q9GZY8-5]3EBI-2820517,EBI-11956541
MFSD5 [Q6N075]3EBI-2820517,EBI-3920969
MIP [P30301]3EBI-2820517,EBI-8449636
MS4A13 [Q5J8X5]3EBI-2820517,EBI-12070086
MTIF3 [Q9H2K0]3EBI-2820517,EBI-3923617
NINJ2 [Q9NZG7]3EBI-2820517,EBI-10317425
NIPAL4 [Q0D2K0]3EBI-2820517,EBI-9550165
NKG7 [Q16617]3EBI-2820517,EBI-3919611
NRAC [Q8N912]3EBI-2820517,EBI-12051377
NRG4 [Q8WWG1]3EBI-2820517,EBI-8637292
PDZK1IP1 [Q13113]3EBI-2820517,EBI-716063
PLLP [Q9Y342]3EBI-2820517,EBI-3919291
PLP1 - isoform DM-20 [P60201-2]3EBI-2820517,EBI-12188331
PLP2 [Q04941]3EBI-2820517,EBI-608347
RMDN3 [Q96TC7]3EBI-2820517,EBI-1056589
RPRM [Q9NS64]3EBI-2820517,EBI-1052363
SAR1A [Q9NR31]3EBI-2820517,EBI-3920694
SEC22A [Q96IW7]3EBI-2820517,EBI-8652744
SEC22B [O75396]3EBI-2820517,EBI-1058865
SERP1 [Q9Y6X1]3EBI-2820517,EBI-10329948
SERP2 [Q8N6R1]3EBI-2820517,EBI-749270
SERTM1 [A2A2V5]3EBI-2820517,EBI-17284533
SLC34A2 - isoform 2 [O95436-2]3EBI-2820517,EBI-12811757
SLC35A1 [P78382]3EBI-2820517,EBI-12870360
SLC35B4 [Q969S0]3EBI-2820517,EBI-10281213
SLC35C2 - isoform 3 [Q9NQQ7-3]3EBI-2820517,EBI-17295964
SLC41A1 [Q8IVJ1]3EBI-2820517,EBI-12266234
SMIM1 [B2RUZ4]3EBI-2820517,EBI-12188413
SYNJ2BP [P57105]3EBI-2820517,EBI-1049004
TEX264 [Q9Y6I9]3EBI-2820517,EBI-10329860
TFRC [P02786]3EBI-2820517,EBI-355727
TIMMDC1 [Q9NPL8]3EBI-2820517,EBI-6268651
TM4SF18 [Q96CE8]3EBI-2820517,EBI-13351685
TM4SF4 [P48230]3EBI-2820517,EBI-8650934
TMEM100 [Q9NV29]3EBI-2820517,EBI-8644968
TMEM107 [Q6UX40]3EBI-2820517,EBI-12845616
TMEM128 - isoform 2 [Q5BJH2-2]3EBI-2820517,EBI-10694905
TMEM201 - isoform 2 [Q5SNT2-2]3EBI-2820517,EBI-11994282
TMEM218 [A2RU14]3EBI-2820517,EBI-10173151
TMEM229B [Q8NBD8]3EBI-2820517,EBI-12195227
TMEM248 [Q9NWD8]3EBI-2820517,EBI-10314986
TMEM254 [Q8TBM7]3EBI-2820517,EBI-11956809
TMEM42 [Q69YG0]3EBI-2820517,EBI-12038591
TMEM50B [P56557]3EBI-2820517,EBI-12366453
TMEM52B [Q4KMG9]3EBI-2820517,EBI-18178701
TMEM60 [Q9H2L4]3EBI-2820517,EBI-2852148
TMEM86A [Q8N2M4]3EBI-2820517,EBI-12015604
TMEM97 [Q5BJF2]3EBI-2820517,EBI-12111910
TMX1 [Q9H3N1]3EBI-2820517,EBI-1051115
TMX2 [Q9Y320]3EBI-2820517,EBI-6447886
TSPAN33 [Q86UF1]3EBI-2820517,EBI-12045841
TSPAN7 [P41732]3EBI-2820517,EBI-1042779
TSPO [P30536]3EBI-2820517,EBI-6623146
TTMP [Q5BVD1]3EBI-2820517,EBI-10243654
TUSC5 [A5PKU2]3EBI-2820517,EBI-11988865
UBIAD1 [Q9Y5Z9]3EBI-2820517,EBI-2819725
VAMP3 [Q15836]3EBI-2820517,EBI-722343
VMA21 [Q3ZAQ7]3EBI-2820517,EBI-1055364
ZDHHC15 [Q96MV8]3EBI-2820517,EBI-12837904

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		128811, 4 interactors

Protein interaction database and analysis system

More...IntActi		Q8TAF8, 124 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000353346

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8TAF8, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LHFP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4026, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00990000203541

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_084868_1_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8TAF8

KEGG Orthology (KO)

More...KOi		K23893

Identification of Orthologs from Complete Genome Data

More...OMAi		WIVFTIT

Database of Orthologous Groups

More...OrthoDBi		1219117at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8TAF8

TreeFam database of animal gene trees

More...TreeFami		TF321143

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR019372, LHFPL

The PANTHER Classification System

More...PANTHERi		PTHR12489, PTHR12489, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF10242, L_HMGIC_fpl, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8TAF8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVKLLPAQEA AKIYHTNYVR NSRAVGVMWG TLTICFSVLV MALFIQPYWI 
        60         70         80         90        100
GDSVNTPQAG YFGLFSYCVG NVLSSELICK GGPLDFSSIP SRAFKTAMFF 
       110        120        130        140        150
VALGMFLIIG SIICFSLFFI CNTATVYKIC AWMQLAAATG LMIGCLVYPD 
       160        170        180        190        200
GWDSSEVRRM CGEQTGKYTL GHCTIRWAFM LAILSIGDAL ILSFLAFVLG 
       210 
YRQDKLLPDD YKADGTEEV
Length:219
Mass (Da):24,201
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1972C1A8F0FAE545
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A494C136A0A494C136_HUMAN
LHFPL tetraspan subfamily member 5 ...
LHFPL5
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494BZZ7A0A494BZZ7_HUMAN
LHFPL tetraspan subfamily member 5 ...
LHFPL5
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4L → M in BAG54378 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032055127Y → C in DFNB67. 1 PublicationCorresponds to variant dbSNP:rs104893975EnsemblClinVar.1
Natural variantiVAR_079038158R → W in DFNB67. 1 PublicationCorresponds to variant dbSNP:rs753739358EnsemblClinVar.1
Natural variantiVAR_032056165T → M in DFNB67. 1 PublicationCorresponds to variant dbSNP:rs104893976EnsemblClinVar.1
Natural variantiVAR_032057176R → L in DFNB67. 1 PublicationCorresponds to variant dbSNP:rs774466373Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK126841 mRNA Translation: BAG54378.1
AL157823 Genomic DNA No translation available.
BC028630 mRNA Translation: AAH28630.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4812.1

NCBI Reference Sequences

More...RefSeqi		NP_872354.1, NM_182548.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000360215; ENSP00000353346; ENSG00000197753
ENST00000651132; ENSP00000498322; ENSG00000197753
ENST00000651676; ENSP00000498699; ENSG00000197753

Database of genes from NCBI RefSeq genomes

More...GeneIDi		222662

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:222662

UCSC genome browser

More...UCSCi		uc003olg.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126841 mRNA Translation: BAG54378.1
AL157823 Genomic DNA No translation available.
BC028630 mRNA Translation: AAH28630.1
CCDSiCCDS4812.1
RefSeqiNP_872354.1, NM_182548.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi128811, 4 interactors
IntActiQ8TAF8, 124 interactors
STRINGi9606.ENSP00000353346

Protein family/group databases

TCDBi1.A.82.1.1, the lhfpl tetraspan protein (ltsp) family

Polymorphism and mutation databases

BioMutaiLHFPL5
DMDMi74751349

Proteomic databases

PaxDbiQ8TAF8
PRIDEiQ8TAF8
ProteomicsDBi73878

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		55280, 84 antibodies

The DNASU plasmid repository

More...DNASUi		222662

Genome annotation databases

EnsembliENST00000360215; ENSP00000353346; ENSG00000197753
ENST00000651132; ENSP00000498322; ENSG00000197753
ENST00000651676; ENSP00000498699; ENSG00000197753
GeneIDi222662
KEGGihsa:222662
UCSCiuc003olg.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		222662
DisGeNETi222662
EuPathDBiHostDB:ENSG00000197753.8

GeneCards: human genes, protein and diseases

More...GeneCardsi		LHFPL5
GeneReviewsiLHFPL5
HGNCiHGNC:21253, LHFPL5
HPAiENSG00000197753, Group enriched (bone marrow, brain, epididymis, pancreas)
MalaCardsiLHFPL5
MIMi609427, gene
610265, phenotype
neXtProtiNX_Q8TAF8
OpenTargetsiENSG00000197753
Orphaneti90636, Autosomal recessive non-syndromic sensorineural deafness type DFNB
PharmGKBiPA134943389

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4026, Eukaryota
GeneTreeiENSGT00990000203541
HOGENOMiCLU_084868_1_2_1
InParanoidiQ8TAF8
KOiK23893
OMAiWIVFTIT
OrthoDBi1219117at2759
PhylomeDBiQ8TAF8
TreeFamiTF321143

Enzyme and pathway databases

PathwayCommonsiQ8TAF8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		222662, 8 hits in 842 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		LHFPL5, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		222662
PharosiQ8TAF8, Tbio

Protein Ontology

More...PROi		PR:Q8TAF8
RNActiQ8TAF8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000197753, Expressed in body of pancreas and 51 other tissues
ExpressionAtlasiQ8TAF8, baseline and differential
GenevisibleiQ8TAF8, HS

Family and domain databases

InterProiView protein in InterPro
IPR019372, LHFPL
PANTHERiPTHR12489, PTHR12489, 1 hit
PfamiView protein in Pfam
PF10242, L_HMGIC_fpl, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLHPL5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TAF8
Secondary accession number(s): B3KX66
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: June 1, 2002
Last modified: August 12, 2020
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again