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Protein

Interleukin-17D

Gene

IL17D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Induces expression of IL6, CXCL8/IL8, and CSF2/GM-CSF from endothelial cells.1 Publication

Caution

IL17D nucleotide sequence has been submitted under the name IL27 in INSDC AY078238 (Ref. 2). However, the protein shown in this entry should not be confused with the actual IL27 protein, which forms a heterodimeric cytokine by interaction with EBI3. In order to avoid any ambiguity, we strongly recommend using the official HGNC nomenclature.1 Publication

GO - Molecular functioni

  • cytokine activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • receptor ligand activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionCytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-17D
Short name:
IL-17D
Alternative name(s):
Interleukin-271 Publication
Short name:
IL-271 Publication
Gene namesi
Name:IL17D
ORF Names:UNQ3096/PRO21175
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000172458.4
HGNCiHGNC:5984 IL17D
MIMi607587 gene
neXtProtiNX_Q8TAD2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi53342
OpenTargetsiENSG00000172458
PharmGKBiPA29798

Polymorphism and mutation databases

BioMutaiIL17D
DMDMi46576614

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_000001543016 – 202Interleukin-17DAdd BLAST187

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi68N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi181N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8TAD2
PeptideAtlasiQ8TAD2
PRIDEiQ8TAD2
ProteomicsDBi73860

PTM databases

iPTMnetiQ8TAD2
PhosphoSitePlusiQ8TAD2

Expressioni

Tissue specificityi

Expressed preferentially in adipose, skeletal muscle and CNS.1 Publication

Gene expression databases

BgeeiENSG00000172458 Expressed in 156 organ(s), highest expression level in quadriceps femoris
CleanExiHS_IL17D
HS_IL27
ExpressionAtlasiQ8TAD2 baseline and differential
GenevisibleiQ8TAD2 HS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000302924

Structurei

3D structure databases

ProteinModelPortaliQ8TAD2
SMRiQ8TAD2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-17 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHY3 Eukaryota
ENOG4112BXJ LUCA
GeneTreeiENSGT00730000110983
HOGENOMiHOG000049074
HOVERGENiHBG058772
InParanoidiQ8TAD2
KOiK05492
OMAiGGRHSYT
OrthoDBiEOG091G17O0
PhylomeDBiQ8TAD2
TreeFamiTF314701

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR020440 IL-17_chr
IPR010345 IL-17_fam
PfamiView protein in Pfam
PF06083 IL17, 1 hit
PRINTSiPR01932 INTRLEUKIN17
SUPFAMiSSF57501 SSF57501, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8TAD2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLVAGFLLAL PPSWAAGAPR AGRRPARPRG CADRPEELLE QLYGRLAAGV
60 70 80 90 100
LSAFHHTLQL GPREQARNAS CPAGGRPADR RFRPPTNLRS VSPWAYRISY
110 120 130 140 150
DPARYPRYLP EAYCLCRGCL TGLFGEEDVR FRSAPVYMPT VVLRRTPACA
160 170 180 190 200
GGRSVYTEAY VTIPVGCTCV PEPEKDADSI NSSIDKQGAK LLLGPNDAPA

GP
Length:202
Mass (Da):21,893
Last modified:June 1, 2002 - v1
Checksum:iD171C5FB2DD039C3
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WW17A0A087WW17_HUMAN
Interleukin-17D
IL17D
35Annotation score:
A0A087WWZ4A0A087WWZ4_HUMAN
Interleukin-17D
IL17D
90Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti78A → G in AAQ89471 (PubMed:12975309).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY078238 mRNA Translation: AAL86911.1
AF479775 mRNA Translation: AAM12734.1
AF458062 mRNA Translation: AAM77566.1
AY359113 mRNA Translation: AAQ89471.1
AL161772 Genomic DNA No translation available.
AL512652 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08276.1
BC036243 mRNA Translation: AAH36243.1
CCDSiCCDS9292.1
RefSeqiNP_612141.1, NM_138284.1
UniGeneiHs.655142

Genome annotation databases

EnsembliENST00000304920; ENSP00000302924; ENSG00000172458
GeneIDi53342
KEGGihsa:53342
UCSCiuc001unm.3 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Interleukin-17 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY078238 mRNA Translation: AAL86911.1
AF479775 mRNA Translation: AAM12734.1
AF458062 mRNA Translation: AAM77566.1
AY359113 mRNA Translation: AAQ89471.1
AL161772 Genomic DNA No translation available.
AL512652 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08276.1
BC036243 mRNA Translation: AAH36243.1
CCDSiCCDS9292.1
RefSeqiNP_612141.1, NM_138284.1
UniGeneiHs.655142

3D structure databases

ProteinModelPortaliQ8TAD2
SMRiQ8TAD2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000302924

PTM databases

iPTMnetiQ8TAD2
PhosphoSitePlusiQ8TAD2

Polymorphism and mutation databases

BioMutaiIL17D
DMDMi46576614

Proteomic databases

PaxDbiQ8TAD2
PeptideAtlasiQ8TAD2
PRIDEiQ8TAD2
ProteomicsDBi73860

Protocols and materials databases

DNASUi53342
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304920; ENSP00000302924; ENSG00000172458
GeneIDi53342
KEGGihsa:53342
UCSCiuc001unm.3 human

Organism-specific databases

CTDi53342
DisGeNETi53342
EuPathDBiHostDB:ENSG00000172458.4
GeneCardsiIL17D
HGNCiHGNC:5984 IL17D
MIMi607587 gene
neXtProtiNX_Q8TAD2
OpenTargetsiENSG00000172458
PharmGKBiPA29798
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHY3 Eukaryota
ENOG4112BXJ LUCA
GeneTreeiENSGT00730000110983
HOGENOMiHOG000049074
HOVERGENiHBG058772
InParanoidiQ8TAD2
KOiK05492
OMAiGGRHSYT
OrthoDBiEOG091G17O0
PhylomeDBiQ8TAD2
TreeFamiTF314701

Miscellaneous databases

GenomeRNAii53342
PROiPR:Q8TAD2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172458 Expressed in 156 organ(s), highest expression level in quadriceps femoris
CleanExiHS_IL17D
HS_IL27
ExpressionAtlasiQ8TAD2 baseline and differential
GenevisibleiQ8TAD2 HS

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR020440 IL-17_chr
IPR010345 IL-17_fam
PfamiView protein in Pfam
PF06083 IL17, 1 hit
PRINTSiPR01932 INTRLEUKIN17
SUPFAMiSSF57501 SSF57501, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIL17D_HUMAN
AccessioniPrimary (citable) accession number: Q8TAD2
Secondary accession number(s): B1AM69
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: June 1, 2002
Last modified: September 12, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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