UniProtKB - Q8T5C6 (RXR_BIOGL)
Retinoic acid receptor RXR
RXR
Functioni
Ligand-dependent transcription factor probably involved in the retinoic acid response pathway. Binds 9-cis-retinoic acid (9C-RA) and, to a lesser extent, docosahexaenoic acid (DHA), phytanic acid, methoprene acid and oleic acid. Binds to double-stranded DNA sequences containing direct repeats (DR) with the consensus sequence 5'-[AG]GGTCA-3' and 1, 2, 3, 4 or 5 nucleotides in between (DR1, DR2, DR3. DR4 and DR5, respectively). Binding to DR1 is strongest. Transactivates gene expression when 9C-RA or DHA is bound.
1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 117 – 182 | Nuclear receptorPROSITE-ProRule annotationBy similarityAdd BLAST | 66 | |
Zinc fingeri | 117 – 137 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 153 – 172 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 20 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: InterPro
- retinal binding Source: UniProtKB-KW
- sequence-specific DNA binding Source: InterPro
- steroid hormone receptor activity Source: InterPro
- zinc ion binding Source: InterPro
Keywordsi
Molecular function | DNA-binding, Receptor |
Biological process | Transcription, Transcription regulation |
Ligand | Lipid-binding, Metal-binding, Vitamin A, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Retinoic acid receptor RXRAlternative name(s): RXR-like proteinImported Retinoid X receptor2 Publications Short name: BgRXR2 Publications |
Gene namesi | Name:RXRImported |
Organismi | Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail) |
Taxonomic identifieri | 6526 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Spiralia › Lophotrochozoa › Mollusca › Gastropoda › Heterobranchia › Euthyneura › Panpulmonata › Hygrophila › Lymnaeoidea › Planorbidae › Biomphalaria |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | VectorBase:BGLB010204 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation1 Publication
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000394456 | 1 – 436 | Retinoic acid receptor RXRAdd BLAST | 436 |
Interactioni
Subunit structurei
Homodimer (via ligand-binding domain). Heterodimer (Probable). Homotetramer consisting of 2 canonical homodimers. Within the tetramer, each monomer binds one molecule of 9C-RA and a NCOA1-derived peptide containing an L-X2-L-L motif (Probable).
Curated2 PublicationsProtein-protein interaction databases
STRINGi | 6526.Q8T5C6 |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q8T5C6 |
SMRi | Q8T5C6 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8T5C6 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 209 – 432 | NR LBDPROSITE-ProRule annotation1 PublicationAdd BLAST | 224 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 116 | ModulatingBy similarityAdd BLAST | 116 | |
Regioni | 1 – 108 | DisorderedSequence analysisAdd BLAST | 108 | |
Regioni | 183 – 206 | HingeBy similarityAdd BLAST | 24 | |
Regioni | 189 – 209 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 239 – 249 | 9-cis-retinoic acid-binding1 PublicationAdd BLAST | 11 | |
Regioni | 279 – 290 | 9-cis-retinoic acid-binding1 PublicationAdd BLAST | 12 | |
Regioni | 299 – 301 | 9-cis-retinoic acid-binding1 Publication | 3 | |
Regioni | 316 – 323 | 9-cis-retinoic acid-binding1 Publication | 8 | |
Regioni | 406 – 413 | 9-cis-retinoic acid-binding1 Publication | 8 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 60 – 92 | Polar residuesSequence analysisAdd BLAST | 33 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 117 – 137 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 153 – 172 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 20 |
Keywords - Domaini
Zinc-fingerFamily and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
IDEALi | IID50154 |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR000003, Retinoid-X_rcpt/HNF4 IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00545, RETINOIDXR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MDRSEGMDTL ENSMPSGMSM GMTMGGHQGH PPPDIKPDIS SLTSPTSTHG
60 70 80 90 100
YYGFGPGGMP SMASSTQPSP GPQQMHSPGM HSPTSSMGSP PMLCLSPSGP
110 120 130 140 150
SPSPGLPHSS LHTKHICAIC GDRASGKHYG VYSCEGCKGF FKRTVRKDLT
160 170 180 190 200
YACRDDKNCM IDKRQRNRCQ YCRYMKCLSM GMKREAVQEE RQRVKEKGDG
210 220 230 240 250
EVESTSGANN DMPVEQILEA ELAVDPKIDT YIDAQKDPVT NICQAADKQL
260 270 280 290 300
FTLVEWAKRI PHFTELPLED QVILLRAGWN ELLIAGFSHR SIMAKDGILL
310 320 330 340 350
ATGLHVHRSS AHQAGVGTIF DRVLTELVAK MRDMKMDKTE LGCLRAVVLF
360 370 380 390 400
NPDAKGLTAV QEVEQLREKV YASLEEYTKS RYPEEPGRFA KLLLRLPALR
410 420 430
SIGLKCLEHL FFFKLIGDQP IDTFLMEMLE NPSPAT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY048663 mRNA Translation: AAL86461.1 |
RefSeqi | NP_001298239.1, NM_001311310.1 |
Genome annotation databases
GeneIDi | 106073343 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY048663 mRNA Translation: AAL86461.1 |
RefSeqi | NP_001298239.1, NM_001311310.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1XIU | X-ray | 2.50 | A/B | 207-436 | [»] | |
AlphaFoldDBi | Q8T5C6 | |||||
SMRi | Q8T5C6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 6526.Q8T5C6 |
Genome annotation databases
GeneIDi | 106073343 |
Organism-specific databases
VEuPathDBi | VectorBase:BGLB010204 |
Miscellaneous databases
EvolutionaryTracei | Q8T5C6 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
IDEALi | IID50154 |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR000003, Retinoid-X_rcpt/HNF4 IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00545, RETINOIDXR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RXR_BIOGL | |
Accessioni | Q8T5C6Primary (citable) accession number: Q8T5C6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 15, 2010 |
Last sequence update: | June 1, 2002 | |
Last modified: | May 25, 2022 | |
This is version 109 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families