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Entry version 98 (16 Oct 2019)
Sequence version 2 (01 Jun 2003)
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Protein

Probable UDP-glucose:glycoprotein glucosyltransferase A

Gene

ggtA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum (By similarity).By similarity

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+By similarity, Mn2+By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00378

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT24 Glycosyltransferase Family 24

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable UDP-glucose:glycoprotein glucosyltransferase A (EC:2.4.1.-)
Alternative name(s):
Developmental gene 1109 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ggtA
Synonyms:DG1109
ORF Names:DDB_G0274103
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0274103 ggtA

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000032746926 – 1681Probable UDP-glucose:glycoprotein glucosyltransferase AAdd BLAST1656

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi81N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi174N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi391N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1233N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1338N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8T191

PRoteomics IDEntifications database

More...
PRIDEi
Q8T191

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0220030

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1346 – 1657GlucosyltransferaseBy similarityAdd BLAST312

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi209 – 217Poly-Ser9
Compositional biasi569 – 579Poly-AsnAdd BLAST11
Compositional biasi689 – 695Poly-Thr7
Compositional biasi1061 – 1071Poly-SerAdd BLAST11

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyltransferase 8 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1879 Eukaryota
ENOG410XRK6 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8T191

KEGG Orthology (KO)

More...
KOi
K11718

Identification of Orthologs from Complete Genome Data

More...
OMAi
EFAIDIR

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8T191

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.550.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040497 Glyco_transf_24
IPR029044 Nucleotide-diphossugar_trans
IPR009448 UDP-g_GGtrans
IPR040693 UGGT_TRXL_1
IPR040694 UGGT_TRXL_2
IPR040692 UGGT_TRXL_3

The PANTHER Classification System

More...
PANTHERi
PTHR11226 PTHR11226, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18404 Glyco_transf_24, 1 hit
PF18400 Thioredoxin_12, 1 hit
PF18401 Thioredoxin_13, 1 hit
PF18402 Thioredoxin_14, 1 hit
PF06427 UDP-g_GGTase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53448 SSF53448, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q8T191-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARIFKFFVF LLIVFISNVL LLVESNEGDN SFSSKSIQLS LVSNWGETPS
60 70 80 90 100
YLEAAEFLHN QDKSLFWKFI EEFNKIDFST NYSDKIYYES TISLMKSVLS
110 120 130 140 150
SNTQFLSEFL SIDLAMRTYS PRVETYRQLA ISNMKLNNIE HSITTADNKT
160 170 180 190 200
ITLFNSGGWV QIKNKIITDV NEINESLFKD VAVVDDEENE FIRLYDFDHI
210 220 230 240 250
FPTLANTVSS SSSSPSSIPI VILYVDIKSE FFKLVHPKLK QFSQMGKIKY
260 270 280 290 300
CLRYVVQESN QKLNLQGYGY ELSIKNLEYK VMDDSAIKKD IIIDGVKSKT
310 320 330 340 350
IINIPNEDVQ GFNFHKLQKR KPELTSKLST FRSYLMAKSQ EAKELKVWEL
360 370 380 390 400
KDLGIQSAQK IIQSGDPLRS LEYISQKFPT LSNSLSKITL NESLKSVIES
410 420 430 440 450
NQKIIPSTTD QTLLLNGRLI DTNELSPIEL SRIILEEYEH STTIQQQGPL
460 470 480 490 500
SSKTVQDIIS AQLPIRIQLL PTKEELELNG GNEPFVSLNN LELDYIYRQW
510 520 530 540 550
EPKLQSSVLD KPVTSPQDIF IRKNLLTTVI VLDWNNINTF EIIPEIQEMV
560 570 580 590 600
QGNSLIPTRI QLLFNTKSNN NNNNNNNNND QNSQTSNFIQ GKDLAKVFLT
610 620 630 640 650
IKNSNLGNRG AFFFITALNY FKKMYIPNEL GITRSVLSSS FQAVLQQMGG
660 670 680 690 700
SVRSLQHALT NTDFDNLLES SNQLIERLEL LDTTTSQSTT TTTTTKILPK
710 720 730 740 750
VFVNGVQVKY SNIDQLSFDL LVSLYDEFDN LKPLFKESIL STTTAQYYET
760 770 780 790 800
ILTSSYWKDN NLPFLKKLNS MISNEKYSHL ITNSKNRNQE VDAQNVLKNL
810 820 830 840 850
LYFRNNENKD EQNLLNLIVI GDFDHYNTRD ISLELLRQLE KGELKNCKLT
860 870 880 890 900
FISNPIDINS VVNTAGNENQ ILGKLITILK HYGKILTPQL VIGLFEKVQS
910 920 930 940 950
DPTIIDSFKT MKQIIELSGF DIAANDIWVA QSVNLFKQSS KVCKQYLGIQ
960 970 980 990 1000
STNKSPLSIL VNGRIITPPL SYDDAASFIQ SDFKLLLEIE MIKAKKTFEL
1010 1020 1030 1040 1050
LNSDPILKDK SNLKISDLLN KVQSLVGYYY NGNNQLDSNI KRKRIPNSLS
1060 1070 1080 1090 1100
ISFSHKPPTL SSSSSSSSSN SNDVPLKFLM IINPFNKVSQ KLVPMVREFS
1110 1120 1130 1140 1150
NKLNIPVDVI LNPPVSLSEL PLKTYYTYVI KLSSEFNNEN VLYNQPLGIA
1160 1170 1180 1190 1200
TDIPEDRVVT LALDIPSSWL VQPIIAKYDL DNIRLKDLGD EQVLTAVYEL
1210 1220 1230 1240 1250
ENIVIEGSAN DMTTDNAPAG LELLLNPIST QTNKTQDTIV MNNFGYYQLK
1260 1270 1280 1290 1300
SNPGIWKLTI APGRSSDIMD MVDHPNQKEK ETFVIVPHRL VVIDSLYQSL
1310 1320 1330 1340 1350
SSLSVVRKAG QELRPILQPI DEYEKQKEQE KEQKLKQNSS GFFSNLFSSK
1360 1370 1380 1390 1400
NDATDSVATH QKKSNLDTIH IFSVASGHLY ERFLKIMMLS VVKNTESPIK
1410 1420 1430 1440 1450
FWFLKNYLSP AFKEFIPEMA KEYGFQYELV TYKWPWWLRK QTEKQRIIWS
1460 1470 1480 1490 1500
YKILFLDVLF PLDVPKIIFV DADQVVRTDL KELWDMDLHG ASLGYTPFCD
1510 1520 1530 1540 1550
SNKDTEGFRF WKSGYWRQHL AGRSYHISAL YVVDLVRFRR LAAGDQLRAT
1560 1570 1580 1590 1600
YDQLSRDPNS LANLDQDLPN YLQHYVRIHS LPQEWLWCET WCDQESKSKA
1610 1620 1630 1640 1650
KTIDLCNNPL TKTPKLENAV RIIDEWTTLD NEAKEFELKI DQSKHHRQIE
1660 1670 1680
LDHQNQLPNS KPIENIDDIL LNLAESQKDL F
Length:1,681
Mass (Da):192,629
Last modified:June 1, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i946F082CE2E58B18
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAFI02000012 Genomic DNA Translation: EAL69944.1

NCBI Reference Sequences

More...
RefSeqi
XP_644005.1, XM_638913.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL69944; EAL69944; DDB_G0274103

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8619433

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0274103

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000012 Genomic DNA Translation: EAL69944.1
RefSeqiXP_644005.1, XM_638913.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi44689.DDB0220030

Protein family/group databases

CAZyiGT24 Glycosyltransferase Family 24

Proteomic databases

PaxDbiQ8T191
PRIDEiQ8T191

Genome annotation databases

EnsemblProtistsiEAL69944; EAL69944; DDB_G0274103
GeneIDi8619433
KEGGiddi:DDB_G0274103

Organism-specific databases

dictyBaseiDDB_G0274103 ggtA

Phylogenomic databases

eggNOGiKOG1879 Eukaryota
ENOG410XRK6 LUCA
InParanoidiQ8T191
KOiK11718
OMAiEFAIDIR
PhylomeDBiQ8T191

Enzyme and pathway databases

UniPathwayiUPA00378

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8T191

Family and domain databases

Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR040497 Glyco_transf_24
IPR029044 Nucleotide-diphossugar_trans
IPR009448 UDP-g_GGtrans
IPR040693 UGGT_TRXL_1
IPR040694 UGGT_TRXL_2
IPR040692 UGGT_TRXL_3
PANTHERiPTHR11226 PTHR11226, 1 hit
PfamiView protein in Pfam
PF18404 Glyco_transf_24, 1 hit
PF18400 Thioredoxin_12, 1 hit
PF18401 Thioredoxin_13, 1 hit
PF18402 Thioredoxin_14, 1 hit
PF06427 UDP-g_GGTase, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUGGG_DICDI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8T191
Secondary accession number(s): Q555Q8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2003
Last modified: October 16, 2019
This is version 98 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
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