SNIP1

Functionⁱ

Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.4 Publications

GO - Molecular functionⁱ

mRNA binding Source: GO_Central
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

I-kappaB kinase/NF-kappaB signaling Source: Ensembl
production of miRNAs involved in gene silencing by miRNA
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18632581
regulation of transcription, DNA-templated Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	RNA-mediated gene silencing

Biological process

RNA-mediated gene silencing

Enzyme and pathway databases

SignaLinkⁱ	Q8TAD8
SIGNORⁱ	Q8TAD8

Protein family/group databases

MoonDBⁱ	Q8TAD8 Predicted

MoonDBⁱ

Q8TAD8 Predicted

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Smad nuclear-interacting protein 1 Alternative name(s): FHA domain-containing protein SNIP1
Gene namesⁱ	Name:SNIP1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000163877.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30587 SNIP1
MIMⁱ	608241 gene
neXtProtⁱ	NX_Q8TAD8

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disease characterized by severe psychomotor retardation, intractable seizures, dysmorphic features, and a lumpy skull surface. Patients are hypotonic and have poor feeding in the neonatal period.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	30	K → R: Abolishes sumoylation. 1 Publication		1

Keywords - Diseaseⁱ

Disease mutation, Epilepsy

Organism-specific databases

DisGeNET More...DisGeNETⁱ	79753
MalaCards human disease database More...MalaCardsⁱ	SNIP1
MIMⁱ	614501 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000163877
PharmGKBⁱ	PA142670893

Polymorphism and mutation databases

BioMutaⁱ	SNIP1
DMDMⁱ	48428655

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000072009	1 – 396	Smad nuclear-interacting protein 1Add BLAST		396

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	30	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate
Cross-linkⁱ	30	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linkⁱ	30	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residueⁱ	35	PhosphoserineCombined sources	1
Modified residueⁱ	49	PhosphoserineCombined sources	1
Modified residueⁱ	52	PhosphoserineCombined sources	1
Modified residueⁱ	54	PhosphoserineCombined sources	1
Modified residueⁱ	57	PhosphothreonineCombined sources	1
Modified residueⁱ	58	PhosphoserineCombined sources	1
Modified residueⁱ	99	PhosphoserineBy similarity	1
Cross-linkⁱ	108	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	153	PhosphoserineBy similarity	1
Modified residueⁱ	202	PhosphoserineCombined sources	1
Cross-linkⁱ	223	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	394	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Degraded by the proteasome upon binding to the SMAD1/OAZ1/PSMB4 complex.

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q8TAD8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8TAD8
PaxDbⁱ	Q8TAD8
PeptideAtlas More...PeptideAtlasⁱ	Q8TAD8
PRIDEⁱ	Q8TAD8
ProteomicsDBⁱ	73865

PTM databases

iPTMnetⁱ	Q8TAD8
PhosphoSitePlusⁱ	Q8TAD8

Expressionⁱ

Tissue specificityⁱ

Ubiquitous, with highest expression in heart and skeletal muscle.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000163877 Expressed in 198 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_SNIP1
ExpressionAtlasⁱ	Q8TAD8 baseline and differential
Genevisibleⁱ	Q8TAD8 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA036896

HPAⁱ

HPA036896

Interactionⁱ

Subunit structureⁱ

Binds SMAD4 and CREBBP/EP300. Binds the SMAD1/OAZ1/PSMB4 complex. Interacts with DROSHA and SMARCA4. Component of the SNARP complex which consists at least of SNIP1, SNW1, THRAP3, BCLAF1 and PNN.6 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CLK2	P49760	6	EBI-749336,EBI-750020
IK	Q13123	2	EBI-749336,EBI-713456
MFAP1	P55081	3	EBI-749336,EBI-1048159
MYC	P01106	9	EBI-749336,EBI-447544
SNW1	Q13573	7	EBI-749336,EBI-632715
SRPK2	P78362	3	EBI-749336,EBI-593303
TNIP1	Q15025	3	EBI-749336,EBI-357849
ZBTB9	Q96C00	4	EBI-749336,EBI-395708

Protein-protein interaction databases

BioGridⁱ	122864, 75 interactors
Database of interacting proteins More...DIPⁱ	DIP-38956N
IntActⁱ	Q8TAD8, 59 interactors
Molecular INTeraction database More...MINTⁱ	Q8TAD8
STRINGⁱ	9606.ENSP00000296215

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8TAD8
SMRⁱ	Q8TAD8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	281 – 344	FHAPROSITE-ProRule annotationAdd BLAST		64

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	165 – 196	Sequence analysisAdd BLAST		32

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	62 – 192	Arg-richAdd BLAST		131
Compositional biasⁱ	385 – 392	Poly-Glu		8

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG1882 Eukaryota ENOG4111F4H LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000110659
HOGENOMⁱ	HOG000264922
HOVERGENⁱ	HBG056615
InParanoidⁱ	Q8TAD8
KEGG Orthology (KO) More...KOⁱ	K13108
OMAⁱ	LKYHEPA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0M70
PhylomeDBⁱ	Q8TAD8
TreeFamⁱ	TF312797

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00060 FHA, 1 hit
InterProⁱ	View protein in InterPro IPR000253 FHA_dom IPR008984 SMAD_FHA_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00498 FHA, 1 hit
SMARTⁱ	View protein in SMART SM00240 FHA, 1 hit
SUPFAMⁱ	SSF49879 SSF49879, 1 hit
PROSITEⁱ	View protein in PROSITE PS50006 FHA_DOMAIN, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q8TAD8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKAVKSERER GSRRRHRDGD VVLPAGVVVK QERLSPEVAP PAHRRPDHSG 
        60         70         80         90        100
GSPSPPTSEP ARSGHRGNRA RGVSRSPPKK KNKASGRRSK SPRSKRNRSP 
       110        120        130        140        150
HHSTVKVKQE REDHPRRGRE DRQHREPSEQ EHRRARNSDR DRHRGHSHQR 
       160        170        180        190        200
RTSNERPGSG QGQGRDRDTQ NLQAQEEERE FYNARRREHR QRNDVGGGGS 
       210        220        230        240        250
ESQELVPRPG GNNKEKEVPA KEKPSFELSG ALLEDTNTFR GVVIKYSEPP 
       260        270        280        290        300
EARIPKKRWR LYPFKNDEVL PVMYIHRQSA YLLGRHRRIA DIPIDHPSCS 
       310        320        330        340        350
KQHAVFQYRL VEYTRADGTV GRRVKPYIID LGSGNGTFLN NKRIEPQRYY 
       360        370        380        390 
ELKEKDVLKF GFSSREYVLL HESSDTSEID RKDDEDEEEE EEVSDS

Length:396

Mass (Da):45,778

Last modified:June 1, 2002 - v1

Checksum:ⁱB183F83EC3184676

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A1W2PRA0	A0A1W2PRA0_HUMAN		Smad nuclear-interacting protein 1 Smad nuclear-interacting protein 1	SNIP1	68	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	181	F → S in BAB55241 (PubMed:14702039).Curated		1
Sequence conflictⁱ	364	S → I in BAB14134 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_067542	366	E → G in PMRED. 1 PublicationCorresponds to variant dbSNP:rs387906986EnsemblClinVar.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY081909 mRNA Translation: AAL91140.1 AK022615 mRNA Translation: BAB14134.1 AK027622 mRNA Translation: BAB55241.1 BC027040 mRNA Translation: AAH27040.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS419.1
NCBI Reference Sequences More...RefSeqⁱ	NP_078976.2, NM_024700.3
UniGeneⁱ	Hs.47232

Genome annotation databases

Ensemblⁱ	ENST00000296215; ENSP00000296215; ENSG00000163877
GeneIDⁱ	79753
KEGGⁱ	hsa:79753
UCSC genome browser More...UCSCⁱ	uc001cbi.5 human

Protein	Similar proteins		Species	Score	Length	Source
Q8TAD8	Smad nuclear interacting protein 1		HUMAN		396	UniRef100_Q8TAD8

Protein	Similar proteins		Species	Score	Length	Source
Q8TAD8	Smad nuclear interacting protein 1		HUMAN		396	UniRef90_Q8TAD8
Uncharacterized protein		PAPAN		402
Uncharacterized protein		MACNE		397
SNIP1 isoform 1		PANTR		396
Uncharacterized protein		PANPA		396
+27

Protein	Similar proteins		Species	Score	Length	Source
Q8TAD8	Smad nuclear interacting protein 1		RAT		389	UniRef50_Q8TAD8
Smad nuclear-interacting protein 1		MOUSE		383
Smad nuclear interacting protein 1		HUMAN		396
Uncharacterized protein		PAPAN		402
Uncharacterized protein		MACNE		397
+173

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY081909 mRNA Translation: AAL91140.1 AK022615 mRNA Translation: BAB14134.1 AK027622 mRNA Translation: BAB55241.1 BC027040 mRNA Translation: AAH27040.1
CCDSⁱ	CCDS419.1
RefSeqⁱ	NP_078976.2, NM_024700.3
UniGeneⁱ	Hs.47232

3D structure databases

ProteinModelPortalⁱ	Q8TAD8
SMRⁱ	Q8TAD8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122864, 75 interactors
DIPⁱ	DIP-38956N
IntActⁱ	Q8TAD8, 59 interactors
MINTⁱ	Q8TAD8
STRINGⁱ	9606.ENSP00000296215

Protein family/group databases

MoonDBⁱ	Q8TAD8 Predicted

MoonDBⁱ

Q8TAD8 Predicted

PTM databases

iPTMnetⁱ	Q8TAD8
PhosphoSitePlusⁱ	Q8TAD8

Polymorphism and mutation databases

BioMutaⁱ	SNIP1
DMDMⁱ	48428655

Proteomic databases

EPDⁱ	Q8TAD8
MaxQBⁱ	Q8TAD8
PaxDbⁱ	Q8TAD8
PeptideAtlasⁱ	Q8TAD8
PRIDEⁱ	Q8TAD8
ProteomicsDBⁱ	73865

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	79753
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000296215; ENSP00000296215; ENSG00000163877
GeneIDⁱ	79753
KEGGⁱ	hsa:79753
UCSCⁱ	uc001cbi.5 human

Organism-specific databases

CTDⁱ	79753
DisGeNETⁱ	79753
EuPathDBⁱ	HostDB:ENSG00000163877.9
GeneCardsⁱ	SNIP1
HGNCⁱ	HGNC:30587 SNIP1
HPAⁱ	HPA036896
MalaCardsⁱ	SNIP1
MIMⁱ	608241 gene 614501 phenotype
neXtProtⁱ	NX_Q8TAD8
OpenTargetsⁱ	ENSG00000163877
PharmGKBⁱ	PA142670893
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1882 Eukaryota ENOG4111F4H LUCA
GeneTreeⁱ	ENSGT00730000110659
HOGENOMⁱ	HOG000264922
HOVERGENⁱ	HBG056615
InParanoidⁱ	Q8TAD8
KOⁱ	K13108
OMAⁱ	LKYHEPA
OrthoDBⁱ	EOG091G0M70
PhylomeDBⁱ	Q8TAD8
TreeFamⁱ	TF312797

Enzyme and pathway databases

SignaLinkⁱ	Q8TAD8
SIGNORⁱ	Q8TAD8

Miscellaneous databases

ChiTaRSⁱ	SNIP1 human
GeneWikiⁱ	SNIP1
GenomeRNAiⁱ	79753
Protein Ontology More...PROⁱ	PR:Q8TAD8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000163877 Expressed in 198 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_SNIP1
ExpressionAtlasⁱ	Q8TAD8 baseline and differential
Genevisibleⁱ	Q8TAD8 HS

Family and domain databases

CDDⁱ	cd00060 FHA, 1 hit
InterProⁱ	View protein in InterPro IPR000253 FHA_dom IPR008984 SMAD_FHA_dom_sf
Pfamⁱ	View protein in Pfam PF00498 FHA, 1 hit
SMARTⁱ	View protein in SMART SM00240 FHA, 1 hit
SUPFAMⁱ	SSF49879 SSF49879, 1 hit
PROSITEⁱ	View protein in PROSITE PS50006 FHA_DOMAIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SNIP1_HUMAN
Accessionⁱ	Q8TAD8Primary (citable) accession number: Q8TAD8 Secondary accession number(s): Q96SP9, Q9H9T7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 7, 2004
	Last sequence update:	June 1, 2002
	Last modified:	September 12, 2018
	This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8TAD8 (SNIP1_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Smad nuclear-interacting protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ