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Entry version 188 (02 Dec 2020)
Sequence version 1 (01 Jun 2002)
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Protein

Non-specific serine/threonine protein kinase

Gene

Lkb1

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseARBA annotation, Transferase
LigandATP-bindingARBA annotation, MagnesiumARBA annotation, Metal-bindingARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Non-specific serine/threonine protein kinaseARBA annotation (EC:2.7.11.1ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lkb1Imported
Synonyms:anon-EST:Posey135Imported, dLKB1Imported, dlkb1Imported, Dmel\CG9374Imported, DmLKB1Imported, LKB1Imported, lkb1Imported, PAR-4Imported, par-4Imported, PAR4Imported, Par4Imported, PEUTZ JEGHERS KINASEImported, STK11Imported
ORF Names:CG9374Imported, Dmel_CG9374Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0038167, Lkb1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0038167, Expressed in adult organism and 34 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8T9L5, 1 interactor

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0082276

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini172 – 435Protein kinaseInterPro annotationAdd BLAST264

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 24DisorderedSequence analysisAdd BLAST24
Regioni36 – 63DisorderedSequence analysisAdd BLAST28
Regioni519 – 545DisorderedSequence analysisAdd BLAST27

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.ARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0583, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158050

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000288_1_1_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
DPWRSMT

Database of Orthologous Groups

More...
OrthoDBi
856506at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14119, STKc_LKB1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR039154, LKB1_c
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8T9L5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQCSSSRPVG GKAAGGAEAG GAGATGQMTV TTMEAQVKAA HHHHLHHPTG
60 70 80 90 100
GGAQHKVEEE EPDPVEDEMT VLLANKNFHY DVASDLDDDA FVELKEDTAQ
110 120 130 140 150
ADDAGAGVGF YNPDELLLDD QPHPQVTWLD DDEIETLDRV TLDMGNMFFN
160 170 180 190 200
RVDSQDIIYQ QKKKSIKMVG KYIMGDVLGE GSYGKVKEAM NSENLCRLAV
210 220 230 240 250
KILTKRKLRR IPNGEQNVTR EIALLKQLKH RHVVELVDVL YNEEKQKMYL
260 270 280 290 300
VMEYCVGGLQ EMIDYQPDKR MPLFQAHGYF KQLVDGLEYL HSCRVIHKDI
310 320 330 340 350
KPGNLLLSLD QTLKISDFGV AEQLDLFAPD DTCTTGQGSP AFQPPEIANG
360 370 380 390 400
HETFAGFKVD IWSSGVTLYN LATGQYPFEG DNIYRLLENI GRGQWEAPAW
410 420 430 440 450
LYEMDADFAN LILGMLQADP SKRLSLQEIR HDTWFRSAPV KTGPPIPIPP
460 470 480 490 500
LKGDKYRNST VIPYLEAYHY GTQEEDVYFT EHDVNQELAR QAAAAASEIR
510 520 530 540 550
AKQSAAALAA CHTYEPPSTS AAAASNSLGN GSREEAPVKK KGSALKRRAK
560
KLTSCISVRK LSHCRTS
Length:567
Mass (Da):62,893
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD4847C809DB067A1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF54972.2
AY069241 mRNA Translation: AAL39386.1
AE014297 Genomic DNA Translation: AAN13580.1
AE014297 Genomic DNA Translation: AAN13581.1
AE014297 Genomic DNA Translation: AAN13582.1
AE014297 Genomic DNA Translation: AAN13583.1
AE014297 Genomic DNA Translation: AAN13584.1
AE014297 Genomic DNA Translation: AAN13585.1
AE014297 Genomic DNA Translation: AAN13586.1
AE014297 Genomic DNA Translation: ACZ94903.1

NCBI Reference Sequences

More...
RefSeqi
NP_001163606.1, NM_001170135.2
NP_650302.1, NM_142045.4
NP_731840.1, NM_169541.3
NP_731841.1, NM_169542.3
NP_731842.1, NM_169543.3
NP_731843.1, NM_169544.2
NP_731844.1, NM_169545.3
NP_731845.1, NM_169546.3
NP_731846.1, NM_169547.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0082808; FBpp0082276; FBgn0038167
FBtr0082809; FBpp0082277; FBgn0038167
FBtr0082810; FBpp0082278; FBgn0038167
FBtr0082811; FBpp0082279; FBgn0038167
FBtr0082812; FBpp0082280; FBgn0038167
FBtr0082813; FBpp0082281; FBgn0038167
FBtr0082814; FBpp0082282; FBgn0038167
FBtr0082815; FBpp0082283; FBgn0038167
FBtr0301488; FBpp0290703; FBgn0038167

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
41673

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG9374

UCSC genome browser

More...
UCSCi
CG9374-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF54972.2
AY069241 mRNA Translation: AAL39386.1
AE014297 Genomic DNA Translation: AAN13580.1
AE014297 Genomic DNA Translation: AAN13581.1
AE014297 Genomic DNA Translation: AAN13582.1
AE014297 Genomic DNA Translation: AAN13583.1
AE014297 Genomic DNA Translation: AAN13584.1
AE014297 Genomic DNA Translation: AAN13585.1
AE014297 Genomic DNA Translation: AAN13586.1
AE014297 Genomic DNA Translation: ACZ94903.1
RefSeqiNP_001163606.1, NM_001170135.2
NP_650302.1, NM_142045.4
NP_731840.1, NM_169541.3
NP_731841.1, NM_169542.3
NP_731842.1, NM_169543.3
NP_731843.1, NM_169544.2
NP_731844.1, NM_169545.3
NP_731845.1, NM_169546.3
NP_731846.1, NM_169547.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ8T9L5, 1 interactor
STRINGi7227.FBpp0082276

Genome annotation databases

EnsemblMetazoaiFBtr0082808; FBpp0082276; FBgn0038167
FBtr0082809; FBpp0082277; FBgn0038167
FBtr0082810; FBpp0082278; FBgn0038167
FBtr0082811; FBpp0082279; FBgn0038167
FBtr0082812; FBpp0082280; FBgn0038167
FBtr0082813; FBpp0082281; FBgn0038167
FBtr0082814; FBpp0082282; FBgn0038167
FBtr0082815; FBpp0082283; FBgn0038167
FBtr0301488; FBpp0290703; FBgn0038167
GeneIDi41673
KEGGidme:Dmel_CG9374
UCSCiCG9374-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
41673
FlyBaseiFBgn0038167, Lkb1

Phylogenomic databases

eggNOGiKOG0583, Eukaryota
GeneTreeiENSGT00940000158050
HOGENOMiCLU_000288_1_1_1
OMAiDPWRSMT
OrthoDBi856506at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
41673, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
41673

Protein Ontology

More...
PROi
PR:Q8T9L5

Gene expression databases

BgeeiFBgn0038167, Expressed in adult organism and 34 other tissues

Family and domain databases

CDDicd14119, STKc_LKB1, 1 hit
InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR039154, LKB1_c
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8T9L5_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8T9L5
Secondary accession number(s): Q9VFS7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: December 2, 2020
This is version 188 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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