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Protein

Neuronal acetylcholine receptor subunit alpha-5

Gene

CHRNA5

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
R-BTA-629597 Highly calcium permeable nicotinic acetylcholine receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal acetylcholine receptor subunit alpha-5
Gene namesi
Name:CHRNA5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 21

Organism-specific databases

VGNCiVGNC:27327 CHRNA5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 261ExtracellularBy similarityAdd BLAST232
Transmembranei262 – 282HelicalSequence analysisAdd BLAST21
Transmembranei289 – 309HelicalSequence analysisAdd BLAST21
Transmembranei324 – 344HelicalSequence analysisAdd BLAST21
Topological domaini345 – 437CytoplasmicBy similarityAdd BLAST93
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Topological domaini459 – 475ExtracellularBy similarityAdd BLAST17

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000024464630 – 475Neuronal acetylcholine receptor subunit alpha-5Add BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi177 ↔ 191By similarity
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi236N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi241 ↔ 242Associated with receptor activationBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8SPU7

Expressioni

Gene expression databases

BgeeiENSBTAG00000013657
ExpressionAtlasiQ8SPU7 baseline

Interactioni

Subunit structurei

Neuronal AChR seems to be composed of two different types of subunits: alpha and non-alpha (beta). Interacts with LYPD6.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000055853

Structurei

3D structure databases

ProteinModelPortaliQ8SPU7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
GeneTreeiENSGT00760000118930
HOGENOMiHOG000006756
HOVERGENiHBG003756
InParanoidiQ8SPU7
KOiK04807
OMAiRYFTQKE

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 2 hits
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8SPU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPGWGRWV LGLGPLLLQV FLPFQLVAGR WGPEGAGGGV RRGLAEPSVV
60 70 80 90 100
AKHEDSLFKD LFQDYERWVR PVEHLNDRIK IKFGLAISQL VDVDEKNQLM
110 120 130 140 150
TTNVWLKQEW IDVKLRWNPD DYGGIKLIRV PSDSLWTPDI VLFDNADGRF
160 170 180 190 200
EGASTKTVVR YDGTVTWTPP ANYKSSCTID VTFFPFDLQN CSMKFGSWTY
210 220 230 240 250
DGSQVDIILE DQDVDKRDFF DNGEWEIVSA TGSKGNRTDS CCWYPYITYS
260 270 280 290 300
FVIKRLPLFY TLFLIIPCIG LSFLTVLVFY LPSNEGEKIC LCTSVLVSLT
310 320 330 340 350
VFLLVIEEII PSSSKVIPLI GEYLVFTMIF VTLSIMVTVF AINIHHRSSS
360 370 380 390 400
THDAMAPWVR KIFLHKLPKL LCMRSHVDRY FSQKEEARSS RGPRSSRNAL
410 420 430 440 450
EAALDSVRYI TRHVMKETDV REVVEDWKFI AQVLDRMFLW TFLLVSVVGS
460 470
LGLFVPVIYK WANIIVPIHI GNENK
Length:475
Mass (Da):54,260
Last modified:June 1, 2002 - v1
Checksum:i24658023DF0E3D1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF487464 mRNA Translation: AAL88711.1
RefSeqiNP_776939.1, NM_174514.2
UniGeneiBt.9979

Genome annotation databases

EnsembliENSBTAT00000018151; ENSBTAP00000018151; ENSBTAG00000013657
GeneIDi282177
KEGGibta:282177

Similar proteinsi

Entry informationi

Entry nameiACHA5_BOVIN
AccessioniPrimary (citable) accession number: Q8SPU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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