Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 158 (02 Dec 2020)
Sequence version 4 (07 Jul 2009)
Previous versions | rss
Add a publicationFeedback
Protein

Protein enabled

Gene

ena

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions, together with Abl, trio and fra, in a complex signaling network that regulates axon guidance at the CNS midline. Required in part for robo-mediated repulsive axon guidance. May be involved in lamellipodial dynamics.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-446353, Cell-extracellular matrix interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein enabled
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ena
Synonyms:enb
ORF Names:CG15112
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0000578, ena

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002277571 – 980Protein enabledAdd BLAST980

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei425Phosphotyrosine1 Publication1
Modified residuei607Phosphotyrosine1 Publication1
Modified residuei625Phosphotyrosine1 Publication1
Modified residuei650Phosphotyrosine1 Publication1
Modified residuei666Phosphotyrosine1 Publication1
Modified residuei826Phosphotyrosine1 Publication1
Modified residuei905Phosphoserine1 Publication1
Modified residuei914Phosphoserine1 Publication1
Modified residuei924Phosphoserine2 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Tyrosine phosphorylated on multiple sites by Abl kinase. In vitro, phosphorylation on specific tyrosine residues inhibits interaction with Abl and Src SH3 domains.4 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8T4F7

PRoteomics IDEntifications database

More...
PRIDEi
Q8T4F7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8T4F7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in axons of the embryonic nervous system.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0000578, Expressed in adult organism and 41 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8T4F7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8T4F7, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with Abl and Src SH3 domains. Binds, in vitro and in vivo, the cytoplasmic domain of robo.

Interacts with Zyx102EF and chic.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
62866, 67 interactors

Protein interaction database and analysis system

More...
IntActi
Q8T4F7, 33 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0113115

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8T4F7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini146 – 407WH1PROSITE-ProRule annotationAdd BLAST262

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni791 – 980EVH2Add BLAST190
Regioni791 – 810EVH2 block AAdd BLAST20
Regioni837 – 854EVH2 block BAdd BLAST18
Regioni947 – 980EVH2 block CAdd BLAST34

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi800 – 803KLKR4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi157 – 220Ser-richAdd BLAST64
Compositional biasi244 – 279Gln-richAdd BLAST36
Compositional biasi457 – 685Gln-richAdd BLAST229
Compositional biasi633 – 784Pro-richAdd BLAST152

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The EVH2 domain is comprised of 3 regions. Block A is a thymosin-like domain required for G-actin binding. The KLKR motif within this block is essential for the G-actin binding and for actin polymerization. Block B is required for F-actin binding and subcellular location, and Block C for tetramerization.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Ena/VASP family.Curated

Keywords - Domaini

SH3-binding

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4590, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000171456

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8T4F7

Database of Orthologous Groups

More...
OrthoDBi
1161962at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8T4F7

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.5.1160, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR042180, IF_rod_dom_coil1B
IPR011993, PH-like_dom_sf
IPR038023, VASP_sf
IPR014885, VASP_tetra
IPR000697, WH1/EVH1_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08776, VASP_tetra, 1 hit
PF00568, WH1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00461, WH1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF118370, SSF118370, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50229, WH1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 4 (identifier: Q8T4F7-4) [UniParc]FASTAAdd to basket
Also known as: F

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAMKKLYAKT SFTSKKPSSA ANSTPILAYH QQQHQQPGNG ICEFQVVAPG
60 70 80 90 100
HSGELMIRRS QSMHHKMSPP VGGLGSKSEY YSIEELQELD LLDYRHPMYH
110 120 130 140 150
HYQQQELRQR YHEHEQLVLQ LPKATSPKAG PIYEAPQRSQ QQQDQMLYVP
160 170 180 190 200
TAAQRDSSSS AAATSIASSS TLTSSPSPSS SSSLIFSTLR KCVSPSNPSV
210 220 230 240 250
NPNQPSKTQP SKLGCSMSFS IRTTTATAAT AAAANAATAT LSTQQQQQQA
260 270 280 290 300
QQQHKQHLYS NIHHYLIRQQ QQKQHYTLQR RHNSVKDKFI GGITTIFAEQ
310 320 330 340 350
SIIGARASVM VYDDNQKKWV PSGSSSGLSK VQIYHHQQNN TFRVVGRKLQ
360 370 380 390 400
DHEVVINCSI LKGLKYNQAT ATFHQWRDSK FVYGLNFSSQ NDAENFARAM
410 420 430 440 450
MHALEVLSGR VANNPGGPPT NGNGYEEDMG YRTMTSEDAA ILRQNNSIGG
460 470 480 490 500
HVTPSAQTPT SQTNQNNIPQ SPPTPQGHHR TSSAPPAPQP QQQQQQQQAQ
510 520 530 540 550
QMGQPGSHYG PTGNGPTSNG LPQQVNSQIP PAPQQQPQQQ QFQQQQQQQQ
560 570 580 590 600
YQQMVQAGYA PSQQYQQPHY VLSNSNPNLT VHQYPTQQAQ QQPPQAPQPP
610 620 630 640 650
LQNGGMYMVG HGHLPSSASA NSVVYASQQQ MLPQAHPQAP QAPTMPGPGY
660 670 680 690 700
GGPPVPPPQQ QAENPYGQVP MPPPMNPSQQ QQPGQVPLNR MSSQGGPGGP
710 720 730 740 750
PAPAPPPPPP SFGGAAGGGP PPPAPPQMFN GAPPPPAMGG GPPPAPPAPP
760 770 780 790 800
AMGGGPPPAP GGPGAPPPPP PPPGLGGAPK KEDPQADLMG SLASQLQQIK
810 820 830 840 850
LKKNKVTTSA PENSGSSTSS GGSGNYGTIG RSSNGMASMM DEMAKTLARR
860 870 880 890 900
RAQAEKKDPD PEAEVKKRPW EKSNTLPHKL SGGAGSGSAG SGHEGANGNS
910 920 930 940 950
GGAGSNTTNS GGESPRPMRK RFGSASEETI LKVNGDGLSL ALSNGDLDTL
960 970 980
KAEIVREMRL EIQKVKNEII DAIKSEFNRR
Length:980
Mass (Da):104,824
Last modified:July 7, 2009 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7B084A0AEC098297
GO
Isoform 1 (identifier: Q8T4F7-1) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     147-147: L → F
     148-298: Missing.
     482-482: S → SRNSL
     932-932: K → KQ

Show »
Length:834
Mass (Da):89,280
Checksum:i7E0CD375D351C674
GO
Isoform 2 (identifier: Q8T4F7-2) [UniParc]FASTAAdd to basket
Also known as: A, C, E

The sequence of this isoform differs from the canonical sequence as follows:
     2-297: Missing.
     298-298: A → T

Show »
Length:684
Mass (Da):71,985
Checksum:iE1FFB5A8091FA77E
GO
Isoform 3 (identifier: Q8T4F7-3) [UniParc]FASTAAdd to basket
Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     2-297: Missing.
     298-298: A → T
     482-482: S → SRNSL
     563-563: Missing.

Show »
Length:687
Mass (Da):72,327
Checksum:iF480275EB4CC79A8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4LFX0A0A0B4LFX0_DROME
Enabled, isoform G
ena Dmel\CG15112, ENA, Ena, Enb, enb
664Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti120Q → H in AAL89948 (PubMed:12537569).Curated1
Sequence conflicti491 – 493Missing in AAL89948 (PubMed:12537569).Curated3
Sequence conflicti612G → S in AAA85120 (PubMed:7535279).Curated1
Sequence conflicti799I → F in AAA85120 (PubMed:7535279).Curated1
Sequence conflicti799I → F in AAL89948 (PubMed:12537569).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0175742 – 297Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST296
Alternative sequenceiVSP_037651147L → F in isoform 1. 1 Publication1
Alternative sequenceiVSP_037652148 – 298Missing in isoform 1. 1 PublicationAdd BLAST151
Alternative sequenceiVSP_017575298A → T in isoform 2 and isoform 3. 1 Publication1
Alternative sequenceiVSP_019865482S → SRNSL in isoform 1 and isoform 3. 2 Publications1
Alternative sequenceiVSP_019866563Missing in isoform 3. 1 Publication1
Alternative sequenceiVSP_037653932K → KQ in isoform 1. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U21123 Genomic DNA Translation: AAA85120.1
AE013599 Genomic DNA Translation: AAF57598.2
AE013599 Genomic DNA Translation: AAM68438.2
AE013599 Genomic DNA Translation: AAM68439.2
AE013599 Genomic DNA Translation: AAX52696.1
AE013599 Genomic DNA Translation: AAX52697.1
AE013599 Genomic DNA Translation: ACL83163.1
AY084210 mRNA Translation: AAL89948.1
BT004488 mRNA Translation: AAO42652.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A56154

NCBI Reference Sequences

More...
RefSeqi
NP_001014536.1, NM_001014536.2 [Q8T4F7-2]
NP_001014537.1, NM_001014537.3 [Q8T4F7-3]
NP_001137709.1, NM_001144237.2 [Q8T4F7-4]
NP_725857.1, NM_166329.2 [Q8T4F7-2]
NP_725858.1, NM_166330.2 [Q8T4F7-2]
NP_725859.2, NM_166331.3 [Q8T4F7-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0086582; FBpp0085766; FBgn0000578 [Q8T4F7-2]
FBtr0086583; FBpp0085767; FBgn0000578 [Q8T4F7-2]
FBtr0086584; FBpp0085768; FBgn0000578 [Q8T4F7-1]
FBtr0100174; FBpp0099530; FBgn0000578 [Q8T4F7-3]
FBtr0100176; FBpp0099532; FBgn0000578 [Q8T4F7-2]
FBtr0114623; FBpp0113115; FBgn0000578 [Q8T4F7-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
37201

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG15112

UCSC genome browser

More...
UCSCi
CG15112-RA, d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21123 Genomic DNA Translation: AAA85120.1
AE013599 Genomic DNA Translation: AAF57598.2
AE013599 Genomic DNA Translation: AAM68438.2
AE013599 Genomic DNA Translation: AAM68439.2
AE013599 Genomic DNA Translation: AAX52696.1
AE013599 Genomic DNA Translation: AAX52697.1
AE013599 Genomic DNA Translation: ACL83163.1
AY084210 mRNA Translation: AAL89948.1
BT004488 mRNA Translation: AAO42652.1
PIRiA56154
RefSeqiNP_001014536.1, NM_001014536.2 [Q8T4F7-2]
NP_001014537.1, NM_001014537.3 [Q8T4F7-3]
NP_001137709.1, NM_001144237.2 [Q8T4F7-4]
NP_725857.1, NM_166329.2 [Q8T4F7-2]
NP_725858.1, NM_166330.2 [Q8T4F7-2]
NP_725859.2, NM_166331.3 [Q8T4F7-1]

3D structure databases

SMRiQ8T4F7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi62866, 67 interactors
IntActiQ8T4F7, 33 interactors
STRINGi7227.FBpp0113115

PTM databases

iPTMnetiQ8T4F7

Proteomic databases

PaxDbiQ8T4F7
PRIDEiQ8T4F7

Genome annotation databases

EnsemblMetazoaiFBtr0086582; FBpp0085766; FBgn0000578 [Q8T4F7-2]
FBtr0086583; FBpp0085767; FBgn0000578 [Q8T4F7-2]
FBtr0086584; FBpp0085768; FBgn0000578 [Q8T4F7-1]
FBtr0100174; FBpp0099530; FBgn0000578 [Q8T4F7-3]
FBtr0100176; FBpp0099532; FBgn0000578 [Q8T4F7-2]
FBtr0114623; FBpp0113115; FBgn0000578 [Q8T4F7-4]
GeneIDi37201
KEGGidme:Dmel_CG15112
UCSCiCG15112-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
37201
FlyBaseiFBgn0000578, ena

Phylogenomic databases

eggNOGiKOG4590, Eukaryota
GeneTreeiENSGT00940000171456
InParanoidiQ8T4F7
OrthoDBi1161962at2759
PhylomeDBiQ8T4F7

Enzyme and pathway databases

ReactomeiR-DME-446353, Cell-extracellular matrix interactions

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
37201, 0 hits in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ena, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
37201

Protein Ontology

More...
PROi
PR:Q8T4F7

Gene expression databases

BgeeiFBgn0000578, Expressed in adult organism and 41 other tissues
ExpressionAtlasiQ8T4F7, baseline and differential
GenevisibleiQ8T4F7, DM

Family and domain databases

Gene3Di1.20.5.1160, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR042180, IF_rod_dom_coil1B
IPR011993, PH-like_dom_sf
IPR038023, VASP_sf
IPR014885, VASP_tetra
IPR000697, WH1/EVH1_dom
PfamiView protein in Pfam
PF08776, VASP_tetra, 1 hit
PF00568, WH1, 1 hit
SMARTiView protein in SMART
SM00461, WH1, 1 hit
SUPFAMiSSF118370, SSF118370, 1 hit
PROSITEiView protein in PROSITE
PS50229, WH1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiENA_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8T4F7
Secondary accession number(s): A4UZP3
, B7YZL0, Q24035, Q86NN6, Q8MMB3, Q9V8R3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: July 7, 2009
Last modified: December 2, 2020
This is version 158 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again