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Entry version 123 (26 Feb 2020)
Sequence version 1 (01 Jun 2002)
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Protein

ABC transporter A family member 2

Gene

abcA2

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi520 – 527ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1331 – 1338ATP 2PROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DDI-1369062 ABC transporters in lipid homeostasis
R-DDI-2453902 The canonical retinoid cycle in rods (twilight vision)
R-DDI-382556 ABC-family proteins mediated transport
R-DDI-5683826 Surfactant metabolism
R-DDI-6798695 Neutrophil degranulation
R-DDI-8963896 HDL assembly

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.1.211.19 the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ABC transporter A family member 2
Alternative name(s):
ABC transporter ABCA.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:abcA2
ORF Names:DDB_G0267438
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyosteliaDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0267438 abcA2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Transmembranei276 – 296HelicalSequence analysisAdd BLAST21
Transmembranei309 – 329HelicalSequence analysisAdd BLAST21
Transmembranei338 – 358HelicalSequence analysisAdd BLAST21
Transmembranei365 – 385HelicalSequence analysisAdd BLAST21
Transmembranei405 – 425HelicalSequence analysisAdd BLAST21
Transmembranei856 – 876HelicalSequence analysisAdd BLAST21
Transmembranei1033 – 1053HelicalSequence analysisAdd BLAST21
Transmembranei1083 – 1103HelicalSequence analysisAdd BLAST21
Transmembranei1111 – 1131HelicalSequence analysisAdd BLAST21
Transmembranei1142 – 1162HelicalSequence analysisAdd BLAST21
Transmembranei1183 – 1203HelicalSequence analysisAdd BLAST21
Transmembranei1227 – 1247HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003638341 – 1621ABC transporter A family member 2Add BLAST1621

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8T6J5

PRoteomics IDEntifications database

More...
PRIDEi
Q8T6J5

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8T6J5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini484 – 717ABC transporter 1PROSITE-ProRule annotationAdd BLAST234
Domaini1293 – 1528ABC transporter 2PROSITE-ProRule annotationAdd BLAST236

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi315 – 325Poly-LeuAdd BLAST11
Compositional biasi1266 – 1269Poly-Pro4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0059 Eukaryota
COG1131 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000604_19_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8T6J5

KEGG Orthology (KO)

More...
KOi
K05643

Identification of Orthologs from Complete Genome Data

More...
OMAi
QLKGRSW

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8T6J5

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR026082 ABCA
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR19229 PTHR19229, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8T6J5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGEFKSQLRT LLKKNLLLKG KSKCAICCEI LFPIIVILVI FAILVLVMAF
60 70 80 90 100
KANYDPYNAS NFVNRFENTV LLYGNADGAL NVEQLGVMNI LKNEVATAKN
110 120 130 140 150
LNSTQIDQLF IEINDQTAME AFFQNKSDFV FSAVWFNNSA LSSGTNPFQY
160 170 180 190 200
NIRVDSDDVM DTEELIKEDD TSDSEVYVKK RFVATQVAMD QAIFSYFGLN
210 220 230 240 250
KTLNVKGQRY PDPWTELWQK WIQGRDGIFK DAGSVFITAA LMIFGFRLIT
260 270 280 290 300
DLVIEKETKI RESMKMMGLN DLAYFISWMI TSLVTALPVN LIISIILKGS
310 320 330 340 350
SVIHHTNWGV VIFTLILYLL TLLLLAFILS MFFDKSKFCG LLSFVIIIAI
360 370 380 390 400
NIGGIFVAKY DFAPGAKLFL CLISPIAIAC SIFAMSARDL EEINTYNWDM
410 420 430 440 450
MVTENQVIGM LVLDIFFYIF LVWYLDNVVT TEFGTKQKWY FLFTKKYWFP
460 470 480 490 500
KKCNENGDEQ DIESTYQNED VEMTPVGVGQ KVTISIRNLR KEYNTGDGLR
510 520 530 540 550
VAVNDLYLDM YENQIHALLG PNGSGKSTTI GMMTGLTPPT NGNAFVHGYG
560 570 580 590 600
ILNQMSSVRK HLGVCPQTDI IWQQLTVLDH LKIYASLKGV SPSEIQREAE
610 620 630 640 650
KMAVEVDLGE KIHSQAGSLS GGQKRKLCLG IAFIGRSDVI FLDEVSSGMD
660 670 680 690 700
PLSRRVVWDF LLKYKKGRTI ILTTHYLEEA DYLGDRIAII SHGKLRCDGS
710 720 730 740 750
SLYLKNKFGC GYLLTCSKIL SSMNNFNAQQ VTEFIHNYIP EATILSNAGT
760 770 780 790 800
ELSYRLPTAS LPHFAQFFRE FDDRLQSFGL LTYGISVTTL EEVFLSLGRE
810 820 830 840 850
AALEKGGFNI DQNENQDLEQ LRKSIAISST GVKAGQQFKG LLIKRIKTSI
860 870 880 890 900
KDAKSFFLTL VIPLVFIIGS IIMYKAMDKP QIFYNNATVP LTMNLGIYSG
910 920 930 940 950
LENNFVPMQS SNELNWENSL NSSPYFNKFR FIPQTENFED YLIEGKTNGS
960 970 980 990 1000
FAYKSSAGAI NFTLPIDVSS TTIDYTAFYN KDYIHSLPVH INLVNDAVLR
1010 1020 1030 1040 1050
KHNNIGIQVT NMPFKHVLSN FDLASEGMNI SSIVYFIIIM MAGYALMAGS
1060 1070 1080 1090 1100
FAGNVAQERT NRVKRLLYIS GCKKYVYWLS NLVWDYFFSF ILILLTTCIL
1110 1120 1130 1140 1150
AGIRENYKSQ FGLMFLCLIL FCVSVVPLSY LLSYRFASFG KATGAITAIH
1160 1170 1180 1190 1200
FAIGIIFVII SLNLRIQVLI DQDVDFQKAA DAVDIVFCIL SPLFAYSRIL
1210 1220 1230 1240 1250
FLVSEFPGSV RVGTLKVDNY WSMDYGGSPM IILAAHCIVW VSWIMILDYT
1260 1270 1280 1290 1300
PELIGKIRNP KNIEAPPPPD DEDSDVTAER TRLLSVGPND EPLQFRNLHK
1310 1320 1330 1340 1350
LFPAVGKAAP KAAVYNSTLS IPKGQTFGLL GLNGAGKTTT IAMLCGDIVP
1360 1370 1380 1390 1400
SSGEVTINGH DLITDRGQAL RSNGLCPQFD ALITLLSARE QLTLYCAIKG
1410 1420 1430 1440 1450
VPEDKVKEVV EAFIKMMDLG AIANSNTGGY SGGNKRKTSL SIAMLGNPSI
1460 1470 1480 1490 1500
VSLDEPSTGC DAVVRKYIWN VVSELAKDKV IILTSHSMAE VEALCYRMTI
1510 1520 1530 1540 1550
MRDGKMKCLG SIQHIKSKFG AGYTFDVKFK KEYLDSGIQT VLKAIPNSIV
1560 1570 1580 1590 1600
LDEHDVMASF EIPNPPDNPV KISTLFESLS HLTILDDYNV SQTSLESVFL
1610 1620
KLTGASYEDR LNLNNQKHTS D
Length:1,621
Mass (Da):181,214
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE1CA0A8FA25358A2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF465304 Genomic DNA Translation: AAL85295.1
AAFI02000003 Genomic DNA Translation: EAL73171.1

NCBI Reference Sequences

More...
RefSeqi
XP_647274.1, XM_642182.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL73171; EAL73171; DDB_G0267438

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8616081

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0267438

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF465304 Genomic DNA Translation: AAL85295.1
AAFI02000003 Genomic DNA Translation: EAL73171.1
RefSeqiXP_647274.1, XM_642182.1

3D structure databases

SMRiQ8T6J5
ModBaseiSearch...

Protein family/group databases

TCDBi3.A.1.211.19 the atp-binding cassette (abc) superfamily

Proteomic databases

PaxDbiQ8T6J5
PRIDEiQ8T6J5

Genome annotation databases

EnsemblProtistsiEAL73171; EAL73171; DDB_G0267438
GeneIDi8616081
KEGGiddi:DDB_G0267438

Organism-specific databases

dictyBaseiDDB_G0267438 abcA2

Phylogenomic databases

eggNOGiKOG0059 Eukaryota
COG1131 LUCA
HOGENOMiCLU_000604_19_1_1
InParanoidiQ8T6J5
KOiK05643
OMAiQLKGRSW
PhylomeDBiQ8T6J5

Enzyme and pathway databases

ReactomeiR-DDI-1369062 ABC transporters in lipid homeostasis
R-DDI-2453902 The canonical retinoid cycle in rods (twilight vision)
R-DDI-382556 ABC-family proteins mediated transport
R-DDI-5683826 Surfactant metabolism
R-DDI-6798695 Neutrophil degranulation
R-DDI-8963896 HDL assembly

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8T6J5

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR026082 ABCA
IPR027417 P-loop_NTPase
PANTHERiPTHR19229 PTHR19229, 1 hit
PfamiView protein in Pfam
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiABCA2_DICDI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8T6J5
Secondary accession number(s): Q55GB0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: June 1, 2002
Last modified: February 26, 2020
This is version 123 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
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