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Protein

Probable phosphoacetylglucosamine mutase

Gene

PCM1

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins.By similarity

Catalytic activityi

N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate.By similarity

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Pathwayi: UDP-N-acetyl-alpha-D-glucosamine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I).By similarity
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Probable phosphoacetylglucosamine mutase (PCM1)
This subpathway is part of the pathway UDP-N-acetyl-alpha-D-glucosamine biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I), the pathway UDP-N-acetyl-alpha-D-glucosamine biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei62Phosphoserine intermediateBy similarity1
Metal bindingi62Magnesium; via phosphate groupBy similarity1
Metal bindingi278MagnesiumBy similarity1
Metal bindingi280MagnesiumBy similarity1
Metal bindingi282MagnesiumBy similarity1
Binding sitei490SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism, Cell wall biogenesis/degradation
LigandMagnesium, Metal-binding

Enzyme and pathway databases

UniPathwayi
UPA00113;UER00530

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phosphoacetylglucosamine mutaseBy similarity (EC:5.4.2.3By similarity)
Short name:
PAGM
Alternative name(s):
Acetylglucosamine phosphomutaseBy similarity
N-acetylglucosamine-phosphate mutaseBy similarity
Gene namesi
Name:PCM1By similarity
Ordered Locus Names:ECU01_0650
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiFungi incertae sedisMicrosporidiaUnikaryonidaeEncephalitozoon
Proteomesi
  • UP000000819 Componenti: Chromosome I

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU01_0650

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003817471 – 530Probable phosphoacetylglucosamine mutaseAdd BLAST530

Proteomic databases

PRIDEiQ8SSL7

Expressioni

Developmental stagei

Expressed in late sporogonial stages.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi284813.XP_965900.1

Structurei

3D structure databases

ProteinModelPortaliQ8SSL7
SMRiQ8SSL7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni369 – 371Substrate bindingBy similarity3
Regioni481 – 485Substrate bindingBy similarity5

Sequence similaritiesi

Belongs to the phosphohexose mutase family.Curated

Phylogenomic databases

eggNOGiKOG2537 Eukaryota
COG1109 LUCA
HOGENOMiHOG000210027
InParanoidiQ8SSL7
KOiK01836
OMAiLHYMVCC
OrthoDBiEOG092C236M

Family and domain databases

CDDicd03086 PGM3, 1 hit
InterProiView protein in InterPro
IPR005844 A-D-PHexomutase_a/b/a-I
IPR016055 A-D-PHexomutase_a/b/a-I/II/III
IPR005845 A-D-PHexomutase_a/b/a-II
IPR005846 A-D-PHexomutase_a/b/a-III
IPR005843 A-D-PHexomutase_C
IPR036900 A-D-PHexomutase_C_sf
IPR016066 A-D-PHexomutase_CS
IPR016657 PAGM
PfamiView protein in Pfam
PF02878 PGM_PMM_I, 2 hits
PF02879 PGM_PMM_II, 1 hit
PF02880 PGM_PMM_III, 1 hit
PF00408 PGM_PMM_IV, 1 hit
PIRSFiPIRSF016408 PAGM, 1 hit
SUPFAMiSSF53738 SSF53738, 4 hits
SSF55957 SSF55957, 1 hit
PROSITEiView protein in PROSITE
PS00710 PGM_PMM, 1 hit

Sequencei

Sequence statusi: Complete.

Q8SSL7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDNALIADEN LKKPSKPAYY GTAGYRSKTS DLNNILCRAS LIAYLRSTTF
60 70 80 90 100
AGKIIGVMIT ASHNPVEYNG IKIIDHNGDM LDEVWEEYSD RIVNCDDEKL
110 120 130 140 150
AREMKKILRS CSNQSELGEG VRGHVVLGRD TRDSGERLCN NIRSVLGKLN
160 170 180 190 200
CTVDDYGVVT TPELHFLVRK CNTENRVVDK AEYMKNIAHN FNSLSSITKG
210 220 230 240 250
NLRMMIDTAN GVADMKLKEL DGMLDGKLNY EVLNDPKGIL NLDCGADFVK
260 270 280 290 300
TKKRAPRLEA LSSSGFSQAA NRICASFDGD VDRLIFFTGP KDTEIFDGDS
310 320 330 340 350
QAVFLALYIR SLLDRIESRL SIGVVLSYYS NNAAVDVLPP ESFKVVMAQT
360 370 380 390 400
GVKNFVSAAR EFDVGIYFEP NGHGSVCFSQ ACIDEIEKGS TKSHAILKIL
410 420 430 440 450
ANLFDPCIGD ALANFVIFKA LMGSADDLRK FRENPSRLLT VKIVDKNSIK
460 470 480 490 500
VDQKNQVIEP KELQDKIDVE ALSLGGRSFV RPSGTEDVVR VYAECPSEAD
510 520 530
ADLLCLKVAQ HVYDMCNGIG DHPEIDYTSK
Length:530
Mass (Da):58,611
Last modified:June 1, 2002 - v1
Checksum:iE74F296E1F93C1B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL391737 Genomic DNA Translation: CAD24935.1
RefSeqiXP_965900.1, XM_960807.1

Genome annotation databases

EnsemblFungiiCAD24935; CAD24935; CAD24935
GeneIDi860240
KEGGiecu:ECU01_0650

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL391737 Genomic DNA Translation: CAD24935.1
RefSeqiXP_965900.1, XM_960807.1

3D structure databases

ProteinModelPortaliQ8SSL7
SMRiQ8SSL7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi284813.XP_965900.1

Proteomic databases

PRIDEiQ8SSL7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAD24935; CAD24935; CAD24935
GeneIDi860240
KEGGiecu:ECU01_0650

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU01_0650

Phylogenomic databases

eggNOGiKOG2537 Eukaryota
COG1109 LUCA
HOGENOMiHOG000210027
InParanoidiQ8SSL7
KOiK01836
OMAiLHYMVCC
OrthoDBiEOG092C236M

Enzyme and pathway databases

UniPathwayi
UPA00113;UER00530

Family and domain databases

CDDicd03086 PGM3, 1 hit
InterProiView protein in InterPro
IPR005844 A-D-PHexomutase_a/b/a-I
IPR016055 A-D-PHexomutase_a/b/a-I/II/III
IPR005845 A-D-PHexomutase_a/b/a-II
IPR005846 A-D-PHexomutase_a/b/a-III
IPR005843 A-D-PHexomutase_C
IPR036900 A-D-PHexomutase_C_sf
IPR016066 A-D-PHexomutase_CS
IPR016657 PAGM
PfamiView protein in Pfam
PF02878 PGM_PMM_I, 2 hits
PF02879 PGM_PMM_II, 1 hit
PF02880 PGM_PMM_III, 1 hit
PF00408 PGM_PMM_IV, 1 hit
PIRSFiPIRSF016408 PAGM, 1 hit
SUPFAMiSSF53738 SSF53738, 4 hits
SSF55957 SSF55957, 1 hit
PROSITEiView protein in PROSITE
PS00710 PGM_PMM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAGM1_ENCCU
AccessioniPrimary (citable) accession number: Q8SSL7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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