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Entry version 147 (02 Jun 2021)
Sequence version 2 (10 Oct 2003)
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Protein

Protein split ends

Gene

spen

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable corepressor protein, which regulates different key pathways such as the EGF receptor and Wg pathways. Involved in neuronal cell fate, survival and axon guidance, cell cycle regulation and repression of head identity in the embryonic trunk. May act with the Hox gene Deformed and the EGF receptor signaling pathway. Positive regulator of the Wg pathway in larval tissues but not in embryonic tissues. May act as a transcriptional corepressor protein, which repress transcription via the recruitment of large complexes containing histone deacetylase proteins.

4 Publications

Caution

It is uncertain whether Met-1 or Met-7 is the initiator.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Repressor, RNA-binding
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein split ends
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:spen
ORF Names:CG18497
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0016977, spen

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi5471C → Y in E9; induces head-like skeletal structures in the trunk. 1
Mutagenesisi5507G → D in D57; induces head-like skeletal structures in the trunk. 1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000819581 – 5560Protein split endsAdd BLAST5560

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1174Phosphoserine1 Publication1
Modified residuei1596Phosphoserine1 Publication1
Modified residuei1600Phosphoserine1 Publication1
Modified residuei1907Phosphoserine1 Publication1
Modified residuei1908Phosphoserine1 Publication1
Modified residuei2276Phosphothreonine1 Publication1
Modified residuei2277Phosphoserine1 Publication1
Modified residuei2329Phosphothreonine1 Publication1
Modified residuei2345Phosphoserine1 Publication1
Modified residuei2349Phosphoserine1 Publication1
Modified residuei2351Phosphoserine1 Publication1
Modified residuei2403Phosphoserine1 Publication1
Modified residuei2404Phosphoserine1 Publication1
Modified residuei2407Phosphoserine1 Publication1
Modified residuei2410Phosphothreonine1 Publication1
Modified residuei2476Phosphoserine1 Publication1
Modified residuei2478Phosphothreonine1 Publication1
Modified residuei2501Phosphoserine1 Publication1
Modified residuei2502Phosphoserine1 Publication1
Modified residuei2503Phosphoserine1 Publication1
Modified residuei2517Phosphoserine1 Publication1
Modified residuei2518Phosphoserine1 Publication1
Modified residuei2520Phosphoserine1 Publication1
Modified residuei2557Phosphoserine1 Publication1
Modified residuei2558Phosphoserine1 Publication1
Modified residuei2584Phosphoserine1 Publication1
Modified residuei2586Phosphoserine1 Publication1
Modified residuei2588Phosphoserine1 Publication1
Modified residuei3011Phosphoserine1 Publication1
Modified residuei3018Phosphoserine1 Publication1
Modified residuei3125Phosphothreonine1 Publication1
Modified residuei3408Phosphothreonine1 Publication1
Modified residuei3411Phosphoserine1 Publication1
Modified residuei3650Phosphoserine1 Publication1
Modified residuei3653Phosphoserine1 Publication1
Modified residuei3657Phosphoserine1 Publication1
Modified residuei3672Phosphoserine1 Publication1
Modified residuei3707Phosphoserine1 Publication1
Modified residuei4938Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8SX83

PRoteomics IDEntifications database

More...
PRIDEi
Q8SX83

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8SX83

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Expressed prior to cellularization in stage 3 embryos, and in blastoderm cells, including pole cells. Expressed throughout the rest of embryogenesis. Later, it is expressed at higher level in epidermal cells and CNS.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoform 3 is expressed both maternally and zygotically.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0016977, Expressed in brain and 40 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8SX83, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
68897, 28 interactors

Protein interaction database and analysis system

More...
IntActi
Q8SX83, 7 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0077781

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8SX83

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini554 – 632RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini656 – 730RRM 2PROSITE-ProRule annotationAdd BLAST75
Domaini734 – 806RRM 3PROSITE-ProRule annotationAdd BLAST73
Domaini5393 – 5560SPOCPROSITE-ProRule annotationAdd BLAST168

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni42 – 72DisorderedSequence analysisAdd BLAST31
Regioni114 – 145DisorderedSequence analysisAdd BLAST32
Regioni166 – 204DisorderedSequence analysisAdd BLAST39
Regioni236 – 287DisorderedSequence analysisAdd BLAST52
Regioni326 – 366DisorderedSequence analysisAdd BLAST41
Regioni425 – 545DisorderedSequence analysisAdd BLAST121
Regioni814 – 876DisorderedSequence analysisAdd BLAST63
Regioni1027 – 1054DisorderedSequence analysisAdd BLAST28
Regioni1089 – 1114DisorderedSequence analysisAdd BLAST26
Regioni1131 – 1150DisorderedSequence analysisAdd BLAST20
Regioni1196 – 1298DisorderedSequence analysisAdd BLAST103
Regioni1386 – 1521DisorderedSequence analysisAdd BLAST136
Regioni1640 – 2428DisorderedSequence analysisAdd BLAST789
Regioni2450 – 2537DisorderedSequence analysisAdd BLAST88
Regioni2549 – 2637DisorderedSequence analysisAdd BLAST89
Regioni2664 – 2695DisorderedSequence analysisAdd BLAST32
Regioni2736 – 2832DisorderedSequence analysisAdd BLAST97
Regioni2844 – 3215DisorderedSequence analysisAdd BLAST372
Regioni3257 – 3313DisorderedSequence analysisAdd BLAST57
Regioni3341 – 3487DisorderedSequence analysisAdd BLAST147
Regioni3572 – 3597DisorderedSequence analysisAdd BLAST26
Regioni3673 – 3750DisorderedSequence analysisAdd BLAST78
Regioni3787 – 3807DisorderedSequence analysisAdd BLAST21
Regioni3821 – 4024DisorderedSequence analysisAdd BLAST204
Regioni4036 – 4075DisorderedSequence analysisAdd BLAST40
Regioni4098 – 4138DisorderedSequence analysisAdd BLAST41
Regioni4248 – 4306DisorderedSequence analysisAdd BLAST59
Regioni4426 – 4453DisorderedSequence analysisAdd BLAST28
Regioni4471 – 4558DisorderedSequence analysisAdd BLAST88
Regioni4723 – 4771DisorderedSequence analysisAdd BLAST49
Regioni4920 – 4963DisorderedSequence analysisAdd BLAST44
Regioni4984 – 5009DisorderedSequence analysisAdd BLAST26
Regioni5176 – 5197DisorderedSequence analysisAdd BLAST22
Regioni5220 – 5241DisorderedSequence analysisAdd BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1449 – 1465Sequence analysisAdd BLAST17
Coiled coili1902 – 2071Sequence analysisAdd BLAST170
Coiled coili2732 – 2760Sequence analysisAdd BLAST29
Coiled coili2925 – 2957Sequence analysisAdd BLAST33
Coiled coili3026 – 3063Sequence analysisAdd BLAST38
Coiled coili3905 – 3965Sequence analysisAdd BLAST61
Coiled coili4465 – 4486Sequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi129 – 145Polar residuesSequence analysisAdd BLAST17
Compositional biasi182 – 201Polar residuesSequence analysisAdd BLAST20
Compositional biasi346 – 366Polar residuesSequence analysisAdd BLAST21
Compositional biasi436 – 545Polar residuesSequence analysisAdd BLAST110
Compositional biasi815 – 876Polar residuesSequence analysisAdd BLAST62
Compositional biasi1100 – 1114Polar residuesSequence analysisAdd BLAST15
Compositional biasi1205 – 1233Polar residuesSequence analysisAdd BLAST29
Compositional biasi1283 – 1298Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi1386 – 1444Polar residuesSequence analysisAdd BLAST59
Compositional biasi1452 – 1466Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1470 – 1521Polar residuesSequence analysisAdd BLAST52
Compositional biasi1640 – 1666Polar residuesSequence analysisAdd BLAST27
Compositional biasi1685 – 1706Polar residuesSequence analysisAdd BLAST22
Compositional biasi1708 – 1735Pro residuesSequence analysisAdd BLAST28
Compositional biasi1739 – 1826Polar residuesSequence analysisAdd BLAST88
Compositional biasi1839 – 1853Polar residuesSequence analysisAdd BLAST15
Compositional biasi1854 – 1885Basic and acidic residuesSequence analysisAdd BLAST32
Compositional biasi1886 – 1901Polar residuesSequence analysisAdd BLAST16
Compositional biasi1902 – 2083Basic and acidic residuesSequence analysisAdd BLAST182
Compositional biasi2098 – 2128Polar residuesSequence analysisAdd BLAST31
Compositional biasi2196 – 2221Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi2251 – 2276Polar residuesSequence analysisAdd BLAST26
Compositional biasi2277 – 2300Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi2303 – 2320Basic residuesSequence analysisAdd BLAST18
Compositional biasi2321 – 2339Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi2340 – 2365Polar residuesSequence analysisAdd BLAST26
Compositional biasi2378 – 2393Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi2408 – 2422Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi2466 – 2489Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi2507 – 2522Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi2523 – 2537Polar residuesSequence analysisAdd BLAST15
Compositional biasi2552 – 2567Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi2576 – 2596Polar residuesSequence analysisAdd BLAST21
Compositional biasi2605 – 2637Basic and acidic residuesSequence analysisAdd BLAST33
Compositional biasi2757 – 2771Polar residuesSequence analysisAdd BLAST15
Compositional biasi2793 – 2828Polar residuesSequence analysisAdd BLAST36
Compositional biasi2854 – 2920Polar residuesSequence analysisAdd BLAST67
Compositional biasi2954 – 2970Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi2988 – 3002Polar residuesSequence analysisAdd BLAST15
Compositional biasi3011 – 3026Polar residuesSequence analysisAdd BLAST16
Compositional biasi3058 – 3082Polar residuesSequence analysisAdd BLAST25
Compositional biasi3156 – 3215Polar residuesSequence analysisAdd BLAST60
Compositional biasi3270 – 3284Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi3285 – 3313Polar residuesSequence analysisAdd BLAST29
Compositional biasi3359 – 3383Acidic residuesSequence analysisAdd BLAST25
Compositional biasi3391 – 3418Basic and acidic residuesSequence analysisAdd BLAST28
Compositional biasi3435 – 3487Polar residuesSequence analysisAdd BLAST53
Compositional biasi3676 – 3750Polar residuesSequence analysisAdd BLAST75
Compositional biasi4098 – 4120Polar residuesSequence analysisAdd BLAST23
Compositional biasi4471 – 4499Polar residuesSequence analysisAdd BLAST29
Compositional biasi4500 – 4521Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi4522 – 4537Polar residuesSequence analysisAdd BLAST16
Compositional biasi4736 – 4771Polar residuesSequence analysisAdd BLAST36
Compositional biasi4938 – 4963Polar residuesSequence analysisAdd BLAST26
Compositional biasi5179 – 5197Polar residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RRM Spen family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0112, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157087

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_223086_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8SX83

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8SX83

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12349, RRM2_SHARP, 1 hit
cd12350, RRM3_SHARP, 1 hit
cd12351, RRM4_SHARP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.290.10, 1 hit
3.30.70.330, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR034173, SHARP_RRM2
IPR034174, SHARP_RRM3
IPR034175, SHARP_RRM4
IPR016194, SPOC-like_C_dom_sf
IPR012921, SPOC_C
IPR010912, SPOC_met

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00076, RRM_1, 1 hit
PF07744, SPOC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00360, RRM, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100939, SSF100939, 1 hit
SSF54928, SSF54928, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102, RRM, 3 hits
PS50917, SPOC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8SX83-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFRCRNMVRD NSRNICFGKL AETTTTQQQQ QQQQFVVDSS TIINNNNNNN
60 70 80 90 100
NNNNNQKLKR STEEPPTNSF ERNYYDRTTS RLVTQYQANN STSLANSNSS
110 120 130 140 150
PSSVSASASV FATAAGGSSE RSRNRDRPYR NGSASVQGGG INSSNTTTTT
160 170 180 190 200
AACTAGGSGS GAIGTGTGGL VGSGPGGVPQ ALGDRSSTQN IHQNHQSARV
210 220 230 240 250
APPQSWYEAA TAATTAQLKS SGGSGNAGAS AAVGFTMSSS PINHHPHQHP
260 270 280 290 300
HLQNPQHPHY TSSPVVGAGS CPSAAQGQPQ IQSQSQTTAV HRSVAYAGSA
310 320 330 340 350
ADDLLNTATS RNMLLHSSKL NKLLKGAGAT GSGGERSGSE SPGRAGGATP
360 370 380 390 400
LTTTSTITNN SFSSNSLNNT ITTATPTMPT IASGAAGSVG LGSGAEAGVC
410 420 430 440 450
SNSGTASGDI LNVAAVLAAA VDNGVPTHPI RTRHNLHGRS TTSSSRSHSR
460 470 480 490 500
SPSSYSSSHS SSSSSHSSSH SHASSPVQSS GNCAMAEGRS SRTVNSVTVT
510 520 530 540 550
SNSSNPSGTA VTVSSAGVGG GCGSSSSSSS SSSSSGSSCL TANPVVHSED
560 570 580 590 600
NRPLAIRVRN LPARSSDTSL KDGLFHEYKK HGKVTWVKVV GQNSERYALV
610 620 630 640 650
CFKKPDDVEK ALEVSHDKHF FGCKIEVEPY QGYDVEDNEF RPYEAELDEY
660 670 680 690 700
HPKSTRTLFI GNLEKDITAG ELRSHFEAFG EIIEIDIKKQ GLNAYAFCQY
710 720 730 740 750
SDIVSVVKAM RKMDGEHLGS NRIKLGFGKS MPTNCVWIDG VDEKVSESFL
760 770 780 790 800
QSQFTRFGAV TKVSIDRNRQ LALVLYDQVQ NAQAAVKDMR GTILRRKKLQ
810 820 830 840 850
VDFASRECQD AFYDKQEKQQ QQSSGSNPRF SRYESSASSL QSRSRASSFS
860 870 880 890 900
RHQNNSNDDC SPINTPGGAS SGISSASNLI NQSTSINISN IGTNACSAMP
910 920 930 940 950
APSLASAVVS CNVNASGTVP ASTSMPSGVS SSSSSLPMSP AALAQRHRMV
960 970 980 990 1000
RNARQTVDCD FNEVGRLRFR SSEEVSGGAG NSTQFEDVRC DSPVTARQGS
1010 1020 1030 1040 1050
AVNCFTGPTA AVGESIDGTL NNNQITGGAE GFTGSGGSIL SRRRCGKTPK
1060 1070 1080 1090 1100
DLHPVHNQRI QLAEQVEECP SSGDEGVVSP RKRIKMDYHH HHHHSNASGV
1110 1120 1130 1140 1150
ESTGEHSSIN KPSPLLLSNC DVIHDPLNRK SEIRRVSETP SGSPSIKFPG
1160 1170 1180 1190 1200
HLPSAPQSLM LSCRRPSIDV GALSALSSSS AFRHGIVGAS SMDQQHMMNA
1210 1220 1230 1240 1250
SAAAKRRRVT TTMQQPSSSS TTNSSSGSGL GGISSLTPAD EYHHHVSRGR
1260 1270 1280 1290 1300
GHQLHSHHSH EASGGESADG SRPGTPLCDE RPEVLPTEPR RLPPPRERVR
1310 1320 1330 1340 1350
ERTRDVMWLP LPKFGVLFFQ QQQSRSSGGG GAGNSYLQQQ LGGGSTGGLG
1360 1370 1380 1390 1400
CIGAASSSAC SLNNSSLNAS QGMGSCSGST FLPSPSSRYW RSSSHHQNQQ
1410 1420 1430 1440 1450
NNHQQQSQQL HGSSSSNTCL MASPARPRSL SSNSSDSDVP GQNAGGSPSL
1460 1470 1480 1490 1500
DERLRNFEEN YERWSGGSSR EHISGHTPSS ATPSWQLSMH MNLSTGLNSH
1510 1520 1530 1540 1550
QTSSASGNSN SSSGTVSSSA SNSRHKFLDI DELQPSDIVK SVLAKKSVFD
1560 1570 1580 1590 1600
DDFQRLNKNQ WYDPSSSDFA LGSSSNIVTG SSLVANVSRH PGGPCSGNTS
1610 1620 1630 1640 1650
PALPNLAATK ATPIIGNCSG GLGNSTGSKS AGLLQRLSSL SPMNSPQASM
1660 1670 1680 1690 1700
SPYNSPSPSP SVGGVTACLG QLTKPAAPGT ASAGLSGGTA ASSSSPAANS
1710 1720 1730 1740 1750
GPTKGLQYPF PSHPPLPNTA APPPAVQPAP PPLPEMGKQS RLTGQSSGNN
1760 1770 1780 1790 1800
LTKSLSVPDG PQSSPARVQL QKSASVPGST NVGAPSSLSL DSTTASVETS
1810 1820 1830 1840 1850
ASISSSTSNG NSSLTSAAIH VQKPQQSTFV EEEHTKKSGT STSQSSSSSS
1860 1870 1880 1890 1900
KKISSTHDKL HSKHNNRSES DKKIKKSDKN ASSSDKRKNS STSQSSKSAT
1910 1920 1930 1940 1950
PRIEDDSSEA DDTADKAEKN QRHEKEKKER QEKREKDLRK QVEREEKDRK
1960 1970 1980 1990 2000
AQQEEREKED RKAKEEEKER EREKKAQEDR EKKEREEREL REKEQRDKEQ
2010 2020 2030 2040 2050
KEKEIREKDL REKEQRERDN REKELRDKDL REKEMREKEQ REKELHREKD
2060 2070 2080 2090 2100
QREREHREKE QSRRAMDVEQ EGRGGRMREL SSYQKSKMDI AGEASSLTAI
2110 2120 2130 2140 2150
DCQHNKENAM DTIAQGTPGA SPSTPSDNTP KERSRKLSRN SPVRLHKRRL
2160 2170 2180 2190 2200
SSQESNHSAG GGGSCGGSSH QIHHEDYVKR IRMENSQNIS VHSSNQRLND
2210 2220 2230 2240 2250
RRDSKEHKSS SFKEDKNSSS HISRPHGCGG SSASSSKHHH RRDKHHQKGS
2260 2270 2280 2290 2300
ASSIETNSSI EVVVDPISQT KHNLNTSEEE LQSHQPKREK EREHFSSHAN
2310 2320 2330 2340 2350
SSSSRHKSKR DHHHHREKKR HSVAESTNTD EEHTPQQHNP HRRISAAGSG
2360 2370 2380 2390 2400
SAGELSSAAT NTSSGKLHHQ HHRRSVERKS SRGSDEGHHS SSKSLRAKLM
2410 2420 2430 2440 2450
MLSSADSDDT DDASKKHSIF DIPDDCPNVS MYDKVKARSC KNMQRQAEEK
2460 2470 2480 2490 2500
KIKAKFSQLK QSRAKKKRST SYDGDSDTEF EDRQHRNSGS SSFHGRYPGL
2510 2520 2530 2540 2550
SSSDDDDDEE THQRRISSDS DAEHGGQDNQ GASTLADANR VRQMQQNLRR
2560 2570 2580 2590 2600
LCDGDDSSED EIRRNVMKHS HFGKRNSNST RIASDSESQS QPAPDLTIKQ
2610 2620 2630 2640 2650
EHPIAPAQEI KREQLSDEEQ KFKSRHDSNS SIEERKLKTE REIKTELGDF
2660 2670 2680 2690 2700
YNSSEYTYTG KLKEYSPETR KKHKKSKRRL KSSSTADTSA AQTPLVMTPL
2710 2720 2730 2740 2750
TPSIFDVHSS SECKTKFDNF DDLKTECSSI PLEISAGERR KHKERKEKKR
2760 2770 2780 2790 2800
EKLRNMTEAT VPNSPTTNDT SSEKLSKEER HRLKKSKKSK SMDNSCNTKI
2810 2820 2830 2840 2850
YNSSGAHPST SPSLPATPTS APSTAQTSKR GEDKMEFIFG IISDEEESQF
2860 2870 2880 2890 2900
PEQAETNKDI IPSSVSTTGP IVSAALQTYK QEPSTPNSKN EEAHIQLTVH
2910 2920 2930 2940 2950
EPEQQQQLER SRLSGGSSSS SHADRERHRR EKREKKRREK SQREQQNQIH
2960 2970 2980 2990 3000
QKSSKVETKV DDDNSVDMDE AGRALEAQLM SDFDTKPISE EATPSTAATY
3010 3020 3030 3040 3050
RSDMTDVFRF SDNEDNNSVD MTKQGVKSEQ QEQHKSKDKK KKKKRSKEEK
3060 3070 3080 3090 3100
QEKLLQQQRR ESLPNVASTS SAPPTPGKLT VNVQAASKHA DLQLDAKHIS
3110 3120 3130 3140 3150
SPPVCKPSPS LPCLIGDDDD DALHTPKAKP TTPSSRGNDG LTPSREKPRL
3160 3170 3180 3190 3200
ISPIPKTPTI ANSSTLSTQS AETPVSSGTV ISSSALATTP TSSTAAGVSA
3210 3220 3230 3240 3250
APGLDNSPTS ASAQCKKKES FIPGFDGQLD DRISESAVQS ISAEFNSTSL
3260 3270 3280 3290 3300
LDNIADEPKI PVASPPRATK PLDKLEESKS RVTISQEETE SAVSALLGES
3310 3320 3330 3340 3350
FGTSSTTDYS LDGMDEMSSV NELETPTLVI AEPDEEAALA AKAIETAGEP
3360 3370 3380 3390 3400
ASILEEPEME PEREAEPDPD PEAEIESEPV VEVLDPEELN KAVQSLKHED
3410 3420 3430 3440 3450
MMDIKADTPQ SERDLQIDTD TEENPDEADS SGPSLKIDET VQSSSSPEKS
3460 3470 3480 3490 3500
ISNNSPTPRE TANIDIPNVE SQPKLSNEST PQPSVITKLP FLDTPKTVPA
3510 3520 3530 3540 3550
GLPPSPVKIE PPTISKLQQP LVQPVQTVLP APHSTGSGIS ANSVINLDLS
3560 3570 3580 3590 3600
NVISSCSNTS AASATASASA SISFGSPTAS QNAMPQASTP KQGPITPQQA
3610 3620 3630 3640 3650
IRTQSLIMQP PTISIPEQTP HFAVPQMVLS PQSHHPQQPG TYMVGIRAPS
3660 3670 3680 3690 3700
PHSPLHSPGR GVAQSRLVGQ LSPVGRPMVS QPSPQQQVQQ TQQQHALITS
3710 3720 3730 3740 3750
PQSSNISPLA SPTTRVLSSS NSPTTSKVNS YQPRNQQVPQ QPSPKSVAEV
3760 3770 3780 3790 3800
QTTPQLMTIP LQKMTPIQVP HHPTIISKVV TVQPQQATQS QVASSPPLGS
3810 3820 3830 3840 3850
LPPHKNVHLN AHQNQQQPQV IAKMTAHQHQ QHMQQFMHQQ MIQRQQHMQQ
3860 3870 3880 3890 3900
QQLHGQSQQI TSAPQHQMHQ QHQAQQQQQH HNQQHLNQQL HAQQHPTQKQ
3910 3920 3930 3940 3950
HQAQQQFNQQ IQQHQSQQQH QVQQQNQAQQ QHLSQQQHQS QQQLNQQHQA
3960 3970 3980 3990 4000
QQQQLQQIQK LQQMHGPQQQ QKSPQGVGHL GGSTSIFASQ QHNSQLPARG
4010 4020 4030 4040 4050
VPQQQHPQQL SHSSPCKPNT LVSVNQGVQP PAILTRVGSH SQPNQQQQLP
4060 4070 4080 4090 4100
HQQSSSGHPH QKQLSSPGAN LPLQTPLNVI QNTPKIIVQQ HIVAQNQVPP
4110 4120 4130 4140 4150
PQTQGNAIHY PQNQGKDSTP PGHVEPTPAM SAQKTSESVS VIRTPTPTTG
4160 4170 4180 4190 4200
LAVISANTVG SLLTEENLIK ISQPKQDELI EQDSKEVDSD YWSAKEVNID
4210 4220 4230 4240 4250
SVIKKLDTPL ASKDAKRAVE MQAIAPAPIP NPQPGNQSMA QETALPTTSM
4260 4270 4280 4290 4300
SVNNSNDHDT EDETETRQLP PAKPPIPTVG RPPGRGGSAK RGRQPRGAKK
4310 4320 4330 4340 4350
VGGFPLNSVT AAPPGVDSLV VQPGDNGVQT RLRKPVTAPV TRGRKGRPPR
4360 4370 4380 4390 4400
NLLLQQQQLQ QQQLDIQRKG MEMVTSATSS TPLPTPIPTS SVLTAAEKKA
4410 4420 4430 4440 4450
RNQALTQAQE QNQVASQVGT GQDIYEFHED GGEEPKPKTI SSVAPSAEDQ
4460 4470 4480 4490 4500
RPRLILTINK TQPSIKNISE MEQTIQQQQQ QQSEVISNTD PIGGDNSESC
4510 4520 4530 4540 4550
NTRKSRRLQE KEDRSTVDDI IEDVVRNTNT PTGTGPHLPK GAQTPPRRSG
4560 4570 4580 4590 4600
RNAQAKKTDA VQIINAVGRP RRSKDRKTIG EQTANLIEEV TASNATVAAS
4610 4620 4630 4640 4650
HLAPPEGAGV ESHVPQLDAK EVEPVSVVTP ISTPAPVSVA APVTVPVPAM
4660 4670 4680 4690 4700
VPVKPTMPQH PKKKAIAAAE IESYQAINSS IPSGGLPMHQ TAAPATQKIT
4710 4720 4730 4740 4750
GGVADAVSKA LVDPVTGVIT AGMPQGKEGN LPAATAAAPA NSSNEDGQAA
4760 4770 4780 4790 4800
PPPQLQHQQQ QQHPQQPPQQ QANLQINTTL IPSGLPNPIT ALGKSVQLET
4810 4820 4830 4840 4850
SAAALLNKPV SVLVKGNASQ VIQQQQPQIV APAKQPIILQ QNPLPTVLHH
4860 4870 4880 4890 4900
AQHTTVRPPQ PLKAHVLNRE KNIQQQLTPT KQAVAQPPQH APHSGHMLLT
4910 4920 4930 4940 4950
DTAGNQQLVQ PQIIARHLQQ QQHLQVNVPP PTAHSPHSPR IPSQQQQLGP
4960 4970 4980 4990 5000
GASISPQQQQ PQTVVIKQAA SAAQPQILHV VSSKASVVPQ PQQQQLPPTS
5010 5020 5030 5040 5050
STGPHLQLAK PNYSYAPTVL TPTLPAVQQQ QQQHLYKQNN QQKGAQIQMP
5060 5070 5080 5090 5100
PHGIIMPTHP GMLLQQKLPA HLQPQQHQLN PSPPPGKPNP VLHGLQSGQI
5110 5120 5130 5140 5150
MPGSVGSPPP VSAAVLKTAQ QQVNSVVPVA GIRTAIPNIS PQSQPRVSPL
5160 5170 5180 5190 5200
VLPPGISGVP PFDASLHDLG AYVSGRRTQS PPPAHQQASP ITPNDSTYRG
5210 5220 5230 5240 5250
VTASRDFMLY QHHLMRGGDY DDKMGSSPPL ELRRPGSGPP RTIAVPHSLQ
5260 5270 5280 5290 5300
SPQDRTAADS PQMAQVYVHN TRIPPAHFSE IASRGLYDSG ALQLEPPPAH
5310 5320 5330 5340 5350
RPTATISVVV PQQMPAVSSG SPFIGRDGSV QPGSHHHPGK AMDMQLDEMD
5360 5370 5380 5390 5400
RMSMIAAVVQ QQQEHLPPAL PAGMELASQQ APPAMAPPPG DSLVTLLQRY
5410 5420 5430 5440 5450
PVMWQGLLAL KTDQAAVQMH FVHGNPNVAR ASLPSLVETN TPLLRIAQRM
5460 5470 5480 5490 5500
RLEQTQLEGV AKKMQVDKEH CMLLALPCGR DHADVLQHSR NLQTGFITYL
5510 5520 5530 5540 5550
QQKMAAGIVN IPIPGSEQAA YVVHIFPSCD FANENLERAA PDLKNRVAEL
5560
AHLLIVIATV
Note: Produced by alternative promoter usage.
Length:5,560
Mass (Da):600,000
Last modified:October 10, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i58F19621AF40D2A8
GO
Isoform 2 (identifier: Q8SX83-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: Missing.
     58-59: LK → MR

Note: Produced by alternative promoter usage.Curated
Show »
Length:5,503
Mass (Da):593,386
Checksum:i935A74EE704B28E3
GO
Isoform 3 (identifier: Q8SX83-3) [UniParc]FASTAAdd to basket
Also known as: SpenL

The sequence of this isoform differs from the canonical sequence as follows:
     5167-5193: Missing.

Note: Produced by alternative splicing of isoform 1.Curated
Show »
Length:5,533
Mass (Da):597,149
Checksum:i713E21117EAF2CCD
GO
Isoform 4 (identifier: Q8SX83-4) [UniParc]FASTAAdd to basket
Also known as: SpenS

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: Missing.
     58-59: LK → MR
     5167-5193: Missing.

Note: Produced by alternative splicing of isoform 2.Curated
Show »
Length:5,476
Mass (Da):590,534
Checksum:i93FAA8C7860770C2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PBZ3M9PBZ3_DROME
Split ends, isoform H
spen 136, 24, BcDNA:GM01870, Dmel\CG18497, E(E2F)2A
5,458Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PBJ8M9PBJ8_DROME
Split ends, isoform G
spen 136, 24, BcDNA:GM01870, Dmel\CG18497, E(E2F)2A
5,487Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PDR5M9PDR5_DROME
Split ends, isoform F
spen 136, 24, BcDNA:GM01870, Dmel\CG18497, E(E2F)2A
5,510Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9NCM6M9NCM6_DROME
Split ends, isoform D
spen 136, 24, BcDNA:GM01870, Dmel\CG18497, E(E2F)2A
5,505Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF34661 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4074Q → P (PubMed:10556062).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0085651 – 57Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST57
Alternative sequenceiVSP_00856658 – 59LK → MR in isoform 2 and isoform 4. 2 Publications2
Alternative sequenceiVSP_0085675167 – 5193Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST27

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF188205 mRNA Translation: AAF13218.1
AF184612 mRNA Translation: AAF26299.1
AF221715 mRNA Translation: AAF34661.1 Different initiation.
AE014134 Genomic DNA Translation: AAF51534.2
AE014134 Genomic DNA Translation: AAF51535.2
AE014134 Genomic DNA Translation: AAN10511.1
AY094788 mRNA Translation: AAM11141.1 Sequence problems.

NCBI Reference Sequences

More...
RefSeqi
NP_524718.2, NM_079979.5 [Q8SX83-3]
NP_722615.1, NM_164374.3 [Q8SX83-1]
NP_722616.1, NM_164375.3 [Q8SX83-4]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0078121; FBpp0077780; FBgn0016977 [Q8SX83-3]
FBtr0078122; FBpp0077781; FBgn0016977 [Q8SX83-1]
FBtr0078123; FBpp0077782; FBgn0016977 [Q8SX83-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
44205

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG18497

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188205 mRNA Translation: AAF13218.1
AF184612 mRNA Translation: AAF26299.1
AF221715 mRNA Translation: AAF34661.1 Different initiation.
AE014134 Genomic DNA Translation: AAF51534.2
AE014134 Genomic DNA Translation: AAF51535.2
AE014134 Genomic DNA Translation: AAN10511.1
AY094788 mRNA Translation: AAM11141.1 Sequence problems.
RefSeqiNP_524718.2, NM_079979.5 [Q8SX83-3]
NP_722615.1, NM_164374.3 [Q8SX83-1]
NP_722616.1, NM_164375.3 [Q8SX83-4]

3D structure databases

SMRiQ8SX83
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi68897, 28 interactors
IntActiQ8SX83, 7 interactors
STRINGi7227.FBpp0077781

PTM databases

iPTMnetiQ8SX83

Proteomic databases

PaxDbiQ8SX83
PRIDEiQ8SX83

Genome annotation databases

EnsemblMetazoaiFBtr0078121; FBpp0077780; FBgn0016977 [Q8SX83-3]
FBtr0078122; FBpp0077781; FBgn0016977 [Q8SX83-1]
FBtr0078123; FBpp0077782; FBgn0016977 [Q8SX83-4]
GeneIDi44205
KEGGidme:Dmel_CG18497

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23013
FlyBaseiFBgn0016977, spen

Phylogenomic databases

eggNOGiKOG0112, Eukaryota
GeneTreeiENSGT00940000157087
HOGENOMiCLU_223086_0_0_1
InParanoidiQ8SX83
PhylomeDBiQ8SX83

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
44205, 0 hits in 1 CRISPR screen

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
spen, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
44205

Protein Ontology

More...
PROi
PR:Q8SX83

Gene expression databases

BgeeiFBgn0016977, Expressed in brain and 40 other tissues
ExpressionAtlasiQ8SX83, baseline and differential

Family and domain databases

CDDicd12349, RRM2_SHARP, 1 hit
cd12350, RRM3_SHARP, 1 hit
cd12351, RRM4_SHARP, 1 hit
Gene3Di2.40.290.10, 1 hit
3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR034173, SHARP_RRM2
IPR034174, SHARP_RRM3
IPR034175, SHARP_RRM4
IPR016194, SPOC-like_C_dom_sf
IPR012921, SPOC_C
IPR010912, SPOC_met
PfamiView protein in Pfam
PF00076, RRM_1, 1 hit
PF07744, SPOC, 1 hit
SMARTiView protein in SMART
SM00360, RRM, 3 hits
SUPFAMiSSF100939, SSF100939, 1 hit
SSF54928, SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102, RRM, 3 hits
PS50917, SPOC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPEN_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8SX83
Secondary accession number(s): Q9NHN1
, Q9NJ17, Q9U6C3, Q9VPL1, Q9VPL2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: June 2, 2021
This is version 147 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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