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UniProtKB - Q8SXY6 (TMEDA_DROME)

Entry version 126 (29 Sep 2021)
Sequence version 1 (01 Jun 2002)
Previous versions | rss
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Protein

Transmembrane emp24 domain-containing protein bai

Gene

bai

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Eca and bai are essential, though not redundant, for dorsoventral patterning of the embryo. Specifically required during early embryogenesis for the activity of maternal tkv, while the zygotic tkv is not affected.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-6807878, COPI-mediated anterograde transport
R-DME-6811434, COPI-dependent Golgi-to-ER retrograde traffic

Protein family/group databases

Transport Classification Database

More...TCDBi		9.B.188.1.6, the transmembrane emp24 domain-containing protein (tmed) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane emp24 domain-containing protein bai1 PublicationImported
Alternative name(s):
Protein baiserImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:bai
ORF Names:CG11785
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0045866, bai

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		VectorBase:FBgn0045866

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 172LumenalSequence analysisImportedAdd BLAST152
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Topological domaini194 – 206CytoplasmicSequence analysisImportedAdd BLAST13

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mutant embryos exhibit reduced dpp signaling during early embryogenesis. Maternal tkv is not active and is not secreted.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisImportedAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000039391721 – 206Transmembrane emp24 domain-containing protein baiImportedAdd BLAST186

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8SXY6

PRoteomics IDEntifications database

More...PRIDEi		Q8SXY6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed both maternally and zygotically.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0045866, Expressed in spermathecum and 48 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8SXY6, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		67917, 6 interactors

STRING: functional protein association networks

More...STRINGi		7227.FBpp0084133

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8SXY6

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 140GOLDPROSITE-ProRule annotationImportedAdd BLAST111

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the EMP24/GP25L family.Imported

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1691, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00550000074954

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_066963_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8SXY6

Identification of Orthologs from Complete Genome Data

More...OMAi		GWQIMYL

Database of Orthologous Groups

More...OrthoDBi		1370889at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8SXY6

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR015720, Emp24-like
IPR009038, GOLD_dom

The PANTHER Classification System

More...PANTHERi		PTHR22811, PTHR22811, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01105, EMP24_GP25L, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01190, EMP24_GP25L, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50866, GOLD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q8SXY6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARAAFIVCL LMACAWSSHA VMFKLSPNTQ KCLKEDIQAN QLVMGEFEVS 
        60         70         80         90        100
DVPGQIIDYI ARDTKGHILS QKEHITKGKF SFMSEVYDTY EICFISKVPA 
       110        120        130        140        150
HQRGVIQEVS LLTKKGVETK SYEGIGEASK LKPLEVDLKR LEDLSDSIVR 
       160        170        180        190        200
DFVLMRKREE EMRDTNEKTN SRVLFFSIFS MCCLLGLATW QVLYLRRYFK 

AKKLIE
Length:206
Mass (Da):23,692
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i97289D8AC3BD15CE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti14C → S in strain: ZBMEL131. 1 Publication1
Natural varianti60I → V in strain: MEL18 and MEL20. 1 Publication1
Natural varianti95I → T in strain: ZBMEL82. 1 Publication1
Natural varianti106I → V in strain: MEL11, MEL12, ZBMEL82, ZBMEL131, ZBMEL186, ZBMEL191 and ZBMEL229. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AM294798 Genomic DNA Translation: CAL26784.1
AM294799 Genomic DNA Translation: CAL26785.1
AM294800 Genomic DNA Translation: CAL26786.1
AM294801 Genomic DNA Translation: CAL26787.1
AM294802 Genomic DNA Translation: CAL26788.1
AM294803 Genomic DNA Translation: CAL26789.1
AM294804 Genomic DNA Translation: CAL26790.1
AM294805 Genomic DNA Translation: CAL26791.1
AM294806 Genomic DNA Translation: CAL26792.1
AM294807 Genomic DNA Translation: CAL26793.1
AM294808 Genomic DNA Translation: CAL26794.1
FM245923 Genomic DNA Translation: CAR93849.1
FM245924 Genomic DNA Translation: CAR93850.1
FM245925 Genomic DNA Translation: CAR93851.1
FM245926 Genomic DNA Translation: CAR93852.1
FM245927 Genomic DNA Translation: CAR93853.1
FM245928 Genomic DNA Translation: CAR93854.1
FM245929 Genomic DNA Translation: CAR93855.1
FM245930 Genomic DNA Translation: CAR93856.1
FM245931 Genomic DNA Translation: CAR93857.1
FM245932 Genomic DNA Translation: CAR93858.1
FM245933 Genomic DNA Translation: CAR93859.1
AE014297 Genomic DNA Translation: AAF56382.2
AY075503 mRNA Translation: AAL68312.1

NCBI Reference Sequences

More...RefSeqi		NP_651323.3, NM_143066.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0084758; FBpp0084133; FBgn0045866

Database of genes from NCBI RefSeq genomes

More...GeneIDi		42996

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG11785

UCSC genome browser

More...UCSCi		CG11785-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM294798 Genomic DNA Translation: CAL26784.1
AM294799 Genomic DNA Translation: CAL26785.1
AM294800 Genomic DNA Translation: CAL26786.1
AM294801 Genomic DNA Translation: CAL26787.1
AM294802 Genomic DNA Translation: CAL26788.1
AM294803 Genomic DNA Translation: CAL26789.1
AM294804 Genomic DNA Translation: CAL26790.1
AM294805 Genomic DNA Translation: CAL26791.1
AM294806 Genomic DNA Translation: CAL26792.1
AM294807 Genomic DNA Translation: CAL26793.1
AM294808 Genomic DNA Translation: CAL26794.1
FM245923 Genomic DNA Translation: CAR93849.1
FM245924 Genomic DNA Translation: CAR93850.1
FM245925 Genomic DNA Translation: CAR93851.1
FM245926 Genomic DNA Translation: CAR93852.1
FM245927 Genomic DNA Translation: CAR93853.1
FM245928 Genomic DNA Translation: CAR93854.1
FM245929 Genomic DNA Translation: CAR93855.1
FM245930 Genomic DNA Translation: CAR93856.1
FM245931 Genomic DNA Translation: CAR93857.1
FM245932 Genomic DNA Translation: CAR93858.1
FM245933 Genomic DNA Translation: CAR93859.1
AE014297 Genomic DNA Translation: AAF56382.2
AY075503 mRNA Translation: AAL68312.1
RefSeqiNP_651323.3, NM_143066.3

3D structure databases

SMRiQ8SXY6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi67917, 6 interactors
STRINGi7227.FBpp0084133

Protein family/group databases

TCDBi9.B.188.1.6, the transmembrane emp24 domain-containing protein (tmed) family

Proteomic databases

PaxDbiQ8SXY6
PRIDEiQ8SXY6

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		42996

Genome annotation databases

EnsemblMetazoaiFBtr0084758; FBpp0084133; FBgn0045866
GeneIDi42996
KEGGidme:Dmel_CG11785
UCSCiCG11785-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		42996
FlyBaseiFBgn0045866, bai
VEuPathDBiVectorBase:FBgn0045866

Phylogenomic databases

eggNOGiKOG1691, Eukaryota
GeneTreeiENSGT00550000074954
HOGENOMiCLU_066963_3_1_1
InParanoidiQ8SXY6
OMAiGWQIMYL
OrthoDBi1370889at2759
PhylomeDBiQ8SXY6

Enzyme and pathway databases

ReactomeiR-DME-6807878, COPI-mediated anterograde transport
R-DME-6811434, COPI-dependent Golgi-to-ER retrograde traffic

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		42996, 0 hits in 1 CRISPR screen

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		bai, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		42996

Protein Ontology

More...PROi		PR:Q8SXY6

Gene expression databases

BgeeiFBgn0045866, Expressed in spermathecum and 48 other tissues
GenevisibleiQ8SXY6, DM

Family and domain databases

InterProiView protein in InterPro
IPR015720, Emp24-like
IPR009038, GOLD_dom
PANTHERiPTHR22811, PTHR22811, 1 hit
PfamiView protein in Pfam
PF01105, EMP24_GP25L, 1 hit
SMARTiView protein in SMART
SM01190, EMP24_GP25L, 1 hit
PROSITEiView protein in PROSITE
PS50866, GOLD, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTMEDA_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8SXY6
Secondary accession number(s): A0AQ60
, A0AQ63, A0AQ65, C0MKQ9, Q9VBZ4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: June 1, 2002
Last modified: September 29, 2021
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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