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Protein

Growth arrest and DNA damage-inducible proteins-interacting protein 1

Gene

GADD45GIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.

Miscellaneous

Cells overexpressing GADD45GIP1 were more likely to be in G1 and less likely to be in S phase and grow more slowly than control cells. Inhibiting the expression of GADD45GIP1 promotes cell cycle progression.

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein
Biological processCell cycle, Host-virus interaction

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
Growth arrest and DNA damage-inducible proteins-interacting protein 1
Alternative name(s):
39S ribosomal protein L59, mitochondrial
Short name:
MRP-L59
CKII beta-associating protein
CR6-interacting factor 1
Short name:
CRIF1
Mitochondrial large ribosomal subunit protein mL641 Publication
Papillomavirus L2-interacting nuclear protein 1
Short name:
PLINP
Short name:
PLINP-1
p53-responsive gene 6 protein
Gene namesi
Name:GADD45GIP1
Synonyms:MRPL59, PLINP1, PRG6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000179271.2
HGNCiHGNC:29996 GADD45GIP1
MIMi605162 gene
neXtProtiNX_Q8TAE8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi90480
OpenTargetsiENSG00000179271
PharmGKBiPA134954784

Polymorphism and mutation databases

DMDMi74730346

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002286201 – 222Growth arrest and DNA damage-inducible proteins-interacting protein 1Add BLAST222

Proteomic databases

EPDiQ8TAE8
MaxQBiQ8TAE8
PaxDbiQ8TAE8
PeptideAtlasiQ8TAE8
PRIDEiQ8TAE8
ProteomicsDBi73869

PTM databases

iPTMnetiQ8TAE8
PhosphoSitePlusiQ8TAE8

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in the thyroid gland, heart, lymph nodes, trachea and adrenal tissues. Expressed at lower level in liver skeletal muscle, kidney, pancreas, testis, ovary and stomach. Barely detectable in adrenal adenoma and papillary thyroid cancer.1 Publication

Inductioni

Down-regulated by p53/TP53 in apoptotic cells.1 Publication

Gene expression databases

BgeeiENSG00000179271 Expressed in 201 organ(s), highest expression level in apex of heart
CleanExiHS_GADD45GIP1
GenevisibleiQ8TAE8 HS

Organism-specific databases

HPAiHPA055205
HPA065048

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:23908630, PubMed:25278503, PubMed:25838379). Interacts with GADD45A, GADD45B and GADD45G (PubMed:12716909). Interacts with NR4A1 via the NR4A1 AB domain (PubMed:15459248). Interacts with ATAD3A and ATAD3B (PubMed:22453275).7 Publications
(Microbial infection) Interacts with the human papilloma virus type 16 (HPV 16) minor capsid protein L2.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi124721, 98 interactors
IntActiQ8TAE8, 82 interactors
MINTiQ8TAE8
STRINGi9606.ENSP00000323065

Structurei

Secondary structure

1222
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8TAE8
SMRiQ8TAE8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili99 – 212Sequence analysisAdd BLAST114

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi184 – 200Nuclear localization signalSequence analysisAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi136 – 139Poly-Gln4

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4848 Eukaryota
ENOG410XVD1 LUCA
GeneTreeiENSGT00390000013719
HOGENOMiHOG000112686
HOVERGENiHBG068845
InParanoidiQ8TAE8
OMAiAEEREWY
OrthoDBiEOG091G158K
PhylomeDBiQ8TAE8
TreeFamiTF323794

Family and domain databases

InterProiView protein in InterPro
IPR018472 Damage-induce-interacting_prot
PANTHERiPTHR31761 PTHR31761, 1 hit
PfamiView protein in Pfam
PF10147 CR6_interact, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TAE8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAASVRQARS LLGVAATLAP GSRGYRARPP PRRRPGPRWP DPEDLLTPRW
60 70 80 90 100
QLGPRYAAKQ FARYGAASGV VPGSLWPSPE QLRELEAEER EWYPSLATMQ
110 120 130 140 150
ESLRVKQLAE EQKRREREQH IAECMAKMPQ MIVNWQQQQR ENWEKAQADK
160 170 180 190 200
ERRARLQAEA QELLGYQVDP RSARFQELLQ DLEKKERKRL KEEKQKRKKE
210 220
ARAAALAAAV AQDPAASGAP SS
Length:222
Mass (Da):25,384
Last modified:June 1, 2002 - v1
Checksum:i304C397AEC958804
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7 – 10QARS → KALN in CAD22344 (PubMed:12482659).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ429498 mRNA Translation: CAD22344.1
AF479749 mRNA Translation: AAL85877.1
AF475095 mRNA Translation: AAM10639.1
BC004944 mRNA Translation: AAH04944.1
BC013039 mRNA Translation: AAH13039.2
BC013027 mRNA Translation: AAH13027.2
BC069200 mRNA Translation: AAH69200.1
AJ295986 mRNA Translation: CAC82499.1
AF147080 mRNA No translation available.
CCDSiCCDS12290.1
RefSeqiNP_443082.2, NM_052850.3
UniGeneiHs.515164

Genome annotation databases

EnsembliENST00000316939; ENSP00000323065; ENSG00000179271
GeneIDi90480
KEGGihsa:90480
UCSCiuc002mwb.5 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ429498 mRNA Translation: CAD22344.1
AF479749 mRNA Translation: AAL85877.1
AF475095 mRNA Translation: AAM10639.1
BC004944 mRNA Translation: AAH04944.1
BC013039 mRNA Translation: AAH13039.2
BC013027 mRNA Translation: AAH13027.2
BC069200 mRNA Translation: AAH69200.1
AJ295986 mRNA Translation: CAC82499.1
AF147080 mRNA No translation available.
CCDSiCCDS12290.1
RefSeqiNP_443082.2, NM_052850.3
UniGeneiHs.515164

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40q1-222[»]
3J9Melectron microscopy3.50q1-222[»]
5OOLelectron microscopy3.06q1-222[»]
5OOMelectron microscopy3.03q1-222[»]
ProteinModelPortaliQ8TAE8
SMRiQ8TAE8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124721, 98 interactors
IntActiQ8TAE8, 82 interactors
MINTiQ8TAE8
STRINGi9606.ENSP00000323065

PTM databases

iPTMnetiQ8TAE8
PhosphoSitePlusiQ8TAE8

Polymorphism and mutation databases

DMDMi74730346

Proteomic databases

EPDiQ8TAE8
MaxQBiQ8TAE8
PaxDbiQ8TAE8
PeptideAtlasiQ8TAE8
PRIDEiQ8TAE8
ProteomicsDBi73869

Protocols and materials databases

DNASUi90480
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316939; ENSP00000323065; ENSG00000179271
GeneIDi90480
KEGGihsa:90480
UCSCiuc002mwb.5 human

Organism-specific databases

CTDi90480
DisGeNETi90480
EuPathDBiHostDB:ENSG00000179271.2
GeneCardsiGADD45GIP1
HGNCiHGNC:29996 GADD45GIP1
HPAiHPA055205
HPA065048
MIMi605162 gene
neXtProtiNX_Q8TAE8
OpenTargetsiENSG00000179271
PharmGKBiPA134954784
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4848 Eukaryota
ENOG410XVD1 LUCA
GeneTreeiENSGT00390000013719
HOGENOMiHOG000112686
HOVERGENiHBG068845
InParanoidiQ8TAE8
OMAiAEEREWY
OrthoDBiEOG091G158K
PhylomeDBiQ8TAE8
TreeFamiTF323794

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

GeneWikiiGADD45GIP1
GenomeRNAii90480
PROiPR:Q8TAE8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000179271 Expressed in 201 organ(s), highest expression level in apex of heart
CleanExiHS_GADD45GIP1
GenevisibleiQ8TAE8 HS

Family and domain databases

InterProiView protein in InterPro
IPR018472 Damage-induce-interacting_prot
PANTHERiPTHR31761 PTHR31761, 1 hit
PfamiView protein in Pfam
PF10147 CR6_interact, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG45IP_HUMAN
AccessioniPrimary (citable) accession number: Q8TAE8
Secondary accession number(s): Q8IVM3
, Q8TE51, Q969P9, Q9BSM6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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