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Entry version 157 (07 Oct 2020)
Sequence version 2 (16 Aug 2004)
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Protein

Zinc finger protein 461

Gene

ZNF461

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri192 – 214C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri246 – 267C2H2-type 2PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri273 – 295C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri301 – 323C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri329 – 351C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri357 – 379C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri385 – 407C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri413 – 435C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri441 – 463C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri469 – 491C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 519C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri522 – 544C2H2-type 12; degeneratePROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8TAF7

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436, Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 461
Alternative name(s):
Gonadotropin-inducible ovary transcription repressor 1
Short name:
GIOT-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF461
Synonyms:GIOT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000197808.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21629, ZNF461

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608640, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TAF7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000197808

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA145149895

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TAF7, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF461

Domain mapping of disease mutations (DMDM)

More...
DMDMi
51338811

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000471961 – 563Zinc finger protein 461Add BLAST563

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TAF7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TAF7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8TAF7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8TAF7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TAF7

PeptideAtlas

More...
PeptideAtlasi
Q8TAF7

PRoteomics IDEntifications database

More...
PRIDEi
Q8TAF7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
73876 [Q8TAF7-1]
73877 [Q8TAF7-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TAF7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TAF7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with highest levels in liver, kidney, pancreas, thymus, and small intestine.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197808, Expressed in frontal cortex and 126 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TAF7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TAF7, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000197808, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124926, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q8TAF7, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000467931

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8TAF7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TAF7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 77KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri192 – 214C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri246 – 267C2H2-type 2PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri273 – 295C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri301 – 323C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri329 – 351C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri357 – 379C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri385 – 407C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri413 – 435C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri441 – 463C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri469 – 491C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 519C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri522 – 544C2H2-type 12; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163325

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_44_5_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TAF7

KEGG Orthology (KO)

More...
KOi
K09228

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TAF7

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 9 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 12 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 10 hits
PS50157, ZINC_FINGER_C2H2_2, 12 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TAF7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAHELVMFRD VAIDVSQEEW ECLNPAQRNL YKEVMLENYS NLVSLGLSVS
60 70 80 90 100
KPAVISSLEQ GKEPWMVVRE ETGRWCPGTW KTWGFHNNFL DNNEATDINA
110 120 130 140 150
DLASRDEPQK LSPKRDIYET ELSQWVNMEE FKSHSPERSI FSAIWEGNCH
160 170 180 190 200
FEQHQGQEEG YFRQLMINHE NMPIFSQHTL LTQEFYDREK ISECKKCRKI
210 220 230 240 250
FSYHLFFSHH KRTHSKELSE CKECTEIVNT PCLFKQQTIQ NGDKCNECKE
260 270 280 290 300
CWKAFVHCSQ LKHLRIHNGE KRYECNECGK AFNYGSELTL HQRIHTGEKP
310 320 330 340 350
YECKECGKAF RQRSQLTQHQ RLHTGEKPYE CKQCGKAFIR GFQLTEHLRL
360 370 380 390 400
HTGEKPYECK ECGKTFRHRS HLTIHQRIHT GEKPYECREC GKAFSYHSSF
410 420 430 440 450
SHHQKIHSGK KPYECHECGK AFCDGLQLTL HQRIHTGEKP YECKECGKTF
460 470 480 490 500
RQCSHLKRHQ RIHTGEKPHE CMICGKAFRL HSHLIQHQRI HTGEKPYECK
510 520 530 540 550
ECGKAFSYHS SFSHHQRIHS GKKPYQCGKA FNHRLQLNLH QTLHTGEKPV
560
RFPLLPPHPS LAS
Length:563
Mass (Da):66,214
Last modified:August 16, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7530043A4940F028
GO
Isoform 2 (identifier: Q8TAF7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-127: Missing.

Show »
Length:436
Mass (Da):51,516
Checksum:i57674438DDC06395
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DRP8B4DRP8_HUMAN
Zinc finger protein 461
ZNF461
540Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WVP9A0A087WVP9_HUMAN
Zinc finger protein 461
ZNF461
563Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EIW1K7EIW1_HUMAN
Zinc finger protein 461
ZNF461
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKL0K7EKL0_HUMAN
Zinc finger protein 461
ZNF461
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJM1K7EJM1_HUMAN
Zinc finger protein 461
ZNF461
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RBI5X6RBI5_HUMAN
Zinc finger protein 461
ZNF461
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WV02A0A087WV02_HUMAN
Zinc finger protein 461
ZNF461
258Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ESQ5K7ESQ5_HUMAN
Zinc finger protein 461
ZNF461
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05283487N → S. Corresponds to variant dbSNP:rs10419469Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0113961 – 127Missing in isoform 2. 1 PublicationAdd BLAST127

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY329493 mRNA Translation: AAR00226.1
AK292834 mRNA Translation: BAF85523.1
BC028631 mRNA Translation: AAH28631.1
AB021641 mRNA Translation: BAA86987.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS54257.1 [Q8TAF7-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001284552.1, NM_001297623.2
NP_694989.2, NM_153257.4 [Q8TAF7-1]
XP_011525788.1, XM_011527486.2 [Q8TAF7-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000588268; ENSP00000467931; ENSG00000197808 [Q8TAF7-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
92283

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:92283

UCSC genome browser

More...
UCSCi
uc002oem.4, human [Q8TAF7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY329493 mRNA Translation: AAR00226.1
AK292834 mRNA Translation: BAF85523.1
BC028631 mRNA Translation: AAH28631.1
AB021641 mRNA Translation: BAA86987.1
CCDSiCCDS54257.1 [Q8TAF7-1]
RefSeqiNP_001284552.1, NM_001297623.2
NP_694989.2, NM_153257.4 [Q8TAF7-1]
XP_011525788.1, XM_011527486.2 [Q8TAF7-2]

3D structure databases

SMRiQ8TAF7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124926, 6 interactors
IntActiQ8TAF7, 2 interactors
STRINGi9606.ENSP00000467931

PTM databases

iPTMnetiQ8TAF7
PhosphoSitePlusiQ8TAF7

Polymorphism and mutation databases

BioMutaiZNF461
DMDMi51338811

Proteomic databases

EPDiQ8TAF7
jPOSTiQ8TAF7
MassIVEiQ8TAF7
MaxQBiQ8TAF7
PaxDbiQ8TAF7
PeptideAtlasiQ8TAF7
PRIDEiQ8TAF7
ProteomicsDBi73876 [Q8TAF7-1]
73877 [Q8TAF7-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
8537, 108 antibodies

The DNASU plasmid repository

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DNASUi
92283

Genome annotation databases

EnsembliENST00000588268; ENSP00000467931; ENSG00000197808 [Q8TAF7-1]
GeneIDi92283
KEGGihsa:92283
UCSCiuc002oem.4, human [Q8TAF7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
92283
EuPathDBiHostDB:ENSG00000197808.11

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF461
HGNCiHGNC:21629, ZNF461
HPAiENSG00000197808, Low tissue specificity
MIMi608640, gene
neXtProtiNX_Q8TAF7
OpenTargetsiENSG00000197808
PharmGKBiPA145149895

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000163325
HOGENOMiCLU_002678_44_5_1
InParanoidiQ8TAF7
KOiK09228
PhylomeDBiQ8TAF7

Enzyme and pathway databases

PathwayCommonsiQ8TAF7
ReactomeiR-HSA-212436, Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
92283, 4 hits in 895 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF461, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
92283
PharosiQ8TAF7, Tdark

Protein Ontology

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PROi
PR:Q8TAF7
RNActiQ8TAF7, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000197808, Expressed in frontal cortex and 126 other tissues
ExpressionAtlasiQ8TAF7, baseline and differential
GenevisibleiQ8TAF7, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 9 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 12 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 10 hits
PS50157, ZINC_FINGER_C2H2_2, 12 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN461_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TAF7
Secondary accession number(s): A8K9W9, Q6VSF7, Q9ULZ8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: August 16, 2004
Last modified: October 7, 2020
This is version 157 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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