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Entry version 156 (03 Jul 2019)
Sequence version 1 (01 Jun 2002)
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Protein

Protein Gawky

Gene

gw

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for gene silencing mediated by micro-RNAs (miRNAs). Silences both polyadenylated and deadenylated mRNAs. Required for miRNA-mediated translational repression and mRNA decay. Not required for miRNA target recognition. Necessary to initiate but not to maintain silencing. Promotes mRNA deadenylation through the recruitment of the CCR4-NOT and PAN complexes and promotes decapping by the DCP1-DCP2 complex. Dissociates from silenced mRNAs after deadenylation. Required for completion of nuclear divisions during early embryonic development.6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, RNA-binding
Biological processRNA-mediated gene silencing, Translation regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-426496 Post-transcriptional silencing by small RNAs
R-DME-5578749 Transcriptional regulation by small RNAs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein GawkyImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:gw
Synonyms:GW1821 Publication
ORF Names:CG31992
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0051992 gw

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004159481 – 1384Protein GawkyAdd BLAST1384

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8SY33

PRoteomics IDEntifications database

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PRIDEi
Q8SY33

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Highest levels are found during early embryonic development until approximately 18 hours and during pupariation.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
FBgn0051992 Expressed in 31 organ(s), highest expression level in embryo

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8SY33 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via N-terminal region) with AGO1 (via Piwi domain); the interaction is essential for localization of AGO1 in P-bodies and for miRNA-mediated silencing.

Interacts with pAbp/PABPC1; this interaction interferes with the binding of pAbp to eIF4G and is required for miRNA-mediated silencing.

Interacts with CCR4-NOT complex members Not1, Rga/NOT2, twin/CCR4, Pop2 and NOT3/5 and with PAN complex members CG8232/PAN2 and CG11486/PAN3.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
68639, 22 interactors

Database of interacting proteins

More...
DIPi
DIP-35525N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q8SY33

Protein interaction database and analysis system

More...
IntActi
Q8SY33, 12 interactors

Molecular INTeraction database

More...
MINTi
Q8SY33

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0088165

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11384
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8SY33

Database of comparative protein structure models

More...
ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8SY33

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini547 – 588UBAPROSITE-ProRule annotationAdd BLAST42
Domaini1117 – 1189RRMSequence analysisAdd BLAST73

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 605Sufficient for miRNA-mediated silencing1 PublicationAdd BLAST605
Regioni1 – 205Required for interaction with AGO11 PublicationAdd BLAST205
Regioni205 – 490Minimal N-terminal region required for miRNA-mediated silencing1 PublicationAdd BLAST286
Regioni605 – 830Sufficient for miRNA-mediated silencing1 PublicationAdd BLAST226
Regioni862 – 1115Not required for interaction with AGO1 or miRNAs or for localization to P-bodies but necessary for miRNA-mediated silencing and for interaction with pAbp3 PublicationsAdd BLAST254
Regioni940 – 1215Sufficient for miRNA-mediated silencing1 PublicationAdd BLAST276
Regioni1200 – 1384Not required for interaction with AGO1 or miRNAs or for localization to P-bodies but necessary for miRNA-mediated silencing, dissociation from AGO1 and miRNAs and interaction with pAbp3 PublicationsAdd BLAST185

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi81 – 281Gly-richSequence analysisAdd BLAST201
Compositional biasi527 – 530Poly-GlnSequence analysis4
Compositional biasi713 – 824Gln-richSequence analysisAdd BLAST112
Compositional biasi1204 – 1366Ser-richSequence analysisAdd BLAST163

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The UBA domain is not required for correct subcellular location, gene silencing or interaction with pAbp.1 Publication
The RRM domain lacks RNA-binding properties and does not bind RNA in vitro. It is not required for P-body localization or for interaction with AGO1 or miRNAs but is required for silencing. May play a role in protein-protein interactions.1 Publication1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GW182 family.Sequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IFAU Eukaryota
ENOG41110AX LUCA

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8SY33

KEGG Orthology (KO)

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KOi
K18412

Identification of Orthologs from Complete Genome Data

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OMAi
NCVLSNT

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8SY33

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14284 UBA_GAWKY, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR019486 Argonaute_hook_dom
IPR041971 Gawky_UBA
IPR033503 GW182
IPR026805 GW182_M_dom
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR015940 UBA
IPR009060 UBA-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR13020:SF25 PTHR13020:SF25, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF10427 Ago_hook, 1 hit
PF12938 M_domain, 1 hit
PF00627 UBA, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46934 SSF46934, 1 hit
SSF54928 SSF54928, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50030 UBA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform A (identifier: Q8SY33-1) [UniParc]FASTAAdd to basket
Also known as: B, E, F

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MREALFSQDG WGCQHVNQDT NWEVPSSPEP ANKDAPGPPM WKPSINNGTD
60 70 80 90 100
LWESNLRNGG QPAAQQVPKP SWGHTPSSNL GGTWGEDDDG ADSSSVWTGG
110 120 130 140 150
AVSNAGSGAA VGVNQAGVNV GPGGVVSSGG PQWGQGVVGV GLGSTGGNGS
160 170 180 190 200
SNITGSSGVA TGSSGNSSNA GNGWGDPREI RPLGVGGSMD IRNVEHRGGN
210 220 230 240 250
GSGATSSDPR DIRMIDPRDP IRGDPRGISG RLNGTSEMWG HHPQMSHNQL
260 270 280 290 300
QGINKMVGQS VATASTSVGT SGSGIGPGGP GPSTVSGNIP TQWGPAQPVS
310 320 330 340 350
VGVSGPKDMS KQISGWEEPS PPPQRRSIPN YDDGTSLWGQ QTRVPAASGH
360 370 380 390 400
WKDMTDSIGR SSHLMRGQSQ TGGIGIAGVG NSNVPVGANP SNPISSVVGP
410 420 430 440 450
QARIPSVGGV QHKPDGGAMW VHSGNVGGRN NVAAVTTWGD DTHSVNVGAP
460 470 480 490 500
SSGSVSSNNW VDDKSNSTLA QNSWSDPAPV GVSWGNKQSK PPSNSASSGW
510 520 530 540 550
STAAGVVDGV DLGSEWNTHG GIIGKSQQQQ KLAGLNVGMV NVINAEIIKQ
560 570 580 590 600
SKQYRILVEN GFKKEDVERA LVIANMNIEE AADMLRANSS LSMDGWRRHD
610 620 630 640 650
ESLGSYADHN SSTSSGGFAG RYPVNSGQPS MSFPHNNLMN NMGGTAVTGG
660 670 680 690 700
NNNTNMTALQ VQKYLNQGQH GVAVGPQAVG NSSAVSVGFG QNTSNAAVAG
710 720 730 740 750
AASVNIAANT NNQPSGQQIR MLGQQIQLAI HSGFISSQIL TQPLTQTTLN
760 770 780 790 800
LLNQLLSNIK HLQAAQQSLT RGGNVNPMAV NVAISKYKQQ IQNLQNQINA
810 820 830 840 850
QQAVYVKQQN MQPTSQQQQP QQQQLPSVHL SNSGNDYLRG HDAINNLQSN
860 870 880 890 900
FSELNINKPS GYQGASNQQS RLNQWKLPVL DKEINSDSTE FSRAPGATKQ
910 920 930 940 950
NLTANTSNIN SLGLQNDSTW STGRSIGDGW PDPSSDNENK DWSVAQPTSA
960 970 980 990 1000
ATAYTDLVQE FEPGKPWKGS QIKSIEDDPS ITPGSVARSP LSINSTPKDA
1010 1020 1030 1040 1050
DIFANTGKNS PTDLPPLSLS SSTWSFNPNQ NYPSHSWSDN SQQCTATSEL
1060 1070 1080 1090 1100
WTSPLNKSSS RGPPPGLTAN SNKSANSNAS TPTTITGGAN GWLQPRSGGV
1110 1120 1130 1140 1150
QTTNTNWTGG NTTWGSSWLL LKNLTAQIDG PTLRTLCMQH GPLVSFHPYL
1160 1170 1180 1190 1200
NQGIALCKYT TREEANKAQM ALNNCVLANT TIFAESPSEN EVQSIMQHLP
1210 1220 1230 1240 1250
QTPSSTSSSG TSGGNVGGVG TSANNANSGS AACLSGNNSG NGNGSASGAG
1260 1270 1280 1290 1300
SGNNGNSSCN NSAAGGGSSS NNTITTVANS NLVGSSGSVS NSSGVTANSS
1310 1320 1330 1340 1350
TVSVVSCTAS GNSINGAGTA NSSGSKSSAN NLASGQSSAS NLTNSTNSTW
1360 1370 1380
RQTSQNQALQ SQSRPSGREA DFDYISLVYS IVDD
Length:1,384
Mass (Da):142,973
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4E87DFE49050883E
GO
Isoform I (identifier: Q8SY33-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     969-971: Missing.

Note: No experimental confirmation available.
Show »
Length:1,381
Mass (Da):142,701
Checksum:i9823EFFFE67253C4
GO
Isoform J (identifier: Q8SY33-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1035-1036: Missing.

Note: No experimental confirmation available.
Show »
Length:1,382
Mass (Da):142,749
Checksum:iBCBC248F4836B070
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAM50720 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_047895969 – 971Missing in isoform I. Curated3
Alternative sequenceiVSP_0478961035 – 1036Missing in isoform J. Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014135 Genomic DNA Translation: AAF59322.2
AE014135 Genomic DNA Translation: AAF59323.2
AE014135 Genomic DNA Translation: AAN06507.2
AE014135 Genomic DNA Translation: AAN06508.1
AE014135 Genomic DNA Translation: AAN06509.1
AE014135 Genomic DNA Translation: AAX52511.2
AY075429 mRNA Translation: AAL68245.1
AY118860 mRNA Translation: AAM50720.1 Different initiation.

NCBI Reference Sequences

More...
RefSeqi
NP_001014691.2, NM_001014691.2 [Q8SY33-3]
NP_726596.1, NM_166780.2 [Q8SY33-1]
NP_726597.1, NM_166781.2 [Q8SY33-1]
NP_726599.2, NM_166783.2 [Q8SY33-2]
NP_726600.1, NM_166784.2 [Q8SY33-1]
NP_726601.1, NM_166785.2 [Q8SY33-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0089096; FBpp0088165; FBgn0051992 [Q8SY33-1]
FBtr0089097; FBpp0088166; FBgn0051992 [Q8SY33-1]
FBtr0089100; FBpp0088169; FBgn0051992 [Q8SY33-1]
FBtr0089101; FBpp0088170; FBgn0051992 [Q8SY33-1]
FBtr0310542; FBpp0302679; FBgn0051992 [Q8SY33-2]
FBtr0310543; FBpp0302680; FBgn0051992 [Q8SY33-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
43808

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG31992

UCSC genome browser

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UCSCi
CG31992-RA d. melanogaster [Q8SY33-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014135 Genomic DNA Translation: AAF59322.2
AE014135 Genomic DNA Translation: AAF59323.2
AE014135 Genomic DNA Translation: AAN06507.2
AE014135 Genomic DNA Translation: AAN06508.1
AE014135 Genomic DNA Translation: AAN06509.1
AE014135 Genomic DNA Translation: AAX52511.2
AY075429 mRNA Translation: AAL68245.1
AY118860 mRNA Translation: AAM50720.1 Different initiation.
RefSeqiNP_001014691.2, NM_001014691.2 [Q8SY33-3]
NP_726596.1, NM_166780.2 [Q8SY33-1]
NP_726597.1, NM_166781.2 [Q8SY33-1]
NP_726599.2, NM_166783.2 [Q8SY33-2]
NP_726600.1, NM_166784.2 [Q8SY33-1]
NP_726601.1, NM_166785.2 [Q8SY33-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WBRNMR-A1114-1198[»]
SMRiQ8SY33
ModBaseiSearch...

Protein-protein interaction databases

BioGridi68639, 22 interactors
DIPiDIP-35525N
ELMiQ8SY33
IntActiQ8SY33, 12 interactors
MINTiQ8SY33
STRINGi7227.FBpp0088165

Proteomic databases

PaxDbiQ8SY33
PRIDEiQ8SY33

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0089096; FBpp0088165; FBgn0051992 [Q8SY33-1]
FBtr0089097; FBpp0088166; FBgn0051992 [Q8SY33-1]
FBtr0089100; FBpp0088169; FBgn0051992 [Q8SY33-1]
FBtr0089101; FBpp0088170; FBgn0051992 [Q8SY33-1]
FBtr0310542; FBpp0302679; FBgn0051992 [Q8SY33-2]
FBtr0310543; FBpp0302680; FBgn0051992 [Q8SY33-3]
GeneIDi43808
KEGGidme:Dmel_CG31992
UCSCiCG31992-RA d. melanogaster [Q8SY33-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
43808
FlyBaseiFBgn0051992 gw

Phylogenomic databases

eggNOGiENOG410IFAU Eukaryota
ENOG41110AX LUCA
InParanoidiQ8SY33
KOiK18412
OMAiNCVLSNT
PhylomeDBiQ8SY33

Enzyme and pathway databases

ReactomeiR-DME-426496 Post-transcriptional silencing by small RNAs
R-DME-5578749 Transcriptional regulation by small RNAs

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
gw fly
EvolutionaryTraceiQ8SY33

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
43808

Protein Ontology

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PROi
PR:Q8SY33

Gene expression databases

BgeeiFBgn0051992 Expressed in 31 organ(s), highest expression level in embryo
GenevisibleiQ8SY33 DM

Family and domain databases

CDDicd14284 UBA_GAWKY, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR019486 Argonaute_hook_dom
IPR041971 Gawky_UBA
IPR033503 GW182
IPR026805 GW182_M_dom
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR015940 UBA
IPR009060 UBA-like_sf
PANTHERiPTHR13020:SF25 PTHR13020:SF25, 1 hit
PfamiView protein in Pfam
PF10427 Ago_hook, 1 hit
PF12938 M_domain, 1 hit
PF00627 UBA, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50030 UBA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGAWKY_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8SY33
Secondary accession number(s): Q8MSF0, Q9V4F1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: June 1, 2002
Last modified: July 3, 2019
This is version 156 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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