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Protein

Phospholipid-transporting ATPase

Gene

CG17034

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).UniRule annotationSAAS annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-UniRule
  • magnesium ion binding Source: UniProtKB-UniRule
  • phospholipid-translocating ATPase activity Source: FlyBase

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-6798695 Neutrophil degranulation
R-DME-936837 Ion transport by P-type ATPases

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid-transporting ATPaseUniRule annotation (EC:3.6.3.1UniRule annotation)
Gene namesi
ORF Names:CG17034Imported, CG42321Imported, Dmel_CG42321Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0259221 CG42321

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei304 – 325HelicalUniRule annotationAdd BLAST22
Transmembranei345 – 365HelicalUniRule annotationAdd BLAST21
Transmembranei881 – 902HelicalUniRule annotationAdd BLAST22
Transmembranei923 – 944HelicalUniRule annotationAdd BLAST22
Transmembranei964 – 984HelicalUniRule annotationAdd BLAST21
Transmembranei996 – 1016HelicalUniRule annotationAdd BLAST21
Transmembranei1036 – 1056HelicalUniRule annotationAdd BLAST21

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiFBgn0259221 Expressed in 39 organ(s), highest expression level in second segment of antenna (Drosophila)

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 108PhoLip_ATPase_NInterPro annotationAdd BLAST57
Domaini815 – 1065PhoLip_ATPase_CInterPro annotationAdd BLAST251

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410ITKD Eukaryota
ENOG410XPYK LUCA
GeneTreeiENSGT00910000144008
OrthoDBiEOG091G0139

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c
PANTHERiPTHR24092 PTHR24092, 1 hit
PfamiView protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01652 ATPase-Plipid, 2 hits
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All

Q8T0I4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSIFRFRLP FRRSELPETG LLNTYDEDFT SSAGYDADDG ERRIINLNGP
60 70 80 90 100
QPTKYGNNRI TTAKYSFISF LPAFLFEQFR RYSNCFFLLI AILQQIPEVS
110 120 130 140 150
PTGRYTTLVP LMFILSVSAI KEIIEDIKRH RADNEINHRS IERLDSGSWC
160 170 180 190 200
TVRWSELTVG DIIKVGINTF FPADLILLSS SEPQAMCFIE TANLDGETNL
210 220 230 240 250
KIRQALPATA ELLETKDLQR LEGRIECELP NRHLYEFNGV LRETGKPPAA
260 270 280 290 300
LGNDQVLQRG AILRNTAWVF GIVVYSGQET KLMKNSTSAP LKRSTVDKLT
310 320 330 340 350
NTQILMLFMI LISLCIISGL CNLFWTREHS ETDWYLGLTD FKTKSLGYNL
360 370 380 390 400
LTFFILYNNL IPISLQVTLE LVRFLQAIFI NYDIEMYHEE SNTPAMARTS
410 420 430 440 450
NLNEELGMVK YIFSDKTGTL TQNVMEFKKC SIAGYVYTAE RTPEESQLVQ
460 470 480 490 500
NILGRHETSA VIEEFLELLS VCHTVIPERK ENGNMIYHAA SPDERALVEG
510 520 530 540 550
AQKFGYIFDT RTPKYVEINA LGVRKRYEVL NVLEFTSSRK RMSLIVRTPE
560 570 580 590 600
NKIKLFCKGA DTVIYERLAP QGQAFREQTL RHLEEFASDG LRTLCLAVAD
610 620 630 640 650
IRPDVYQEWS QTFDKASVAL QNRESKLEDA ANLIENNLRL LGATAIEDRL
660 670 680 690 700
QDGVPETIAS LLDAGIYIWV LTGDKQETAI NIGYSCRLIS HSMDIIILNE
710 720 730 740 750
ESLDATREVI HRHYGEFKSS SAKDANVALV IDGTTLKYAL SCDLRNDFQD
760 770 780 790 800
LCILCRVVIC CRVSPMQKAE VVEMVTQSTN AVTLAIGDGA NDVAMIQKAN
810 820 830 840 850
VGIGISGVEG LQAACASDYS IAQFRYLQRL LLVHGAWNYA RISKLILYSF
860 870 880 890 900
YKNVCLYVIE LWFAVYSGWS GQILFERWTI GLYNVLFTAM PPFAMGLFEK
910 920 930 940 950
FCTAETMIRY PMLYKTSQNA KLFNVKVFWI WIFNALLHSV FLFWLPLAAY
960 970 980 990 1000
TKEVIWSDGK TSDYLLMGNL VYTYVIVTVC LKAGLITNSW TWLTHLAIWG
1010 1020 1030 1040 1050
SIVLWFGFLL IYSHVWPMFK FASNFRGMDI QLLSTPVFYF CLMLVPITTL
1060 1070 1080 1090 1100
LIDVICKLVH NTVFKTLTEA VRETEIRRSD ISEVMNEPRS SFTETARLLR
1110 1120 1130 1140 1150
NVFTRRANTR VETDLELSHG YAFSQEEGGA VPQSIIIRAY DTNLPKPEGN
Length:1,150
Mass (Da):130,907
Last modified:June 1, 2002 - v1
Checksum:i3A07D6FCCCA54A8C
GO

Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7YZF8B7YZF8_DROME
Phospholipid-transporting ATPase
CG42321, Dmel_CG42321
1,350Annotation score:
A1Z9C8A1Z9C8_DROME
Phospholipid-transporting ATPase
CG42321, Dmel_CG42321
1,176Annotation score:
Q0E990Q0E990_DROME
Phospholipid-transporting ATPase
CG42321, Dmel_CG42321
1,301Annotation score:
B7YZF5B7YZF5_DROME
Phospholipid-transporting ATPase
CG42321, Dmel_CG42321
1,324Annotation score:
B7YZF9B7YZF9_DROME
Phospholipid-transporting ATPase
CG42321, Dmel_CG42321
1,091Annotation score:
B7YZF7B7YZF7_DROME
Phospholipid-transporting ATPase
CG42321, Dmel_CG42321
1,095Annotation score:
B7YZG0B7YZG0_DROME
Phospholipid-transporting ATPase
CG42321, Dmel_CG42321
1,265Annotation score:
A0A0B4JD16A0A0B4JD16_DROME
Phospholipid-transporting ATPase
CG42321, Dmel_CG42321
1,082Annotation score:
Q6AWM7Q6AWM7_DROME
Phospholipid-transporting ATPase
CG17034, CG42321, Dmel_CG42321
1,216Annotation score:
A0A0B4K7Y0A0A0B4K7Y0_DROME
Phospholipid-transporting ATPase
CG42321, Dmel_CG42321
1,127Annotation score:
There is more potential isoformShow all

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY069236 mRNA Translation: AAL39381.1
AE013599 Genomic DNA Translation: AAM68573.1
AE013599 Genomic DNA Translation: ACL83108.1
RefSeqiNP_001137654.1, NM_001144182.3
NP_610873.1, NM_137029.4
UniGeneiDm.7647

Genome annotation databases

EnsemblMetazoaiFBtr0299754; FBpp0289032; FBgn0259221
FBtr0299761; FBpp0289039; FBgn0259221
GeneIDi36488
UCSCiCG42321-RE d. melanogaster

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY069236 mRNA Translation: AAL39381.1
AE013599 Genomic DNA Translation: AAM68573.1
AE013599 Genomic DNA Translation: ACL83108.1
RefSeqiNP_001137654.1, NM_001144182.3
NP_610873.1, NM_137029.4
UniGeneiDm.7647

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0299754; FBpp0289032; FBgn0259221
FBtr0299761; FBpp0289039; FBgn0259221
GeneIDi36488
UCSCiCG42321-RE d. melanogaster

Organism-specific databases

FlyBaseiFBgn0259221 CG42321

Phylogenomic databases

eggNOGiENOG410ITKD Eukaryota
ENOG410XPYK LUCA
GeneTreeiENSGT00910000144008
OrthoDBiEOG091G0139

Enzyme and pathway databases

ReactomeiR-DME-6798695 Neutrophil degranulation
R-DME-936837 Ion transport by P-type ATPases

Miscellaneous databases

ChiTaRSiCG42321 fly
GenomeRNAii36488

Gene expression databases

BgeeiFBgn0259221 Expressed in 39 organ(s), highest expression level in second segment of antenna (Drosophila)

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c
PANTHERiPTHR24092 PTHR24092, 1 hit
PfamiView protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01652 ATPase-Plipid, 2 hits
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ8T0I4_DROME
AccessioniPrimary (citable) accession number: Q8T0I4
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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