UniProtKB - Q8T9L5 (Q8T9L5_DROME)
Protein
Non-specific serine/threonine protein kinase
Gene
Lkb1
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Catalytic activityi
Cofactori
Protein has several cofactor binding sites:GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- protein kinase activator activity Source: InterPro
- protein serine/threonine kinase activity Source: FlyBase
GO - Biological processi
- asymmetric neuroblast division Source: FlyBase
- border follicle cell delamination Source: FlyBase
- determination of adult lifespan Source: FlyBase
- dorsal closure Source: FlyBase
- establishment of cell polarity Source: InterPro
- glucose homeostasis Source: InterPro
- intracellular signal transduction Source: GO_Central
- maintenance of neuroblast polarity Source: FlyBase
- mitotic spindle organization Source: FlyBase
- negative regulation of triglyceride catabolic process Source: FlyBase
- oocyte microtubule cytoskeleton organization Source: FlyBase
- peptidyl-threonine phosphorylation Source: FlyBase
- positive regulation of apoptotic process Source: FlyBase
- protein localization to cell cortex Source: FlyBase
- protein phosphorylation Source: FlyBase
- regulation of cell growth Source: InterPro
- regulation of JNK cascade Source: FlyBase
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinaseARBA annotation, Transferase |
Ligand | ATP-bindingARBA annotation, MagnesiumARBA annotation, Metal-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Non-specific serine/threonine protein kinaseARBA annotation (EC:2.7.11.1ARBA annotation) |
Gene namesi | Name:Lkb1Imported Synonyms:anon-EST:Posey135Imported, dLKB1Imported, dlkb1Imported, Dmel\CG9374Imported, DmLKB1Imported, LKB1Imported, lkb1Imported, PAR-4Imported, par-4Imported, PAR4Imported, Par4Imported, PEUTZ JEGHERS KINASEImported, STK11Imported ORF Names:CG9374Imported, Dmel_CG9374Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0038167, Lkb1 |
Subcellular locationi
Endosome
- endosome Source: FlyBase
Nucleus
- nucleus Source: FlyBase
Other locations
- cell cortex Source: FlyBase
- cytoplasm Source: FlyBase
Keywords - Cellular componenti
CytoplasmARBA annotationExpressioni
Gene expression databases
Bgeei | FBgn0038167, Expressed in adult organism and 34 other tissues |
Interactioni
Protein-protein interaction databases
IntActi | Q8T9L5, 1 interactor |
STRINGi | 7227.FBpp0082276 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 172 – 435 | Protein kinaseInterPro annotationAdd BLAST | 264 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 24 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 36 – 63 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 519 – 545 | DisorderedSequence analysisAdd BLAST | 27 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.ARBA annotation
Phylogenomic databases
eggNOGi | KOG0583, Eukaryota |
GeneTreei | ENSGT00940000158050 |
HOGENOMi | CLU_000288_1_1_1 |
OMAi | DPWRSMT |
OrthoDBi | 856506at2759 |
Family and domain databases
CDDi | cd14119, STKc_LKB1, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR039154, LKB1_c IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8T9L5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQCSSSRPVG GKAAGGAEAG GAGATGQMTV TTMEAQVKAA HHHHLHHPTG
60 70 80 90 100
GGAQHKVEEE EPDPVEDEMT VLLANKNFHY DVASDLDDDA FVELKEDTAQ
110 120 130 140 150
ADDAGAGVGF YNPDELLLDD QPHPQVTWLD DDEIETLDRV TLDMGNMFFN
160 170 180 190 200
RVDSQDIIYQ QKKKSIKMVG KYIMGDVLGE GSYGKVKEAM NSENLCRLAV
210 220 230 240 250
KILTKRKLRR IPNGEQNVTR EIALLKQLKH RHVVELVDVL YNEEKQKMYL
260 270 280 290 300
VMEYCVGGLQ EMIDYQPDKR MPLFQAHGYF KQLVDGLEYL HSCRVIHKDI
310 320 330 340 350
KPGNLLLSLD QTLKISDFGV AEQLDLFAPD DTCTTGQGSP AFQPPEIANG
360 370 380 390 400
HETFAGFKVD IWSSGVTLYN LATGQYPFEG DNIYRLLENI GRGQWEAPAW
410 420 430 440 450
LYEMDADFAN LILGMLQADP SKRLSLQEIR HDTWFRSAPV KTGPPIPIPP
460 470 480 490 500
LKGDKYRNST VIPYLEAYHY GTQEEDVYFT EHDVNQELAR QAAAAASEIR
510 520 530 540 550
AKQSAAALAA CHTYEPPSTS AAAASNSLGN GSREEAPVKK KGSALKRRAK
560
KLTSCISVRK LSHCRTS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014297 Genomic DNA Translation: AAF54972.2 AY069241 mRNA Translation: AAL39386.1 AE014297 Genomic DNA Translation: AAN13580.1 AE014297 Genomic DNA Translation: AAN13581.1 AE014297 Genomic DNA Translation: AAN13582.1 AE014297 Genomic DNA Translation: AAN13583.1 AE014297 Genomic DNA Translation: AAN13584.1 AE014297 Genomic DNA Translation: AAN13585.1 AE014297 Genomic DNA Translation: AAN13586.1 AE014297 Genomic DNA Translation: ACZ94903.1 |
RefSeqi | NP_001163606.1, NM_001170135.2 NP_650302.1, NM_142045.4 NP_731840.1, NM_169541.3 NP_731841.1, NM_169542.3 NP_731842.1, NM_169543.3 NP_731843.1, NM_169544.2 NP_731844.1, NM_169545.3 NP_731845.1, NM_169546.3 NP_731846.1, NM_169547.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0082808; FBpp0082276; FBgn0038167 FBtr0082809; FBpp0082277; FBgn0038167 FBtr0082810; FBpp0082278; FBgn0038167 FBtr0082811; FBpp0082279; FBgn0038167 FBtr0082812; FBpp0082280; FBgn0038167 FBtr0082813; FBpp0082281; FBgn0038167 FBtr0082814; FBpp0082282; FBgn0038167 FBtr0082815; FBpp0082283; FBgn0038167 FBtr0301488; FBpp0290703; FBgn0038167 |
GeneIDi | 41673 |
KEGGi | dme:Dmel_CG9374 |
UCSCi | CG9374-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014297 Genomic DNA Translation: AAF54972.2 AY069241 mRNA Translation: AAL39386.1 AE014297 Genomic DNA Translation: AAN13580.1 AE014297 Genomic DNA Translation: AAN13581.1 AE014297 Genomic DNA Translation: AAN13582.1 AE014297 Genomic DNA Translation: AAN13583.1 AE014297 Genomic DNA Translation: AAN13584.1 AE014297 Genomic DNA Translation: AAN13585.1 AE014297 Genomic DNA Translation: AAN13586.1 AE014297 Genomic DNA Translation: ACZ94903.1 |
RefSeqi | NP_001163606.1, NM_001170135.2 NP_650302.1, NM_142045.4 NP_731840.1, NM_169541.3 NP_731841.1, NM_169542.3 NP_731842.1, NM_169543.3 NP_731843.1, NM_169544.2 NP_731844.1, NM_169545.3 NP_731845.1, NM_169546.3 NP_731846.1, NM_169547.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q8T9L5, 1 interactor |
STRINGi | 7227.FBpp0082276 |
Genome annotation databases
EnsemblMetazoai | FBtr0082808; FBpp0082276; FBgn0038167 FBtr0082809; FBpp0082277; FBgn0038167 FBtr0082810; FBpp0082278; FBgn0038167 FBtr0082811; FBpp0082279; FBgn0038167 FBtr0082812; FBpp0082280; FBgn0038167 FBtr0082813; FBpp0082281; FBgn0038167 FBtr0082814; FBpp0082282; FBgn0038167 FBtr0082815; FBpp0082283; FBgn0038167 FBtr0301488; FBpp0290703; FBgn0038167 |
GeneIDi | 41673 |
KEGGi | dme:Dmel_CG9374 |
UCSCi | CG9374-RA, d. melanogaster |
Organism-specific databases
CTDi | 41673 |
FlyBasei | FBgn0038167, Lkb1 |
Phylogenomic databases
eggNOGi | KOG0583, Eukaryota |
GeneTreei | ENSGT00940000158050 |
HOGENOMi | CLU_000288_1_1_1 |
OMAi | DPWRSMT |
OrthoDBi | 856506at2759 |
Miscellaneous databases
BioGRID-ORCSi | 41673, 0 hits in 3 CRISPR screens |
GenomeRNAii | 41673 |
PROi | PR:Q8T9L5 |
Gene expression databases
Bgeei | FBgn0038167, Expressed in adult organism and 34 other tissues |
Family and domain databases
CDDi | cd14119, STKc_LKB1, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR039154, LKB1_c IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8T9L5_DROME | |
Accessioni | Q8T9L5Primary (citable) accession number: Q8T9L5 Secondary accession number(s): Q9VFS7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 1, 2002 |
Last sequence update: | June 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 188 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |