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Entry version 99 (08 May 2019)
Sequence version 2 (14 Apr 2009)
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Protein

Overexpressed in colon carcinoma 1 protein

Gene

OCC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Was reported to be transcribed but not translated (PubMed:11890990). However, it was later shown that it is expressed at protein level (PubMed:19531736).2 Publications

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Overexpressed in colon carcinoma 1 protein
Short name:
OCC-1
Alternative name(s):
AGD3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OCC1
Synonyms:C12orf75
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:35164 C12orf75

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TAD7

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
387882

Open Targets

More...
OpenTargetsi
ENSG00000235162

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164716815

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C12orf75

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003682211 – 63Overexpressed in colon carcinoma 1 proteinAdd BLAST63

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TAD7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TAD7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8TAD7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TAD7

PeptideAtlas

More...
PeptideAtlasi
Q8TAD7

PRoteomics IDEntifications database

More...
PRIDEi
Q8TAD7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
73864

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q8TAD7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TAD7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TAD7

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8TAD7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

High expression in placenta, skeletal muscle, kidney and pancreas tissues. Absent or very faint expression in heart, brain, lung and liver. Expressed during adipogenic differentiation of mesenchymal stem cells (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000235162 Expressed in 189 organ(s), highest expression level in popliteal artery

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TAD7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TAD7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA065311

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
132482, 14 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000448536

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the OCC1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JMVI Eukaryota
ENOG41115A6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00610000087444

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TAD7

Database of Orthologous Groups

More...
OrthoDBi
1633686at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TAD7

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029133 OCC1

The PANTHER Classification System

More...
PANTHERi
PTHR38502 PTHR38502, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15506 OCC1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8TAD7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGCGNSTATS AGAGQGPAGA AKDVTEESVT EDDKRRNYGG VYVGLPSEAV
60
NMVSSQTKTV RKN
Length:63
Mass (Da):6,407
Last modified:April 14, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i60F992759DB5FCCD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I7HHH9I7HHH9_HUMAN
Chromosome 12 open reading frame 75
C12orf75 OCC-1
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VQD4F8VQD4_HUMAN
Chromosome 12 open reading frame 75
C12orf75
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VXK5F8VXK5_HUMAN
Chromosome 12 open reading frame 75
C12orf75
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W1S6F8W1S6_HUMAN
Chromosome 12 open reading frame 75
C12orf75
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH13920 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence AAH45812 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence AAH61920 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence AAH67897 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence CAC85391 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence CAC85392 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ311378 mRNA Translation: CAC85391.1 Sequence problems.
AJ311377 mRNA Translation: CAC85392.1 Sequence problems.
AK056999 mRNA No translation available.
AC011313 Genomic DNA No translation available.
BC013920 mRNA Translation: AAH13920.2 Sequence problems.
BC045812 mRNA Translation: AAH45812.1 Sequence problems.
BC061920 mRNA Translation: AAH61920.1 Sequence problems.
BC067897 mRNA Translation: AAH67897.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55879.1

NCBI Reference Sequences

More...
RefSeqi
NP_001138671.1, NM_001145199.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000443585; ENSP00000448536; ENSG00000235162

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
387882

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:387882

UCSC genome browser

More...
UCSCi
uc001tlh.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ311378 mRNA Translation: CAC85391.1 Sequence problems.
AJ311377 mRNA Translation: CAC85392.1 Sequence problems.
AK056999 mRNA No translation available.
AC011313 Genomic DNA No translation available.
BC013920 mRNA Translation: AAH13920.2 Sequence problems.
BC045812 mRNA Translation: AAH45812.1 Sequence problems.
BC061920 mRNA Translation: AAH61920.1 Sequence problems.
BC067897 mRNA Translation: AAH67897.1 Sequence problems.
CCDSiCCDS55879.1
RefSeqiNP_001138671.1, NM_001145199.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi132482, 14 interactors
STRINGi9606.ENSP00000448536

PTM databases

iPTMnetiQ8TAD7
PhosphoSitePlusiQ8TAD7
SwissPalmiQ8TAD7

Polymorphism and mutation databases

BioMutaiC12orf75

Proteomic databases

EPDiQ8TAD7
jPOSTiQ8TAD7
MaxQBiQ8TAD7
PaxDbiQ8TAD7
PeptideAtlasiQ8TAD7
PRIDEiQ8TAD7
ProteomicsDBi73864
TopDownProteomicsiQ8TAD7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000443585; ENSP00000448536; ENSG00000235162
GeneIDi387882
KEGGihsa:387882
UCSCiuc001tlh.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
387882
DisGeNETi387882

GeneCards: human genes, protein and diseases

More...
GeneCardsi
C12orf75

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0019089
HGNCiHGNC:35164 C12orf75
HPAiHPA065311
neXtProtiNX_Q8TAD7
OpenTargetsiENSG00000235162
PharmGKBiPA164716815

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410JMVI Eukaryota
ENOG41115A6 LUCA
GeneTreeiENSGT00610000087444
InParanoidiQ8TAD7
OrthoDBi1633686at2759
PhylomeDBiQ8TAD7

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
C12orf75 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
387882

Protein Ontology

More...
PROi
PR:Q8TAD7

Gene expression databases

BgeeiENSG00000235162 Expressed in 189 organ(s), highest expression level in popliteal artery
ExpressionAtlasiQ8TAD7 baseline and differential
GenevisibleiQ8TAD7 HS

Family and domain databases

InterProiView protein in InterPro
IPR029133 OCC1
PANTHERiPTHR38502 PTHR38502, 1 hit
PfamiView protein in Pfam
PF15506 OCC1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOCC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TAD7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 14, 2009
Last modified: May 8, 2019
This is version 99 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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