UniProtKB - Q8TAA3 (PSMA8_HUMAN)
Proteasome subunit alpha-type 8
PSMA8
Functioni
Catalytic activityi
- Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation EC:3.4.25.1
GO - Molecular functioni
- endopeptidase activity Source: GO_Central
- threonine-type endopeptidase activity Source: UniProtKB-KW
GO - Biological processi
- anaphase-promoting complex-dependent catabolic process Source: Reactome
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
- Fc-epsilon receptor signaling pathway Source: Reactome
- interleukin-1-mediated signaling pathway Source: Reactome
- MAPK cascade Source: Reactome
- negative regulation of canonical Wnt signaling pathway Source: Reactome
- negative regulation of G2/M transition of mitotic cell cycle Source: Reactome
- NIK/NF-kappaB signaling Source: Reactome
- positive regulation of canonical Wnt signaling pathway Source: Reactome
- post-translational protein modification Source: Reactome
- proteasomal protein catabolic process Source: GO_Central
- proteasomal ubiquitin-independent protein catabolic process Source: GO_Central
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: GO_Central
- protein deubiquitination Source: Reactome
- protein polyubiquitination Source: Reactome
- regulation of cellular amino acid metabolic process Source: Reactome
- regulation of hematopoietic stem cell differentiation Source: Reactome
- regulation of mitotic cell cycle phase transition Source: Reactome
- regulation of mRNA stability Source: Reactome
- regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: Reactome
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: Reactome
- stimulatory C-type lectin receptor signaling pathway Source: Reactome
- T cell receptor signaling pathway Source: Reactome
- transmembrane transport Source: Reactome
- tumor necrosis factor-mediated signaling pathway Source: Reactome
- Wnt signaling pathway, planar cell polarity pathway Source: Reactome
Keywordsi
Molecular function | Hydrolase, Protease, Threonine protease |
Enzyme and pathway databases
Reactomei | R-HSA-1169091 Activation of NF-kappaB in B cells R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1236974 ER-Phagosome pathway R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-180534 Vpu mediated degradation of CD4 R-HSA-180585 Vif-mediated degradation of APOBEC3G R-HSA-195253 Degradation of beta-catenin by the destruction complex R-HSA-202424 Downstream TCR signaling R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-2467813 Separation of Sister Chromatids R-HSA-2871837 FCERI mediated NF-kB activation R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-350562 Regulation of ornithine decarboxylase (ODC) R-HSA-382556 ABC-family proteins mediated transport R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-4608870 Asymmetric localization of PCP proteins R-HSA-4641257 Degradation of AXIN R-HSA-4641258 Degradation of DVL R-HSA-5358346 Hedgehog ligand biogenesis R-HSA-5362768 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607764 CLEC7A (Dectin-1) signaling R-HSA-5610780 Degradation of GLI1 by the proteasome R-HSA-5610783 Degradation of GLI2 by the proteasome R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome R-HSA-5632684 Hedgehog 'on' state R-HSA-5658442 Regulation of RAS by GAPs R-HSA-5668541 TNFR2 non-canonical NF-kB pathway R-HSA-5676590 NIK-->noncanonical NF-kB signaling R-HSA-5678895 Defective CFTR causes cystic fibrosis R-HSA-5687128 MAPK6/MAPK4 signaling R-HSA-5689603 UCH proteinases R-HSA-5689880 Ub-specific processing proteases R-HSA-68827 CDT1 association with the CDC6:ORC:origin complex R-HSA-68949 Orc1 removal from chromatin R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69481 G2/M Checkpoints R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939902 Regulation of RUNX2 expression and activity R-HSA-8948751 Regulation of PTEN stability and activity R-HSA-8951664 Neddylation R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-9020702 Interleukin-1 signaling R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation |
Protein family/group databases
MEROPSi | T01.974 |
Names & Taxonomyi
Protein namesi | Recommended name: Proteasome subunit alpha-type 8 (EC:3.4.25.1)Alternative name(s): Proteasome subunit alpha-type 7-like |
Gene namesi | Name:PSMA8 Synonyms:PSMA7L |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:22985 PSMA8 |
MIMi | 617841 gene |
neXtProti | NX_Q8TAA3 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: GO_Central
- proteasome core complex Source: GO_Central
- proteasome core complex, alpha-subunit complex Source: UniProtKB
- spermatoproteasome complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Nucleus, ProteasomePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000154611 |
PharmGKBi | PA134969470 |
Miscellaneous databases
Pharosi | Q8TAA3 |
Chemistry databases
ChEMBLi | CHEMBL2364701 CHEMBL3831201 |
Polymorphism and mutation databases
BioMutai | PSMA8 |
DMDMi | 108936006 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000124149 | 1 – 256 | Proteasome subunit alpha-type 8Add BLAST | 256 |
Proteomic databases
jPOSTi | Q8TAA3 |
MassIVEi | Q8TAA3 |
MaxQBi | Q8TAA3 |
PaxDbi | Q8TAA3 |
PeptideAtlasi | Q8TAA3 |
PRIDEi | Q8TAA3 |
ProteomicsDBi | 73844 [Q8TAA3-1] 73845 [Q8TAA3-2] 73846 [Q8TAA3-5] |
PTM databases
iPTMneti | Q8TAA3 |
PhosphoSitePlusi | Q8TAA3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000154611 Expressed in 47 organ(s), highest expression level in female gonad |
ExpressionAtlasi | Q8TAA3 baseline and differential |
Genevisiblei | Q8TAA3 HS |
Interactioni
Subunit structurei
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).
Component of the spermatoproteasome, a form of the proteasome specifically found in testis.
By similarityProtein-protein interaction databases
BioGridi | 126804, 43 interactors |
IntActi | Q8TAA3, 7 interactors |
STRINGi | 9606.ENSP00000311121 |
Chemistry databases
BindingDBi | Q8TAA3 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0183 Eukaryota ENOG410XP21 LUCA |
GeneTreei | ENSGT00940000160354 |
HOGENOMi | HOG000091085 |
InParanoidi | Q8TAA3 |
KOi | K02731 |
OMAi | HVGMAFA |
OrthoDBi | 1222564at2759 |
PhylomeDBi | Q8TAA3 |
TreeFami | TF106212 |
Family and domain databases
Gene3Di | 3.60.20.10, 1 hit |
InterProi | View protein in InterPro IPR029055 Ntn_hydrolases_N IPR023332 Proteasome_alpha-type IPR000426 Proteasome_asu_N IPR001353 Proteasome_sua/b |
Pfami | View protein in Pfam PF00227 Proteasome, 1 hit PF10584 Proteasome_A_N, 1 hit |
SMARTi | View protein in SMART SM00948 Proteasome_A_N, 1 hit |
SUPFAMi | SSF56235 SSF56235, 1 hit |
PROSITEi | View protein in PROSITE PS00388 PROTEASOME_ALPHA_1, 1 hit PS51475 PROTEASOME_ALPHA_2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASRYDRAIT VFSPDGHLFQ VEYAQEAVKK GSTAVGIRGT NIVVLGVEKK
60 70 80 90 100
SVAKLQDERT VRKICALDDH VCMAFAVLTI FIGLTADARV VINRARVECQ
110 120 130 140 150
SHKLTVEDPV TVEYITRFIA TLKQKYTQSN GRRPFGISAL IVGFDDDGIS
160 170 180 190 200
RLYQTDPSGT YHAWKANAIG RSAKTVREFL EKNYTEDAIA SDSEAIKLAI
210 220 230 240 250
KALLEVVQSG GKNIELAIIR RNQPLKMFSA KEVELYVTEI EKEKEEAEKK
KSKKSV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WYS6 | A0A087WYS6_HUMAN | Proteasome endopeptidase complex | PSMA8 hCG_38481 | 224 | Annotation score: | ||
F5GY34 | F5GY34_HUMAN | Proteasome subunit alpha-type 8 | PSMA8 | 63 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 212 | K → R in AAH28371 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 212 | K → R in AAH28686 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005285 | 40 – 83 | Missing in isoform 2. 1 PublicationAdd BLAST | 44 | |
Alternative sequenceiVSP_018602 | 77 – 82 | Missing in isoform 3. 1 Publication | 6 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF445014 Genomic DNA Translation: ACA06053.1 AC091021 Genomic DNA No translation available. AC016839 Genomic DNA No translation available. CH471088 Genomic DNA Translation: EAX01214.1 BC028371 mRNA Translation: AAH28371.1 BC028686 mRNA Translation: AAH28686.1 BC042820 mRNA Translation: AAH42820.1 |
CCDSi | CCDS32808.1 [Q8TAA3-1] CCDS45842.1 [Q8TAA3-5] CCDS45843.1 [Q8TAA3-2] |
RefSeqi | NP_001020267.1, NM_001025096.1 [Q8TAA3-5] NP_001020268.1, NM_001025097.1 [Q8TAA3-2] NP_653263.2, NM_144662.2 [Q8TAA3-1] |
Genome annotation databases
Ensembli | ENST00000308268; ENSP00000311121; ENSG00000154611 [Q8TAA3-1] ENST00000343848; ENSP00000345584; ENSG00000154611 [Q8TAA3-2] ENST00000415576; ENSP00000409284; ENSG00000154611 [Q8TAA3-5] |
GeneIDi | 143471 |
KEGGi | hsa:143471 |
UCSCi | uc002kvo.4 human [Q8TAA3-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF445014 Genomic DNA Translation: ACA06053.1 AC091021 Genomic DNA No translation available. AC016839 Genomic DNA No translation available. CH471088 Genomic DNA Translation: EAX01214.1 BC028371 mRNA Translation: AAH28371.1 BC028686 mRNA Translation: AAH28686.1 BC042820 mRNA Translation: AAH42820.1 |
CCDSi | CCDS32808.1 [Q8TAA3-1] CCDS45842.1 [Q8TAA3-5] CCDS45843.1 [Q8TAA3-2] |
RefSeqi | NP_001020267.1, NM_001025096.1 [Q8TAA3-5] NP_001020268.1, NM_001025097.1 [Q8TAA3-2] NP_653263.2, NM_144662.2 [Q8TAA3-1] |
3D structure databases
SMRi | Q8TAA3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGridi | 126804, 43 interactors |
IntActi | Q8TAA3, 7 interactors |
STRINGi | 9606.ENSP00000311121 |
Chemistry databases
BindingDBi | Q8TAA3 |
ChEMBLi | CHEMBL2364701 CHEMBL3831201 |
Protein family/group databases
MEROPSi | T01.974 |
PTM databases
iPTMneti | Q8TAA3 |
PhosphoSitePlusi | Q8TAA3 |
Polymorphism and mutation databases
BioMutai | PSMA8 |
DMDMi | 108936006 |
Proteomic databases
jPOSTi | Q8TAA3 |
MassIVEi | Q8TAA3 |
MaxQBi | Q8TAA3 |
PaxDbi | Q8TAA3 |
PeptideAtlasi | Q8TAA3 |
PRIDEi | Q8TAA3 |
ProteomicsDBi | 73844 [Q8TAA3-1] 73845 [Q8TAA3-2] 73846 [Q8TAA3-5] |
Genome annotation databases
Ensembli | ENST00000308268; ENSP00000311121; ENSG00000154611 [Q8TAA3-1] ENST00000343848; ENSP00000345584; ENSG00000154611 [Q8TAA3-2] ENST00000415576; ENSP00000409284; ENSG00000154611 [Q8TAA3-5] |
GeneIDi | 143471 |
KEGGi | hsa:143471 |
UCSCi | uc002kvo.4 human [Q8TAA3-1] |
Organism-specific databases
CTDi | 143471 |
GeneCardsi | PSMA8 |
HGNCi | HGNC:22985 PSMA8 |
MIMi | 617841 gene |
neXtProti | NX_Q8TAA3 |
OpenTargetsi | ENSG00000154611 |
PharmGKBi | PA134969470 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0183 Eukaryota ENOG410XP21 LUCA |
GeneTreei | ENSGT00940000160354 |
HOGENOMi | HOG000091085 |
InParanoidi | Q8TAA3 |
KOi | K02731 |
OMAi | HVGMAFA |
OrthoDBi | 1222564at2759 |
PhylomeDBi | Q8TAA3 |
TreeFami | TF106212 |
Enzyme and pathway databases
Reactomei | R-HSA-1169091 Activation of NF-kappaB in B cells R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1236974 ER-Phagosome pathway R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-180534 Vpu mediated degradation of CD4 R-HSA-180585 Vif-mediated degradation of APOBEC3G R-HSA-195253 Degradation of beta-catenin by the destruction complex R-HSA-202424 Downstream TCR signaling R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-2467813 Separation of Sister Chromatids R-HSA-2871837 FCERI mediated NF-kB activation R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-350562 Regulation of ornithine decarboxylase (ODC) R-HSA-382556 ABC-family proteins mediated transport R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-4608870 Asymmetric localization of PCP proteins R-HSA-4641257 Degradation of AXIN R-HSA-4641258 Degradation of DVL R-HSA-5358346 Hedgehog ligand biogenesis R-HSA-5362768 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607764 CLEC7A (Dectin-1) signaling R-HSA-5610780 Degradation of GLI1 by the proteasome R-HSA-5610783 Degradation of GLI2 by the proteasome R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome R-HSA-5632684 Hedgehog 'on' state R-HSA-5658442 Regulation of RAS by GAPs R-HSA-5668541 TNFR2 non-canonical NF-kB pathway R-HSA-5676590 NIK-->noncanonical NF-kB signaling R-HSA-5678895 Defective CFTR causes cystic fibrosis R-HSA-5687128 MAPK6/MAPK4 signaling R-HSA-5689603 UCH proteinases R-HSA-5689880 Ub-specific processing proteases R-HSA-68827 CDT1 association with the CDC6:ORC:origin complex R-HSA-68949 Orc1 removal from chromatin R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69481 G2/M Checkpoints R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939902 Regulation of RUNX2 expression and activity R-HSA-8948751 Regulation of PTEN stability and activity R-HSA-8951664 Neddylation R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-9020702 Interleukin-1 signaling R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation |
Miscellaneous databases
ChiTaRSi | PSMA8 human |
GenomeRNAii | 143471 |
Pharosi | Q8TAA3 |
PROi | PR:Q8TAA3 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000154611 Expressed in 47 organ(s), highest expression level in female gonad |
ExpressionAtlasi | Q8TAA3 baseline and differential |
Genevisiblei | Q8TAA3 HS |
Family and domain databases
Gene3Di | 3.60.20.10, 1 hit |
InterProi | View protein in InterPro IPR029055 Ntn_hydrolases_N IPR023332 Proteasome_alpha-type IPR000426 Proteasome_asu_N IPR001353 Proteasome_sua/b |
Pfami | View protein in Pfam PF00227 Proteasome, 1 hit PF10584 Proteasome_A_N, 1 hit |
SMARTi | View protein in SMART SM00948 Proteasome_A_N, 1 hit |
SUPFAMi | SSF56235 SSF56235, 1 hit |
PROSITEi | View protein in PROSITE PS00388 PROTEASOME_ALPHA_1, 1 hit PS51475 PROTEASOME_ALPHA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PSMA8_HUMAN | |
Accessioni | Q8TAA3Primary (citable) accession number: Q8TAA3 Secondary accession number(s): B0YJ75 Q8TAA2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2002 |
Last sequence update: | May 30, 2006 | |
Last modified: | October 16, 2019 | |
This is version 156 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM - Peptidase families
Classification of peptidase families and list of entries - SIMILARITY comments
Index of protein domains and families - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot