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Entry version 90 (29 Sep 2021)
Sequence version 1 (01 Jun 2002)
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Protein

DNA-directed RNA polymerase subunit beta

Gene

RPA2

Organism
Trypanosoma brucei brucei
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotationARBA annotation, Transferase
Biological processTranscription

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit betaUniRule annotation (EC:2.7.7.6UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPA2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTrypanosoma brucei bruceiImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaDiscobaEuglenozoaKinetoplasteaMetakinetoplastinaTrypanosomatidaTrypanosomatidaeTrypanosoma

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymeraseUniRule annotationARBA annotation, NucleusARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini375 – 797RNA_pol_Rpb2_1InterPro annotationAdd BLAST423
Domaini841 – 903RNA_pol_Rpb2_3InterPro annotationAdd BLAST63
Domaini956 – 1026RNA_pol_Rpa2_4InterPro annotationAdd BLAST71
Domaini1090 – 1488RNA_pol_Rpb2_6InterPro annotationAdd BLAST399
Domaini1490 – 1590RNA_pol_Rpb2_7InterPro annotationAdd BLAST101

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 49DisorderedSequence analysisAdd BLAST49
Regioni1468 – 1490DisorderedSequence analysisAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili302 – 322Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 31Polar residuesSequence analysisAdd BLAST31

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RNA polymerase beta chain family.UniRule annotationARBA annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00653, RNA_pol_B_RPB2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.1110.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015712, DNA-dir_RNA_pol_su2
IPR007120, DNA-dir_RNAP_su2_dom
IPR007121, RNA_pol_bsu_CS
IPR007644, RNA_pol_bsu_protrusion
IPR037034, RNA_pol_Rpb2_2_sf
IPR007645, RNA_pol_Rpb2_3
IPR007641, RNA_pol_Rpb2_7
IPR009674, Rpa2_dom_4

The PANTHER Classification System

More...
PANTHERi
PTHR20856, PTHR20856, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06883, RNA_pol_Rpa2_4, 1 hit
PF04563, RNA_pol_Rpb2_1, 1 hit
PF04565, RNA_pol_Rpb2_3, 1 hit
PF00562, RNA_pol_Rpb2_6, 1 hit
PF04560, RNA_pol_Rpb2_7, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01166, RNA_POL_BETA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8T307-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTKNSVVGS ASGSHASTAG ETVTSTRSGT SSRHSRQRRQ QYDYVKNPSE
60 70 80 90 100
PMTAMERLKL VRCSIARLRY LGERHRHTSK LDTTGGDRLL SFFEGLRKRV
110 120 130 140 150
LKLEYNPRVV AKSKVGAPKH LDYIRGHANV LLGEASTIIS ECEQAMDRSE
160 170 180 190 200
AVYEGLAYHQ LQDTHRELEN LVGLLSGAPS DMESAGSLKL LADLVSPHVA
210 220 230 240 250
EFDAFAEQRV PEFLQELKNE GFLFSSVIND SQQPANAIGL LSVFIVDVAI
260 270 280 290 300
GVRPGRSARL VIQHALHNLA RLKSRVDKAD LTLGAEEDSS NNEHHRMQSL
310 320 330 340 350
EFEVIRGRLR EAKEELERIR DKWDHDEGDI FSRAGTGVQS LQSIIDAKRV
360 370 380 390 400
KESTVIEEAQ AIHDRTVYAC LPFASPQYCR IRSETYSQPC HVRVGFKFVA
410 420 430 440 450
KGDGSVSRTK TQLIYNLMPE FLILMRQQGI APSDHERFAT LAPSKYELWL
460 470 480 490 500
SLGELPEMVL GARCALRGVN QRLDHFRALE EQKEVGGYFV LRGGERILRN
510 520 530 540 550
LILQRCNVPL NIERERFATV DSFFSPRAVI IRCKRPSGLT VQNYFYYATK
560 570 580 590 600
GEVIFTFARR VVWNIPALLV LSALNTRHRT SLDIYKLLTI GLTNGRSPHA
610 620 630 640 650
ARVEALLQHH SQMPYSTLDN FLDYLAVVGL MYRRYHESSF IFRFLPQYHT
660 670 680 690 700
SFATQHDAWY GLFMLRRHML PHLNTAEATS DLPPTATSRE IREWLSAGLQ
710 720 730 740 750
EELAAKFDAL IGILRQLLVF NDGATGNQGN DVLAYQEVFT VSQVLIGAFE
760 770 780 790 800
VSLMKTMGAV TFRMAGQLSP EIFQATMCLA ETPVREAANT LEKLNQLLEY
810 820 830 840 850
SCRNNGPDPL ITLNRLLLTG NFALDREEDF YSPQTAGWAV MTEHLNFYRS
860 870 880 890 900
FEQLMCVHRG KSIAEMRSSD VRRYPCEAYG FICMVHSPDG EDCGVLNHLS
910 920 930 940 950
ISTVLSASPR VGSSQYKILL AFIEEELKNV RNTTSLISCV DQLVGTVPVW
960 970 980 990 1000
LEGRLLGYLS PNEALSASKA LTQKKALRSR GVVGVTGIVR RDSISSLNTM
1010 1020 1030 1040 1050
EVVYIPPGSK DPMGLYIFYQ YGRLMRPVLQ IESPSRGGDL PFPVVYLGTW
1060 1070 1080 1090 1100
EQSWRDIAAV PSDLFDGFDQ LRRKYEFMEQ NGFNILSFTS STIPFFEHNC
1110 1120 1130 1140 1150
SPRNLFQCGL SKQTAGTQLQ TQAWRRDAKL FRMYYPQRYI SRTLPMDYFG
1160 1170 1180 1190 1200
LDDVSLGVNA VVAILAYTGY DLDDAMILNS TAKQFGMLNA GVTVAKIVKA
1210 1220 1230 1240 1250
SGKGDSNDVF VFHNCLPDGQ PFTPELDRHG LPKKRAVPNA TAYFSFDTDH
1260 1270 1280 1290 1300
KYPSLRDSSA VYCCAKRFEY IDPLTNEKTY EYTRHQITKW RHFDKGEDAW
1310 1320 1330 1340 1350
VHSVIPLTYD GPDPTSVLVL FRIPRPPVIG DKFSSRHGQK GTLPLDIRSH
1360 1370 1380 1390 1400
DLPFSTRDGI TPDIIINPHA FPSRMTVGMV LEMMGAKLGC IQGRLCDHSA
1410 1420 1430 1440 1450
WSVIDEQPRS AKTIGDALEA LGYNRYGREK LIDGITGEEI EAEVLVGISG
1460 1470 1480 1490 1500
YQRLRHMVSD KWQARARTDS HTHRAVTKTG QPVKGRKRHG GVRVGEMERD
1510 1520 1530 1540 1550
ALLSHGVAEV VIDRLLHVSD KTKAFICVEC GSMLSIYERH ATEYSTWKTC
1560 1570 1580 1590
KFCSAGLHET DDTIAFVEIP QVLRLWATEL TSVGIRVVLK TSETSL
Length:1,596
Mass (Da):179,504
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5D498D4D9F917377
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ437580 mRNA Translation: CAD26832.1

Genome annotation databases

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
Tb927.11.630:pep

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ437580 mRNA Translation: CAD26832.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneDBiTb927.11.630:pep

Family and domain databases

CDDicd00653, RNA_pol_B_RPB2, 1 hit
Gene3Di3.90.1110.10, 1 hit
InterProiView protein in InterPro
IPR015712, DNA-dir_RNA_pol_su2
IPR007120, DNA-dir_RNAP_su2_dom
IPR007121, RNA_pol_bsu_CS
IPR007644, RNA_pol_bsu_protrusion
IPR037034, RNA_pol_Rpb2_2_sf
IPR007645, RNA_pol_Rpb2_3
IPR007641, RNA_pol_Rpb2_7
IPR009674, Rpa2_dom_4
PANTHERiPTHR20856, PTHR20856, 1 hit
PfamiView protein in Pfam
PF06883, RNA_pol_Rpa2_4, 1 hit
PF04563, RNA_pol_Rpb2_1, 1 hit
PF04565, RNA_pol_Rpb2_3, 1 hit
PF00562, RNA_pol_Rpb2_6, 1 hit
PF04560, RNA_pol_Rpb2_7, 1 hit
PROSITEiView protein in PROSITE
PS01166, RNA_POL_BETA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8T307_TRYBB
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8T307
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: September 29, 2021
This is version 90 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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