UniProtKB - Q8SYG2 (CSN3_DROME)
Protein
COP9 signalosome complex subunit 3
Gene
CSN3
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in oogenesis and embryogenesis and is required for proper photoreceptor R cell differentiation and promote lamina glial cell migration or axon targeting. It also promotes Ubl-dependent degradation of cyclin E (CycE) during early oogenesis.1 Publication
GO - Biological processi
- female germ-line stem cell population maintenance Source: FlyBase
- germarium-derived cystoblast division Source: FlyBase
- germ cell development Source: FlyBase
- male germ-line cyst encapsulation Source: FlyBase
- multicellular organism development Source: UniProtKB-KW
- protein deneddylation Source: FlyBase
- protein stabilization Source: FlyBase
- ubiquitin-dependent protein catabolic process Source: GO_Central
Keywordsi
Molecular function | Developmental protein |
Biological process | Differentiation, Oogenesis |
Enzyme and pathway databases
Reactomei | R-DME-5696394, DNA Damage Recognition in GG-NER R-DME-6781823, Formation of TC-NER Pre-Incision Complex R-DME-8856825, Cargo recognition for clathrin-mediated endocytosis R-DME-8951664, Neddylation |
Names & Taxonomyi
Protein namesi | Recommended name: COP9 signalosome complex subunit 3Short name: Dch3 Short name: Signalosome subunit 3 |
Gene namesi | Name:CSN3 ORF Names:CG18332 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0027055, CSN3 |
Subcellular locationi
Nucleus
- COP9 signalosome Source: FlyBase
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, Nucleus, SignalosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000120983 | 1 – 445 | COP9 signalosome complex subunit 3Add BLAST | 445 |
Proteomic databases
PaxDbi | Q8SYG2 |
PRIDEi | Q8SYG2 |
Expressioni
Gene expression databases
Bgeei | FBgn0027055, Expressed in embryo and 44 other tissues |
ExpressionAtlasi | Q8SYG2, baseline and differential |
Genevisiblei | Q8SYG2, DM |
Interactioni
Subunit structurei
Component of the CSN complex, probably composed of CSN1b, alien/CSN2, CSN3, CSN4, CSN5, CSN6, CSN7 and CSN8.
Protein-protein interaction databases
BioGRIDi | 65565, 17 interactors |
IntActi | Q8SYG2, 9 interactors |
STRINGi | 7227.FBpp0077927 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 217 – 381 | PCIPROSITE-ProRule annotationAdd BLAST | 165 |
Sequence similaritiesi
Belongs to the CSN3 family.Curated
Phylogenomic databases
eggNOGi | KOG2582, Eukaryota |
GeneTreei | ENSGT00940000153653 |
HOGENOMi | CLU_028825_0_1_1 |
InParanoidi | Q8SYG2 |
OMAi | PIHADLC |
OrthoDBi | 929822at2759 |
PhylomeDBi | Q8SYG2 |
Family and domain databases
InterProi | View protein in InterPro IPR037753, CSN3 IPR000717, PCI_dom IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR10758:SF1, PTHR10758:SF1, 1 hit |
Pfami | View protein in Pfam PF01399, PCI, 1 hit |
SMARTi | View protein in SMART SM00088, PINT, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS50250, PCI, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8SYG2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGSALENYVN QVRTLSASGS YRELAEELPE SLSLLARNWS ILDNVLETLD
60 70 80 90 100
MQQHSLGVLY VLLAKLHSAS TANPEPVQLI QLMRDFVQRN NNEQLRYAVC
110 120 130 140 150
AFYETCHLFT EFVVQKNLSI LGIRIISRAI DQIRQLETQL TPIHADLCLL
160 170 180 190 200
SLKAKNFSVV LPYLDADITD ISTVAAECKT QQQQQSQHAD ANNDAKYFLL
210 220 230 240 250
YFYYGGMIYT AVKNYERALY FFEVCITTPA MAMSHIMLEA YKKFLMVSLI
260 270 280 290 300
VEGKIAYIPK NTQVIGRFMK PMANHYHDLV NVYANSSSEE LRIIILKYSE
310 320 330 340 350
AFTRDNNMGL AKQVATSLYK RNIQRLTKTF LTLSLSDVAS RVQLASAVEA
360 370 380 390 400
ERYILNMIKS GEIYASINQK DGMVLFKDDP EKYNSPEMFL NVQNNITHVL
410 420 430 440
DQVRQINKME EEIILNPMYV KKALGSQDDD LTSQHPKTFS GDPTD
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 104 | E → K in AAD28606 (PubMed:10531038).Curated | 1 | |
Sequence conflicti | 160 | V → A in AAD28606 (PubMed:10531038).Curated | 1 | |
Sequence conflicti | 275 | H → Y in AAD28606 (PubMed:10531038).Curated | 1 | |
Sequence conflicti | 343 | Q → H in AAL49197 (PubMed:12537569).Curated | 1 | |
Sequence conflicti | 428 | D → E in AAD28606 (PubMed:10531038).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF129081 mRNA Translation: AAD28606.1 AE014296 Genomic DNA Translation: AAF51652.1 AY071575 mRNA Translation: AAL49197.1 |
RefSeqi | NP_524190.2, NM_079466.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0078269; FBpp0077927; FBgn0027055 |
GeneIDi | 40308 |
KEGGi | dme:Dmel_CG18332 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF129081 mRNA Translation: AAD28606.1 AE014296 Genomic DNA Translation: AAF51652.1 AY071575 mRNA Translation: AAL49197.1 |
RefSeqi | NP_524190.2, NM_079466.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 65565, 17 interactors |
IntActi | Q8SYG2, 9 interactors |
STRINGi | 7227.FBpp0077927 |
Proteomic databases
PaxDbi | Q8SYG2 |
PRIDEi | Q8SYG2 |
Genome annotation databases
EnsemblMetazoai | FBtr0078269; FBpp0077927; FBgn0027055 |
GeneIDi | 40308 |
KEGGi | dme:Dmel_CG18332 |
Organism-specific databases
CTDi | 1448 |
FlyBasei | FBgn0027055, CSN3 |
Phylogenomic databases
eggNOGi | KOG2582, Eukaryota |
GeneTreei | ENSGT00940000153653 |
HOGENOMi | CLU_028825_0_1_1 |
InParanoidi | Q8SYG2 |
OMAi | PIHADLC |
OrthoDBi | 929822at2759 |
PhylomeDBi | Q8SYG2 |
Enzyme and pathway databases
Reactomei | R-DME-5696394, DNA Damage Recognition in GG-NER R-DME-6781823, Formation of TC-NER Pre-Incision Complex R-DME-8856825, Cargo recognition for clathrin-mediated endocytosis R-DME-8951664, Neddylation |
Miscellaneous databases
BioGRID-ORCSi | 40308, 0 hits in 1 CRISPR screen |
GenomeRNAii | 40308 |
PROi | PR:Q8SYG2 |
Gene expression databases
Bgeei | FBgn0027055, Expressed in embryo and 44 other tissues |
ExpressionAtlasi | Q8SYG2, baseline and differential |
Genevisiblei | Q8SYG2, DM |
Family and domain databases
InterProi | View protein in InterPro IPR037753, CSN3 IPR000717, PCI_dom IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR10758:SF1, PTHR10758:SF1, 1 hit |
Pfami | View protein in Pfam PF01399, PCI, 1 hit |
SMARTi | View protein in SMART SM00088, PINT, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS50250, PCI, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CSN3_DROME | |
Accessioni | Q8SYG2Primary (citable) accession number: Q8SYG2 Secondary accession number(s): Q9VPA3, Q9XYW4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 23, 2004 |
Last sequence update: | November 23, 2004 | |
Last modified: | December 2, 2020 | |
This is version 127 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families