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Protein

Uridine phosphorylase

Gene

CG3788

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.UniRule annotation

Catalytic activityi

Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi: UMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes uracil from uridine (phosphorylase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Uridine phosphorylase (CG3788)
This subpathway is part of the pathway UMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes uracil from uridine (phosphorylase route), the pathway UMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotationImported, Transferase

Enzyme and pathway databases

ReactomeiR-DME-73614 Pyrimidine salvage
R-DME-73621 Pyrimidine catabolism
UniPathwayiUPA00574; UER00633

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine phosphorylaseUniRule annotation (EC:2.4.2.3UniRule annotation)
Gene namesi
ORF Names:CG3788Imported, Dmel_CG3788Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0034800 CG3788

Subcellular locationi

PTM / Processingi

Proteomic databases

PRIDEiQ8T8S2

Expressioni

Gene expression databases

BgeeiFBgn0034800

Interactioni

Protein-protein interaction databases

IntActiQ8T8S2, 2 interactors
STRINGi7227.FBpp0292517

Structurei

3D structure databases

SMRiQ8T8S2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini89 – 340PNP_UDP_1InterPro annotationAdd BLAST252

Sequence similaritiesi

Belongs to the PNP/UDP phosphorylase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3728 Eukaryota
COG2820 LUCA
GeneTreeiENSGT00390000004400
KOiK00757
OMAiNPCLKCL
OrthoDBiEOG091G0EIO

Family and domain databases

InterProiView protein in InterPro
IPR018016 Nucleoside_phosphorylase_CS
IPR000845 Nucleoside_phosphorylase_d
IPR035994 Nucleoside_phosphorylase_sf
IPR010059 Uridine_phosphorylase_euk
PfamiView protein in Pfam
PF01048 PNP_UDP_1, 1 hit
SUPFAMiSSF53167 SSF53167, 1 hit
TIGRFAMsiTIGR01719 euk_UDPppase, 1 hit
PROSITEiView protein in PROSITE
PS01232 PNP_UDP_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q8T8S2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKSNCSDCT CRLANEVGQL KAIVNAQSRT LAKLVRQMKE GCKKDEEAKE
60 70 80 90 100
STLCGLNPCL KCLQPDILYH LGLNTETTDF PKVFGDVRFV CMGGTPGRME
110 120 130 140 150
NFAYYVMQEI GLKINAATKL RNISEAGQRF SLFKVGPVLC ASHGMGCPSI
160 170 180 190 200
SILLHELIKM MYHAKCKDPV FIRIGTSGGI GVEPGTVIIS SEAIDGRLNP
210 220 230 240 250
VHEILVHGVS VQHASQLDES LADEIKMCHD PCKDKYEAVI GRTLCAHDFY
260 270 280 290 300
EGQSRLDGAF CEYTPEMKKS YLETLQSQQV KNIEMESLAF AALTSRANIR
310 320 330 340 350
GAVVCVAILN RLNGDQIKTP HDVLSKWEKR PQELVARYIR KVLYHNDDDD
360 370
ESEQPEDEAE AGAAGGGDTQ KAPVEEAE
Length:378
Mass (Da):41,660
Last modified:June 1, 2002 - v1
Checksum:i53CAB878BC5660E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF46930.2
AY075301 mRNA Translation: AAL68168.1
AE013599 Genomic DNA Translation: ADV37237.1
RefSeqiNP_001188991.1, NM_001202062.2
NP_611738.1, NM_137894.3
UniGeneiDm.5542

Genome annotation databases

EnsemblMetazoaiFBtr0071995; FBpp0071904; FBgn0034800
FBtr0303465; FBpp0292517; FBgn0034800
GeneIDi37644
KEGGidme:Dmel_CG3788
UCSCiCG3788-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiQ8T8S2_DROME
AccessioniPrimary (citable) accession number: Q8T8S2
Secondary accession number(s): Q9W1X2
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: July 18, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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