Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 89 (07 Oct 2020)
Sequence version 2 (29 May 2013)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Probable myosin heavy chain ECU04_1000

Gene

ECU04_1000

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi146 – 153ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Motor protein, Myosin
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable myosin heavy chain ECU04_1000
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:ECU04_1000
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284813 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiFungi incertae sedisMicrosporidiaUnikaryonidaeEncephalitozoon
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000819 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
MicrosporidiaDB:ECU04_1000

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003833311 – 1649Probable myosin heavy chain ECU04_1000Add BLAST1649

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q8SS35

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in late sporogonial stages.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8SS35

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 49Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST49
Domaini53 – 724Myosin motorPROSITE-ProRule annotationAdd BLAST672

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni594 – 616Actin-bindingPROSITE-ProRule annotationAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili793 – 1614Sequence analysisAdd BLAST822

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000192_7_14_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8SS35

KEGG Orthology (KO)

More...
KOi
K10352

Database of Orthologous Groups

More...
OrthoDBi
119761at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.360, 1 hit
3.40.850.10, 1 hit
4.10.270.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036961, Kinesin_motor_dom_sf
IPR001609, Myosin_head_motor_dom
IPR027401, Myosin_IQ_contain_sf
IPR004009, Myosin_N
IPR008989, Myosin_S1_N
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00063, Myosin_head, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00193, MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00242, MYSc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51456, MYOSIN_MOTOR, 1 hit
PS51844, SH3_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8SS35-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKKWVWAPS SKEAYVCGFV VKEEGDVLEI DCRGVIVRHK SCEVFRMNPP
60 70 80 90 100
KFDMVDDLAE LSYLNEPGVL HNLRRRYQNG RIYTYSGLFL LAINPYKDLR
110 120 130 140 150
IYGEKDARKY TLSKKYELEP HIFAVANEAY RLMLSNRENQ SILITGESGA
160 170 180 190 200
GKTENTKRVV EFLAMVGGCK GMEVSIDRQI IDANPILEAF GNAQTVKNDN
210 220 230 240 250
SSRFGKFIKI KFNGGNICGA HIEKYLLEKS RVTSQNRNER NYHIFYQLLG
260 270 280 290 300
CDDQMLKKQL FLDGEPKDYR FLKDSRFKIP DVDDAKEFRS LRESMRVLGI
310 320 330 340 350
GEEEQIGYFK IVSAILHLGN IEFREKDGAA EIANLDVAEK ACKLLSIPLA
360 370 380 390 400
EFIKRLIHPV IKAGNEYVAH SRSREQALKI VDGLSRILYD KMFEGVIDRI
410 420 430 440 450
NMSLDSPHKG NFIGVLDIAG FEIFEKNSFE QLCINYTNEK LQQFFNHHMF
460 470 480 490 500
ILEQEVYRQE NIEWDFIDFG LDLQPTIDLI EKSNPIGILS YLDEECVMPM
510 520 530 540 550
ATEKTFLGKL MKNIRDEKFE VDKIRDAFVL NHYAGDVEYT VDDWLSKNKD
560 570 580 590 600
SHSEALTSLI RASGSELVSR LSLNEEAVKK GFFRTVSQKH KEQLASLMSE
610 620 630 640 650
LRRTNPHFVR CIIPNLEKSG EHLDNGIVLG QLKCNGVLEG IRISRQGFPS
660 670 680 690 700
RMGHREFVQR YRIMMKEKIL VDESWDEGVC MELYKEIGGK ILSEIGISTS
710 720 730 740 750
QYRLGRTKVF FRQGVLADIE DMRDVKVSEV VKEIQALIRR RLAFRKYNQA
760 770 780 790 800
QRRMQGILVI QRNGRICCDL QRWNWWRLYL KIKPLLDVRK RDGEMKEKEA
810 820 830 840 850
MIQEYARMLD AEKSRREEVE DMLKAMSLKR ELLEKSVEDE KRFSMEKDEL
860 870 880 890 900
LMALRYKSDE TAQELEKARK EVFDGHEERK MWETRVNEVA IQLEEKDSEI
910 920 930 940 950
LRLRREVSEQ KGALSQQEKE ICSLREEVVS KLSEKDAMVE KMLRERDSEV
960 970 980 990 1000
QALKEKVKEK DAEVERILEG MKRMEREGEE RNRMLKENES TIDELRTRCL
1010 1020 1030 1040 1050
NMKRWKDEYA ELREDYEALQ KKLKDEVEDM QVENDRLHNE IRKISKEREE
1060 1070 1080 1090 1100
LGRMQKKLLD DLEFERNRGS KLEKAFQELR GEYEAVEGQL QKERQFRDST
1110 1120 1130 1140 1150
QESLLEKTRG LERRVKSLNE KLRREEMANR QLMSEKDEMY REIHVLQQSK
1160 1170 1180 1190 1200
LDEIFDREAG FNSIKKNLQM EIQRLEMENQ RLSVDLMEAK CMGEASEESI
1210 1220 1230 1240 1250
SATERFCGML EEERKKRKEI EYQASEHENR NVILSSEVEM LREMVEMERR
1260 1270 1280 1290 1300
SKEEVIRGHE KETGLCKAIA GVRKEVEDLG NEIDMAIEGF NGMYLNVLDG
1310 1320 1330 1340 1350
YKRDLKECKE QVMSKEQVIE ELNGRIVRLG REVEERKEIE EEMSRKVHGL
1360 1370 1380 1390 1400
MKQYNGVMND FSLLSTKCSS LERTVSEKEE EIKGYSERCS EYDKRFEGLV
1410 1420 1430 1440 1450
CRVDEEIENL RRSDEERRRC VEKLESGLNG SIAGIRKLDE RYKARIEECA
1460 1470 1480 1490 1500
QSVLDGERRK LKAMEELCEQ LSKKLGELEE EHQGLLDEKM KGLLRIEQLE
1510 1520 1530 1540 1550
GELCAFRESE VHRQDMISMY ESEISTLKRC TRFKDEVLGS LSGERNPVVV
1560 1570 1580 1590 1600
HVSDKEKCQV LDRKRMTVEH ELARANDERQ SLMAINKKLR EEVEKLRGEI
1610 1620 1630 1640
DAGRSKMLEM KKKLGCQSLA VGHLSRELEE EREMVRFFRT LGGARKKKV
Length:1,649
Mass (Da):193,288
Last modified:May 29, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFCFF7BA673B391DE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL590444 Genomic DNA Translation: CAD25287.2

NCBI Reference Sequences

More...
RefSeqi
NP_584783.1, NM_001041133.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
858931

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecu:ECU04_1000

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590444 Genomic DNA Translation: CAD25287.2
RefSeqiNP_584783.1, NM_001041133.1

3D structure databases

SMRiQ8SS35
ModBaseiSearch...

Proteomic databases

PRIDEiQ8SS35

Genome annotation databases

GeneIDi858931
KEGGiecu:ECU04_1000

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU04_1000

Phylogenomic databases

HOGENOMiCLU_000192_7_14_1
InParanoidiQ8SS35
KOiK10352
OrthoDBi119761at2759

Family and domain databases

Gene3Di2.30.30.360, 1 hit
3.40.850.10, 1 hit
4.10.270.10, 1 hit
InterProiView protein in InterPro
IPR036961, Kinesin_motor_dom_sf
IPR001609, Myosin_head_motor_dom
IPR027401, Myosin_IQ_contain_sf
IPR004009, Myosin_N
IPR008989, Myosin_S1_N
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF00063, Myosin_head, 1 hit
PRINTSiPR00193, MYOSINHEAVY
SMARTiView protein in SMART
SM00242, MYSc, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51456, MYOSIN_MOTOR, 1 hit
PS51844, SH3_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiY4A0_ENCCU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8SS35
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: May 29, 2013
Last modified: October 7, 2020
This is version 89 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again