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UniProtKB - Q8SXY6 (TMEDA_DROME)
Protein
Transmembrane emp24 domain-containing protein bai
Gene
bai
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Eca and bai are essential, though not redundant, for dorsoventral patterning of the embryo. Specifically required during early embryogenesis for the activity of maternal tkv, while the zygotic tkv is not affected.
1 PublicationGO - Molecular functioni
- cargo receptor activity Source: FlyBase
GO - Biological processi
- dorsal/ventral pattern formation Source: UniProtKB
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: GO_Central
- Golgi organization Source: GO_Central
- Golgi vesicle transport Source: FlyBase
- intracellular protein transport Source: GO_Central
- maternal specification of dorsal/ventral axis, oocyte, germ-line encoded Source: FlyBase
- Wnt protein secretion Source: FlyBase
Keywordsi
Molecular function | Developmental protein |
Enzyme and pathway databases
Reactomei | R-DME-6807878, COPI-mediated anterograde transport R-DME-6811434, COPI-dependent Golgi-to-ER retrograde traffic |
Protein family/group databases
TCDBi | 9.B.188.1.6, the transmembrane emp24 domain-containing protein (tmed) family |
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane emp24 domain-containing protein bai1 PublicationImportedAlternative name(s): Protein baiserImported |
Gene namesi | Name:bai ORF Names:CG11785 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0045866, bai |
VEuPathDBi | VectorBase:FBgn0045866 |
Subcellular locationi
Other locations
- Membrane By similarity; Single-pass type I membrane protein By similarityImported
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
Golgi apparatus
- Golgi apparatus Source: GO_Central
Other locations
- COPII-coated ER to Golgi transport vesicle Source: GO_Central
- endomembrane system Source: FlyBase
- endoplasmic reticulum-Golgi intermediate compartment Source: GO_Central
- integral component of membrane Source: FlyBase
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 21 – 172 | LumenalSequence analysisImportedAdd BLAST | 152 | |
Transmembranei | 173 – 193 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 194 – 206 | CytoplasmicSequence analysisImportedAdd BLAST | 13 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Disruption phenotypei
Mutant embryos exhibit reduced dpp signaling during early embryogenesis. Maternal tkv is not active and is not secreted.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisImportedAdd BLAST | 20 | |
ChainiPRO_0000393917 | 21 – 206 | Transmembrane emp24 domain-containing protein baiImportedAdd BLAST | 186 |
Proteomic databases
PaxDbi | Q8SXY6 |
PRIDEi | Q8SXY6 |
Expressioni
Developmental stagei
Expressed both maternally and zygotically.1 Publication
Gene expression databases
Bgeei | FBgn0045866, Expressed in spermathecum and 48 other tissues |
Genevisiblei | Q8SXY6, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 67917, 6 interactors |
STRINGi | 7227.FBpp0084133 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 30 – 140 | GOLDPROSITE-ProRule annotationImportedAdd BLAST | 111 |
Sequence similaritiesi
Belongs to the EMP24/GP25L family.Imported
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1691, Eukaryota |
GeneTreei | ENSGT00550000074954 |
HOGENOMi | CLU_066963_3_1_1 |
InParanoidi | Q8SXY6 |
OMAi | GWQIMYL |
OrthoDBi | 1370889at2759 |
PhylomeDBi | Q8SXY6 |
Family and domain databases
InterProi | View protein in InterPro IPR015720, Emp24-like IPR009038, GOLD_dom |
PANTHERi | PTHR22811, PTHR22811, 1 hit |
Pfami | View protein in Pfam PF01105, EMP24_GP25L, 1 hit |
SMARTi | View protein in SMART SM01190, EMP24_GP25L, 1 hit |
PROSITEi | View protein in PROSITE PS50866, GOLD, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q8SXY6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARAAFIVCL LMACAWSSHA VMFKLSPNTQ KCLKEDIQAN QLVMGEFEVS
60 70 80 90 100
DVPGQIIDYI ARDTKGHILS QKEHITKGKF SFMSEVYDTY EICFISKVPA
110 120 130 140 150
HQRGVIQEVS LLTKKGVETK SYEGIGEASK LKPLEVDLKR LEDLSDSIVR
160 170 180 190 200
DFVLMRKREE EMRDTNEKTN SRVLFFSIFS MCCLLGLATW QVLYLRRYFK
AKKLIE
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 14 | C → S in strain: ZBMEL131. 1 Publication | 1 | |
Natural varianti | 60 | I → V in strain: MEL18 and MEL20. 1 Publication | 1 | |
Natural varianti | 95 | I → T in strain: ZBMEL82. 1 Publication | 1 | |
Natural varianti | 106 | I → V in strain: MEL11, MEL12, ZBMEL82, ZBMEL131, ZBMEL186, ZBMEL191 and ZBMEL229. 2 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AM294798 Genomic DNA Translation: CAL26784.1 AM294799 Genomic DNA Translation: CAL26785.1 AM294800 Genomic DNA Translation: CAL26786.1 AM294801 Genomic DNA Translation: CAL26787.1 AM294802 Genomic DNA Translation: CAL26788.1 AM294803 Genomic DNA Translation: CAL26789.1 AM294804 Genomic DNA Translation: CAL26790.1 AM294805 Genomic DNA Translation: CAL26791.1 AM294806 Genomic DNA Translation: CAL26792.1 AM294807 Genomic DNA Translation: CAL26793.1 AM294808 Genomic DNA Translation: CAL26794.1 FM245923 Genomic DNA Translation: CAR93849.1 FM245924 Genomic DNA Translation: CAR93850.1 FM245925 Genomic DNA Translation: CAR93851.1 FM245926 Genomic DNA Translation: CAR93852.1 FM245927 Genomic DNA Translation: CAR93853.1 FM245928 Genomic DNA Translation: CAR93854.1 FM245929 Genomic DNA Translation: CAR93855.1 FM245930 Genomic DNA Translation: CAR93856.1 FM245931 Genomic DNA Translation: CAR93857.1 FM245932 Genomic DNA Translation: CAR93858.1 FM245933 Genomic DNA Translation: CAR93859.1 AE014297 Genomic DNA Translation: AAF56382.2 AY075503 mRNA Translation: AAL68312.1 |
RefSeqi | NP_651323.3, NM_143066.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0084758; FBpp0084133; FBgn0045866 |
GeneIDi | 42996 |
KEGGi | dme:Dmel_CG11785 |
UCSCi | CG11785-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AM294798 Genomic DNA Translation: CAL26784.1 AM294799 Genomic DNA Translation: CAL26785.1 AM294800 Genomic DNA Translation: CAL26786.1 AM294801 Genomic DNA Translation: CAL26787.1 AM294802 Genomic DNA Translation: CAL26788.1 AM294803 Genomic DNA Translation: CAL26789.1 AM294804 Genomic DNA Translation: CAL26790.1 AM294805 Genomic DNA Translation: CAL26791.1 AM294806 Genomic DNA Translation: CAL26792.1 AM294807 Genomic DNA Translation: CAL26793.1 AM294808 Genomic DNA Translation: CAL26794.1 FM245923 Genomic DNA Translation: CAR93849.1 FM245924 Genomic DNA Translation: CAR93850.1 FM245925 Genomic DNA Translation: CAR93851.1 FM245926 Genomic DNA Translation: CAR93852.1 FM245927 Genomic DNA Translation: CAR93853.1 FM245928 Genomic DNA Translation: CAR93854.1 FM245929 Genomic DNA Translation: CAR93855.1 FM245930 Genomic DNA Translation: CAR93856.1 FM245931 Genomic DNA Translation: CAR93857.1 FM245932 Genomic DNA Translation: CAR93858.1 FM245933 Genomic DNA Translation: CAR93859.1 AE014297 Genomic DNA Translation: AAF56382.2 AY075503 mRNA Translation: AAL68312.1 |
RefSeqi | NP_651323.3, NM_143066.3 |
3D structure databases
SMRi | Q8SXY6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 67917, 6 interactors |
STRINGi | 7227.FBpp0084133 |
Protein family/group databases
TCDBi | 9.B.188.1.6, the transmembrane emp24 domain-containing protein (tmed) family |
Proteomic databases
PaxDbi | Q8SXY6 |
PRIDEi | Q8SXY6 |
Protocols and materials databases
DNASUi | 42996 |
Genome annotation databases
EnsemblMetazoai | FBtr0084758; FBpp0084133; FBgn0045866 |
GeneIDi | 42996 |
KEGGi | dme:Dmel_CG11785 |
UCSCi | CG11785-RA, d. melanogaster |
Organism-specific databases
CTDi | 42996 |
FlyBasei | FBgn0045866, bai |
VEuPathDBi | VectorBase:FBgn0045866 |
Phylogenomic databases
eggNOGi | KOG1691, Eukaryota |
GeneTreei | ENSGT00550000074954 |
HOGENOMi | CLU_066963_3_1_1 |
InParanoidi | Q8SXY6 |
OMAi | GWQIMYL |
OrthoDBi | 1370889at2759 |
PhylomeDBi | Q8SXY6 |
Enzyme and pathway databases
Reactomei | R-DME-6807878, COPI-mediated anterograde transport R-DME-6811434, COPI-dependent Golgi-to-ER retrograde traffic |
Miscellaneous databases
BioGRID-ORCSi | 42996, 0 hits in 1 CRISPR screen |
ChiTaRSi | bai, fly |
GenomeRNAii | 42996 |
PROi | PR:Q8SXY6 |
Gene expression databases
Bgeei | FBgn0045866, Expressed in spermathecum and 48 other tissues |
Genevisiblei | Q8SXY6, DM |
Family and domain databases
InterProi | View protein in InterPro IPR015720, Emp24-like IPR009038, GOLD_dom |
PANTHERi | PTHR22811, PTHR22811, 1 hit |
Pfami | View protein in Pfam PF01105, EMP24_GP25L, 1 hit |
SMARTi | View protein in SMART SM01190, EMP24_GP25L, 1 hit |
PROSITEi | View protein in PROSITE PS50866, GOLD, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TMEDA_DROME | |
Accessioni | Q8SXY6Primary (citable) accession number: Q8SXY6 Secondary accession number(s): A0AQ60 Q9VBZ4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 18, 2010 |
Last sequence update: | June 1, 2002 | |
Last modified: | September 29, 2021 | |
This is version 126 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families