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UniProtKB - Q8T6B9 (PUF68_DROME)

Entry version 162 (02 Dec 2020)
Sequence version 2 (02 Feb 2004)
Previous versions | rss
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Protein

Poly(U)-binding-splicing factor half pint

Gene

hfp

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Splicing factor that regulates oogenesis and controls both mitosis and mRNA localization in the germline by regulating mRNA splicing of a subset of genes within the ovary. Probably acts by regulating the alternative splice site selection of the otu transcript. Also regulates the alternative splicing of eIF4E1 and grk, while it is not involved in the splicing of par-1, sqd and psq.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, RNA-binding
Biological processDifferentiation, mRNA processing, mRNA splicing, Oogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-72163, mRNA Splicing - Major Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Poly(U)-binding-splicing factor half pint1 Publication
Short name:
Protein half pint1 Publication
Alternative name(s):
68 kDa poly(U)-binding-splicing factorCurated
PUF60 homolog1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hfp1 PublicationImported
Synonyms:pUf681 Publication
ORF Names:CG12085Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0028577, hfp

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000817441 – 637Poly(U)-binding-splicing factor half pintAdd BLAST637

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei13Phosphoserine1 Publication1
Modified residuei30Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8T6B9

PRoteomics IDEntifications database

More...PRIDEi		Q8T6B9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8T6B9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all germline cells and within the follicle cell.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0028577, Expressed in brain and 47 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8T6B9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8T6B9, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with enc. However, given the cytoplasmic localization of enc, the relevance of such interaction is unclear.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		63711, 56 interactors

Protein interaction database and analysis system

More...IntActi		Q8T6B9, 15 interactors

Molecular INTeraction database

More...MINTi		Q8T6B9

STRING: functional protein association networks

More...STRINGi		7227.FBpp0072593

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8T6B9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini130 – 208RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini227 – 305RRM 2PROSITE-ProRule annotationAdd BLAST79
Domaini537 – 627RRM 3; atypicalPROSITE-ProRule annotationAdd BLAST91

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi322 – 479Ala-richAdd BLAST158

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The third RNA recognition motif, called PUMP domain in PubMed:10606266, is atypical and may rather mediate protein-protein interactions.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RRM half pint family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0124, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155594

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8T6B9

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8T6B9

Family and domain databases

Conserved Domains Database

More...CDDi		cd12370, RRM1_PUF60, 1 hit
cd12371, RRM2_PUF60, 1 hit
cd12648, RRM3_UHM_PUF60, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.330, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR006532, PolyU-bd
IPR034209, PUF60_RRM1
IPR034211, PUF60_RRM2
IPR034212, PUF60_RRM3
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR003954, RRM_dom_euk

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00076, RRM_1, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00360, RRM, 3 hits
SM00361, RRM_1, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54928, SSF54928, 2 hits

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01645, half-pint, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50102, RRM, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform A (identifier: Q8T6B9-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGSNDRASRS PRSDDQREIS DMPATKRTRS DSGKSTDSKI PYLSQPLYDL 
        60         70         80         90        100
KQTGDVKFGP GTRSALLGLL GGALPKLSSE QHDLVSKAKK YAMEQSIKMV 
       110        120        130        140        150
LMKQTLAHQQ QQLATQRTQV QRQQALALMC RVYVGSISFE LKEDTIRVAF 
       160        170        180        190        200
TPFGPIKSIN MSWDPITQKH KGFAFVEYEI PEGAQLALEQ MNGALMGGRN 
       210        220        230        240        250
IKVGRPSNMP QAQQVIDEVQ EEAKSFNRIY VASIHPDLSE EDIKSVFEAF 
       260        270        280        290        300
GPILYCKLAQ GTSLHTHKGY GFIEYANKQA MDEAIASMNL FDLGGQLLRV 
       310        320        330        340        350
GRSITPPNAL ACPTTNSTMP TAAAVAAAAA TAKIQALDAV ASNAVLGLSQ 
       360        370        380        390        400
NTPVMAAGAV VTKVGAMPVV SAATSAAALH PALAQAAPAL LPPGIFQAPT 
       410        420        430        440        450
PVAPSLLGVP AGLQPLQAVV PTLPPPALLA TPTLPMTVGG VGVGLVPTVA 
       460        470        480        490        500
TLAGAEASKG AAAAAALSAA ANNAAVTAAN LSENIKKAHE KQQEELQKKL 
       510        520        530        540        550
MDEGDVQTLQ QQENMSIKGQ SARQLVMQRL MRPVDSRVII LRNMVGPEDV 
       560        570        580        590        600
DETLQEEIQE ECSKFGTVSR VIIFNEKQTE NEDDDEAEII VKIFVEFSAG 
       610        620        630 
AEAMRGKEAL DGRFFGGRRV VAELYDQGIF DQGDLSG
Length:637
Mass (Da):67,940
Last modified:February 2, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF0AD184D9EEF145F
GO
Isoform B (identifier: Q8T6B9-2) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: Missing.

Show »
Length:545
Mass (Da):57,989
Checksum:iE75E378F7D07F24E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A4V193A4V193_DROME
Half pint, isoform D
hfp anon-WO0118547.408, dFIR, Dmel\CG12085, DPUF68, Fir
545Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti583D → A in AAL86452 (PubMed:11879639).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0093281 – 92Missing in isoform B. 1 PublicationAdd BLAST92

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF190745 mRNA Translation: AAF04132.1
AF479079 mRNA Translation: AAL86452.1
AE014296 Genomic DNA Translation: AAF47501.1
AE014296 Genomic DNA Translation: AAG22221.1
AY061006 mRNA Translation: AAL28554.1
BT003317 mRNA Translation: AAO25077.1

NCBI Reference Sequences

More...RefSeqi		NP_001163315.1, NM_001169844.2 [Q8T6B9-2]
NP_001163316.1, NM_001169845.2 [Q8T6B9-2]
NP_001163317.1, NM_001169846.2 [Q8T6B9-2]
NP_001163318.1, NM_001169847.2 [Q8T6B9-2]
NP_001163319.1, NM_001169848.2 [Q8T6B9-2]
NP_001163320.1, NM_001169849.2 [Q8T6B9-2]
NP_525123.2, NM_080384.4 [Q8T6B9-1]
NP_728610.1, NM_167880.3 [Q8T6B9-2]
NP_728611.1, NM_167881.3 [Q8T6B9-2]
NP_728612.1, NM_167882.3 [Q8T6B9-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0072707; FBpp0072591; FBgn0028577 [Q8T6B9-2]
FBtr0072708; FBpp0072592; FBgn0028577 [Q8T6B9-2]
FBtr0072709; FBpp0072593; FBgn0028577 [Q8T6B9-1]
FBtr0072710; FBpp0072594; FBgn0028577 [Q8T6B9-2]
FBtr0300416; FBpp0289645; FBgn0028577 [Q8T6B9-2]
FBtr0300417; FBpp0289646; FBgn0028577 [Q8T6B9-2]
FBtr0300418; FBpp0289647; FBgn0028577 [Q8T6B9-2]
FBtr0300419; FBpp0289648; FBgn0028577 [Q8T6B9-2]
FBtr0300420; FBpp0289649; FBgn0028577 [Q8T6B9-2]
FBtr0301523; FBpp0290738; FBgn0028577 [Q8T6B9-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		38173

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG12085

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF190745 mRNA Translation: AAF04132.1
AF479079 mRNA Translation: AAL86452.1
AE014296 Genomic DNA Translation: AAF47501.1
AE014296 Genomic DNA Translation: AAG22221.1
AY061006 mRNA Translation: AAL28554.1
BT003317 mRNA Translation: AAO25077.1
RefSeqiNP_001163315.1, NM_001169844.2 [Q8T6B9-2]
NP_001163316.1, NM_001169845.2 [Q8T6B9-2]
NP_001163317.1, NM_001169846.2 [Q8T6B9-2]
NP_001163318.1, NM_001169847.2 [Q8T6B9-2]
NP_001163319.1, NM_001169848.2 [Q8T6B9-2]
NP_001163320.1, NM_001169849.2 [Q8T6B9-2]
NP_525123.2, NM_080384.4 [Q8T6B9-1]
NP_728610.1, NM_167880.3 [Q8T6B9-2]
NP_728611.1, NM_167881.3 [Q8T6B9-2]
NP_728612.1, NM_167882.3 [Q8T6B9-2]

3D structure databases

SMRiQ8T6B9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi63711, 56 interactors
IntActiQ8T6B9, 15 interactors
MINTiQ8T6B9
STRINGi7227.FBpp0072593

PTM databases

iPTMnetiQ8T6B9

Proteomic databases

PaxDbiQ8T6B9
PRIDEiQ8T6B9

Genome annotation databases

EnsemblMetazoaiFBtr0072707; FBpp0072591; FBgn0028577 [Q8T6B9-2]
FBtr0072708; FBpp0072592; FBgn0028577 [Q8T6B9-2]
FBtr0072709; FBpp0072593; FBgn0028577 [Q8T6B9-1]
FBtr0072710; FBpp0072594; FBgn0028577 [Q8T6B9-2]
FBtr0300416; FBpp0289645; FBgn0028577 [Q8T6B9-2]
FBtr0300417; FBpp0289646; FBgn0028577 [Q8T6B9-2]
FBtr0300418; FBpp0289647; FBgn0028577 [Q8T6B9-2]
FBtr0300419; FBpp0289648; FBgn0028577 [Q8T6B9-2]
FBtr0300420; FBpp0289649; FBgn0028577 [Q8T6B9-2]
FBtr0301523; FBpp0290738; FBgn0028577 [Q8T6B9-2]
GeneIDi38173
KEGGidme:Dmel_CG12085

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		38173
FlyBaseiFBgn0028577, hfp

Phylogenomic databases

eggNOGiKOG0124, Eukaryota
GeneTreeiENSGT00940000155594
InParanoidiQ8T6B9
PhylomeDBiQ8T6B9

Enzyme and pathway databases

ReactomeiR-DME-72163, mRNA Splicing - Major Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		38173, 0 hits in 1 CRISPR screen

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		pUf68, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		38173

Protein Ontology

More...PROi		PR:Q8T6B9

Gene expression databases

BgeeiFBgn0028577, Expressed in brain and 47 other tissues
ExpressionAtlasiQ8T6B9, baseline and differential
GenevisibleiQ8T6B9, DM

Family and domain databases

CDDicd12370, RRM1_PUF60, 1 hit
cd12371, RRM2_PUF60, 1 hit
cd12648, RRM3_UHM_PUF60, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR006532, PolyU-bd
IPR034209, PUF60_RRM1
IPR034211, PUF60_RRM2
IPR034212, PUF60_RRM3
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR003954, RRM_dom_euk
PfamiView protein in Pfam
PF00076, RRM_1, 2 hits
SMARTiView protein in SMART
SM00360, RRM, 3 hits
SM00361, RRM_1, 2 hits
SUPFAMiSSF54928, SSF54928, 2 hits
TIGRFAMsiTIGR01645, half-pint, 1 hit
PROSITEiView protein in PROSITE
PS50102, RRM, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPUF68_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8T6B9
Secondary accession number(s): Q0E8J8
, Q95S11, Q9U696, Q9W0E6, Q9W0E7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: February 2, 2004
Last modified: December 2, 2020
This is version 162 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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