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Entry version 71 (12 Aug 2020)
Sequence version 1 (01 Jun 2002)
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Protein

Midasin

Gene

MDN1

Organism
Giardia intestinalis (Giardia lamblia)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits. Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi31 – 38ATPPROSITE-ProRule annotation8
Nucleotide bindingi356 – 363ATPSequence analysis8
Nucleotide bindingi814 – 821ATPSequence analysis8
Nucleotide bindingi1127 – 1134ATPSequence analysis8
Nucleotide bindingi1513 – 1520ATPSequence analysis8
Nucleotide bindingi1839 – 1846ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Midasin
Alternative name(s):
Dynein-related AAA-ATPase MDN1
MIDAS-containing protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MDN1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGiardia intestinalis (Giardia lamblia)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5741 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetamonadaDiplomonadidaHexamitidaeGiardiinaeGiardia

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000963351 – 4835MidasinAdd BLAST4835

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q8T5T1

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with pre-60S ribosomes in the nucleoplasm.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5741.EDO76863

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8T5T1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4629 – 4818VWFAPROSITE-ProRule annotationAdd BLAST190

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni12 – 161AAA-ATPase protomer 1Sequence analysisAdd BLAST150
Regioni324 – 689AAA-ATPase protomer 2Sequence analysisAdd BLAST366
Regioni797 – 1049AAA-ATPase protomer 3Sequence analysisAdd BLAST253
Regioni1096 – 1375AAA-ATPase protomer 4Sequence analysisAdd BLAST280
Regioni1489 – 1738AAA-ATPase protomer 5Sequence analysisAdd BLAST250
Regioni1821 – 2110AAA-ATPase protomer 6Sequence analysisAdd BLAST290
Regioni2197 – 4058LinkerBy similarityAdd BLAST1862

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi110 – 113Poly-Leu4
Compositional biasi3004 – 3007Poly-Leu4
Compositional biasi4031 – 4417Asp/Glu-richSequence analysisAdd BLAST387
Compositional biasi4156 – 4161Poly-Asn6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the midasin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1808, Eukaryota

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR040848, AAA_lid_7
IPR011704, ATPase_dyneun-rel_AAA
IPR012099, Midasin
IPR041190, Midasin_AAA_lid_5
IPR027417, P-loop_NTPase
IPR002035, VWF_A
IPR036465, vWFA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07728, AAA_5, 5 hits
PF17865, AAA_lid_5, 1 hit
PF17867, AAA_lid_7, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF010340, Midasin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 6 hits
SSF53300, SSF53300, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50234, VWFA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8T5T1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGYFTDLQN AEVLRAAESI VSSGQAVLLC GPSASGRTAL LSHLASKLGA
60 70 80 90 100
KPPIPLHLTT AQDTRDLIGS YVMTNKPGDF RFILGPLAYA AQSGRWISIE
110 120 130 140 150
EITTISQDSL LLLSSVVNTR TLSVGSYQIS VHPDFRIHAK TSADPALLST
160 170 180 190 200
IVKSMFYPLV LPPLGNHLFQ VLTKHCNRGI CTILAHIHVQ FETHRLTAGR
210 220 230 240 250
ISASDMVKWA RRIDLDLKNG GAVLNKAVQE ASAGTAATTL VSWLDDNTRM
260 270 280 290 300
VMIKNAWEAF VLRYSKEQTR RAFLDILRLS LNIHEELMLS TLLKIKVDIR
310 320 330 340 350
HDYTQKRLVC GRVSLPFYES PDERSLDDIC RTNHTTRLLE IISSAIRNNE
360 370 380 390 400
PLLLVGPTGI GKTTCLQVIA RALGKKLHVV NMSSQTDAAD LLGGYVPATL
410 420 430 440 450
DRILRNLYDA ITGSLGLYIS VRKNQIFVTE LHKSYAEKDI AKFLANCETA
460 470 480 490 500
LSGMRQVLRK EVGEVVEQGS TEQRVSHDKK YARRGTYENS LYFLQSLGDT
510 520 530 540 550
LEQATELHKI LCHEVETKKP TMAFKYQEGL LVQALVKGDW ILIDEINLAS
560 570 580 590 600
YDLLDVISQL VNPEHNEIAI PDKGFVAKNP HFRVFAAMNP GSDVGKKDLP
610 620 630 640 650
PTIRRCFTEI NVSEMSDDVD IVALTKSYLR MDDAMIEDRQ GLDPNVVYQL
660 670 680 690 700
FTVLKARAKT DLVTAAEAKS PCFSLRSLCR ALSFAHRFRA AAGLRRSMYE
710 720 730 740 750
GFMLAFGSML NEKSRQAVHA LILDKLLNGN KEYLLNPFII QPFNKPCTAM
760 770 780 790 800
IFQATTKDEA VTVEYQEPQA AHGFLEEEKS RARSTDYVLT KSTRSYMTTI
810 820 830 840 850
SRAIAAQLPI LLEGTTSSGK TSLIKHIAKQ FGCPITRINN HEHTDLSEYF
860 870 880 890 900
GSYQPDPLTG QLVFKDGPLV TGMKQGHWVI LDELNMASSE ILEALNRLLD
910 920 930 940 950
DNRELLVPDT QEIVRPAPGF LLFATQNPSG SYAGRKMLSE AFQNRFIMIE
960 970 980 990 1000
FADISTEELK EILINRSTSR HLAPQYCEKL ITTIQAIKMQ LSHRNNNAVM
1010 1020 1030 1040 1050
TNALITLRDL FRVADRLPRT LTELAMGIFE LIGERQRDPA DKQLVAEIIA
1060 1070 1080 1090 1100
KNLGLKTFSV SAAEQEYAIR VRPIQSMIEK ALKAGADSPK SAFLLKFQDI
1110 1120 1130 1140 1150
VWTPSMIRLF ALLFTSVSNG ESPLLVGVSG AGKTTSVELI AAIMAQQLVQ
1160 1170 1180 1190 1200
VNLHKHTESA DFIGSLRPLR SRESMHAHLS VLKEYAATTT NVDKAVYAEI
1210 1220 1230 1240 1250
KRLETTLGTK LFEWEDGPIL NCMKRGHILL LDEVSLADES VLERLNSVLE
1260 1270 1280 1290 1300
TSRELTVAEN PNMPRPVIAH TGFKLIATMN PAGDYGKKEL SPAMRSRLTE
1310 1320 1330 1340 1350
FWMPHIRDIN EVRMILTRKL QKTAIYRLGH QQGLDVVSLL ADFFAEMDRI
1360 1370 1380 1390 1400
TQSGRLGDVF TLSIRDILAV CDYITEVQTK EGTELGQMLI DAVTLSILDG
1410 1420 1430 1440 1450
LPVRTQLGNM PACREVKHEM VLYLANRILS ANLTDIDLIQ DLTVSISKDT
1460 1470 1480 1490 1500
NELTFLQAST QTVLATIPPG PQYNHAKALR KMTSFRLDAP TTIKNACRIA
1510 1520 1530 1540 1550
KALRFQRPIL LEGDPGVGKS ALVSAIAEIC GYSLVRINLS EQTDLSDLLG
1560 1570 1580 1590 1600
SDLPAENGFR WVDGVLLKAV KEGAFILLDE LNLANQTVLE GLNSLLDHRR
1610 1620 1630 1640 1650
SLFIPELMLS VKSPDTLRIF GTQNPRSQGS GRKGLPQSFI NRFLNVYVDV
1660 1670 1680 1690 1700
LKSQDYDWIL SNLFTDIPTY VLDYILGSTK QLRAGLEELK FGISGGPWEL
1710 1720 1730 1740 1750
NVRDMMRLCD MLTTTPGLAQ GITLAHAKHY AHILFGYRFR TADDDAYVQN
1760 1770 1780 1790 1800
VLFSPHSLDS VAEATQSHHW YSLRPLWNVT EDVVKIGSLA IPRIDPVFRD
1810 1820 1830 1840 1850
VLGTKLSYAH TSCFLTAQLV ALEALAVAVT QNLSCILVGS PESGKSSILR
1860 1870 1880 1890 1900
TLADVVRQPL VHISASTATD VSDLIGAYEQ VDVLYDLKSV IRDLCLFVHS
1910 1920 1930 1940 1950
LPIKASYSAI SFSEFLKDLT ASLDREIGDG LGSKSRAISM ESIVSEVVQK
1960 1970 1980 1990 2000
LLLEFMAKFS PDLDSGGLAA KNFSLFCSEI LTQDTTPVDE RFSPHMPTIP
2010 2020 2030 2040 2050
ELCKSMASLY LSTQQSQTGR FVWRDSELIR ALERGYWVEL TNANFCMPSV
2060 2070 2080 2090 2100
LDRLNSLLER GGGLEILEQG LEETRSIKVH PNFRLFISYA PTSDISRALR
2110 2120 2130 2140 2150
NRSLELSIDI QVSHYNLLDI VRCVYTSSTA SGVSLDPYLI KLVSLVYFEL
2160 2170 2180 2190 2200
SRDNPEIVGL GLLFKWLKLL VTYHKRFSTS VGDPKAVSSW VDRSFSSVFI
2210 2220 2230 2240 2250
ASTLNADLHR QYMQVYQNAR LALQGDGSLE ACTLVEAAAV LNQLTLGAVR
2260 2270 2280 2290 2300
KLSISNSLQH SLALLELRTT VKPLDQLVSL ADQEPQIMEP FSQVSGWLAI
2310 2320 2330 2340 2350
CVGHSLDFQH HKELVSNLLT STDINPMYLL TPPEPSSQAL LKYISQGYLD
2360 2370 2380 2390 2400
MYSSPDSIIH QVIKYVSLCS PFYASILKLF IEGKFTTKDS YLLLYLIELS
2410 2420 2430 2440 2450
QHLATDPNNY DYVALFFSLF ELLISHSIDP STKTYSLGQR QVMRTFFDMI
2460 2470 2480 2490 2500
LTDQYFESMP RLLSGYIRSL FISAARNDLE TAWLAVRKNL ALARISVHYL
2510 2520 2530 2540 2550
PELFKVFRYV IERLNLCISP EGVVFLQEGL SDSITASLWK DILATVIYMA
2560 2570 2580 2590 2600
CRADDQTGDY VPKLAILQDS ANRIDLCASK LSGNQHPTAR ALAQMQSLFL
2610 2620 2630 2640 2650
LFTGKAFCMQ VSDTLEGWSQ RDLTTQLPIL LFRSMSFYHR NAAGPITYLR
2660 2670 2680 2690 2700
GPIFVSTGEF VTSSLSVPAL LTNAIEEQAT SVLKSLLCRS EDFLSYVGNV
2710 2720 2730 2740 2750
INSITTIVLR LFFAALEREA PSCDFTDGSF QLFALILETI VHSSNPLLAS
2760 2770 2780 2790 2800
LTQGVEDILK AIISVQLSPS PLLLSGLVLT VASLVLYLLT SIANQRDPIV
2810 2820 2830 2840 2850
MTKHREVLYR RLAKLIATSI EDSKLHALFV FGDGALSESS SIYKELSTLY
2860 2870 2880 2890 2900
NSYAEAADQY AAELLVRADD EDNTFFEDLS SQLASLDGFE VHVLTFVSGV
2910 2920 2930 2940 2950
LNLEKVLQMH ESTECIEAIL DGLAVAERQI STTLAALLPR LINYTVESSY
2960 2970 2980 2990 3000
YLDMTIPIAS FLMCLRVGLS AVISSVYAHV CDAINAARRL SSEGIGLQIT
3010 3020 3030 3040 3050
LQDLLLLIQR VVVGTGDEFL DLLCYDKFIR SCCSSKTVST LHVARLFTLS
3060 3070 3080 3090 3100
LLQYSSCSKG VQGDVSQFLL ADTLRPERVS SIAAQFEIEE ARSYRKYIAD
3110 3120 3130 3140 3150
HSIFKTRNQS STAEGVSEED ELKTQIAALF PKNDSHFIKS DTSSDDEQPI
3160 3170 3180 3190 3200
SMSAQTKVDY DDAYATSFFT RMNMILIIGN CILHLYTSDT EALPIQERLQ
3210 3220 3230 3240 3250
NLSSILQAHV PHLSRPLVAL QAVTYALSIC AGGVSSNLSI RSPLTPETDR
3260 3270 3280 3290 3300
LMYPLVTGAT MGLVRVLSSR SPNVDYAKLQ TGKTRRAIHC EDIYSRPYPY
3310 3320 3330 3340 3350
ETAEFCSTLL RKIIVRTQHL LTEWPDNVQL LDIMHVCDKL MELPVLEAPL
3360 3370 3380 3390 3400
VMFLTGAEVL VRHLETWDKG APAVYKYVTN PNVPVPESLT KSLIHLMVTW
3410 3420 3430 3440 3450
RRVELMSWNG FFSRVHTQFS NVSLTYWPEL LIASLTYQRS VTQGEPSTEA
3460 3470 3480 3490 3500
YYAQMREFLY ESNVGEFPVR LKLLYTLSAL LSNIEELAEP ELVSSPHKTM
3510 3520 3530 3540 3550
TSAVLFSIAS EAVEFAKYMN KEFEEEAAQI KKRFEDQIRI FEWNERSSYT
3560 3570 3580 3590 3600
SWLTAQNSHR LCTKIIREYT EVLQHATRAF HMGYSATYDR IPLSVTVQEY
3610 3620 3630 3640 3650
LPLSSESGML PPALSQELVE RLNYCVEQMC HGRKESETLK RNEKNRLLSD
3660 3670 3680 3690 3700
VLDVLKETLG CVLSSGFAFK QSFGWKLAHL CLPSVHSTFE LMHMFHDSLC
3710 3720 3730 3740 3750
QRCNEVEPHD IERMKRIIAC LNQVFVQLSE LVVELADIEL LSRVMRTAPT
3760 3770 3780 3790 3800
GSSKSQADSV LYVYLADNSV PQLLTTQVMS HVTKAHKMCM SLQEFLIGLP
3810 3820 3830 3840 3850
LDSCKSSPTK LHEQIGGFLE RFSADSVTAL NRIKIFSKFS ALIKRLCSIT
3860 3870 3880 3890 3900
LIPLAFFEEA KAILQQILAD LSPIFSALIA VLPTAPISTF VTEHAKYLAQ
3910 3920 3930 3940 3950
VTEVIDTLTE TAAQCRVEEA ATVSSIEWPY FALPFASVGE EGLSVEIIVD
3960 3970 3980 3990 4000
NAKKQVSAYM TAFFTSTLQP ILQCATRHVV SLPVLPQKLL CQIETLKGDM
4010 4020 4030 4040 4050
QALADVLAKF IGPLISGAIA LLRTGFHCHV DDDQKETDND NQSGLGLGDG
4060 4070 4080 4090 4100
TGDQNVSKEA AKELCEDDLM GNQNDRDQQE QQEKDGDDEA IEMQNDFGGM
4110 4120 4130 4140 4150
SESLHHDIEE EDSNGSDEEE VLEKEMGDEQ GEAIDERNYN EDDDSAEEYS
4160 4170 4180 4190 4200
DEQKKNTNNN NDTMELAAQE KDQDSINSEL SDPSGEQHEE QADATGSTDE
4210 4220 4230 4240 4250
QAQEDDYNDL DDKNLSGQSD LSVPEADGED ETVNEELEEE QQQMSDLSNP
4260 4270 4280 4290 4300
DQDACAIEED DDRDLPSSDE NAEEHDEHEA PVDIDDNEAS DEQSTYNDND
4310 4320 4330 4340 4350
RDDAINISAQ QQATNDEEEM QKDTEYDQEN ITDSNPDANE VGTNDQKQTH
4360 4370 4380 4390 4400
EDNDQFRQEN IEDQWEAEST ENSQGEGAES ADLKEGNPDM SLEEFQRIWK
4410 4420 4430 4440 4450
ERLNIHDRES EKDEAAEPQD MPLQSNKTVE FDDSKSGRDG ALGLTESKHR
4460 4470 4480 4490 4500
NLTNQEFDNP NEERNVEHNS SCETSQSSHD RPPAEHLNPE ISDEGEESST
4510 4520 4530 4540 4550
ASDKQEQAVL SHMRESSKDL LNPEGEVYQE LAVSLASEET KRAPEDVAAA
4560 4570 4580 4590 4600
SARGNHLLLD LIKQTSAAAF SLAERLRIIL EPTVTSDLKG DFRTGKKLNL
4610 4620 4630 4640 4650
RRIIPFIASE FQKDKIWLRR TKPSKRVYQV LLAVDDSSSM APIAKYALQA
4660 4670 4680 4690 4700
ITLLFNACKF LEVGQLSVFS FGQKFELLLP ITDQYNDASL AYAIGSFTFA
4710 4720 4730 4740 4750
QNETRVSDAI SIASDYLDSV RFFKGSDSAL QLLLMISDGR LKEKGGVARE
4760 4770 4780 4790 4800
IRKCMGRGQL PVLIVLDTDK KSIMDIKSVS FITDSSGKRV RQTSMYLDDF
4810 4820 4830
PFQCYALLRH IEDLPETLVA VIKRWIESVS VYNAV
Length:4,835
Mass (Da):539,740
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3A9E12417DB04A50
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF494287 Genomic DNA Translation: AAM12656.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF494287 Genomic DNA Translation: AAM12656.1

3D structure databases

SMRiQ8T5T1
ModBaseiSearch...

Protein-protein interaction databases

STRINGi5741.EDO76863

Proteomic databases

PRIDEiQ8T5T1

Phylogenomic databases

eggNOGiKOG1808, Eukaryota

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR040848, AAA_lid_7
IPR011704, ATPase_dyneun-rel_AAA
IPR012099, Midasin
IPR041190, Midasin_AAA_lid_5
IPR027417, P-loop_NTPase
IPR002035, VWF_A
IPR036465, vWFA_dom_sf
PfamiView protein in Pfam
PF07728, AAA_5, 5 hits
PF17865, AAA_lid_5, 1 hit
PF17867, AAA_lid_7, 1 hit
PIRSFiPIRSF010340, Midasin, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 5 hits
SUPFAMiSSF52540, SSF52540, 6 hits
SSF53300, SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50234, VWFA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMDN1_GIAIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8T5T1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: June 1, 2002
Last modified: August 12, 2020
This is version 71 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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