We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q8SXP0 (Q8SXP0_DROME)
Protein
Phosphatidate phosphatase
Gene
Lpin
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Catalytic activityi
Cofactori
Mg2+ARBA annotation
GO - Molecular functioni
- phosphatidate phosphatase activity Source: FlyBase
- transcription coactivator activity Source: FlyBase
GO - Biological processi
- cellular lipid metabolic process Source: GO_Central
- cellular response to insulin stimulus Source: FlyBase
- cellular response to starvation Source: FlyBase
- fatty acid catabolic process Source: GO_Central
- imaginal disc-derived wing margin morphogenesis Source: FlyBase
- imaginal disc-derived wing vein specification Source: FlyBase
- lipid homeostasis Source: FlyBase
- negative regulation of BMP signaling pathway Source: FlyBase
- positive regulation of insulin receptor signaling pathway Source: FlyBase
- positive regulation of phosphatidylinositol 3-kinase signaling Source: FlyBase
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of cell cycle phase transition Source: FlyBase
- regulation of cellular ketone metabolic process Source: FlyBase
- regulation of DNA damage checkpoint Source: FlyBase
- regulation of fatty acid metabolic process Source: FlyBase
- regulation of transcription by RNA polymerase II Source: FlyBase
- response to starvation Source: FlyBase
- triglyceride biosynthetic process Source: FlyBase
Keywordsi
Molecular function | HydrolaseImportedARBA annotation |
Enzyme and pathway databases
Reactomei | R-DME-1483191, Synthesis of PC R-DME-1483213, Synthesis of PE R-DME-4419969, Depolymerisation of the Nuclear Lamina R-DME-75109, Triglyceride biosynthesis |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:LpinImported Synonyms:anon-WO0118547.133Imported, dLipinImported, DLpinImported, Dmel\CG8709Imported, DmLpinImported, EP2431Imported, LIPINImported ORF Names:CG8709Imported, Dmel_CG8709Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0263593, Lpin |
VEuPathDBi | VectorBase:FBgn0263593 |
Subcellular locationi
Cytosol
- cytosol Source: FlyBase
Extracellular region or secreted
- female germline ring canal inner rim Source: FlyBase
Nucleus
- nucleus Source: FlyBase
Other locations
- cytoplasm Source: FlyBase
Expressioni
Gene expression databases
Bgeei | FBgn0263593, Expressed in capitellum (Drosophila) and 56 other tissues |
Interactioni
Protein-protein interaction databases
IntActi | Q8SXP0, 2 interactors |
STRINGi | 7227.FBpp0292618 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 808 – 963 | LNS2InterPro annotationAdd BLAST | 156 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 159 – 180 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 209 – 415 | DisorderedSequence analysisAdd BLAST | 207 | |
Regioni | 508 – 550 | DisorderedSequence analysisAdd BLAST | 43 | |
Regioni | 681 – 725 | DisorderedSequence analysisAdd BLAST | 45 | |
Regioni | 1014 – 1043 | DisorderedSequence analysisAdd BLAST | 30 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 237 – 254 | Basic and acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 273 – 287 | Basic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 288 – 302 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 323 – 346 | Polar residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 520 – 539 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 703 – 725 | Polar residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 1025 – 1041 | Acidic residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the lipin family.ARBA annotation
Phylogenomic databases
eggNOGi | KOG2116, Eukaryota |
GeneTreei | ENSGT00940000168260 |
Family and domain databases
InterProi | View protein in InterPro IPR036412, HAD-like_sf IPR026058, LIPIN IPR031703, Lipin_mid IPR007651, Lipin_N IPR013209, LNS2 IPR031315, LNS2/PITP |
PANTHERi | PTHR12181, PTHR12181, 1 hit |
Pfami | View protein in Pfam PF16876, Lipin_mid, 1 hit PF04571, Lipin_N, 1 hit PF08235, LNS2, 1 hit |
SMARTi | View protein in SMART SM00775, LNS2, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
Q8SXP0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNSLARVFSN FRDFYNDINA ATLTGAIDVI VVEQRDGEFQ CSPFHVRFGK
60 70 80 90 100
LGVLRSREKV VDIEINGVPV DIQMKLGDSG EAFFVEECLE DEDEELPANL
110 120 130 140 150
ATSPIPNSFL ASRDKANDTM EDISGVVTDK NASEELLLPL PLPRRNSIDF
160 170 180 190 200
SKEEPKEAVV EGSKFENQVS DYTQRRHTDN TLERRNLSEK LKEFTTQKIR
210 220 230 240 250
QEWAEHEELF QGEKKPADSD SLDNQSKASN EAETEKAIPA VIEDTEKEKD
260 270 280 290 300
QIKPDVNLTT VTTSEATKEV SKSKTKKRRK KSQMKKNAQR KNSSSSSLGS
310 320 330 340 350
AGGGDLPSAE TPSLGVSNID EGDAPISSAT NNNNTSSSND EQLSAPLVTA
360 370 380 390 400
RTGDDSPLSE IPHTPTSNPR LDLDIHFFSD TEITTPVGGG GAGSGRAAGG
410 420 430 440 450
RPSTPIQSDS ELETTMRDNR HVVTEESTAS WKWGELPTPE QAKNEAMSAA
460 470 480 490 500
QVQQSEHQSM LSNMFSFMKR ANRLRKEKGV GEVGDIYLSD LDAGSMDPEM
510 520 530 540 550
AALYFPSPLS KAASPPEEDG ESGNGTSLPH SPSSLEEGQK SIDSDFDETK
560 570 580 590 600
QQRDNNRYLD FVAMSMCGMS EQGAPPSDEE FDRHLVNYPD VCKSPSIFSS
610 620 630 640 650
PNLVVRLNGK YYTWMAACPI VMTMITFQKP LTHDAIEQLM SQTVDGKCLP
660 670 680 690 700
GDEKQEAVAQ ADNGGQTKRY WWSWRRSQDA APNHLNNTHG MPLGKDEKDG
710 720 730 740 750
DQAAVATQTS RPTSPDITDP TLSKSDSLVN AENTSALVDN LEELTMASNK
760 770 780 790 800
SDEPKERYKK SLRLSSAAIK KLNLKEGMNE IEFSVTTAYQ GTTRCKCYLF
810 820 830 840 850
RWKHNDKVVI SDIDGTITKS DVLGHILPMV GKDWAQLGVA QLFSKIEQNG
860 870 880 890 900
YKLLYLSARA IGQSRVTREY LRSIRQGNVM LPDGPLLLNP TSLISAFHRE
910 920 930 940 950
VIEKKPEQFK IACLSDIRDL FPDKEPFYAG YGNRINDVWA YRAVGIPIMR
960 970 980 990 1000
IFTINTKGEL KHELTQTFQS SGYINQSLEV DEYFPLLTNQ DEFDYRTDIF
1010 1020 1030 1040 1050
DDEESEEELQ FSDDYDVDVE HGSSEESSGD EDDDEALYND DFANDDNGIQ
1060 1070 1080
AVVASGDERT ADVGLIMRVR RVSTKNEVIM ASPPKWINS
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketI0E2I4 | I0E2I4_DROME | Phosphatidate phosphatase | Lpin anon-WO0118547.133, CG8709-RH, dLipin, DLpin, Dmel\CG8709 | 1,043 | Annotation score: | ||
A8DY69 | A8DY69_DROME | Phosphatidate phosphatase | Lpin anon-WO0118547.133, dLipin, DLpin, Dmel\CG8709, DmLpin | 1,035 | Annotation score: | ||
A0A0B4JCQ5 | A0A0B4JCQ5_DROME | Phosphatidate phosphatase | Lpin anon-WO0118547.133, dLipin, DLpin, Dmel\CG8709, DmLpin | 1,088 | Annotation score: | ||
A0A0B4JD00 | A0A0B4JD00_DROME | Phosphatidate phosphatase | Lpin anon-WO0118547.133, dLipin, DLpin, Dmel\CG8709, DmLpin | 1,034 | Annotation score: | ||
A0A0B4JD27 | A0A0B4JD27_DROME | Lipin, isoform E | Lpin anon-WO0118547.133, dLipin, DLpin, Dmel\CG8709, DmLpin | 1,045 | Annotation score: | ||
A0A0B4JD31 | A0A0B4JD31_DROME | Lipin, isoform L | Lpin anon-WO0118547.133, dLipin, DLpin, Dmel\CG8709, DmLpin | 992 | Annotation score: | ||
A0A0B4JCS1 | A0A0B4JCS1_DROME | Lipin, isoform G | Lpin anon-WO0118547.133, dLipin, DLpin, Dmel\CG8709, DmLpin | 1,016 | Annotation score: | ||
E5DK16 | E5DK16_DROME | Lipin isoform J | Lpin anon-WO0118547.133, dLipin, DLpin, Dmel\CG8709, DmLpin | 962 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF59125.2 AY089509 mRNA Translation: AAL90247.1 AE013599 Genomic DNA Translation: ADV37133.1 |
RefSeqi | NP_001188884.1, NM_001201955.2 NP_610359.2, NM_136515.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0088815; FBpp0087891; FBgn0263593 FBtr0303585; FBpp0292618; FBgn0263593 |
GeneIDi | 35790 |
UCSCi | CG8709-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF59125.2 AY089509 mRNA Translation: AAL90247.1 AE013599 Genomic DNA Translation: ADV37133.1 |
RefSeqi | NP_001188884.1, NM_001201955.2 NP_610359.2, NM_136515.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q8SXP0, 2 interactors |
STRINGi | 7227.FBpp0292618 |
Protocols and materials databases
DNASUi | 35790 |
Genome annotation databases
EnsemblMetazoai | FBtr0088815; FBpp0087891; FBgn0263593 FBtr0303585; FBpp0292618; FBgn0263593 |
GeneIDi | 35790 |
UCSCi | CG8709-RA, d. melanogaster |
Organism-specific databases
CTDi | 35790 |
FlyBasei | FBgn0263593, Lpin |
VEuPathDBi | VectorBase:FBgn0263593 |
Phylogenomic databases
eggNOGi | KOG2116, Eukaryota |
GeneTreei | ENSGT00940000168260 |
Enzyme and pathway databases
Reactomei | R-DME-1483191, Synthesis of PC R-DME-1483213, Synthesis of PE R-DME-4419969, Depolymerisation of the Nuclear Lamina R-DME-75109, Triglyceride biosynthesis |
Miscellaneous databases
BioGRID-ORCSi | 35790, 0 hits in 3 CRISPR screens |
GenomeRNAii | 35790 |
Gene expression databases
Bgeei | FBgn0263593, Expressed in capitellum (Drosophila) and 56 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR036412, HAD-like_sf IPR026058, LIPIN IPR031703, Lipin_mid IPR007651, Lipin_N IPR013209, LNS2 IPR031315, LNS2/PITP |
PANTHERi | PTHR12181, PTHR12181, 1 hit |
Pfami | View protein in Pfam PF16876, Lipin_mid, 1 hit PF04571, Lipin_N, 1 hit PF08235, LNS2, 1 hit |
SMARTi | View protein in SMART SM00775, LNS2, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8SXP0_DROME | |
Accessioni | Q8SXP0Primary (citable) accession number: Q8SXP0 Secondary accession number(s): Q9V374 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 1, 2002 |
Last sequence update: | June 1, 2002 | |
Last modified: | January 19, 2022 | |
This is version 164 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |